WO2002018052A1 - Positioniervorrichtung für mikrotiterplatten - Google Patents
Positioniervorrichtung für mikrotiterplatten Download PDFInfo
- Publication number
- WO2002018052A1 WO2002018052A1 PCT/EP2001/008997 EP0108997W WO0218052A1 WO 2002018052 A1 WO2002018052 A1 WO 2002018052A1 EP 0108997 W EP0108997 W EP 0108997W WO 0218052 A1 WO0218052 A1 WO 0218052A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- positioning device
- microtiter plate
- holding frame
- support surface
- microtiter plates
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
- B01L9/523—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for multisample carriers, e.g. used for microtitration plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00315—Microtiter plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0829—Multi-well plates; Microtitration plates
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
Definitions
- the invention relates to a positioning device for microtiter plates made of glass.
- sample containers usually used in such analyzes consist of many small microreactors, which are arranged in the form of a rectangular, flat disk. For economic or manufacturing reasons such sample containers are mainly made of plastic.
- microtiter plates made of glass are used in this case, for example.
- These microtiter plates can consist of a special glass plate into which a large number of cavities have been etched using a photochemical process.
- the production of a photo-structured special glass plate that corresponds to the external dimensions of the international standards prescribed for use in automated analysis devices is difficult to achieve for technical reasons.
- glass microtiter plates are relatively susceptible to mechanical stress, such as can occur during use in an automated analysis device or during transport within the laboratory. For economic reasons, such glass microtiter plates are often used several times. Then, especially when cleaning microtiter plates made of glass, high mechanical stresses occur.
- the object of the invention is therefore to design a positioning device for holding microtiter plates made of glass in such a way that an exact positioning of the microtiter plates made of glass for use in automated analysis devices is possible such that the inserted microtiter plates plate is adequately protected from mechanical damage and the microplate can be easily inserted and removed without the need for additional tools.
- the solution to this problem according to the invention is based on a positioning device for microtiter plates made of glass with a holding frame, with a support surface at least partially surrounded by lateral elevations for receiving the microtiter plate and with spring elements pressing against the microtiter plate.
- the glass microtiter plate inserted in the holding frame rests securely on the support surface provided.
- the spring elements make the microtiter plate reproducible and sufficiently firmly positioned within the holding frame.
- the external dimensions of the positioning device are expediently adapted to the requirements of the international standards, so that the positioning device can be used in automated analysis devices without problems.
- the dimensions of the support surface can be chosen freely, so that significantly smaller and thus much cheaper microtiter plates can be used for the automated analysis methods.
- the holding frame has inwardly projecting projections above the support surface of the microtiter plate. These inward protrusions above the support surface encompass the inserted microtiter plate and thus prevent it from accidentally falling out.
- the spring elements are designed as resilient locking tongues.
- the pressing spring elements hold the microtiter plate in the intended position in the holding frame solely by means of the non-positive connection.
- the spring elements designed as latching tongues encompass the inserted microtiter plate and thus prevent it from slipping unintentionally even when subjected to heavy loads, such as in the case of unintentional impacts. This latching gripping of the microtiter plate by the spring elements designed as latching tongues can easily be released again by pressing the spring elements sideways and removing the microtiter plate.
- the holding frame has a continuous recess in the area of the support surface.
- Many reactions can be evaluated relatively easily, for example on the basis of discoloration of the sample material.
- Such an evaluation is considerably simplified since, as a result of the recess, the microtiter plate can be freely viewed from both sides and simple, automatable evaluation methods, such as, for example, transmitted light measurements, can be used.
- the positioning device consists essentially of plastic or a metal.
- the production can then preferably be made as an inexpensive molded part from various commercially available plastics in accordance with the chemical requirements.
- a holding frame made of plastic causes due to its much smaller Hardness no signs of wear on the inserted microtiter plate.
- Fig. 1 is a view of the positioning device
- Fig. 2 is a view of the positioning device with an inserted microtiter plate.
- the positioning device shown in both figures has an essentially rectangular, flat holding frame 1.
- the holding frame 1 has a support surface 2.
- This support surface 2 provided for receiving a microtiter plate 3 made of glass is delimited from three sides by side elevations 4 of the holding frame 1.
- On the fourth side in the exemplary embodiment shown, a short end face, the bearing surface 2 is not delimited by a lateral elevation 4. From this side, the microtiter plate 3 can be pushed laterally onto the support surface 2 like a drawer.
- the side elevations 4 are designed as resilient locking tongues 5. These are slightly bent back during the insertion of the microtiter plate 3 and engage when the microtiter plate 3 has reached the intended position on the support surface 2.
- the resilient latching tongues 5 prevent the microtiter plate made of glass 3 from slipping in the holding frame 1. By slightly bending the resilient latching tongues 5 to the side, the microtiter plate 3 is released and can be easily removed again.
- inwardly projecting projections 6 are formed on the lateral elevations 4 above the support surface 2. These serve to improve the guidance of the microtiter plate 3 during insertion into the holding frame 1 and prevent the microtiter plate 3 from accidentally falling out.
- the holding frame 1 has a continuous recess 7 in the area of the support surface 2.
- the dimensions of the recess 7 are smaller than those of the microtiter plate 3, so that the remaining support surface 2 thereby essentially forms a circumferential frame.
- the microtiter plate 3 rests securely on the support surface 2 designed as a peripheral frame, the individual reaction cavities are freely visible from both sides and are accessible to automatic evaluation methods.
- the positioning device can be inexpensively manufactured as a one-piece injection molding process from commercially available plastics. For special applications, however, production from high-quality special plastics by machining is also conceivable.
Landscapes
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Sampling And Sample Adjustment (AREA)
- Devices For Use In Laboratory Experiments (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002523016A JP2004521316A (ja) | 2000-09-01 | 2001-08-03 | マイクロタイタープレート用の位置決め装置 |
EP01965169A EP1318870A1 (de) | 2000-09-01 | 2001-08-03 | Positioniervorrichtung für mikrotiterplatten |
AU2001285870A AU2001285870A1 (en) | 2000-09-01 | 2001-08-03 | Positioning device for microtiter plates |
KR10-2003-7002860A KR20030041134A (ko) | 2000-09-01 | 2001-08-03 | 마이크로티터 판용 위치결정 장치 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10042999.8 | 2000-09-01 | ||
DE10042999A DE10042999A1 (de) | 2000-09-01 | 2000-09-01 | Positioniervorrichtung |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002018052A1 true WO2002018052A1 (de) | 2002-03-07 |
Family
ID=7654561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2001/008997 WO2002018052A1 (de) | 2000-09-01 | 2001-08-03 | Positioniervorrichtung für mikrotiterplatten |
Country Status (7)
Country | Link |
---|---|
US (1) | US20030184745A1 (de) |
EP (1) | EP1318870A1 (de) |
JP (1) | JP2004521316A (de) |
KR (1) | KR20030041134A (de) |
AU (1) | AU2001285870A1 (de) |
DE (1) | DE10042999A1 (de) |
WO (1) | WO2002018052A1 (de) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009152092A2 (en) * | 2008-06-09 | 2009-12-17 | Qiagen Gaithersburg, Inc. | Magnetic microplate assembly |
DE102019109207B3 (de) * | 2019-04-08 | 2020-06-18 | Leica Microsystems Cms Gmbh | Vorrichtung zur Aufnahme von Proben in einem Mikroskop |
GB2603460A (en) * | 2021-01-22 | 2022-08-10 | Randox Teoranta | Bracket |
GB2625130A (en) * | 2022-12-08 | 2024-06-12 | Charles Reardon Paul | Microplate |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050030615A1 (en) * | 2003-08-06 | 2005-02-10 | Jiming Mei | Measured array for slides |
JP2006126066A (ja) * | 2004-10-29 | 2006-05-18 | Shimadzu Corp | マイクロタイタープレート用のアダプタ |
WO2011127390A2 (en) * | 2010-04-09 | 2011-10-13 | Luminex Corporation | Magnetic separation device |
US8790599B2 (en) | 2012-08-13 | 2014-07-29 | David Childs | Microtiter plate system and method |
CH708820A1 (de) * | 2013-11-07 | 2015-05-15 | Tecan Trading Ag | Inkubationskassette. |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4159875A (en) * | 1976-10-21 | 1979-07-03 | Abbott Laboratories | Specimen holder |
US5592289A (en) * | 1995-01-09 | 1997-01-07 | Molecular Dynamics | Self-aligning mechanism for positioning analyte receptacles |
WO1999004228A2 (en) * | 1997-07-16 | 1999-01-28 | Ljl Biosystems, Inc. | Light detection device |
US5993746A (en) * | 1995-09-22 | 1999-11-30 | Labsystems Oy | Plate holder |
EP1111391A1 (de) * | 1999-12-21 | 2001-06-27 | Tecan Schweiz AG | Klemmvorrichtung zur Aufnahme und genauer Positionierung eines Gegenstandes, vorzüglich einer Mikrotiterplatte, sowie Verfahren zu ihrem Betrieb |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4682891A (en) * | 1985-05-31 | 1987-07-28 | Health Research, Incorporated | Microcircle system |
SE506755C2 (sv) * | 1996-04-15 | 1998-02-09 | Med Ai Europ Ab | Anordning för optisk analys av ett prov |
US5882603A (en) * | 1997-10-15 | 1999-03-16 | Point Plastics Incorporated | Support rack for pipette tips |
US6118582A (en) * | 1999-07-12 | 2000-09-12 | Immuno Concepts, Inc. | Slide holder |
-
2000
- 2000-09-01 DE DE10042999A patent/DE10042999A1/de not_active Ceased
-
2001
- 2001-08-03 AU AU2001285870A patent/AU2001285870A1/en not_active Abandoned
- 2001-08-03 JP JP2002523016A patent/JP2004521316A/ja active Pending
- 2001-08-03 WO PCT/EP2001/008997 patent/WO2002018052A1/de not_active Application Discontinuation
- 2001-08-03 KR KR10-2003-7002860A patent/KR20030041134A/ko not_active Application Discontinuation
- 2001-08-03 EP EP01965169A patent/EP1318870A1/de not_active Withdrawn
- 2001-08-03 US US10/362,992 patent/US20030184745A1/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4159875A (en) * | 1976-10-21 | 1979-07-03 | Abbott Laboratories | Specimen holder |
US5592289A (en) * | 1995-01-09 | 1997-01-07 | Molecular Dynamics | Self-aligning mechanism for positioning analyte receptacles |
US5993746A (en) * | 1995-09-22 | 1999-11-30 | Labsystems Oy | Plate holder |
WO1999004228A2 (en) * | 1997-07-16 | 1999-01-28 | Ljl Biosystems, Inc. | Light detection device |
EP1111391A1 (de) * | 1999-12-21 | 2001-06-27 | Tecan Schweiz AG | Klemmvorrichtung zur Aufnahme und genauer Positionierung eines Gegenstandes, vorzüglich einer Mikrotiterplatte, sowie Verfahren zu ihrem Betrieb |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009152092A2 (en) * | 2008-06-09 | 2009-12-17 | Qiagen Gaithersburg, Inc. | Magnetic microplate assembly |
WO2009152092A3 (en) * | 2008-06-09 | 2010-04-01 | Qiagen Gaithersburg, Inc. | Magnetic microplate assembly |
US8647593B2 (en) | 2008-06-09 | 2014-02-11 | Qiagen Gaithersburg, Inc. | Magnetic microplate assembly |
AU2009257644B2 (en) * | 2008-06-09 | 2015-05-07 | Qiagen Gaithersburg, Inc. | Magnetic microplate assembly |
US9079183B2 (en) | 2008-06-09 | 2015-07-14 | Qiagen Gaithersburg, Inc. | Magnetic microplate assembly |
DE102019109207B3 (de) * | 2019-04-08 | 2020-06-18 | Leica Microsystems Cms Gmbh | Vorrichtung zur Aufnahme von Proben in einem Mikroskop |
GB2603460A (en) * | 2021-01-22 | 2022-08-10 | Randox Teoranta | Bracket |
GB2625130A (en) * | 2022-12-08 | 2024-06-12 | Charles Reardon Paul | Microplate |
Also Published As
Publication number | Publication date |
---|---|
US20030184745A1 (en) | 2003-10-02 |
DE10042999A1 (de) | 2002-03-14 |
KR20030041134A (ko) | 2003-05-23 |
EP1318870A1 (de) | 2003-06-18 |
AU2001285870A1 (en) | 2002-03-13 |
JP2004521316A (ja) | 2004-07-15 |
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