WO2002016338A1 - Aminoalkenylbenzoyl-benzofuranes ou benzothiophenes, leur procede de preparation et les compositions les contenant - Google Patents

Aminoalkenylbenzoyl-benzofuranes ou benzothiophenes, leur procede de preparation et les compositions les contenant Download PDF

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Publication number
WO2002016338A1
WO2002016338A1 PCT/FR2001/002656 FR0102656W WO0216338A1 WO 2002016338 A1 WO2002016338 A1 WO 2002016338A1 FR 0102656 W FR0102656 W FR 0102656W WO 0216338 A1 WO0216338 A1 WO 0216338A1
Authority
WO
WIPO (PCT)
Prior art keywords
group
benzofuran
compound
general formula
compounds
Prior art date
Application number
PCT/FR2001/002656
Other languages
English (en)
French (fr)
Other versions
WO2002016338A8 (fr
Inventor
Jean-Louis Assens
Claude Bernhart
Frédérique Cabanel-Haudricourt
Victor Dos Santos
Patrick Gautier
Dino Nisato
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU2001284154A priority Critical patent/AU2001284154A1/en
Priority to CA002415846A priority patent/CA2415846A1/fr
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Priority to SK211-2003A priority patent/SK2112003A3/sk
Priority to KR10-2003-7002619A priority patent/KR20030023768A/ko
Priority to AT01963120T priority patent/ATE273293T1/de
Priority to MXPA03001592A priority patent/MXPA03001592A/es
Priority to DE60104866T priority patent/DE60104866T2/de
Priority to EA200300063A priority patent/EA200300063A1/ru
Priority to PL01362123A priority patent/PL362123A1/xx
Priority to JP2002521439A priority patent/JP4918209B2/ja
Priority to EP01963120A priority patent/EP1315708B1/fr
Priority to HU0302892A priority patent/HUP0302892A3/hu
Priority to US10/362,291 priority patent/US6946483B2/en
Priority to IL15363701A priority patent/IL153637A0/xx
Priority to BR0113350-0A priority patent/BR0113350A/pt
Publication of WO2002016338A1 publication Critical patent/WO2002016338A1/fr
Publication of WO2002016338A8 publication Critical patent/WO2002016338A8/fr
Priority to IS6676A priority patent/IS6676A/is
Priority to BG107553A priority patent/BG107553A/xx
Priority to NO20030801A priority patent/NO20030801L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
PCT/FR2001/002656 2000-08-23 2001-08-23 Aminoalkenylbenzoyl-benzofuranes ou benzothiophenes, leur procede de preparation et les compositions les contenant WO2002016338A1 (fr)

Priority Applications (18)

Application Number Priority Date Filing Date Title
EP01963120A EP1315708B1 (fr) 2000-08-23 2001-08-23 Aminoalkenylbenzoyl-benzofuranes ou benzothiophenes, leur procede de preparation et les compositions les contenant
JP2002521439A JP4918209B2 (ja) 2000-08-23 2001-08-23 アミノアルケニルベンゾイル−ベンゾフランまたはベンゾチオフェン誘導体、その製造方法およびそれを含む組成物
HU0302892A HUP0302892A3 (en) 2000-08-23 2001-08-23 Aminoalkenylbenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same
CA002415846A CA2415846A1 (fr) 2000-08-23 2001-08-23 Aminoalkenylbenzoyl-benzofuranes ou benzothiophenes, leur procede de preparation et les compositions les contenant
AT01963120T ATE273293T1 (de) 2000-08-23 2001-08-23 Aminoalkenylbenzoyl-benzofurane oder benzothiophene, verfahren zur ihrer herstellung und sie enthaltende zubereitungen
MXPA03001592A MXPA03001592A (es) 2000-08-23 2001-08-23 Benzotiofenos o benzofuranos de aminoalquenilbenzoil, metodo para preparar los mismos y composiciones que los contienen.
DE60104866T DE60104866T2 (de) 2000-08-23 2001-08-23 Aminoalkenylbenzoyl-benzofurane oder benzothiophene, verfahren zur ihrer herstellung und sie enthaltende zubereitungen
EA200300063A EA200300063A1 (ru) 2000-08-23 2001-08-23 Производные аминоалкенилбензоил-бензофурана или бензотиофена, способы их получения и содержащие их композиции
PL01362123A PL362123A1 (en) 2000-08-23 2001-08-23 Aminoalkenylbenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same
AU2001284154A AU2001284154A1 (en) 2000-08-23 2001-08-23 Aminoalkenylbenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same
KR10-2003-7002619A KR20030023768A (ko) 2000-08-23 2001-08-23 아미노알케닐벤조일―벤조푸란 또는 벤조티오펜 유도체,그의 제조 방법 및 그를 포함하는 조성물
SK211-2003A SK2112003A3 (en) 2000-08-23 2001-08-23 Aminoalkenylbenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same
US10/362,291 US6946483B2 (en) 2000-08-23 2001-08-23 Aminoalkenylbenzoyl-benzofuran or benzothiophene, method for preparing same and compositions containing same
IL15363701A IL153637A0 (en) 2000-08-23 2001-08-23 Aminoalkenylbenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same
BR0113350-0A BR0113350A (pt) 2000-08-23 2001-08-23 Aminoalquenilbenzoil-benzofuranos ou benzotiofenos, seu processo de preparação e as composições que os contêm
IS6676A IS6676A (is) 2000-08-23 2003-01-13 Amínóalkenýlbensóýl-bensófúran eða bensóþíófenafleiður, aðferð til framleiðslu þeirra og samsetningar sem innihalda þær
BG107553A BG107553A (en) 2000-08-23 2003-02-13 Aminoalkenylbenzoyl-benzofuran or benzothiophene derivatives, methods for preparing same and compositions containing same
NO20030801A NO20030801L (no) 2000-08-23 2003-02-20 Aminoalkenylbenzoyl-benzofuran- eller benzotiofenderivater, fremgangsmåte for deres fremstilling og preparater inneholdende de samme

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR00/10835 2000-08-23
FR0010835A FR2813307B1 (fr) 2000-08-23 2000-08-23 Aminoalkenylbenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation et les compositions les contenant

Publications (2)

Publication Number Publication Date
WO2002016338A1 true WO2002016338A1 (fr) 2002-02-28
WO2002016338A8 WO2002016338A8 (fr) 2002-05-10

Family

ID=8853675

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2001/002656 WO2002016338A1 (fr) 2000-08-23 2001-08-23 Aminoalkenylbenzoyl-benzofuranes ou benzothiophenes, leur procede de preparation et les compositions les contenant

Country Status (25)

Country Link
US (1) US6946483B2 (US06946483-20050920-C00065.png)
EP (1) EP1315708B1 (US06946483-20050920-C00065.png)
JP (1) JP4918209B2 (US06946483-20050920-C00065.png)
KR (1) KR20030023768A (US06946483-20050920-C00065.png)
CN (1) CN1471519A (US06946483-20050920-C00065.png)
AT (1) ATE273293T1 (US06946483-20050920-C00065.png)
AU (1) AU2001284154A1 (US06946483-20050920-C00065.png)
BG (1) BG107553A (US06946483-20050920-C00065.png)
BR (1) BR0113350A (US06946483-20050920-C00065.png)
CA (1) CA2415846A1 (US06946483-20050920-C00065.png)
CZ (1) CZ2003520A3 (US06946483-20050920-C00065.png)
DE (1) DE60104866T2 (US06946483-20050920-C00065.png)
EA (1) EA200300063A1 (US06946483-20050920-C00065.png)
FR (1) FR2813307B1 (US06946483-20050920-C00065.png)
HU (1) HUP0302892A3 (US06946483-20050920-C00065.png)
IL (1) IL153637A0 (US06946483-20050920-C00065.png)
IS (1) IS6676A (US06946483-20050920-C00065.png)
MA (1) MA26944A1 (US06946483-20050920-C00065.png)
MX (1) MXPA03001592A (US06946483-20050920-C00065.png)
NO (1) NO20030801L (US06946483-20050920-C00065.png)
OA (1) OA12358A (US06946483-20050920-C00065.png)
PL (1) PL362123A1 (US06946483-20050920-C00065.png)
SK (1) SK2112003A3 (US06946483-20050920-C00065.png)
WO (1) WO2002016338A1 (US06946483-20050920-C00065.png)
ZA (1) ZA200300746B (US06946483-20050920-C00065.png)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG173014A1 (en) 2009-01-16 2011-08-29 Exelixis Inc Malate salt of n- (4- { [ 6, 7-bis (methyloxy) quin0lin-4-yl] oxy}phenyl)-n' - (4 -fluorophenyl) cyclopropane-1,1-dicarboxamide, and crystalline forms therof for the treatment of cancer
AU2011202542A1 (en) 2010-07-14 2012-02-02 Indian Institute Of Science Benzothiophene carboxamide compounds, composition and applications thereof
CN107935972B (zh) * 2017-11-14 2020-06-02 沈阳药科大学 5-[2-羟基-3-(异丙胺基)丙氧基]苯并呋喃类衍生物及其应用
CN107857748B (zh) * 2017-11-14 2020-06-02 沈阳药科大学 5-[2-羟基-3-(烷胺基)丙氧基]苯并呋喃类化合物及其应用
CN107827849B (zh) * 2017-11-14 2020-06-02 沈阳药科大学 6-[2-羟基-3-(烷胺基)丙氧基]苯并呋喃类化合物及其应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996028152A1 (en) * 1995-03-10 1996-09-19 Eli Lilly And Company Novel benzofuran pharmaceutical compounds
WO1997001549A1 (en) * 1995-06-26 1997-01-16 Eli Lilly And Company Benzothiophene compounds
US5622974A (en) * 1995-03-10 1997-04-22 Eli Lilly And Company α-substituted-3-benzyl-benzofurans
US5827876A (en) * 1996-04-09 1998-10-27 American Home Products Corporation Inhibition of bone loss by 3-(4-acrylamidobenzoyl) benzo b!-thiophenes
WO1999054325A1 (fr) * 1998-04-17 1999-10-28 Senga Pharmaceutical Laboratory Inc. Derives 1-heteroindene et compositions medicinales a base de tels derives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3248401A (en) * 1966-04-26 Diethylaminoe hoxybenzoyl benzofurans
US4831054A (en) * 1988-04-18 1989-05-16 Taro Pharmaceuticals, Ltd. 2-Alkyl-3-benzoylbenzofurans useful for treating cardiac arrhythmia
AT391316B (de) * 1988-09-15 1990-09-25 Ebewe Arzneimittel Neue thienyloxy-alkylamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
FR2665444B1 (fr) * 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
US5364880A (en) * 1993-06-16 1994-11-15 Advanced Therapies, Inc. Compound for treatment of cardiac arrhythmia, synthesis, and methods of use
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996028152A1 (en) * 1995-03-10 1996-09-19 Eli Lilly And Company Novel benzofuran pharmaceutical compounds
US5622974A (en) * 1995-03-10 1997-04-22 Eli Lilly And Company α-substituted-3-benzyl-benzofurans
WO1997001549A1 (en) * 1995-06-26 1997-01-16 Eli Lilly And Company Benzothiophene compounds
US5827876A (en) * 1996-04-09 1998-10-27 American Home Products Corporation Inhibition of bone loss by 3-(4-acrylamidobenzoyl) benzo b!-thiophenes
WO1999054325A1 (fr) * 1998-04-17 1999-10-28 Senga Pharmaceutical Laboratory Inc. Derives 1-heteroindene et compositions medicinales a base de tels derives

Also Published As

Publication number Publication date
CN1471519A (zh) 2004-01-28
HUP0302892A2 (hu) 2003-12-29
EP1315708B1 (fr) 2004-08-11
US6946483B2 (en) 2005-09-20
DE60104866D1 (de) 2004-09-16
ATE273293T1 (de) 2004-08-15
CZ2003520A3 (cs) 2003-05-14
ZA200300746B (en) 2004-02-10
MA26944A1 (fr) 2004-12-20
EP1315708A1 (fr) 2003-06-04
SK2112003A3 (en) 2003-08-05
US20030187060A1 (en) 2003-10-02
WO2002016338A8 (fr) 2002-05-10
AU2001284154A1 (en) 2002-03-04
EA200300063A1 (ru) 2003-08-28
HUP0302892A3 (en) 2005-02-28
NO20030801D0 (no) 2003-02-20
IS6676A (is) 2003-01-13
BG107553A (en) 2004-01-30
JP2004506726A (ja) 2004-03-04
BR0113350A (pt) 2003-07-08
IL153637A0 (en) 2003-07-06
KR20030023768A (ko) 2003-03-19
OA12358A (fr) 2006-05-16
MXPA03001592A (es) 2003-09-10
NO20030801L (no) 2003-04-23
CA2415846A1 (fr) 2002-02-28
PL362123A1 (en) 2004-10-18
DE60104866T2 (de) 2005-10-20
FR2813307B1 (fr) 2002-11-08
FR2813307A1 (fr) 2002-03-01
JP4918209B2 (ja) 2012-04-18

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