WO2002014344A3 - Phosphonamides cycliques derives d'acides amines et procedes de synthese associes - Google Patents

Phosphonamides cycliques derives d'acides amines et procedes de synthese associes Download PDF

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Publication number
WO2002014344A3
WO2002014344A3 PCT/US2001/041606 US0141606W WO0214344A3 WO 2002014344 A3 WO2002014344 A3 WO 2002014344A3 US 0141606 W US0141606 W US 0141606W WO 0214344 A3 WO0214344 A3 WO 0214344A3
Authority
WO
WIPO (PCT)
Prior art keywords
phosphonamide
amino acid
ring
synthesizing
methods
Prior art date
Application number
PCT/US2001/041606
Other languages
English (en)
Other versions
WO2002014344A2 (fr
Inventor
Paul R Hanson
Kevin T Sprott
Matthew D Mcreynolds
Original Assignee
Univ Kansas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Kansas filed Critical Univ Kansas
Priority to CA2419775A priority Critical patent/CA2419775C/fr
Priority to DK01964579.5T priority patent/DK1311515T3/da
Priority to EP01964579A priority patent/EP1311515B1/fr
Priority to DE60141757T priority patent/DE60141757D1/de
Priority to AT01964579T priority patent/ATE463500T1/de
Priority to AU2001285418A priority patent/AU2001285418A1/en
Priority to JP2002519481A priority patent/JP5249486B2/ja
Publication of WO2002014344A2 publication Critical patent/WO2002014344A2/fr
Publication of WO2002014344A3 publication Critical patent/WO2002014344A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2462—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of unsaturated acyclic amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/26—Amides of acids of phosphorus containing P-halide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65848—Cyclic amide derivatives of acids of phosphorus, in which two nitrogen atoms belong to the ring

Abstract

L'invention concerne de nouveaux composés phosphonamides et des procédés de formation de ces composés. Dans un mode de réalisation, selon l'invention, ces procédés consistent à soumettre un modèle de phosphonamide à cycle ouvert à une réaction de métathèse de cyclisation en présence d'un catalyseur de fermeture de cycle (par ex. un catalyseur de Grubbs) afin d'obtenir un phosphonamide. Dans un autre mode de réalisation, selon l'invention, ces procédés consistent à faire réagir une structure modèle avec un composé de phosphore (III) afin d'obtenir le phosphonamide. De façon avantageuse, dans l'un ou l'autre de ces modes de réalisation, les structures modèles peuvent être dotées d'une grande gamme de groupes fonctionnels (par ex. chaînes latérales d'acides aminés, peptides) sélectionnés afin de conférer des propriétés particulières à ce composé.
PCT/US2001/041606 2000-08-15 2001-08-06 Phosphonamides cycliques derives d'acides amines et procedes de synthese associes WO2002014344A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA2419775A CA2419775C (fr) 2000-08-15 2001-08-06 Phosphonamides cycliques derives d'acides amines et procedes de synthese associes
DK01964579.5T DK1311515T3 (da) 2000-08-15 2001-08-06 Aminosyreafledte cykliske phosphonamider og fremgangsmåder til syntese deraf
EP01964579A EP1311515B1 (fr) 2000-08-15 2001-08-06 Phosphonamides cycliques derives d'acides amines et procedes de synthese associes
DE60141757T DE60141757D1 (de) 2000-08-15 2001-08-06 Von aminosäuren abgeleitete zyklische phosphonamide und verfahren zu deren herstellung
AT01964579T ATE463500T1 (de) 2000-08-15 2001-08-06 Von aminosäuren abgeleitete zyklische phosphonamide und verfahren zu deren herstellung
AU2001285418A AU2001285418A1 (en) 2000-08-15 2001-08-06 Amino acid-derived cyclic phosphonamides and methods of synthesizing the same
JP2002519481A JP5249486B2 (ja) 2000-08-15 2001-08-06 アミノ酸由来の環式ホスホアミドおよびその合成方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/639,051 US6420586B1 (en) 2000-08-15 2000-08-15 Amino acid-derived cyclic phosphonamides and methods of synthesizing the same
US09/639,051 2000-08-15

Publications (2)

Publication Number Publication Date
WO2002014344A2 WO2002014344A2 (fr) 2002-02-21
WO2002014344A3 true WO2002014344A3 (fr) 2002-09-06

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/041606 WO2002014344A2 (fr) 2000-08-15 2001-08-06 Phosphonamides cycliques derives d'acides amines et procedes de synthese associes

Country Status (9)

Country Link
US (1) US6420586B1 (fr)
EP (2) EP1806351B1 (fr)
JP (1) JP5249486B2 (fr)
AT (2) ATE503761T1 (fr)
AU (1) AU2001285418A1 (fr)
CA (1) CA2419775C (fr)
DE (2) DE60144349D1 (fr)
DK (2) DK1311515T3 (fr)
WO (1) WO2002014344A2 (fr)

Cited By (1)

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US9579332B2 (en) 2004-07-27 2017-02-28 Gilead Sciences, Inc. Phosphonate analogs of HIV inhibitor compounds

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IL153563A0 (en) * 2000-07-18 2003-07-06 Leo Pharma As Matrix metalloproteinase inhibitors
PL371377A1 (en) * 2002-01-18 2005-06-13 Leo Pharma A/S Mmp inhibitors
EA200401437A1 (ru) * 2002-04-26 2005-04-28 Джилид Сайэнс, Инк. Ненуклеозидные ингибиторы обратной транскриптазы для лечения вич инфекции, способ их получения (варианты), способ увеличения периода полупревращения ненуклеозидного соединения, обладающего активностью против ретровирусов, и способ получения фармацевтической композиции, обладающей специфичностью к лейкоцитам
US7452901B2 (en) 2003-04-25 2008-11-18 Gilead Sciences, Inc. Anti-cancer phosphonate analogs
WO2004096287A2 (fr) 2003-04-25 2004-11-11 Gilead Sciences, Inc. Composes de phosphonate inhibiteurs de l'inosine monophosphate deshydrogenase
DK1628685T3 (da) 2003-04-25 2011-03-21 Gilead Sciences Inc Antivirale phosphonatanaloge
US7407965B2 (en) 2003-04-25 2008-08-05 Gilead Sciences, Inc. Phosphonate analogs for treating metabolic diseases
WO2005002626A2 (fr) 2003-04-25 2005-01-13 Gilead Sciences, Inc. Composes de phosphonate therapeutiques
US7432261B2 (en) 2003-04-25 2008-10-07 Gilead Sciences, Inc. Anti-inflammatory phosphonate compounds
US7470724B2 (en) 2003-04-25 2008-12-30 Gilead Sciences, Inc. Phosphonate compounds having immuno-modulatory activity
JP2006524710A (ja) 2003-04-25 2006-11-02 ギリアード サイエンシーズ， インコーポレイテッド キナーゼインヒビターホスホネート抱合体
WO2004096285A2 (fr) 2003-04-25 2004-11-11 Gilead Sciences, Inc. Analogues anti-infectieux du phosphonate
AU2004290298A1 (en) 2003-10-24 2005-05-26 Gilead Sciences, Inc. Methods and compositions for identifying therapeutic compounds
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9579332B2 (en) 2004-07-27 2017-02-28 Gilead Sciences, Inc. Phosphonate analogs of HIV inhibitor compounds

Also Published As

Publication number Publication date
EP1806351A2 (fr) 2007-07-11
DK1806351T3 (da) 2011-07-18
DK1311515T3 (da) 2010-07-19
CA2419775C (fr) 2014-12-02
AU2001285418A1 (en) 2002-02-25
US6420586B1 (en) 2002-07-16
ATE503761T1 (de) 2011-04-15
ATE463500T1 (de) 2010-04-15
JP5249486B2 (ja) 2013-07-31
EP1806351B1 (fr) 2011-03-30
WO2002014344A2 (fr) 2002-02-21
EP1311515B1 (fr) 2010-04-07
EP1311515A2 (fr) 2003-05-21
JP2004506646A (ja) 2004-03-04
EP1311515A4 (fr) 2003-12-03
DE60141757D1 (de) 2010-05-20
DE60144349D1 (de) 2011-05-12
EP1806351A3 (fr) 2007-09-26
CA2419775A1 (fr) 2002-02-21

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