WO2001086299A3 - Dotierte nanoteilchen als biolabel - Google Patents

Dotierte nanoteilchen als biolabel Download PDF

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Publication number
WO2001086299A3
WO2001086299A3 PCT/EP2001/004545 EP0104545W WO0186299A3 WO 2001086299 A3 WO2001086299 A3 WO 2001086299A3 EP 0104545 W EP0104545 W EP 0104545W WO 0186299 A3 WO0186299 A3 WO 0186299A3
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WO
WIPO (PCT)
Prior art keywords
biolabels
nanoparticles
doped nanoparticles
excitement
radiation
Prior art date
Application number
PCT/EP2001/004545
Other languages
English (en)
French (fr)
Other versions
WO2001086299A2 (de
Inventor
Werner Hoheisel
Christoph Petry
Markus Haase
Karsten Riwotzki
Original Assignee
Bayer Ag
Werner Hoheisel
Christoph Petry
Markus Haase
Karsten Riwotzki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10106643A external-priority patent/DE10106643A1/de
Application filed by Bayer Ag, Werner Hoheisel, Christoph Petry, Markus Haase, Karsten Riwotzki filed Critical Bayer Ag
Priority to CA2407899A priority Critical patent/CA2407899C/en
Priority to EP01931636A priority patent/EP1282824B1/de
Priority to AU5835801A priority patent/AU5835801A/xx
Priority to DE50109214T priority patent/DE50109214D1/de
Priority to US10/275,355 priority patent/US20040014060A1/en
Priority to AU2001258358A priority patent/AU2001258358B2/en
Priority to JP2001583192A priority patent/JP2003532898A/ja
Publication of WO2001086299A2 publication Critical patent/WO2001086299A2/de
Publication of WO2001086299A3 publication Critical patent/WO2001086299A3/de

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587Nanoparticles
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4712Muscle proteins, e.g. myosin, actin, protein
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/795Porphyrin- or corrin-ring-containing peptides
    • G01N2333/805Haemoglobins; Myoglobins

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Nanotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Luminescent Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • Dental Preparations (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Steroid Compounds (AREA)

Abstract

Gegenstand der Erfindung ist eine einfache Nachweissonde enthaltend lumineszierende anorganische dotierte Nanoteilchen (lad-Nanoteilchen), die nach Anregung mit einer Strahlungsquelle durch Absorption und/oder Streuung und/oder Beugung der Anregungsstrahlung oder durch Emission von Fluoreszenzlicht nachweisbar sind und deren Oberfläche so präpariert ist, dass Affinitätsmoleküle zum Nachweis einer biologischen oder sonstigen organischen Substanz an diese präparierte Oberfläche ankoppeln können.
PCT/EP2001/004545 2000-05-05 2001-04-23 Dotierte nanoteilchen als biolabel WO2001086299A2 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA2407899A CA2407899C (en) 2000-05-05 2001-04-23 Doped nanoparticles as biolabels
EP01931636A EP1282824B1 (de) 2000-05-05 2001-04-23 Dotierte nanoteilchen als biolabel
AU5835801A AU5835801A (en) 2000-05-05 2001-04-23 Doped nanoparticles as biolabels
DE50109214T DE50109214D1 (de) 2000-05-05 2001-04-23 Dotierte nanoteilchen als biolabel
US10/275,355 US20040014060A1 (en) 2000-05-05 2001-04-23 Doped nanoparticles as biolabels
AU2001258358A AU2001258358B2 (en) 2000-05-05 2001-04-23 Doped nanoparticles as biolabels
JP2001583192A JP2003532898A (ja) 2000-05-05 2001-04-23 生体標識としてのドープ処理されたナノ粒子

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10021674.9 2000-05-05
DE10021674 2000-05-05
DE10106643A DE10106643A1 (de) 2000-05-05 2001-02-12 Dotierte Nanoteilchen als Biolabel
DE10106643.0 2001-02-12

Publications (2)

Publication Number Publication Date
WO2001086299A2 WO2001086299A2 (de) 2001-11-15
WO2001086299A3 true WO2001086299A3 (de) 2002-05-23

Family

ID=26005546

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/004545 WO2001086299A2 (de) 2000-05-05 2001-04-23 Dotierte nanoteilchen als biolabel

Country Status (9)

Country Link
US (1) US20040014060A1 (de)
EP (1) EP1282824B1 (de)
JP (1) JP2003532898A (de)
AT (1) ATE320605T1 (de)
AU (2) AU5835801A (de)
CA (1) CA2407899C (de)
DE (1) DE50109214D1 (de)
ES (1) ES2258527T3 (de)
WO (1) WO2001086299A2 (de)

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CN110095456B (zh) * 2019-04-12 2021-08-20 中国农业科学院烟草研究所(中国烟草总公司青州烟草研究所) 一种烟草病毒检测显像装置及使用方法

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7241399B2 (en) * 2000-09-08 2007-07-10 Centrum Fuer Angewandte Nanotechnologie (Can) Gmbh Synthesis of nanoparticles
GB2381530A (en) * 2001-11-01 2003-05-07 Oxonica Ltd Water-soluble particles of luminescent materials and their use in Biotagging
DE10154988A1 (de) * 2001-11-08 2003-05-28 Karlsruhe Forschzent Verwendung von oxidischen Nanoteilchen
AU2002366254A1 (en) 2001-12-18 2003-06-30 Nanosolutions Gmbh Printing method with coded individual control of nozzles
US7589029B2 (en) * 2002-05-02 2009-09-15 Micron Technology, Inc. Atomic layer deposition and conversion
US7998923B2 (en) 2002-05-07 2011-08-16 The Regents Of The University Of California Bioactivation of particles
DE10259935A1 (de) * 2002-12-20 2004-07-01 Bayer Ag Herstellung und Verwendung von in-situ-modifizierten Nanopartikeln
DE60310032T2 (de) * 2003-04-30 2007-07-05 Centrum Für Angewandte Nanotechnologie (Can) Gmbh Kern-Mantel Nanoteilchen für (F) RET-Testverfahren
EP1473348B1 (de) * 2003-04-30 2007-03-21 Centrum für Angewandte Nanotechnologie (CAN) GmbH Lumineszente Kern-Mantel-Nanoteilchen
WO2005053649A1 (en) * 2003-11-05 2005-06-16 The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services Biofunctionalized quantum dots for biological imaging
US7462300B2 (en) * 2003-11-10 2008-12-09 Fujifilm Corporation Doped-type metal sulfide phosphor nanoparticle, dispersion thereof, and method for producing the same
JP2007514736A (ja) * 2003-12-17 2007-06-07 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 紫外線放射ナノ粒子を用いた放射線治療および医学画像
FR2867180B1 (fr) * 2004-03-02 2006-06-16 Univ Claude Bernard Lyon Nanoparticules hybrides comprenant un coeur de ln203 porteuses de ligands biologiques et leur procede de preparation
WO2005094902A2 (en) * 2004-04-01 2005-10-13 Philips Intellectual Property & Standards Gmbh Nanoparticles comprising luminescent substances as contrast agent for optical imaging
FR2869803B1 (fr) * 2004-05-10 2006-07-28 Nanobiotix Sarl Particules activables, preparation et utilisations
US7943396B2 (en) 2004-06-22 2011-05-17 The Regents Of The University Of California Peptide-coated nanoparticles with graded shell compositions
WO2006009077A1 (ja) * 2004-07-16 2006-01-26 Fujifilm Corporation 蛍光検出方法
ITMI20041801A1 (it) * 2004-09-21 2004-12-21 Solvay Solexis Spa Uso di lattici submicrometrici di perfluoropolimeri nella determinazione di interazione molecolari mediante laser light scattering (lls)
FR2877571B1 (fr) * 2004-11-05 2007-04-13 Nanobiotix Sarl Nanoparticules pourvues d'un element de ciblage intracellulaire, preparation et utilisations
DE102005026485A1 (de) 2005-06-09 2006-12-14 Bayer Technology Services Gmbh Hydrophile Nanoteilchen mit funktionellen Oberflächengruppen, deren Herstellung und Verwendung
US7927948B2 (en) 2005-07-20 2011-04-19 Micron Technology, Inc. Devices with nanocrystals and methods of formation
US7575978B2 (en) * 2005-08-04 2009-08-18 Micron Technology, Inc. Method for making conductive nanoparticle charge storage element
US7989290B2 (en) * 2005-08-04 2011-08-02 Micron Technology, Inc. Methods for forming rhodium-based charge traps and apparatus including rhodium-based charge traps
AU2006288048A1 (en) * 2005-09-08 2007-03-15 Biterials Co., Ltd. Magnetic nanoparticle having fluorescent and preparation method thereof and use thereof
WO2007044712A2 (en) * 2005-10-07 2007-04-19 University Of Florida Research Foundation, Inc. Portable materials and methods for ultrasensitive detection of pathogens and bioparticles
FR2892819B1 (fr) * 2005-10-28 2008-02-01 Centre Nat Rech Scient Nanoparticules a luminescence persistance pour leur utilisation en tant qu'agent de diagnostic destine a l'imagerie optique in vivo
FR2908891B1 (fr) * 2005-10-28 2017-04-21 Centre Nat De La Rech Scient - Cnrs Nanoparticules a luminescence persistante de type aluminate pour leur utilisation en tant qu'agent de diagnostic destine a l'imagerie optique in vivo
WO2007074722A1 (ja) * 2005-12-27 2007-07-05 The Furukawa Electric Co., Ltd. 蛍光ナノシリカ粒子、ナノ蛍光材料、それを用いたバイオチップ及びそのアッセイ法
ITMI20060480A1 (it) * 2006-03-16 2007-09-17 Solvay Solexis Spa Usom di perfluoropolimeri nella dtermibnazione della costante di legame recettore-ligando
JP5200931B2 (ja) * 2006-05-26 2013-06-05 コニカミノルタエムジー株式会社 III−V型半導体/SiO2型ナノ粒子、及び生体物質標識剤
RU2009110770A (ru) * 2006-08-25 2010-09-27 Конинклейке Филипс Электроникс Н.В. (Nl) Контрастное вещество для оптического формирования изображений
CA2589575A1 (en) 2007-05-22 2008-11-22 Valorbec Societe En Commandite Lanthanide-doped nayf4 nanocrystals, method of preparing and uses thereof
US8367506B2 (en) 2007-06-04 2013-02-05 Micron Technology, Inc. High-k dielectrics with gold nano-particles
US8389958B2 (en) 2009-03-18 2013-03-05 Duke University Up and down conversion systems for production of emitted light from various energy sources
JP5125703B2 (ja) * 2008-04-07 2013-01-23 コニカミノルタエムジー株式会社 希土類元素ドープ蛍光体ナノ粒子、それを用いた生体物質標識剤
WO2010007803A1 (ja) * 2008-07-17 2010-01-21 コニカミノルタエムジー株式会社 ナノ粒子標識薬、及び該ナノ粒子標識薬を用いたシステム
EP2421376A4 (de) 2009-04-21 2016-04-27 Immunolight Llc Nicht-invasive energieaufwärtsumwandlungsverfahren und systeme für in-situ-fotobiomodulation
WO2011038335A1 (en) 2009-09-25 2011-03-31 Immunolight, Llc Up and down conversion systems for improved solar cell performance or other energy conversion
IT1396382B1 (it) 2009-10-30 2012-11-19 Bellini Metodo per la misurazione di interazioni molecolari mediante rilevazione di luce riflessa da multistrati dielettrici funzionalzzati.
CN107149689A (zh) * 2009-11-10 2017-09-12 免疫之光有限责任公司 对可辐射固化介质进行固化的系统和产生光的方法
WO2011084641A2 (en) 2009-12-16 2011-07-14 The Regents Of The University Of California Gold coating of rare earth nano-phosphors and uses thereof
JP6003033B2 (ja) 2010-11-11 2016-10-05 ソニー株式会社 核酸の検出方法及びサンプルの光学観察方法並びに蛍光体
FR2968649B1 (fr) * 2010-12-14 2015-05-01 Rhodia Operations Composition a base d'un aluminate, de type coeur/coquille, luminophore issu de cette composition et procedes de preparation
US10175170B2 (en) 2010-12-16 2019-01-08 The Regents Of The University Of California Metal coating of rare earth nano-phosphors and uses thereof
US8932486B2 (en) 2011-04-07 2015-01-13 Performance Indicator, Llc Persistent phosphors of alkaline earths modified by halides and 3d ions
JP6026305B2 (ja) 2013-02-04 2016-11-16 古河電気工業株式会社 標識抗体の製造方法
ES2791279T3 (es) 2013-08-19 2020-11-03 Univ Houston Indicadores fosforescentes
US10323183B2 (en) * 2015-03-03 2019-06-18 University Of Massachusetts Homogeneous persistent luminescence nanocrystals and methods of preparation and application thereof
CN107708668A (zh) 2015-05-28 2018-02-16 纳米生物技术公司 用作治疗性疫苗的纳米粒子
FR3066501B1 (fr) 2017-05-18 2020-10-09 Ecole Polytech Particules luminescentes a base de terres rares et leur utilisation a titre d'agent de diagnostic
FR3069927B1 (fr) 2017-08-04 2021-06-04 Ecole Polytech Procede de detection ultra-sensible a l'aide de particules photoluminescentes
FR3084165B1 (fr) 2018-07-18 2020-07-10 Ecole Polytechnique Test a diffusion capillaire mettant en œuvre des nanoparticules inorganiques photoluminescentes
CN115161031B (zh) * 2022-08-02 2023-09-22 福州大学 一种高效紫外发光闪烁体纳米材料及其制备方法和应用
CN116731704B (zh) * 2023-08-16 2023-11-03 德州学院 一种发光复合纳米材料及制备方法和在pH测量中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593783A (en) * 1994-06-17 1997-01-14 Advanced Technology Materials, Inc. Photochemically modified diamond surfaces, and method of making the same
US5893999A (en) * 1993-09-13 1999-04-13 Kabushiki Kaisha Toshiba Ultrafine inorganic phosphor, specifically binding material labeled with this phosphor, and detection method using this specific binding material
US5990479A (en) * 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4283382A (en) * 1977-12-28 1981-08-11 Eastman Kodak Company Fluorescent labels comprising rare earth chelates
US4637998A (en) * 1979-10-02 1987-01-20 Kureha Kagaku Kogyo Kabushiki Kaisha Pharmaceutical composition containing a derivative of para-aminobenzoic acid as an active ingredient
NZ211453A (en) * 1984-03-22 1989-01-06 Biotechnology Research Enterpr Aryl azides, their preparation and use in the detection, localisation and isolation of polynucleotides
GB2189345A (en) * 1986-04-16 1987-10-21 Philips Electronic Associated High mobility p channel semi conductor devices
US5205967A (en) * 1992-03-26 1993-04-27 John Macken Method of forming retardation plate utilizing deformed zinc selenide
US5674698A (en) * 1992-09-14 1997-10-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5736410A (en) * 1992-09-14 1998-04-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
EP0663006A1 (de) * 1992-09-30 1995-07-19 Zymogenetics, Inc. Menschlicher calcitonin rezeptor
US5561043A (en) * 1994-01-31 1996-10-01 Trustees Of Boston University Self-assembling multimeric nucleic acid constructs
US5985173A (en) * 1997-11-18 1999-11-16 Gray; Henry F. Phosphors having a semiconductor host surrounded by a shell
US6235540B1 (en) * 1999-03-30 2001-05-22 Coulter International Corp. Semiconductor nanoparticles for analysis of blood cell populations and methods of making same
US7241399B2 (en) * 2000-09-08 2007-07-10 Centrum Fuer Angewandte Nanotechnologie (Can) Gmbh Synthesis of nanoparticles
EP1473348B1 (de) * 2003-04-30 2007-03-21 Centrum für Angewandte Nanotechnologie (CAN) GmbH Lumineszente Kern-Mantel-Nanoteilchen
DE60310032T2 (de) * 2003-04-30 2007-07-05 Centrum Für Angewandte Nanotechnologie (Can) Gmbh Kern-Mantel Nanoteilchen für (F) RET-Testverfahren

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5893999A (en) * 1993-09-13 1999-04-13 Kabushiki Kaisha Toshiba Ultrafine inorganic phosphor, specifically binding material labeled with this phosphor, and detection method using this specific binding material
US5593783A (en) * 1994-06-17 1997-01-14 Advanced Technology Materials, Inc. Photochemically modified diamond surfaces, and method of making the same
US5990479A (en) * 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
MEYSSAMY H ET AL: "WET-CHEMICAL SYNTHESIS OF DOPED COLLOIDAL NANOMATERIALS: PARTICLES AND FIBERS OF LAPO4:EU, LAPO4:CE, AND LAPO4:CE,TB", ADVANCED MATERIALS, VCH VERLAGSGESELLSCHAFT, WEINHEIM, DE, vol. 11, no. 10, 9 July 1999 (1999-07-09), pages 840 - 844, XP000865123, ISSN: 0935-9648 *
RIWOTZKI K ET AL: "Wet-chemical synthesis of doped colloidal nanoparticles: YVO4:Ln (Ln = Eu, Sm, Dy)", J PHYS CHEM B;JOURNAL OF PHYSICAL CHEMISTRY B DEC 10 1998 ACS, WASHINGTON, DC, USA, vol. 102, no. 50, 10 December 1998 (1998-12-10), pages 10129 - 10135, XP001034725 *
ZIJLMANS H J M A A ET AL: "Detection of cell and tissue surface antigens using up-converting phosphors: A new reporter technology.", ANALYTICAL BIOCHEMISTRY, vol. 267, no. 1, 1 February 1999 (1999-02-01), pages 30 - 36, XP002185942, ISSN: 0003-2697 *
ZOBEL H -P ET AL: "Cationic polyhexylcyanoacrylate nanoparticles as carriers for antisense oligonucleotides.", ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT, vol. 7, no. 5, October 1997 (1997-10-01), pages 483 - 493, XP001041977, ISSN: 1087-2906 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110095456B (zh) * 2019-04-12 2021-08-20 中国农业科学院烟草研究所(中国烟草总公司青州烟草研究所) 一种烟草病毒检测显像装置及使用方法

Also Published As

Publication number Publication date
AU2001258358B2 (en) 2005-10-27
AU5835801A (en) 2001-11-20
WO2001086299A2 (de) 2001-11-15
US20040014060A1 (en) 2004-01-22
ATE320605T1 (de) 2006-04-15
CA2407899A1 (en) 2001-11-15
EP1282824B1 (de) 2006-03-15
CA2407899C (en) 2010-11-23
EP1282824A2 (de) 2003-02-12
JP2003532898A (ja) 2003-11-05
ES2258527T3 (es) 2006-09-01
DE50109214D1 (de) 2006-05-11

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