WO2001058413A1 - Procede pour stimuler la pousse des cheveux et kit pour mettre ledit procede en oeuvre - Google Patents

Procede pour stimuler la pousse des cheveux et kit pour mettre ledit procede en oeuvre Download PDF

Info

Publication number
WO2001058413A1
WO2001058413A1 PCT/EP2001/001354 EP0101354W WO0158413A1 WO 2001058413 A1 WO2001058413 A1 WO 2001058413A1 EP 0101354 W EP0101354 W EP 0101354W WO 0158413 A1 WO0158413 A1 WO 0158413A1
Authority
WO
WIPO (PCT)
Prior art keywords
hair
stem cells
cells
preformed
kit
Prior art date
Application number
PCT/EP2001/001354
Other languages
German (de)
English (en)
Inventor
Klaus Rennebeck
Albert Scheller
William Rader
Original Assignee
Klaus Rennebeck
Albert Scheller
William Rader
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Klaus Rennebeck, Albert Scheller, William Rader filed Critical Klaus Rennebeck
Publication of WO2001058413A1 publication Critical patent/WO2001058413A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0627—Hair cells
    • C12N5/0628—Hair stem cells; Hair progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • A61K8/985—Skin or skin outgrowth, e.g. hair, nails
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

Definitions

  • the present invention relates to a method for stimulating hair growth, a kit for carrying out a treatment for stimulating hair growth and the use of the kit.
  • the hair is an appendage of the skin made of keratin, which protects the body surface as fur or fur in the mammal, whereby this protective function has largely been lost in humans.
  • the hair follicle is arranged obliquely in the cutis and occasionally extends into the subcutis.
  • the part of the hair protruding from the skin is the hair shaft, the part in the skin is the hair root, which is enclosed by the inner and outer root sheath and at the bottom end bulges out into the so-called bulb.
  • the bulb contains the germ cells for hair growth and the formation of keratin.
  • the hair goes through a life cycle that comprises three phases. A distinction is made between the anagen or growth phase, the catagen or transition phase and the telogenic or resting phase. In the absence of hair growth disorders, about 80 to 85% of the hair is usually in the anagen phase and 15 to 20% in the Transition or rest phase.
  • the anagen phase is the period of active hair growth and lasts about 3 to 5 years.
  • the catagen phase is a transition phase between active growth and rest phase and lasts about 1 to 2 weeks.
  • the subsequent telogenic phase lasts 3 to 4 months. This is where the growth stops and the hair is rejected if necessary, after which new hair growth can begin.
  • the present invention is based on the object of providing a method for stimulating hair growth in a region of the body which avoids the described disadvantages of the previously known methods. Furthermore, it is a further object of the invention to provide a kit for carrying out a treatment for stimulating hair growth and to propose an advantageous use of the kit.
  • this object is achieved by a method for stimulating hair growth in a body region, in which a preparation containing stem cells and / or preformed hair cells is introduced subcutaneously into the body region to be treated. It has surprisingly been shown that through Subcutaneous introduction of the preparation considerable cosmetic successes can be achieved, in particular in the re-hairing of regions of the body which are affected by hair loss.
  • stem cells are to be understood as cells which, in principle, divide almost indefinitely and can produce specialized cells. Examples of stem cells are embryonic stem cells, fetal stem cells, for example from umbilical cord blood, and juvenile and adult stem cells.
  • Preformed hair cells which can also be referred to as hair formation cells, are to be understood in the context of this application text as cells which can form a physiologically functional hair.
  • the invention teaches a novel use of stem cells to stimulate hair growth. In this way it is possible to help people with hair growth disorders or hair loss to return to a visually appealing appearance of the affected parts of the body.
  • the described effect of the cosmetic process is generally accompanied by a differentiation and / or redifferentiation of the cells introduced.
  • the cells may not be differentiated.
  • the preparation is buffered to a pH of approximately 6.8 to 7.5 and in particular 7.0 to 7.4. Particularly good results are achieved if the preparation has isoosmotic properties in relation to the physiological environment under the skin of the body part to be treated.
  • the term isoosmotic properties of the preparation in relation to a physiological milieu is to be understood in the context of this application text in such a way that the preparation has approximately the same osmotic pressure in relation to a physiological medium.
  • the preparation containing the stem cells and / or preformed hair cells further comprises an isoosmotic rinse or a physiological saline solution. This serves to balance the pressure and prepare the skin for the absorption of the stem cells. It also causes inflammation of the treated skin area avoided or the likelihood of this being reduced and thus the wound arising during the treatment is spared.
  • the subcutaneous introduction of the preparation into the body region to be treated is preferably carried out by a device which comprises one or more cannulas.
  • the device is expediently driven electrically and / or pneumatically.
  • the subcutaneous introduction of the preparation through the device can be compared to a tattooing process.
  • sterility is preferred.
  • Microcannulas and / or brown cannulas are preferably used as cannulas.
  • the use of very thin cannulas enables the preparation to be inserted with minimal trauma to the affected body region.
  • Microcannulas with an outer diameter of approximately 25 to 40 ⁇ m diameter, in particular approximately 30 ⁇ m diameter, are preferably used.
  • microcannulas have textile properties, ie they bend slightly when inserted into the scalp, it is expedient to support the microcannulas by means of larger cannulas which have an outer diameter of approximately 150 to 200 ⁇ m. Titanium or plastic has proven to be particularly suitable materials for the cannulas. It has been shown that particularly good results are obtained when using a device which comprises a multi-cannula wheel.
  • the subcutaneous introduction of the preparation is expediently carried out in a similar manner to a tattoo device by means of a tacker-shaped movement of the cannula or cannulas.
  • the insertion by a linear tacker-shaped movement has proven to be particularly advantageous, 20 to 1200 hair channel formation strokes per cm 2 area preferably being used. Particularly good results are achieved if the preparation is introduced with a laminar flow, in particular with a laminar down flow.
  • the cannula is preferably filled by immersing it in a reservoir before a number of hair channel formation strokes, in particular before each hair channel formation stroke. Medical infusion sets are preferably used for filling.
  • the selected region in front of the staining treatment to stimulate hair growth subcutaneously. This enables precise placement of the desired hairline in the subsequent treatment to stimulate hair growth.
  • Another advantage of this embodiment is that the coloring of the skin makes the hair growth appear optically denser.
  • the method according to the invention is particularly well suited for stimulating the growth of the hair on the head.
  • a further preferred embodiment consists in stimulating the growth of length-limited hair, in particular the eyelashes and eyebrows.
  • the invention further relates to a kit for carrying out a treatment for stimulating hair growth, which comprises a preparation containing stem cells and / or preformed hair cells.
  • the kit preferably includes a device for subcutaneously introducing the preparation containing the stem cells and / or preformed hair cells.
  • the kit comprises a preparation containing stem cells and / or preformed hair cells, as described above, and optionally also a device for subcutaneously introducing the preparation containing the stem cells and / or preformed hair cells, as described above ,
  • the use of the kit described for carrying out a treatment for stimulating hair growth is also the subject of the present invention.
  • the present invention also relates to the use of stem cells for stimulating hair growth.
  • the method described is ideal for stimulating hair growth. Particularly good results are achieved with hair regrowth in a region of the body which is affected by hair loss.
  • the procedure is no more painful than a normal tattoo and does not require any further professional qualifications compared to a tattoo. Since there are also no significant side effects, the method can be carried out by anyone, in particular using the kit described.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Developmental Biology & Embryology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un procédé permettant de stimuler la pousse des cheveux au niveau d'une zone corporelle. Ledit procédé fait appel à un dispositif servant à introduire par voie sous-cutanée une préparation dans la zone corporelle à traiter et s'utilise en particulier pour faire repousser des cheveux dans une zone touchée par la chute de cheveux. L'invention concerne en outre un kit permettant de mettre en oeuvre un traitement visant à stimuler la pousse de cheveux.
PCT/EP2001/001354 2000-02-08 2001-02-08 Procede pour stimuler la pousse des cheveux et kit pour mettre ledit procede en oeuvre WO2001058413A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10005329A DE10005329A1 (de) 2000-02-08 2000-02-08 Humanisiertes, vitalisiertes Haarbewachsen und Haarwiederbewachsen mit subkutanen Kanüleneinstich-Haut-Färbungs-Zeichnungsverfahren
DE10005329.7 2000-02-08

Publications (1)

Publication Number Publication Date
WO2001058413A1 true WO2001058413A1 (fr) 2001-08-16

Family

ID=7630092

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/001354 WO2001058413A1 (fr) 2000-02-08 2001-02-08 Procede pour stimuler la pousse des cheveux et kit pour mettre ledit procede en oeuvre

Country Status (2)

Country Link
DE (1) DE10005329A1 (fr)
WO (1) WO2001058413A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002060396A2 (fr) * 2001-01-29 2002-08-08 Aderans Research Institute, Inc. Neo genese de follicules capillaires par injection de cellules progenitrices de follicules
WO2003068248A1 (fr) * 2002-02-12 2003-08-21 Intercytex Limited Systeme d'administration de cellules
EP1874265A2 (fr) * 2005-03-29 2008-01-09 The Trustees of The University of Pennsylvania Procedes pour la generation de nouveaux follicules capillaires, de traitement de la calvitie, et l'elimination de poils
US7785876B2 (en) 2002-11-14 2010-08-31 Aderans Research Institute, Inc. Cultivation of hair inductive cells
US20140276362A1 (en) * 2013-03-15 2014-09-18 Plum Systems,Co. Apparatus and method for tissue rejuvenation
AU2012204059B2 (en) * 2005-03-29 2015-01-15 The Trustees Of The University Of Pennsylvania Methods for generating new hair follicles, treating baldness and hair removal
US9023380B2 (en) 2005-11-22 2015-05-05 Aderans Research Institute, Inc. Hair follicle graft from tissue engineered skin
US11207511B2 (en) 2010-12-06 2021-12-28 Follica, Inc. Methods for treating baldness and promoting hair growth

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4919664A (en) * 1986-02-21 1990-04-24 Oliver Roy F Stimulation of hair growth
WO1991016419A1 (fr) * 1990-04-17 1991-10-31 Pherin Corporation Procedes d'implantation de tissu
WO1999001034A1 (fr) * 1997-07-01 1999-01-14 Cooley Jerry E Procede de repousse des cheveux
WO2000069449A2 (fr) * 1999-05-14 2000-11-23 Advanced Tissue Sciences, Inc. Compositions de milieu de culture cellulaire conditionne et techniques d'utilisation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4919664A (en) * 1986-02-21 1990-04-24 Oliver Roy F Stimulation of hair growth
WO1991016419A1 (fr) * 1990-04-17 1991-10-31 Pherin Corporation Procedes d'implantation de tissu
WO1999001034A1 (fr) * 1997-07-01 1999-01-14 Cooley Jerry E Procede de repousse des cheveux
WO2000069449A2 (fr) * 1999-05-14 2000-11-23 Advanced Tissue Sciences, Inc. Compositions de milieu de culture cellulaire conditionne et techniques d'utilisation

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002060396A3 (fr) * 2001-01-29 2003-03-13 Bioamide Inc Neo genese de follicules capillaires par injection de cellules progenitrices de follicules
WO2002060396A2 (fr) * 2001-01-29 2002-08-08 Aderans Research Institute, Inc. Neo genese de follicules capillaires par injection de cellules progenitrices de follicules
WO2003068248A1 (fr) * 2002-02-12 2003-08-21 Intercytex Limited Systeme d'administration de cellules
US7785876B2 (en) 2002-11-14 2010-08-31 Aderans Research Institute, Inc. Cultivation of hair inductive cells
US9220926B2 (en) 2005-03-29 2015-12-29 The Trustees Of The University Of Pennsylvania Methods for generating new hair follicles, treating baldness, and hair removal
EP1874265A4 (fr) * 2005-03-29 2012-09-26 Univ Pennsylvania Procedes pour la generation de nouveaux follicules capillaires, de traitement de la calvitie, et l'elimination de poils
AU2012204059B2 (en) * 2005-03-29 2015-01-15 The Trustees Of The University Of Pennsylvania Methods for generating new hair follicles, treating baldness and hair removal
EP1874265A2 (fr) * 2005-03-29 2008-01-09 The Trustees of The University of Pennsylvania Procedes pour la generation de nouveaux follicules capillaires, de traitement de la calvitie, et l'elimination de poils
US9642789B2 (en) 2005-03-29 2017-05-09 The Trustees Of The University Of Pennsylvania Methods for generating new hair follicles, treating baldness, and hair removal
US9700502B2 (en) 2005-03-29 2017-07-11 The Trustees Of The University Of Pennsylvania Methods for generating new hair follicles, treating baldness, and hair removal
US9023380B2 (en) 2005-11-22 2015-05-05 Aderans Research Institute, Inc. Hair follicle graft from tissue engineered skin
US11207511B2 (en) 2010-12-06 2021-12-28 Follica, Inc. Methods for treating baldness and promoting hair growth
US20140276362A1 (en) * 2013-03-15 2014-09-18 Plum Systems,Co. Apparatus and method for tissue rejuvenation

Also Published As

Publication number Publication date
DE10005329A1 (de) 2001-09-20

Similar Documents

Publication Publication Date Title
DE69309051T2 (de) Vorrichtung zum strecken von lebendem gewebe
DE3101011C2 (de) Haarbehandlungsmittel
EP0892635A1 (fr) Preparations cosmetiques contenant des extraits de phyllanthus emblica et de centella asiatica et/ou de bacopa monnieri
KR101569648B1 (ko) 효모 추출물을 포함하는 발모용의 두피 및 모발용 조성물
WO2001058413A1 (fr) Procede pour stimuler la pousse des cheveux et kit pour mettre ledit procede en oeuvre
EP3542863B1 (fr) Huile pour les cheveux et son utilisation
DE4134137A1 (de) Haarboden-bioaktivlotion und verfahren zu ihrer herstellung
DE1953026A1 (de) Verfahren und Vorrichtung zur Anbringung von Fremdhaaren an der Kopfhaut
DE3431266A1 (de) Haarwuchsmittel, enthaltend haarzwiebel mit haarpapille von tierhaaren
DE69208865T2 (de) Haarpflegemittel
DE10043982A1 (de) Verfahren zur Verbesserung des Haarwuchses menschlichen Kopfhaares
EP0281647B1 (fr) Composés organiques pour le développement des seins
EP0016239B1 (fr) Préparation cosmétique pour la peau et les cheveux et sa fabrication
DE3837669C2 (de) Verfahren zur Herstellung von Material für die Zelltherapie
DE3601739A1 (de) Kosmetisches mittel zur behandlung der haare oder der kopfhaut
DE3301158A1 (de) Haarwuchsmittel
DE102017117125A1 (de) Chinesische Medizin zur Beseitigung von Krähenfüßen
DE3429942A1 (de) Mittel und verfahren zum wiederherstellen der urspruenglichen haarfarbe ergrauter haare
DE19904790A1 (de) Schönheitsbehandlungsverfahren
WO2022084285A1 (fr) Cheveux revêtus et leur utilisation
DE10163190B4 (de) Pflanzliche Wirkstoffmischung zur Linderung von Haar- und Hautleiden
DE3621757A1 (de) Mittel zur behandlung der haare und der kopfhaut
WO2008098647A1 (fr) Procédé pour augmenter la circulation sanguine et le transfert de matière de la peau
DE102017117232A1 (de) Chinesische Medizin zur Beseitigung von Fischschwanzlinien
DE2604201A1 (de) Kosmetisches haarpflegemittel

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP