Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
  • A61N7/00—Ultrasound therapy
  • A61N7/02—Localised ultrasound hyperthermia
  • A61N7/022—Localised ultrasound hyperthermia intracavitary
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B17/00—Surgical instruments, devices or methods
  • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
  • A61B17/22004—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
  • A61B17/22012—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
  • A61B17/2202—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being inside patient's body at the distal end of the catheter
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B17/00—Surgical instruments, devices or methods
  • A61B2017/00535—Surgical instruments, devices or methods pneumatically or hydraulically operated
  • A61B2017/00539—Surgical instruments, devices or methods pneumatically or hydraulically operated hydraulically
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B17/00—Surgical instruments, devices or methods
  • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
  • A61B17/22004—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
  • A61B17/22012—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
  • A61B2017/22014—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being outside patient's body; with an ultrasound transmission member; with a wave guide; with a vibrated guide wire
  • A61B2017/22015—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being outside patient's body; with an ultrasound transmission member; with a wave guide; with a vibrated guide wire with details of the transmission member
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
  • A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
  • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
  • A61B90/37—Surgical systems with images on a monitor during operation

Definitions

• the invention relates to a device for the treatment of malignant diseases.
• the classic treatment methods and the treatment devices used are generally based on surgical tumor removal, preoperative, postoperative or combined chemotherapy, additional radiation therapy and, if appropriate, accompanying immunotherapy.
• cytostatics in chemotherapy procedures damages malignant cells more than healthy, non-degenerate cells. Cells with high proliferation rates are mainly damaged. Cells in the G 0 phase generally do not respond to chemical therapy.
• Preoperative, neoadjuvant and postoperative forms of therapy are carried out.
• Preoperative chemotherapy aims at local tumor reduction. The aim is to improve the chances of success of a radical operation. At the same time, non-diagnosable, already existing micrometastasis cells are to be damaged.
• Postoperative, adjuvant chemotherapy is performed after surgical removal of the tumor and regional lymph nodes. Histological examinations of the removed lymph nodes provide information about existing micrometastases and metastatic processes.
• Adjuvant chemotherapy is intended to combat metastatic processes and destroy existing micrometastases. Regional forms of chemotherapy are used to achieve an intensive local effect with reduced systematic toxicity.
• Chemotherapy drugs damage tumor cells in particular, but also normal cells. Their unspecific mode of action leads to acute, short-term, mostly reversible side effects, but often to late, irreversible side effects. Relevant side effects are granulocytopenia, thrombopenia, anemia, fever, cardiac arrhythmia, mucosal ulceration, renal dysfunction, nausea and vomiting, inner ear damage and pulmonary fibrosis. Serious side effects may occur after high doses of chemostatic therapy. Therapy-related secondary neoplasms are also reported. Common diseases after intensive treatment with high doses of certain chemotherapy drugs are leukemia and myelodysplasia.
• Ultrasound is used for therapeutic and particularly intensive for diagnostic purposes. In many tumor diseases, the chances of recovery depend crucially on the time of diagnosis. If diagnosis is suspected, ultrasound is used. The ultrasound examination is user-dependent and the ultrasound images only describe the morphology of the tissue. Recently, measuring devices have been used which also determine histologically relevant parameters: speed of sound, acoustic backscattering, acoustic damping and elasticity parameters. For this purpose, the tissue is mechanized by an X-ray mammograph e.g. compressed. High-frequency ultrasound images are recorded through the upper compression plate. The echoes of the lower compression plate can be used to determine damping and speed of sound. Elastic properties (elastography) can be determined by taking pictures at different compression levels.
• Document EP 774 927 discloses a device for the selective vibration-induced treatment of malignant diseases with the aid of mechanical vibrations such as sound waves or ultrasound waves.
• the invention has the task of proposing a device by means of which a targeted selection of the cells can be made with the To be treated with the help of the device according to the invention.
• a microsurgical device with a vibration generator With the help of a microsurgical device, an organ or a vessel can penetrate and a treatment according to the invention can be carried out in a targeted manner on site.
• the vibration generator can be attached to known microsurgical devices, for example devices for gastric, intestinal or liver mirroring.
• the vibration generator can in principle be attached to any type of endoscopic device in order to achieve the advantages according to the invention, i. H. to achieve treatment on pre-selected cells.
• a flow line for body fluid, in particular blood is provided, to which a vibration generator is coupled.
• This flow line can be arranged intra- or extracorporeally.
• the flow line could be integrated in a known treatment device, for example for dialysis or the like.
• the vibration generator is arranged directly next to a video head. This has the effect that the treatment site is visible to the attending physician through the video head arranged directly next to the vibration generator.
• the vibration generator preferably comprises at least one piezo crystal. With the help of a piezo crystal, a vibration generator with the required frequency responses can be realized in the smallest space.
• a vibration generator according to the invention can be coupled to a hydraulic pressure hose or pressure pipe, which in turn is equipped with a membrane for vibration transmission. In this way, a device can be realize in which the vibration generator is not located directly at the treatment site.
• a flexible tube is coupled to a vibrating table. This is particularly advantageous in connection with an extracorporeal flow line for body fluid such as blood or the like. Vibrations with a defined frequency band or defined frequency bands can be generated via the vibrating table, which can be mechanically coupled directly via the flexible tube and to which the liquid in the interior of the tube can be transmitted.
• a cooling and / or heating device is advantageously attached to a device according to the invention in order to influence the treatment temperatures at the treatment site in a targeted manner.
• the body cavity or the organ is filled with water in order to ensure a better coupling for the mechanical vibrations.
• the device for the selective, vibration-induced treatment of malignant diseases is based on the knowledge that many tumor cells have a different vibration behavior than healthy cells.
• Vibration-relevant cell parameters are the stiffness and nature of the cytoskeleton as well as the viscosity of the cytoplasm, the plasma membrane and the core fluid, the core / plasma relation, the osmotic pressure, the stiffness and nature of the extracellular matrix, the viscosity of the extracellular fluid and the speed of the cellular aggregation processes .
• Malignant cells have a modified cytoskeleton compared to healthy cells, so invasive tumor cells show a remodeling of their intermediate filaments.
• the nuclear-plasma relation is shifted in favor of the cell nucleus.
• the cell nucleus of malignant cells is often changed in size and has an increased chromatin density.
• the device for the selective, vibration-induced treatment of malignant diseases is based on the knowledge that metastatic cells export the cytoplasmic stiffness and viscosity of the mother tumor and thus their tumor-specific vibration properties into the tissue of the metastasis target.
• the resonance peaks of the metastatic cells usually differ clearly from the healthy, surrounding tissue of the target organ.
• the necessary functional parameters of the device for the vibration-induced treatment of malignant diseases are determined with the help of modern instruments of engineering simulation and validated experimentally.
• metastatic cells have low-frequency resonance vibrations due to their reduced cytoplasmic stiffness compared to healthy cells. Due to their reduced viscosity, tumor cells and their metastases have higher vibration amplitudes. Tumor cells are damaged even at lower sound power levels than normal cells. The selective character of the resonance vibration is improved.
• the most striking structural characteristic of malignant cells is a changed organization of the cellular and extracellular filament networks.
• By losing microtubullary Control mechanisms impaired the aggregation of cytoplasmic and extracellular filament structures. Diffuse, unbundled arrangements of cellular filaments occur. The cellular flow of force takes place largely via bundled actin strands. A disruption of the actin bundling and the connection proteins leads to a loss of the functional cell rigidity and to a significantly changed vibration behavior.
• the cytoplasmic and extracellular viscosity is largely determined by the state of matter and the filament organization of cellular and extracellular protein filaments. Loss of the organization of cytoplasmic protein filaments leads to a reduction in the viscosity and to significantly higher vibration amplitudes of malignant cells.
• the visco-elastic properties of malignant cells which are determined by the rate of aggregation of cellular protein filaments, have healthy cells compared to noticeable changes.
• the metastatic cells In the initial stage of the metastatic process, a certain homogeneity of the metastatic cells can be assumed for many tumor diseases.
• the frequencies and powers used damage all cells whose cytoplasmic stiffness and cytoplasmic viscosity have the values of the metastatic cells.
• the metastatic cells are reliably damaged. Healthy cells are not stimulated to resonate vibrations and survive the vibration sequences without damage. Metastasis cells that are smaller than the cells of the calculation models initially survive the initial sonication. For this reason, the sound reinforcement is repeated at defined time intervals. The time intervals are determined by the growth rate of the cells.
• Metastasis cells that are larger than the cells of the calculation models have resonance peaks that are below the calculated values for cells of the simulation models. Such cells survive the initial treatment for the time being. After the initial treatment, treatment with frequencies below the theoretical resonances is carried out. Metastasis cells that are larger than the cells of the calculation models are also recorded. Healthy cells in the target organ usually have resonance peaks that lie above the resonance peaks of the metastatic cells. Treatment frequencies below the resonance peaks of the metastatic cells are harmless for healthy cells of the target organs. The tumor cell is damaged by the device for the vibration-induced treatment of malignant diseases by exceeding the critical one Tangential expansion (1.4%) of the plasma membrane at the nuclear magnetic resonance frequency and due to shear failure of the plasma membrane when the membrane vibrates.
• the device for vibration-induced treatment is designed in such a way that the affected tissue cools down to approx. 30 ° C.
• the frequencies of the vibrations are applied broadband. They have to cover the entire resonance range of all tumor cells. Healthy cells are overdamped. Resonance peaks are not generated here.
• the device for the selective, vibration-induced treatment of malignant diseases homogeneous tumor cells and homogeneous initial metastases can be selectively destroyed without additionally cooling the affected area.
• the device for selective, vibration-induced treatment of malignant diseases applies vibrations which excite the resonance amplitudes of the tumor cells of the respective mother tumor. Healthy cells in the target organ are not stimulated to vibrate and remain undamaged.
• Exemplary embodiment device for the selective, vibration-induced treatment of malignant diseases of the brain.
• the device consists of an extracorporeal frequency generator, an extracorporeal amplifier, a special microsurgical instrument and one or more piezoceramic elements attached behind or next to the video head.
• the shape of the piezoceramic elements is cylindrical or spherical.
• the excitation frequencies and the amplitudes of the vibrations are matched to the tumor cells to be treated.
• the treatment amplitudes, the treatment frequency, the treatment duration and the treatment temperature are determined by metastatic cells from the vibration parameters of the cells of the mother tumor.
• the vibration parameters of the tumor cells and the metastatic cells are used as boundary conditions in the theoretical simulation models.
• the results of the simulation models are validated experimentally and used as treatment parameters for selective, lethal damage to the tumor.
• the treatment temperature varies between 24 ° C and 40 ° C.
• the duration of treatment is 2 to 4 minutes.
• the selectivity of the treatment can be improved by cooling the area to be treated to 20 ° to 30 ° C.
• the duration of treatment is 2 to 4 minutes.
• the area to be treated is cooled to 10 ° to 20 ° C.
• the cooling causes an increase in the viscosity of the cellular and extracellular plasma.
• Malignant and healthy cells can no longer be damaged by the vibrations.
• the metabolism of the tumor cells is then intensified by the addition of specific, metabolically stimulating substances (e.g. glucose).
• the tumor cells absorb the active ingredient more and increase their metabolism. Your temperature rises.
• the tumor cells are now able to vibrate.
• the vibration-induced treatment now takes place. Broad frequency bands are applied.
• the tumor which consists of heterogeneous cells, is destroyed. Healthy, cooled cells survive the treatment without damage.
• micro-hydraulic device for the selective, vibration-induced treatment of malignant diseases of the brain.
• the device consists of an extracorporeal US generator, a micro-hydraulic pressure hose, a spherical or circular membrane for the transmission of vibrations to the tissue to be treated and a special microsurgical instrument.
• the excitation frequencies and the amplitudes of the vibrations are matched to the tumor cells to be treated.
• the treatment amplitudes, the treatment frequency, the treatment duration and the treatment temperature are determined by the vibration parameters of the cells of the mother tumor.
• the vibration parameters of the tumor cells and the metastatic cells are used as boundary conditions in the theoretical simulation models.
• the results of the Simulation models are validated experimentally and used as treatment parameters for selective, lethal damage to the tumor.
• the treatment temperature varies between 24 ° C and 40 ° C.
• the duration of treatment is 2 to 4 minutes.
• the selectivity of the treatment can be improved by cooling the area to be treated to 20 ° to 30 ° C.
• the duration of treatment is 2 to 4 minutes.
• the area to be treated is cooled to 10 ° to 20 ° C.
• the cooling causes an increase in the viscosity of the cellular and extracellular plasma.
• Malignant and healthy cells can no longer be damaged by the vibrations.
• the metabolism of the tumor cells is intensified by the addition of specific, metabolically stimulating active ingredients (eg glucose).
• the tumor cells absorb the active ingredient more and increase their metabolism. Your temperature rises.
• the tumor cells are now able to vibrate.
• the vibration-induced treatment now takes place. Broad frequency bands are applied.
• the tumor which consists of heterogeneous cells, is destroyed. Healthy, cooled cells survive the treatment without damage.
• Exemplary embodiment device for the selective, vibration-induced treatment of malignant diseases of the intestine.
• the device consists of an extracorporeal frequency generator, an extracorporeal amplifier, a microsurgical instrument for colonoscopy and one or more piezoceramic elements attached behind the video head.
• the shape of the piezoceramic elements is cylindrical or hollow cylindrical.
• the excitation frequencies of the piezo elements and the radially or spherically excited vibration amplitudes are matched to the tumor cells and metastatic cells to be treated.
• Treatment amplitudes, treatment frequency, treatment duration and the treatment temperature are determined by the vibration parameters of the cells of the mother tumor and its metastatic cells.
• the vibration parameters of the tumor cells and metastasis cells are used as boundary conditions in theoretical simulation models. The results of the simulation models are validated experimentally and used as treatment parameters for selective, lethal damage.
• the intestine Before the treatment, the intestine is completely emptied and then filled with warm water.
• the temperature of the water depends on the type of tumor and varies between 24 ° C and 40 ° C.
• the duration of treatment is 2 to 4 minutes.
• the selectivity of the treatment can be improved by cooling the intestinal tract to 20 ° to 30 ° C.
• the intestine is filled completely or in the area to be treated with cold water.
• the temperature of the water is 20 ° to 30 ° C.
• the duration of treatment is 2 to 4 minutes.
• the intestine is filled completely or in the area to be treated with cold water before the treatment.
• the temperature of the water is 10 ° to 20 ° C.
• the cooling causes an increase in the viscosity of the cellular and extracellular plasma in the area of the intestine to be treated.
• the vibrations can no longer damage the cells.
• the metabolism of the tumor cells in the intestine is then intensified by the addition of specific, metabolically stimulating substances (e.g. glucose).
• the tumor cells increase their metabolism. Your temperature rises.
• the tumor cells are now able to vibrate.
• the vibration-induced treatment now takes place. Broad frequency bands are applied.
• the tumor which consists of heterogeneous cells, is destroyed. Healthy, still supercooled cells survive the treatment without damage.
• the area of possible metastatic pathways, affected lymph nodes and affected organs is treated with the lethal frequencies of the cells of the mother tumor.
• the duration of treatment is 2 to 4 minutes.
• heating or cooling can be carried out and an active substance that stimulates the metabolism can also be given.
• micro-hydraulic device for the selective, vibration-induced treatment of malignant diseases of the intestine.
• the device consists of an extracorporeal US generator, a micro-hydraulic
• Pressure hose a spherical or circular membrane for the transmission of the
• the excitation frequencies of the sound generator are matched to the tumor cells and metastatic cells to be treated.
• Treatment duration and treatment temperature are determined by the vibration parameters of the cells of the mother tumor and its metasase cells.
• the vibration parameters of the tumor cells and the metastasis cells are used as boundary conditions in the theoretical simulation models.
• the results of the simulation models are validated experimentally and used as treatment parameters for selective, lethal damage to the tumor cells.
• the intestine Before the treatment, the intestine is completely emptied and then filled with warm water.
• the temperature of the water depends on the type of tumor and varies between 24 ° C and 40 ° C.
• the duration of treatment is 2 to 4 minutes.
• the selectivity of the treatment can be improved by cooling the intestinal tract to 20 ° to 30 ° C.
• the intestine is filled completely or in the area to be treated with cold water.
• the temperature of the water is 20 ° to 30 ° C.
• the duration of treatment is 2 to 4 minutes.
• the intestine is filled completely or in the area to be treated with cold water before the treatment.
• the temperature of the water is 10 ° to 20 ° C.
• the cooling causes an increase in the viscosity of the cellular and extracellular plasma in the area of the intestine to be treated.
• the vibrations can no longer damage the cells.
• the metabolism of the tumor cells in the intestine is then intensified by the addition of specific, metabolically stimulating substances (e.g. glucose).
• the tumor cells increase their metabolism. Your temperature rises.
• the tumor cells are now able to vibrate.
• the vibration-induced treatment now takes place. Broad frequency bands are applied.
• the tumor which consists of heterogeneous cells, is destroyed. Healthy, still supercooled cells survive the treatment without damage.
• the area of possible metastatic pathways, affected lymph nodes and affected organs is treated with the lethal frequencies of the cells of the mother tumor.
• the duration of treatment is 2 to 4 minutes.
• heating or cooling can be carried out and an active substance that stimulates the metabolism can also be given.
• Exemplary embodiment device for the selective, vibration-induced treatment of malignant diseases of the stomach and esophagus.
• the device consists of a frequency generator, an amplifier, a microsurgical instrumentation for gastroscopy and one or more piezoceramic elements attached behind the video head.
• the shape of the piezoceramic elements is cylindrical or hollow cylindrical.
• the excitation frequencies of the piezo elements and the radially or spherically excited oscillation amplitudes are matched to the tumor cells and metastasis cells to be treated.
• Treatment amplitudes, treatment frequency, treatment duration and the treatment temperature are determined by the vibration parameters of the cells of the mother tumor and its metasase cells.
• the vibration parameters of the tumor cells and the metastatic cells are used as boundary conditions in the theoretical simulation models.
• the results of the simulation models are validated experimentally and used as treatment parameters for selective, lethal damage to the tumor cells.
• the stomach and esophagus are completely emptied and then filled with warm water.
• the temperature of the water depends on the type of tumor and varies between 24 ° C and 40 ° C.
• the duration of treatment is 2 to 4 minutes.
• the selectivity of the treatment can be improved by cooling the area to be treated to 20 ° to 30 ° C.
• the stomach or esophagus is filled with cold water.
• the temperature of the water is 20 ° to 30 ° C.
• the duration of treatment is 2 to 4 minutes.
• the stomach and the esophagus are completely filled with cold water before the treatment.
• the temperature of the water is 10 ° to 20 ° C.
• the cooling causes an increase in the viscosity of the cellular and extracellular plasma.
• the vibrations can no longer damage the cells.
• the metabolism of the tumor cells is intensified by the addition of specific, metabolically stimulating active ingredients (eg glucose).
• the tumor cells increase their metabolism. Your temperature rises.
• the tumor cells are now able to vibrate.
• the vibration-induced treatment now takes place. Broad frequency bands are applied.
• the tumor which consists of heterogeneous cells, is destroyed.
• micro-hydraulic device for the selective, vibration-induced treatment of malignant diseases of the stomach and esophagus.
• the device consists of an extracorporeal US generator, a micro-hydraulic pressure hose, a spherical or circular membrane for the transmission of vibrations to the tissue to be treated and a microsurgical instrumentation for gastroscopy.
• the excitation frequencies of the sound generator are matched to the tumor cells and metastatic cells to be treated.
• Treatment amplitudes, treatment frequency, treatment duration and the treatment temperature are determined by the vibration parameters of the cells of the mother tumor and its metasase cells.
• the vibration parameters of the tumor cells and the metastasis cells are used as boundary conditions in theoretical simulation models.
• the results of the simulation models are validated experimentally and used as treatment parameters for selective, lethal damage to the tumor cells.
• the stomach and esophagus are completely emptied and then filled with warm water.
• the temperature of the water depends on the type of tumor and varies between 24 ° C and 40 ° C.
• the duration of treatment is 2 to 4 minutes.
• the selectivity of the treatment can be improved by cooling to 20 ° to 30 ° C.
• the stomach and esophagus are completely filled with cold water.
• the temperature of the water is 20 ° to 30 ° C.
• the duration of treatment is 2 to 4 minutes.
• the area to be treated is filled with cold water before the treatment.
• the temperature of the water is 10 ° to 20 ° C.
• the cooling causes an increase in the viscosity of the cellular and extracellular plasma in the tissue to be treated.
• the vibrations can no longer damage the cells.
• the metabolism of the tumor cells by the Addition of specific, metabolically stimulating active ingredients (eg glucose) intensified.
• the tumor cells increase their metabolism. Your temperature rises.
• the tumor cells are now able to vibrate.
• the vibration-induced treatment now takes place. Broad frequency bands are applied.
• the tumor which consists of heterogeneous cells, is destroyed.
• Exemplary embodiment device for the selective, vibration-induced treatment of malignant diseases of the liver.
• the device consists of a frequency generator, an amplifier, a microsurgical instrument for liver mirroring and one or more piezoceramic elements attached behind the video head.
• the excitation frequencies of the piezo elements and the excited vibration amplitudes are matched to the tumor cells or metastasis cells to be treated.
• Treatment amplitudes, treatment frequency, treatment duration and the treatment temperature are determined by the vibration parameters of the cells of the mother tumor and its metasase cells.
• the vibration parameters of the tumor cells and the metastatic cells are used as boundary conditions in the theoretical simulation models. The results of the simulation models are validated experimentally and used as treatment parameters for selective, lethal damage to the tumor cells.
• the treatment temperature varies between 24 ° C and 40 ° C.
• the duration of treatment is 2 to 4 minutes.
• the selectivity of the treatment can be improved by cooling the area to be treated to 20 ° to 30 ° C.
• the duration of treatment is 2 to 4 minutes.
• the area to be treated is cooled to 10 ° C to 20 ° C.
• the cooling causes an increase in the viscosity of the cellular and extracellular plasma. Malignant and healthy cells can no longer be damaged by the vibrations.
• the metabolism of the tumor cells by the Addition of specific, metabolically stimulating active ingredients (eg glucose) intensified.
• the tumor cells absorb the active ingredient more and increase their metabolism. Your temperature rises.
• the tumor cells are now able to vibrate.
• the vibration-induced treatment now takes place. Broad frequency bands are applied.
• the tumor which consists of heterogeneous cells, is destroyed. Healthy, cooled cells survive the treatment without damage.
• the area of possible metastatic pathways, affected lymph nodes and affected organs is treated with the lethal frequencies of the cells of the mother tumor.
• the duration of treatment is 2 to 4 minutes.
• heating or cooling can be carried out and an active substance that stimulates the metabolism can also be given.
• micro-hydraulic device for the selective, vibration-induced treatment of malignant diseases of the liver.
• the device consists of an extracorporeal US generator, a micro-hydraulic pressure hose, a spherical or circular membrane for the transmission of vibrations to the tissue to be treated and a microsurgical instrument for liver mirroring.
• the excitation frequencies of the piezo elements and the excited vibration amplitudes are matched to the tumor cells or metastasis cells to be treated.
• Treatment amplitudes, treatment frequency, treatment duration and the treatment temperature are determined by the vibration parameters of the cells of the mother tumor and its metasase cells.
• the vibration parameters of the tumor cells and the metastatic cells are used as boundary conditions in the theoretical simulation models. The results of the simulation models are validated experimentally and used as treatment parameters for selective, lethal damage to the tumor cells.
• the treatment temperature varies between 24 ° C and 40 ° C.
• the duration of treatment is 2 to 4 minutes.
• the selectivity of the treatment can be improved by cooling the area to be treated to 20 ° to 30 ° C.
• the duration of treatment is 2 to 4 minutes.
• the area to be treated is cooled to 10 ° C to 20 ° C.
• the cooling causes an increase in the viscosity of the cellular and extracellular plasma.
• Malignant and healthy cells can no longer be damaged by the vibrations.
• the metabolism of the tumor cells is intensified by the addition of specific, metabolically stimulating active ingredients (eg glucose).
• the tumor cells absorb the active ingredient more and increase their metabolism. Your temperature rises.
• the tumor cells are now able to vibrate.
• the vibration-induced treatment now takes place. Broad frequency bands are applied.
• the tumor which consists of heterogeneous cells, is destroyed. Healthy, cooled cells survive the treatment without damage.
• Embodiment Device for the selective, vibration-induced treatment of breast cancer and the metastases of breast cancer.
• the device consists of an extracorporeal frequency generator, an extracorporeal amplifier, a special microsurgical instrument and one or more piezoceramic transducers.
• the excitation frequencies and the amplitudes of the vibrations are matched to the tumor cells to be treated.
• the treatment amplitudes, the treatment frequency, the treatment duration and the treatment temperature are determined by the vibration parameters of the cells of the mother tumor.
• the vibration parameters of the tumor cells and the metastatic cells are used as boundary conditions in the theoretical simulation models.
• the results of the simulation models are validated experimentally and used as treatment parameters for selective, lethal damage to the tumor.
• the treatment temperature varies between 24 ° C and 40 ° C.
• the duration of treatment is 2 to 4 minutes.
• the selectivity of the treatment can be improved by cooling the area to be treated to 20 ° to 30 ° C.
• the duration of treatment is 2 to 4 minutes.
• the area to be treated is cooled to 10 ° to 20 ° C.
• the cooling causes an increase in the viscosity of the cellular and extracellular plasma. Malignant and healthy cells can no longer be damaged by the vibrations.
• the metabolism of the tumor cells is intensified by the addition of specific, metabolically stimulating active ingredients (eg glucose).
• the tumor cells absorb the active ingredient more and increase their metabolism. Your temperature rises.
• the tumor cells are now able to vibrate.
• the vibration-induced treatment now takes place. Broad frequency bands are applied.
• the tumor which consists of heterogeneous cells, is destroyed. Healthy, still cooled cells survive treatment without harm.
• the area of possible metastatic pathways, affected lymph nodes and affected organs is treated with the lethal frequencies of the breast cancer cells.
• the duration of treatment is 2 to 4 minutes.
• heating or cooling can be carried out and an active substance that stimulates the metabolism can also be given.
• micro-hydraulic device for the selective, vibration-induced treatment of breast cancer and the metastases of breast cancer.
• the device consists of an extracorporeal US generator, a micro-hydraulic pressure hose and one or more circular membranes for the transmission of the vibrations to the tissue to be treated.
• the excitation frequencies and the amplitudes of the vibrations are matched to the tumor cells to be treated.
• the treatment amplitudes, the treatment frequency, the treatment duration and the treatment temperature are determined by the vibration parameters of the cells of the mother tumor.
• the vibration parameters of the tumor cells and the metastatic cells are used as boundary conditions in the theoretical simulation models.
• the results of the simulation models are validated experimentally and used as treatment parameters for selective, lethal damage to the tumor.
• the treatment temperature varies between 24 ° C and 40 ° C.
• the duration of treatment is 2 to 4 minutes.
• the selectivity of the treatment can be improved by cooling the area to be treated to 20 ° to 30 ° C.
• the duration of treatment is 2 to 4 minutes.
• the area to be treated is cooled to 10 ° to 20 ° C.
• the cooling causes an increase in the viscosity of the cellular and extracellular plasma.
• Malignant and healthy cells can no longer be damaged by the vibrations.
• the metabolism of the tumor cells is intensified by the addition of specific, metabolically stimulating active ingredients (eg glucose).
• the tumor cells absorb the active ingredient more and increase their metabolism. Your temperature rises.
• the tumor cells are now able to vibrate.
• the vibration-induced treatment now takes place. Broad frequency bands are applied.
• the Tumor consisting of heterogeneous cells is destroyed. Healthy, cooled cells survive the treatment without damage.
• the area of possible metastatic pathways, affected lymph nodes and affected organs is treated with the lethal frequencies of the breast cancer cells.
• the duration of treatment is 2 to 4 minutes.
• heating or cooling can be carried out and an active substance that stimulates the metabolism can also be given.
• Exemplary embodiment device for the selective, vibration-induced treatment of malignant diseases of the larynx and throat.
• the device consists of a frequency generator, an amplifier, a microsurgical instrument for non-invasive reflections and one or more piezoceramic elements attached behind the video head.
• Excitation frequencies of the piezo elements excited vibration amplitudes are matched to the tumor cells or metastasis cells to be treated. Treatment amplitudes
• Treatment frequency, treatment duration and treatment temperature are determined by the
• Simulation models are validated experimentally and used as treatment parameters for selective, lethal damage to the tumor cells.
• the treatment temperature varies between 24 ° C and 40 ° C.
• the duration of treatment is
• the selectivity of the treatment can be improved by cooling the area to be treated to 20 ° to 30 ° C.
• the duration of treatment is 2 to 4 minutes.
• the area to be treated is increased to 10 °
• the cooling causes an increase in the viscosity of the cellular and extracellular plasma. Malignant and healthy cells can no longer be damaged by the vibrations. Then the metabolism of the tumor cells by the
• the tumor cells absorb the active ingredient more and increase their metabolism. Your Temperature increases.
• the tumor cells are now able to vibrate.
• the vibration-induced treatment now takes place. Broad frequency bands are applied.
• the tumor which consists of heterogeneous cells, is destroyed. Healthy, cooled cells survive the treatment without damage.
• the area of possible metastatic pathways, affected lymph nodes and affected organs is treated with the lethal frequencies of the cells of the mother tumor.
• the duration of treatment is 2 to 4 minutes.
• heating or cooling can be carried out and an active substance that stimulates the metabolism can also be given.
• Exemplary embodiment device for the selective, vibration-induced treatment of malignant diseases of the skin.
• the device consists of an extracorporeal frequency generator, an extracorporeal amplifier, and one or more piezoceramic transducers.
• the excitation frequencies and the amplitudes of the vibrations are matched to the tumor cells to be treated.
• the treatment amplitudes, the treatment frequency, the treatment duration and the treatment temperature are determined by the vibration parameters of the cells of the mother tumor.
• the vibration parameters of the tumor cells and the metastatic cells are used as boundary conditions in the theoretical simulation models.
• the results of the simulation models are validated experimentally and used as treatment parameters for selective, lethal damage to the tumor.
• the treatment temperature varies between 24 ° C and 40 ° C.
• the duration of treatment is 2 to 4 minutes.
• the selectivity of the treatment can be improved by cooling the area to be treated to 20 ° to 30 ° C.
• the duration of treatment is 2 to 4 minutes.
• the area to be treated is cooled to 10 ° to 20 ° C.
• the cooling causes an increase in the viscosity of the cellular and extracellular plasma. Malignant and healthy cells can no longer be damaged by the vibrations. Then the metabolism of the tumor cells is intensified by the addition of specific, metabolically stimulating active ingredients (eg glucose).
• the tumor cells absorb the active ingredient more and increase their metabolism. Your temperature rises. The tumor cells are now able to vibrate. Now the vibration induced treatment. Broad frequency bands are applied.
• the tumor which consists of heterogeneous cells, is destroyed. Healthy, cooled cells survive the treatment without damage.
• the area of possible metastatic pathways, affected lymph nodes and affected organs is treated with the lethal frequencies of the melanoma cells.
• the duration of treatment is 2 to 4 minutes.
• heating or cooling can be carried out and an active substance that stimulates the metabolism can also be given.
• micro-hydraulic device for the selective, vibration-induced treatment of malignant diseases of the skin.
• the device consists of an extracorporeal US generator, a micro-hydraulic
• the excitation frequencies and the amplitudes of the vibrations are matched to the tumor cells to be treated.
• the amplitudes of the vibrations are matched to the tumor cells to be treated.
• the vibration parameters of the tumor cells and the metastatic cells are as
• Simulation models are validated experimentally and used as treatment parameters for selective, lethal damage to the tumor.
• the treatment temperature varies between 24 ° C and 40 ° C.
• the duration of treatment is 2 to 4 minutes.
• the selectivity of the treatment can be improved by cooling the area to be treated to 20 ° to 30 ° C.
• the duration of treatment is 2 to 4 minutes.
• the area to be treated is cooled to 10 ° to 20 ° C.
• the cooling causes an increase in the viscosity of the cellular and extracellular
• Plasma Malignant and healthy cells can no longer be damaged by the vibrations.
• the metabolism of the tumor cells is then intensified by the addition of specific, metabolically stimulating substances (e.g. glucose).
• specific, metabolically stimulating substances e.g. glucose
• the tumor cells are now able to vibrate. Now the vibration induced treatment. Broad frequency bands are applied.
• the tumor which consists of heterogeneous cells, is destroyed. Healthy, cooled cells survive the treatment without damage.
• the area of possible metastatic pathways, affected lymph nodes and affected organs is treated with the lethal frequencies of the melanoma cells.
• the duration of treatment is 2 to 4 minutes.
• heating or cooling can be carried out and an active substance that stimulates the metabolism can also be given.
• Exemplary embodiment device for the selective, vibration-induced treatment of malignant diseases of the blood and the blood-forming organs.
• the device consists of an extracorporeal frequency generator, an extracorporeal amplifier, a vibrating table with one or more piezoceramic vibrating elements and a commercially available device for the extracorporeal exchange of blood.
• the blood is led through flexible tubes that are attached to the vibrating table.
• the excitation frequencies and the amplitudes of the vibrations are matched to the tumor cells to be treated.
• the treatment amplitudes, the treatment frequency, the treatment duration and the treatment temperature are determined by the vibration parameters of the cells of the mother tumor.
• the vibration parameters of the tumor cells and the metastatic cells are used as boundary conditions in the theoretical simulation models. The results of the simulation models are validated experimentally and used as treatment parameters for selective, lethal damage to the tumor cells.
• the treatment temperature varies between 24 ° C and 40 ° C.
• the blood speed is adjusted so that the blood in the vibrating tubes is exposed to the vibrations for 2 minutes.
• the selectivity of the treatment can be improved by cooling the area to be treated to 20 ° to 30 ° C.
• the area to be treated is cooled to 10 ° to 20 ° C.
• the cooling causes an increase in the viscosity of the cellular and extracellular plasma.
• Malignant and healthy cells can no longer be damaged by the vibrations.
• the metabolism Tumor cells intensified by the addition of specific, metabolically stimulating substances (e.g. glucose).
• the tumor cells absorb the active ingredient more and increase their metabolism. Your temperature rises.
• the tumor cells are now able to vibrate and are fatally damaged when they flow through the vibrating tubes. Healthy, cooled cells survive the treatment without damage.
• the area of possible metastatic pathways, affected lymph nodes and affected organs is treated with the lethal frequencies of the metastatic cells.
• the duration of treatment is 2 to 4 minutes.
• heating or cooling can be carried out and an active substance that stimulates the metabolism can also be given.
• micro-hydraulic device for the selective, vibration-induced treatment of malignant diseases of the blood and the blood-forming organs.
• the device consists of an extraco-oral US generator, extraco-oral amplifier, a hydraulic vibrating table and a commercially available device for the extraco-oral exchange of blood.
• the blood is led through flexible tubes that are attached to the vibrating table.
• the excitation frequencies and the amplitudes of the vibrations are matched to the tumor cells to be treated.
• the treatment amplitudes, the treatment frequency, the treatment duration and the treatment temperature are determined by the vibration parameters of the cells of the mother tumor.
• the vibration parameters of the tumor cells and the metastatic cells are used as boundary conditions in the theoretical simulation models.
• the results of the simulation models are validated experimentally and used as treatment parameters for selective, lethal damage to the tumor cells.
• the treatment temperature varies between 24 ° C and 40 ° C.
• the blood speed is adjusted so that the blood in the vibrating tubes is exposed to the vibrations for 2 minutes.
• the selectivity of the treatment can be improved by cooling the area to be treated to 20 ° to 30 ° C.
• the area to be treated is cooled to 10 ° to 20 ° C.
• the cooling causes an increase in the viscosity of the cellular and extracellular plasma.
• Malignant and healthy cells can be caused by the Vibrations are no longer damaged.
• the metabolism of the tumor cells is intensified by the addition of specific, metabolically stimulating active ingredients (eg glucose).
• the tumor cells absorb the active ingredient more and increase their metabolism. Your temperature rises.
• the tumor cells are now able to vibrate and are fatally damaged when they flow through the vibrating tubes. Healthy, cooled cells survive the treatment without damage.
• the area of possible metastatic pathways, affected lymph nodes and affected organs is treated with the lethal frequencies of the metastatic cells.
• the duration of treatment is 2 to 4 minutes.
• heating or cooling can be carried out and an active substance that stimulates the metabolism can also be given.
• Embodiment Device for the selective, vibration-induced treatment of tumor cells that metastasize via the bloodstream.
• the device consists of an extracorporeal frequency generator, an extracorporeal amplifier, a vibrating table with one or more piezoceramic vibrating elements and a commercially available device for the extracorporeal exchange of blood.
• the blood is led through flexible tubes that are attached to the vibrating table.
• the treatment amplitudes, the treatment frequency, the treatment duration and the treatment temperature are matched to the metastatic cells to be treated.
• the vibration parameters of the metastatic cells are used as boundary conditions in the theoretical simulation models.
• the results of the simulation models are validated experimentally and used as treatment parameters for selective, lethal damage to the metastatic cells.
• the treatment temperature varies between 24 ° C and 40 ° C.
• the blood speed is adjusted so that the blood in the vibrating tubes is exposed to the vibrations for 2 minutes.
• the selectivity of the treatment can be improved by cooling the area to be treated to 20 ° to 30 ° C.
• the area to be treated is cooled to 10 ° to 20 ° C.
• the cooling causes an increase in the viscosity of the cellular and extracellular plasma. Malignant and healthy cells can no longer be damaged by the vibrations.
• the metabolism of the tumor cells is increased by the addition of specific, metabolically stimulating agents (e.g. Glucose) intensified.
• the tumor cells absorb the active ingredient more and increase their metabolism. Your temperature rises.
• the tumor cells are now able to vibrate and are fatally damaged when they flow through the vibrating tubes. Healthy, cooled cells survive the treatment without damage.
• Exemplary embodiment micro-hydraulic device for the selective, vibration-induced treatment of tumor cells that metastasize via the bloodstream.
• the device consists of an extracorporeal frequency generator, an extracorporeal amplifier, a hydraulic vibrating table and a commercially available device for the extracorporeal exchange of blood.
• the blood is led through flexible tubes that are attached to the vibrating table.
• the treatment amplitudes, the treatment frequency, the treatment duration and the treatment temperature are matched to the metastatic cells to be treated.
• the vibration parameters of the metastatic cells are used as boundary conditions in the theoretical simulation models.
• the results of the simulation models are validated experimentally and used as treatment parameters for selective, lethal damage to the metastatic cells.
• the treatment temperature varies between 24 ° C and 40 ° C.
• the blood speed is adjusted so that the blood in the vibrating tubes is exposed to the vibrations for 2 minutes.
• the selectivity of the treatment can be improved by cooling the area to be treated to 20 ° to 30 ° C.
• the area to be treated is cooled to 10 ° to 20 ° C.
• the cooling causes an increase in the viscosity of the cellular and extracellular plasma.
• Malignant and healthy cells can no longer be damaged by the vibrations.
• the metabolism of the tumor cells is then intensified by the addition of specific, metabolically stimulating substances (e.g. glucose).
• the tumor cells absorb the active ingredient more and increase their metabolism. Your temperature rises.
• the tumor cells are now able to vibrate and are fatally damaged when they flow through the vibrating tubes. Healthy, cooled cells survive the treatment without damage.

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