WO2001006996A1 - Produit cosmetique avec extraits de plantes de la famille des piperacees - Google Patents

Produit cosmetique avec extraits de plantes de la famille des piperacees Download PDF

Info

Publication number
WO2001006996A1
WO2001006996A1 PCT/EP2000/006737 EP0006737W WO0106996A1 WO 2001006996 A1 WO2001006996 A1 WO 2001006996A1 EP 0006737 W EP0006737 W EP 0006737W WO 0106996 A1 WO0106996 A1 WO 0106996A1
Authority
WO
WIPO (PCT)
Prior art keywords
acid
oil
extract
derivatives
piperaceae
Prior art date
Application number
PCT/EP2000/006737
Other languages
German (de)
English (en)
Inventor
Wilhelm Johannisbauer
Mehdi Bonakdar
Klaus Rudolf SCHRÖDER
Rolf Wachter
Original Assignee
Cognis Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cognis Deutschland Gmbh filed Critical Cognis Deutschland Gmbh
Publication of WO2001006996A1 publication Critical patent/WO2001006996A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair

Definitions

  • the invention is in the field of cosmetic products and relates to products containing plant extracts from the Piperaceae family.
  • Cosmetic preparations are available to the consumer in a variety of combinations today. Nevertheless, there is still a need in the market for products with an improved range of services. Skin compatibility and the use of natural products by the customer are particularly important here. In addition, it is desirable to obtain significantly better products by combining them with known active ingredients. Of particular interest are substances that both positively influence the technical properties of the cosmetic product, such as storage stability, light stability and formulability, and at the same time represent active ingredients that impart, for example, nourishing, moisturizing, anti-irritant and / or anti-inflammatory properties.
  • the complex object of the invention was therefore to provide cosmetic and / or pharmaceutical preparations which meet the high requirements for phase stability and storage stability as well as compatibility with sensitive skin and, if possible, also have significantly improved skin-care and protective properties.
  • the invention relates to cosmetic compositions which contain an extract of at least one plant from the Piperaceae family, in particular an extract from Piperaceae of the genus Piper L.
  • an extract from Piperaceae gives products which are both good care and protective properties as well as have high skin tolerance at an early stage.
  • the agents obtained in this way are furthermore distinguished by a particularly high antioxidative capacity, which on the one hand protects the skin from inflammatory reactions and against oxidative skin aging processes, and on the other hand protects the cosmetic agents from oxidative degradation (spoilage).
  • the agents obtained in this way are stable against microbial attack, in particular against fungal attack, so that in many cases the addition of further preservatives can be dispensed with. This is particularly advantageous with regard to products for sensitive skin, since allergic reactions or intolerances are often triggered by preservatives.
  • plant means both whole plants and parts of plants (leaves, roots, flowers, fruits) and mixtures thereof.
  • the extracts to be used according to the invention are selected from plants of the Piperaceae family.
  • extracts from Piperaceae of the genus Piper L. are used as plant extracts.
  • Piper betle L, Piper cuba L, Piper longum L. and Piper nigrum L. are preferred.
  • Extracts from Piper betle L. (betel pepper) are particularly preferred.
  • Betel pepper (Piper betle L.) is a perennial, up to 5 m high climbing plant with heart-shaped leaves, tiny yellow-green flowers and small, round fruits. It is native to Malaysia and southern India and is also grown in South Asia, East Africa, Madagascar and the Caribbean. All known Piper betle varieties are to be used according to the invention, such as, for example, the varieties “Bangla”, “Desawari”, “Kapoori”, “Khasi”, “Meetha” and “Sanchi”. Leaves, roots as well as fruits and flowers can be used. In a particularly preferred embodiment of the invention, the leaf extracts (betel leaf extracts) are used. For a comprehensive description of the betel pepper and the botanical classification, reference is made to Hager's Handbook of Pharmaceutical Practice, (5th edition, vol. 4, Springer Verlag Berlin-Heidelberg-New-York, 1992).
  • the extracts to be used according to the invention are produced by customary methods of extracting the plants or parts of plants.
  • suitable conventional extraction methods such as maceration, remaceration, digestion, movement maceration, vortex extraction, ultrasound extraction, countercurrent extraction, percolation, repercolation, evacolation (extraction under reduced pressure), diacolation and solid liquid ex- traction under continuous reflux, which is carried out in a Soxhlet extractor, which is known to the person skilled in the art and in principle all can be used, for the sake of simplicity, for example, on Hager's Handbook of Pharmaceutical Practice, (5th edition. Vol. 2, p. 1026- 1030, Springer Verlag, Berlin-Heidelberg-New-York 1991).
  • the percolation method is advantageous for large-scale use.
  • Fresh plants or parts of plants can be used as the starting material, but usually dried plants and / or parts of plants are used, which can be mechanically comminuted before extraction. All comminution methods known to the person skilled in the art are suitable here, freeze grinding being mentioned as an example.
  • Organic solvents water (preferably hot water at a temperature of above 80 ° C. and in particular above 95 ° C.) or mixtures of organic solvents and water, in particular low molecular weight alcohols with more or less high water contents, can be used as solvents for carrying out the extractions become.
  • Extraction with methanol, ethanol, pentane, hexane, heptane, acetone, propylene glycols, polyethylene glycols and ethyl acetate as well as mixtures thereof and their aqueous mixtures is particularly preferred.
  • the extraction is usually carried out at 20 to 100 ° C, preferably at 30 to 90 ° C, in particular at 60 to 80 ° C.
  • the extraction takes place under an inert gas atmosphere to avoid oxidation of the active ingredients of the extract. This is particularly important for extractions at temperatures above 40 ° C.
  • the extraction times are determined by the person skilled in the art depending on the starting material, the extraction process, the extraction temperature, the ratio of solvent to raw material, etc. set.
  • the crude extracts obtained can optionally be subjected to further customary steps, such as purification, concentration and / or decolorization. If desired, the extracts produced in this way can, for example, be subjected to a selective separation of individual undesirable ingredients.
  • the extraction can take place to any degree of extraction, but is usually carried out to exhaustion.
  • the present invention encompasses the knowledge that the extraction conditions and the yields of the final extracts can be chosen by the person skilled in the art depending on the desired field of use. extracts
  • the Piperaceae extracts to be used according to the invention generally contain the essential oils of the Piperaceae. These are composed differently depending on the selected starting material and the selected extraction method.
  • the ingredients of the extracts from betel pepper leaves are described by, for example, A. Rimando et al. in Arch. Pharm. Res. 9 (2), 93-97, (1986) or M. Sharma et al. in Indian Perf. 27 (2), 91-93 (1983) and in Indian Perf. 31 (4), 319-324 (1987), as well as by S. Carg in Indian Journal of Chemistry, Vol. 35B, 874- 875 (1996), to which express reference is made here.
  • the dry matter content of the extraction solutions can vary within wide limits depending on the starting material and the extraction method used. It is usually between 1 and 20% by weight, in particular between 2 and 10% by weight.
  • non-phenolic phenylpropane derivatives include its anethole and safrol.
  • the following can be present as terpenes: caryophyllene, terpinylacetate, camphene, 1, 8 cineol, p-cymen, ⁇ -pinene, ⁇ -pinene and terpinerol.
  • the extracts from betel pepper leaves contain as main component (> 25% by weight, based on the amount of the total extract, hydroxychavicol (synonyms: allypyrocatechol; 2-hydroxy-4-allylcatechol) and, in subordinate amounts, carvacrol (5-isopropyl -2-methylphenol) and caryophyllene (class of terpenes), particularly preferred is the use of an extract from betel pepper leaves which contains more than 40% by weight, in particular more than 50% by weight, hydroxychavicol.
  • the present invention includes the discovery that the properties of the Piperaceae plant extracts are caused by the interaction of a variety of compounds. For example, the nourishing and skin-friendly properties of betel pepper extracts are due to the interaction of the individual substances present in the extract. menqe
  • the amount of plant extracts used depends on the active ingredient content of the extract. As a rule, 0.01 to 20% by weight, in particular 0.05 to 5, and in particular 0.1 to 2.5% by weight of the plant extract, based on the composition, are used.
  • Another object of the invention relates to the use of an agent containing the extract of at least one plant from the Piperaceae family for the production of cosmetic agents.
  • the agents according to the invention show an excellent skin-care effect with high skin tolerance at the same time. In addition, they show good stability, particularly with regard to oxidative decomposition of the products.
  • the plant extracts according to the invention can be used to produce cosmetic products, such as hair shampoos, hair lotions, foam baths, shower baths, creams, gels, lotions, alcoholic and aqueous / alcoholic solutions, emulsions, wax / fat masses, stick preparations, powders or ointments.
  • cosmetic products such as hair shampoos, hair lotions, foam baths, shower baths, creams, gels, lotions, alcoholic and aqueous / alcoholic solutions, emulsions, wax / fat masses, stick preparations, powders or ointments.
  • agents can also be used as further auxiliaries and additives, mild surfactants, oil bodies, emulsifiers, superfatting agents, pearlescent waxes, consistency agents, thickeners, polymers, silicone compounds, fats, waxes, stabilizers, biogenic agents, deodorants, antiperspirants, antidandruff agents, film formers, swelling agents, Contain UV protection factors, antioxidants, hydrotropes, preservatives, insect repellents, self-tanners, tyrosine inhibitors (depigmentation agents), solubilizers, perfume oils, dyes and the like.
  • mild surfactants oil bodies, emulsifiers, superfatting agents, pearlescent waxes, consistency agents, thickeners, polymers, silicone compounds, fats, waxes, stabilizers, biogenic agents, deodorants, antiperspirants, antidandruff agents, film formers, swelling agents, Contain UV protection factors, antioxidants, hydrotropes, preservatives, insect repellents
  • Suitable mild, i.e. surfactants that are particularly compatible with the skin are fatty alcohol polyglycol ether sulfates, monoglyceride sulfates, mono- and / or dialkyl sulfosuccinates, fatty acid isethionates, fatty acid sarcosinates, fatty acid taurides, fatty acid glutamates, ⁇ -olefin sulfonates, ether carboxylic acids, alkyl or fatty acid alkyl fatty acids, alkyl oligamidoblucosides, preferably fatty acids Wheat protein base.
  • Suitable oil bodies are, for example, Guerbet alcohols based on fatty alcohols having 6 to 18, preferably 8 to 10 carbon atoms, esters of linear C6-C22 fatty acids with linear Ce-C 2 2-fatty alcohols, esters of branched C6-C ⁇ 3 -carboxylic acids with linear C6 -C 2 2 fatty alcohols such as myristyl myristate, myristyl palmitate, myristyl stearate, myristyl isostearate, myristyl oleate, myristyl behenate, myristyl stearate, cetyl stearate, cetyl stearate, cetyl stearate, cetyl stearate, cetyl stearate, cetyl stearate, cetyl stearate, cetyl stearate, cetyl stearate, cetyl stearate, cetyl stearate, cetyl stea
  • esters in particular 2-ethylhexanol, esters of linear C6-C22-fatty acids with branched alcohols, of hydroxycarboxylic acids with linear or branched C6-C 22 koholen -Fettal-, in particular Dioctyl Malate, esters of linear and / or branched fatty acids with polyhydric Alcohols (such as propylene glycol, dimer diol or trimer triol) and / or Guerbet alcohols, triglycerides based on C ⁇ -Cio fatty acids, liquid mono- / di- / triglyceride mixtures based on C ⁇ -Ci ⁇ fatty acids, esters of C6-C 22 - Fatty alcohols and / or Guerbet alcohols with aromatic carboxylic acids, especially benzoic acid, esters of C2-Ci2-dicarboxylic acids with linear or branched alcohols with 1 to 22 carbon atoms or polyols with 2 to 10
  • Finsolv® TN linear or branched, symmetrical or asymmetrical dialkyl ethers with 6 to 22 carbon atoms per alkyl group, ring opening products of epoxidized fatty acid esters with polyols, silicone oils and / or aliphatic or naphthenic hydrocarbons, such as squalane , Squalene or dialkylcyclohexanes.
  • Suitable emulsifiers are nonionic surfactants from at least one of the following groups:
  • the adducts of ethylene oxide and / or of propylene oxide with fatty alcohols, fatty acids, alkylphenols or with castor oil are known, commercially available products. These are mixtures of homologs whose average degree of alkoxylation is the ratio of the amounts of ethylene oxide and / or propylene oxide and substrate, with which the addition reaction is carried out.
  • Ci2 / ⁇ s fatty acid monoesters and diesters of adducts of ethylene oxide with glycerol are known from DE 2024051 PS as refatting agents for cosmetic preparations.
  • Alkyl and / or alkenyl oligoglycosides their preparation and their use are known from the prior art. They are produced in particular by reacting glucose or oligosaccharides with primary alcohols with 8 to 18 carbon atoms.
  • glycoside residue both monoglycosides in which a cyclic sugar residue is glycosidically bonded to the fatty alcohol and oligomeric glycosides with a degree of oligomerization of up to about 8 are suitable.
  • the degree of oligomerization is a statistical mean value which is based on a homolog distribution customary for such technical products.
  • Typical examples of suitable partial glycerides are hydroxystearic xystearin Textrediglycerid hydro, isostearic acid, Isostearinklarediglycerid, ⁇ lklaremonogly- cerid, oleic acid diglyceride, Ricinolklaremoglycerid, Ricinolklarediglycerid, Linolklaremonoglycerid, Linolklarediglycerid, Linolenchuremonoglycerid, Linolenchurediglycerid, Erucaklaklamonoglycerid, Erucaklakladiglycerid, Weinchuremonoglycerid, Weinklarediglycerid, Citronenklamonoglycerid, Citric diglyceride, malic acid monoglyceride, malic acid diglyceride and their technical mixtures, which may still contain small amounts of triglyceride from the manufacturing process. Addition products of 1 to 30, preferably 5 to 10, mol of ethylene oxide onto
  • sorbitan sorbitan As sorbitan sorbitan, sorbitan sesquiisostearate, Sorbitandiisostea- get advice, sorbitan triisostearate, sorbitan monooleate, sorbitan, sorbitan, Sorbitanmonoerucat, Sorbitansesquierucat, Sorbitandierucat, Sorbitantrierucat, Sorbitanmonorici- noleat, Sorbitansesquiricinoleat, Sorbitandiricinoleat, Sorbitantriricinoleat, Sorbitanmonohydro- xystearat, Sorbitansesquihydroxystearat, Sorbitandihydroxystearat, Sorbitantrihydroxystearat, Sor - Bitan monotartrate, sorbitan sesquitartrate, sorbitan ditartrate, sorbitan tritartrate, sorbitan monocitrate, sorbitan sesquic
  • polyglycerol esters are polyglyceryl-2 dipolyhydroxystearate (Dehymuls® PGPH), polyglycerol-3 diisostearate (Lameform® TGI), polyglyceryl-4 isostearate (Isolan® Gl 34), polyglyceryl-3 oleate, diisostearoyl polyglyceryl-3 diisostearate ® PDI), Polyglyceryl-3 Methylglucose Distearate (Tego Care® 450), Polyglyceryl-3 Beeswax (Cera Bellina®), Polyglyceryl-4 Caprate (Polyglycerol Caprate T2010 / 90), Polyglyceryl-3 Cetyl Ether (Chi- mexane® NL) , Polyglyceryl-3 Distearate (Cremophor® GS 32) and Polyglyceryl Polyricinoleate (Admul® WOL 1403) Polyglyceryl Dimerate Is
  • polystyrene resin examples include the mono-, di- and triesters of trimethylolpropane or pentaerythritol with lauric acid, coconut fatty acid, taig fatty acid, palmitic acid, stearic acid, oleic acid, behenic acid and the like which are optionally reacted with 1 to 30 mol of ethylene oxide.
  • Zwitterionic surfactants can also be used as emulsifiers.
  • Zwitterionic surfactants are surface-active compounds that contain at least one quaternary ammonium group and at least one carboxylate and one sulfonate group in the molecule.
  • Particularly suitable zwitterionic surfactants are the so-called betaines such as the N-alkyl-N, N-dimethylammonium glycinate, for example the coconut alkyldimethylammonium glycinate, N-acylaminopropyl-N, N-dimethylammonium glycinate, for example the coconut acylaminopropyldimethylammonium glycinate, and 2-alkylmethyl-3-carboxylate -3-hydroxyethylimidazolines each having 8 to 18 carbon atoms in the alkyl or acyl group and the cocoacylaminoethylhydroxyethylcarboxymethylglycinate.
  • betaines such as the N-alkyl-N, N-dimethylammonium glycinate, for example the coconut alkyldimethylammonium glycinate, N-acylaminopropyl-N, N-dimethylammonium glyc
  • Suitable emulsifiers are ampholytic surfactants.
  • Ampholytic surfactants are surface-active compounds which, in addition to a C ⁇ -alkyl or -acyl group, contain at least one free amino group and at least one -COOH or -S0 3 H group in the molecule and are capable of forming internal salts.
  • ampholytic surfactants are N-alkylglycine, N-alkylpropionic acid, N-alkylaminobutyric acid, N-alkyliminodipropionic acid, N-hydroxyethyl-N-alkylamido propylglycine, N-alkyl taurine, N-alkyl sarcosine, 2-alkyl aminopropionic acid and alkyl amino acetic acid each about 8 to 18 carbon atoms in the alkyl group.
  • Particularly preferred ampholytic surfactants are the N-coconut alkyl aminopropionate, the coconut acylaminoethyl aminopropionate and the C 2 / i8 acyl sarcosine.
  • cationic surfactants are also suitable as emulsifiers, those of the esterquat type, preferably methylquaternized difatty acid triethanolamine ester salts, being particularly preferred.
  • Substances such as, for example, lanolin and lecithin and polyethoxylated or acylated lanolin and lecithin derivatives, polyol fatty acid esters, monoglycerides and fatty acid alkanolamides can be used as superfatting agents, the latter simultaneously serving as foam stabilizers.
  • Pearlescent waxes are: alkylene glycol esters, especially ethylene glycol distearate; Fatty acid alkanolamides, especially coconut fatty acid diethanolamide; Partial glycerides, especially stearic acid monoglyceride; Esters of polyvalent, optionally hydroxy-substituted carboxylic acids with fatty alcohols having 6 to 22 carbon atoms, especially long-chain esters of tartaric acid; Fatty substances, such as, for example, fatty alcohols, fatty ketones, fatty aldehydes, fatty ethers and fatty carbonates, which have a total of at least 24 carbon atoms, especially lauron and distearyl ether; Fatty acids such as stearic acid, hydroxystearic acid or behenic acid, ring opening products of olefin epoxides with 12 to 22 carbon atoms with fatty alcohols with 12 to 22 carbon atoms and / or polyols with 2 to 15 carbon atoms
  • Suitable consistency agents are primarily fatty alcohols or hydroxy fatty alcohols with 12 to 22 and preferably 16 to 18 carbon atoms and, in addition, partial glycerides, fatty acids or hydroxy fatty acids.
  • a combination of these substances with alkyl oligoglucosides and / or fatty acid N-methyl glucamides of the same chain length and / or polyglycerol poly-12-hydroxystearates is preferred.
  • Suitable thickeners are, for example, Aerosil types (hydrophilic silicas), polysaccharides, in particular xanthan gum, guar guar, agar agar, alginates and tyloses, carboxymethyl cellulose and hydroxyethyl cellulose, and also higher molecular weight polyethylene glycol mono- and diesters of fatty acids, polyacrylates , (e.g.
  • surfactants such as ethoxylated fatty acid glycerides, esters of fatty acids with polyols such as pentaerythritol or trimethyl-olpropane, fatty alcohol ethoxylates with a narrow homolog distribution or alkyl oligoglucoside as well as electrolyte oligoglucosides ammonium chloride.
  • Suitable cationic polymers are, for example, cationic cellulose derivatives, e.g. a quaternized hydroxyethyl cellulose available under the name Polymer JR 400® from Amerchol, cationic starch, copolymers of diallylammonium salts and acrylamides, quaternized vinylpyrrolidone / inylimidazole polymers such as e.g.
  • Luviquat® condensation products of polyglycols and amines, quaternized collagen polypeptides, such as, for example, lauryl-dimonium hydroxypropyl hydrolyzed collagen (Lamequat®L / Grünau), quaternized wheat polypeptides, polyethyleneimine, cationic silicone polymers, e.g. Amidomethicones, copolymers of adipic acid and dimethylaminohydroxypropyldiethylenetriamine (Cartaretine® / Sandoz), copolymers of acrylic acid with dimethyldiallylammonium chloride (Merquat® 550 / Chemviron), polyamino polyamides, e.g.
  • cationic chitin derivatives such as quaternized chitosan, optionally microcrystalline, condensation products from dihaloalkylene, such as e.g. Dibromobutane with bisdialkylamines, e.g. Bis-dimethylamino-1, 3-propane, cationic guar gum, e.g. Jaguar® CBS, Jaguar® C-17, Jaguar® C-16 from Celanese, quaternized ammonium salt polymers, e.g. Mirapol® A-15, Mirapol® AD-1, Mirapol® AZ-1 from Miranol.
  • dihaloalkylene such as e.g. Dibromobutane with bisdialkylamines, e.g. Bis-dimethylamino-1, 3-propane
  • cationic guar gum e.g. Jaguar® CBS, Jaguar® C-17, Jaguar® C-16 from Celanese
  • quaternized ammonium salt polymers e.g. Mirapol® A
  • Anionic, zwitterionic, amphoteric and nonionic polymers include, for example, vinyl acetate / crotonic acid copolymers, vinylpyrrolidone ⁇ / inylacrylate copolymers, vinyl acetate / butyl maleate / isobornylacrylate copolymers, methyl vinyl ether / maleic anhydride copolymers and their polyols, and non-crosslinked polyacrylate and their esters, non-crosslinked acrylate - trimethylammonium chloride / acrylate copolymers, octylacrylamide / methyl methacrylate / tert.Butylaminoethylmethacrylat / 2 Hydroxyproylmethacrylat copolymers, polyvinylpyrrolidone, vinylpyrrolidone / vinyl acetate copolymers, vinylpyrrolidone / dimethylaminoethyl methacrylate / Vinylcapro- lac
  • Suitable silicone compounds are, for example, dimethylpolysiloxanes, methylphenylpolysiloxanes, cyclic silicones and amino, fatty acid, alcohol, polyether, epoxy, fluorine, glycoside and / or alkyl-modified silicone compounds which are both liquid and at room temperature can be resinous.
  • Simethicones which are mixtures of dimethicones with an average chain length of 200 to 300 dimethylsiloxane units and hydrogenated silicates, are also suitable.
  • a detailed overview of suitable volatile silicones can also be found by Todd et al. in Cosm.Toil. 91, 27 (1976).
  • fats are glycerides
  • waxes include natural waxes, e.g. Candelilla wax, carnauba wax, Japanese wax, esparto grass wax, cork wax, guaruma wax, rice germ oil wax, sugar cane wax, ouricury wax, montan wax, beeswax, shellac wax, walnut, lanolin (wool wax), pretzel fat, ceresin, ozokerite (earth wax), petrolatum, paraffin waxes, microfax waxes chemically modified waxes (hard waxes), e.g. Montanester waxes, Sasol waxes, hydrogenated jojoba waxes and synthetic waxes, such as Polyalkylene waxes and polyethylene glycol waxes in question.
  • natural waxes e.g. Candelilla wax, carnauba wax, Japanese wax, esparto grass wax, cork wax, guaruma wax, rice germ oil wax, sugar cane wax, our
  • Metal salts of fatty acids such as e.g. Magnesium, aluminum and / or zinc stearate or ricinoleate are used.
  • Cosmetic deodorants counteract, mask or eliminate body odors.
  • Body odors arise from the action of skin bacteria on apocrine sweat, whereby unpleasant smelling breakdown products are formed. Accordingly, deodorants contain active ingredients which act as germ-inhibiting agents, enzyme inhibitors, odor absorbers or odor maskers.
  • germ-inhibiting agents such as.
  • Esterase inhibitors are suitable as enzyme inhibitors. These are preferably trialkyl citrates such as trimethyl citrate, tripropyl citrate, triisopropyl citrate, tributyl citrate and in particular triethyl citrate (Hydagen® CAT, Henkel KGaA, Düsseldorf / FRG). The substances inhibit enzyme activity and thereby reduce odor.
  • trialkyl citrates such as trimethyl citrate, tripropyl citrate, triisopropyl citrate, tributyl citrate and in particular triethyl citrate (Hydagen® CAT, Henkel KGaA, Düsseldorf / FRG).
  • the substances inhibit enzyme activity and thereby reduce odor.
  • esterase inhibitors include sterol sulfates or phosphates, such as, for example Lanosterol, cholesterol, campesterol, stigmasterol and sitosterol sulfate or phosphate, dicarboxylic acids and their esters, such as, for example, glutaric acid, glutaric acid monoethyl ester, glutaric acid diethyl ester, adipic acid, adipic acid monoethyl ester, adipic acid diethyl ester and malonic acid and their malonic acid and malcarboxylic acid, such as malcarboxylic acid and malcarboxylic acid Citric acid, malic acid, tartaric acid or tartaric acid diethyl ester, as well as zinc glycinate.
  • dicarboxylic acids and their esters such as, for example, glutaric acid, glutaric acid monoethyl ester, glutaric acid diethyl ester, adipic acid, adipic acid monoeth
  • Suitable odor absorbers are substances that absorb odor-forming compounds and can retain them to a large extent. They lower the partial pressure of the individual components and thus also reduce their speed of propagation. It is important that perfumes must remain unaffected. Odor absorbers are not effective against bacteria. They contain, for example, a complex zinc salt of ricinoleic acid or special, largely odorless fragrances, which are known to the person skilled in the art as "fixators", such as, for example, the main component. B. extracts of Labdanum or Styrax or certain abietic acid derivatives. Fragrance agents or perfume oils act as odor maskers and, in addition to their function as odor maskers, give the deodorants their respective fragrance.
  • Perfume oils are, for example, mixtures of natural and synthetic fragrances. Natural fragrances are extracts of flowers, stems and leaves, fruits, fruit peels, roots, woods, herbs and grasses, needles and branches as well as resins and balms. Animal raw materials, such as civet and castoreum, are also suitable. Typical synthetic fragrance compounds are products of the ester, ether, aldehyde, ketone, alcohol and hydrocarbon type.
  • Fragrance compounds of the ester type are, for example, benzyl acetate, p-tert-butylcyclohexyl acetate, linalyl acetate, phenylethyl acetate, linalyl benzoate, benzyl formate, allyl cyclohexyl propionate, styralyl propionate and benzyl salicylate.
  • the ethers include, for example, benzyl ethyl ether
  • the aldehydes include, for example, the linear alkanals having 8 to 18 carbon atoms, citral, citronellal, citronellyloxyacetaldehyde, cyclamenaldehyde, hydroxycitronellal, lilial and bourgeonal
  • the ketones for example, the ionones and methylcedryl ketone
  • the alcohols Anethole, citronellol, eugenol, isoeugenol, geraniol, linalool, phenylethyl alcohol and terpineol
  • the hydrocarbons mainly include the terpenes and balsams.
  • fragrance oils of lower volatility which are mostly used as aroma components, are also suitable as perfume oils, e.g. sage oil, chamomile oil, clove oil, melissa oil, mint oil, cinnamon leaf oil, linden blossom oil, juniper berry oil, vetiver oil, oliban oil, galbanumol, labdanum oil and lavandin oil.
  • Antiperspirants reduce sweat formation by influencing the activity of the eccrine sweat glands and thus counteract armpit wetness and body odor.
  • Aqueous or anhydrous formulations of antiperspirants typically contain the following ingredients:
  • non-aqueous solvents such as As ethanol, propylene glycol and / or glycerin.
  • Salts of aluminum, zirconium or zinc are particularly suitable as astringent antiperspirant active ingredients.
  • suitable antiperspirant active ingredients are e.g. Aluminum chloride, aluminum chlorohydrate, aluminum dichlorohydrate, aluminum sesquichlorohydrate and their complex compounds e.g. B. with propylene glycol-1, 2nd Aluminum hydroxyallantoinate, aluminum chloride tartrate, aluminum zirconium trichlorohydrate, aluminum zirconium tetrachlorohydrate, aluminum zirconium pentachlorohydrate and their complex compounds z. B. with amino acids such as glycine.
  • customary oil-soluble and water-soluble auxiliaries can be present in smaller amounts in antiperspirants.
  • oil soluble aids can e.g. his:
  • water-soluble additives are e.g. Preservatives, water-soluble fragrances, pH adjusters, e.g. Buffer mixtures, water soluble thickeners, e.g. water-soluble natural or synthetic polymers such as e.g. Xanthan gum, hydroxyethyl cellulose, polyvinyl pyrrolidone or high molecular weight polyethylene oxides.
  • Octopirox® (1-hydroxy-4-methyl-6- (2,4,4-trimythylpentyl) -2- (1 H) -pyridone-monoethanolamine salt
  • Baypival Pirocton Olamin
  • Ketoconazol® (4-acetyl -1 - ⁇ - 4- [2- (2.4-dichlorophenyl) r-2- (1 H -imidazol-1-ylmethyl) -1, 3-dioxylan-c-4-ylmethoxyphenyl ⁇ piperazine, selendi- sulfide, sulfur colloidal, sulfur polyethylene glycol sorbitan monooleate, sulfur ricinole polyethylen toxylate, sulfur tar distillates, salicylic acid (or in combination with hexachlorophene), undexylene acid monoethanolamide sulfosuccinate Na salt, Lamepon® UD (protein undecionate, zincpyrenium pyrene)
  • Common film formers are, for example, chitosan, microcrystalline chitosan, quaternized chitosan, polyvinylpyrrolidone, vinylpyrrolidone-vinyl acetate copolymers, polymers of the acrylic acid series, quaternary cellulose derivatives, collagen, hyaluronic acid or its salts and similar compounds.
  • Montmorillonites, clay minerals, pemulene and alkyl-modified carbopol types can serve as swelling agents for aqueous phases. Further suitable polymers or swelling agents can be found in the overview by R. Lochhead in Cosm.Toil. 108, 95 (1993).
  • UV light protection factors are understood to mean, for example, organic substances (light protection filters) which are liquid or crystalline at room temperature and which are able to absorb ultraviolet rays and absorb the energy absorbed in the form of longer-wave radiation, e.g. To give off heat again.
  • UVB filters can be oil-soluble or water-soluble. As oil-soluble substances e.g. to call:
  • 4-aminobenzoic acid derivatives preferably 2-ethylhexyl 4- (dimethylamino) benzoate, 2-octyl 4- (dimethylamino) benzoate and amyl 4- (dimethylamino) benzoate;
  • esters of cinnamic acid preferably 2-ethylhexyl 4-methoxycinnamate, propyl 4-methoxycinnamate, 2-cyano-3,3-phenylcinnamate-2-ethylhexyl ester (octocrylene) 4-methoxycinnamate;
  • esters of salicylic acid preferably salicylic acid 2-ethylhexyl ester, salicylic acid 4-isopropyl benzyl ester, salicylic acid homomethyl ester;
  • benzophenone preferably 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone;
  • esters of benzalmalonic acid preferably di-2-ethylhexyl 4-methoxybenzmalonate
  • Triazine derivatives such as 2,4,6-trianilino- (p-carbo-2'-ethyl-1'-hexyloxy) -1, 3,5-triazine and octyl triazone, as described in EP 0818450 A1 or dioctyl butamido Triazone (Uvasorb® HEB); > Propane-1,3-diones, such as 1- (4-tert-butylphenyl) -3- (4'methoxyphenyl) propane-1,3-dione;
  • UV-A filters -4'-methoxy-dibenzoylmethane (Parsol 1789), 1-phenyl-3- (4'-isopropylphenyl) propane-1, 3-dione as well as enamine compounds, as described in DE 19712033 A1 (BASF).
  • the UV-A and UV-B filters can of course also be used in mixtures.
  • insoluble light protection pigments namely finely dispersed metal oxides or salts, are also suitable for this purpose.
  • suitable metal oxides are, in particular, zinc oxide and titanium dioxide and, in addition, oxides of iron, zirconium, silicon, manganese, aluminum and cerium and mixtures thereof.
  • Silicates (talc), barium sulfate or zinc stearate can be used as salts.
  • the oxides and salts are used in the form of the pigments for skin-care and skin-protecting emulsions and decorative cosmetics.
  • the particles should have an average diameter of less than 100 nm, preferably between 5 and 50 nm and in particular between 15 and 30 nm. They can have a spherical shape, but it is also possible to use particles which have an ellipsoidal shape or a shape which differs from the spherical shape in some other way.
  • the pigments can also be surface treated, i.e. are hydrophilized or hydrophobized.
  • Typical examples are coated titanium dioxides, e.g. Titanium dioxide T 805 (Degussa) or Eusolex® T2000 (Merck). Silicones, and in particular trialkoxyoctylsilanes or simethicones, are particularly suitable as hydrophobic coating agents. So-called micro- or nanopigments are preferably used in sunscreens. Micronized zinc oxide is preferably used. Further suitable UV light protection filters can be found in the overview by P.Finkel in S ⁇ FW-Journal 122, 543 (1996).
  • secondary light stabilizers of the antioxidant type can also be used, which interrupt the photochemical reaction chain which is triggered when UV radiation penetrates the skin.
  • typical examples include amino acids (eg glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (eg urocanic acid) and their derivatives, peptides such as D, L-carnosine, D-carnosine, L-carosin and their derivatives (eg anserine ), Carotenoids, carotenes (eg ⁇ -carotene, ⁇ -carotene, lycopene) and their derivatives, chlorogenic acid and their derivatives, lipoic acid and their derivatives (eg dihydrolipoic acid), aurothioglucose, propylthiouracil and other thiols (eg thioredoxin, glutathione) , Cysteine, cystine, cystamine and
  • buthioninsulfoximines homocysteine sulfoximine, butioninsulfones, penta-, hexa-, ximinathion) vertr Daily dosages (e.g. pmol to ⁇ mol / kg), also (metal) chelators (e.g. ⁇ -hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin), ⁇ -hydroxy acids (e.g. citric acid, lactic acid, malic acid), humic acid, bile acid, bile extracts, Bilirubin, Bilidverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (e.g.
  • metal chelators e.g. ⁇ -hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin
  • ⁇ -hydroxy acids e.g. citric acid, lactic acid, malic acid
  • humic acid bile acid, bile extracts
  • Hydrotropes such as ethanol, isopropyl alcohol or polyols can also be used to improve the flow behavior.
  • Polyols that come into consideration here preferably have 2 to 15 carbon atoms and at least two hydroxyl groups.
  • the polyols can also contain further functional groups, in particular amino groups, or be modified with nitrogen. Typical examples are
  • Alkylene glycols such as ethylene glycol, diethylene glycol, propylene glycol, butylene glycol, hexylene glycol and polyethylene glycols with an average molecular weight of 100 to 1,000 daltons;
  • > technical oligoglycerol mixtures with a degree of self-condensation of 1.5 to 10 such as technical diglycerol mixtures with a diglycerol content of 40 to 50% by weight
  • > Methyl compounds such as in particular trimethylolethane, trimethylolpropane, trimethylolbutane, pentaerythritol and dipentaerythritol
  • Lower alkyl glucosides especially those with 1 to 8 carbons in the alkyl radical, such as methyl and butyl glucoside
  • Sugar alcohols with 5 to 12 carbon atoms such as, for example, sorbitol or mannitol, sugars with 5 to 12 carbon atoms, such as, for example, glucose or sucrose
  • Aminosugars such as glucamine
  • Dialcohol amines such as diethanolamine or 2-amino-1,3-propanediol.
  • Suitable preservatives are, for example, phenoxyethanol, formaldehyde solution, parabens, pentanediol or sorbic acid and the other classes of substances listed in Appendix 6, Parts A and B of the Cosmetics Ordinance.
  • N, N-diethyl-m-toluamide, 1, 2-pentanediol or ethyl butylacetylaminopropionate are suitable as insect repellents, and dihydroxyacetone is suitable as a self-tanning agent.
  • Arbutin, kojic acid, coumaric acid and ascorbic acid (vitamin C) can be used as tyrosine inhibitors, which prevent the formation of melanin and are used in depigmenting agents.
  • Perfume oils include mixtures of natural and synthetic fragrances. Natural fragrances are extracts of flowers (lily, lavender, roses, jasmine, neroli, ylang-ylang), stems and leaves (geranium, patchouli, petitgrain), fruits (anise, coriander, caraway, juniper), fruit peel (bergamot, lemon, Oranges), roots (mace, angelica, celery, cardamom, costus, iris, calmus), wood (pine, sandal, guaiac, cedar, rosewood), herbs and grasses (tarragon, lemongrass, sage, thyme), Needles and twigs (spruce, fir, pine, mountain pine), resins and balms (galbanum, elemi, benzoin, myrrh, olibanum, opoponax).
  • Typical synthetic fragrance compounds are products of the ester, ether, aldehyde, ketone, alcohol and hydrocarbon type. Fragrance compounds of the ester type are, for example, benzyl acetate, phenoxyethyl isobutyrate, p-tert.-butylcyclohexyl acetate, linalyl acetate, dimethylbenzylcarbyl acetate, phenylethyl acetate, linalyl benzoate, benzyl formate, ethyl methylphenylglycinate, allyl cyclohexyl benzyl propylateionate, allyl cyclohexyl propyl pionate.
  • the ethers include, for example, benzyl ethyl ether
  • the aldehydes include, for example, the linear alkanals having 8 to 18 carbon atoms, citral, citronellal, citronellyloxyacetaldehyde, cyclamen aldehyde, hydroxycitronellal, lilial and bourgeon
  • the ketones include, for example, the jonones, oc-isomethyl ionone and methyl cedryl ketone the alcohols anethole, citronellol, eugenol, isoeugenol, geraniol, linalool, phenylethyl alcohol and terpinol
  • the hydrocarbons mainly include the terpenes and balsams.
  • fragrance oils which are mostly used as aroma com Components are used as perfume oils, such as sage oil, chamomile oil, clove oil, melissa oil, mint oil, cinnamon leaf oil, linden blossom oil, juniper berry oil, vetiver oil, oliban oil, galbanumol, labolanum oil and lavandin oil.
  • bergamot oil dihydromyrcenol, lilial, lyral, citronellol, phenylethyl alcohol, ⁇ -hexylcinnamaldehyde, geraniol, benzyl acetone, cyclamen aldehyde, linalool, Boisambrene Forte, Ambroxan, indole, hedione, Sandelice, lemon oil, mandarin oil, orange oil, allyl amyl glycolate, Cyclovertal, lavandin oil, muscatel Sage oil, ß-damascone, geranium oil bourbon, cyclohexyl salicylate, Vertofix Coeur, Iso-E-Super, Fixolide NP, evernyl, iraldein gamma, phenylacetic acid, geranyl acetate, benzyl acetate, rose oxide, romilllate, irot
  • the dyes which can be used are those substances which are suitable and approved for cosmetic purposes, as compiled, for example, in the publication "Cosmetic Dyes” by the Dye Commission of the German Research Foundation, Verlag Chemie, Weinheim, 1984, pp. 81-106. These dyes are usually used in concentrations of 0.001 to 0.1% by weight, based on the mixture as a whole.
  • the total proportion of auxiliaries and additives can be 1 to 50, preferably 5 to 40,% by weight, based on the composition.
  • the agents can be produced by customary cold or hot processes; the phase inversion temperature method is preferably used.
  • Example 1 Obtaining an ethanolic Piper betle L extract
  • the extract thus obtained contained 45% by weight of hydroxychavicol.
  • the extract thus obtained contained 52% by weight of hydroxychavicol.
  • Example 3 Obtaining an aqueous Piper betle L. extract
  • the betel pepper extracts obtained according to Examples 1 and 3 were used in the following formulations K1 to K21 and 1 to 40 according to the invention.
  • the cosmetic compositions produced in this way showed very good skin-care properties and, at the same time, good skin tolerance compared to the comparison formulations V1, V2 and V3.
  • the inventive are very stable against oxidative decomposition.
  • Tab. 1 Soft cream formulations K1 to K7
  • Glycerin (86% by weight) 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0
  • Glycerin (86% by weight) 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0
  • Glycerin (86% by weight) 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0
  • Deoxyribonucleic acid molecular weight approx. 70000, purity (determined by spectrophotometric measurement of the absorption at 260 nm and 280 nm): at least 1, 7.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne des produits cosmétiques contenant un extrait d'au moins une plante de la famille des pipéracées, ainsi que leur utilisation pour la production de produits cosmétiques.
PCT/EP2000/006737 1999-07-23 2000-07-14 Produit cosmetique avec extraits de plantes de la famille des piperacees WO2001006996A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19933857.4 1999-07-23
DE19933857A DE19933857A1 (de) 1999-07-23 1999-07-23 Kosmetische Mittel mit Pflanzenextrakten

Publications (1)

Publication Number Publication Date
WO2001006996A1 true WO2001006996A1 (fr) 2001-02-01

Family

ID=7915330

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/006737 WO2001006996A1 (fr) 1999-07-23 2000-07-14 Produit cosmetique avec extraits de plantes de la famille des piperacees

Country Status (2)

Country Link
DE (1) DE19933857A1 (fr)
WO (1) WO2001006996A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008001465A1 (fr) * 2006-06-30 2008-01-03 Noevir Co., Ltd. Agent hydratant, agent anti-âge, agent blanchissant la peau et antioxydant

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0204130B8 (pt) * 2002-09-18 2021-05-25 Fund De Amparo A Pesquisa Do Estado De Sao Paulo Fapesp composição gel à base de extrato de pothomorphe umbellata, seus usos e método cosmético não-terapêutico.

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59161308A (ja) * 1983-03-01 1984-09-12 Shiseido Co Ltd 皮膚外用剤
JPH0761918A (ja) * 1993-08-23 1995-03-07 Tsuneo Nanba 化粧料
JPH09110673A (ja) * 1995-10-16 1997-04-28 Kao Corp 浴用剤組成物
JPH1029927A (ja) * 1996-07-12 1998-02-03 Shiseido Co Ltd 抗老化剤
JPH10265340A (ja) * 1997-03-26 1998-10-06 Shiseido Co Ltd メチレンジオキシベンゼン環−脂肪族化合物含有頭部用組成物
FR2771002A1 (fr) * 1997-11-17 1999-05-21 Sederma Sa Compositions a usage cosmetique ou dermopharmaceutique contenant un extrait vegetal obtenu a partir des racines de kava piper methysticum
JPH11189540A (ja) * 1997-12-26 1999-07-13 Eag Kk テストステロン−５α−レダクターゼ阻害剤

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1437804A (en) * 1973-09-10 1976-06-03 Lepetit Spa Indole derivatives
US4855138A (en) * 1986-06-24 1989-08-08 Tecma Laboratories, Inc. Skin therapeutic mixture containing matico extract
JP3118020B2 (ja) * 1991-05-13 2000-12-18 有限会社野々川商事 化粧料
JPH07157420A (ja) * 1993-12-01 1995-06-20 Mikimoto Pharmaceut Co Ltd 化粧品
JPH0812566A (ja) * 1994-06-29 1996-01-16 Shiseido Co Ltd チロシナーゼ活性阻害剤
JP3453227B2 (ja) * 1995-08-29 2003-10-06 辻本化学工業株式会社 紫外線吸収剤及びそれを配合した皮膚外用剤
JPH09278666A (ja) * 1996-04-09 1997-10-28 Res Inst For Prod Dev 抗菌剤およびその製造法
JPH1045540A (ja) * 1996-08-05 1998-02-17 Pola Chem Ind Inc 発毛・育毛料
JPH1077495A (ja) * 1996-09-03 1998-03-24 Ogawa Koryo Kk 香料の香気香味改質剤及び改質方法
JPH11189541A (ja) * 1997-12-26 1999-07-13 Eag Kk メラニン産生不全症治療剤

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59161308A (ja) * 1983-03-01 1984-09-12 Shiseido Co Ltd 皮膚外用剤
JPH0761918A (ja) * 1993-08-23 1995-03-07 Tsuneo Nanba 化粧料
JPH09110673A (ja) * 1995-10-16 1997-04-28 Kao Corp 浴用剤組成物
JPH1029927A (ja) * 1996-07-12 1998-02-03 Shiseido Co Ltd 抗老化剤
JPH10265340A (ja) * 1997-03-26 1998-10-06 Shiseido Co Ltd メチレンジオキシベンゼン環−脂肪族化合物含有頭部用組成物
FR2771002A1 (fr) * 1997-11-17 1999-05-21 Sederma Sa Compositions a usage cosmetique ou dermopharmaceutique contenant un extrait vegetal obtenu a partir des racines de kava piper methysticum
JPH11189540A (ja) * 1997-12-26 1999-07-13 Eag Kk テストステロン−５α−レダクターゼ阻害剤

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 009, no. 005 (C - 260) 10 January 1985 (1985-01-10) *
PATENT ABSTRACTS OF JAPAN vol. 1995, no. 06 31 July 1995 (1995-07-31) *
PATENT ABSTRACTS OF JAPAN vol. 1997, no. 08 29 August 1997 (1997-08-29) *
PATENT ABSTRACTS OF JAPAN vol. 1998, no. 06 30 April 1998 (1998-04-30) *
PATENT ABSTRACTS OF JAPAN vol. 1999, no. 01 29 January 1999 (1999-01-29) *
PATENT ABSTRACTS OF JAPAN vol. 1999, no. 12 29 October 1999 (1999-10-29) *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008001465A1 (fr) * 2006-06-30 2008-01-03 Noevir Co., Ltd. Agent hydratant, agent anti-âge, agent blanchissant la peau et antioxydant

Also Published As

Publication number Publication date
DE19933857A1 (de) 2001-02-01

Similar Documents

Publication Publication Date Title
EP1284133B1 (fr) Mélanges de principes actifs
WO2002007697A1 (fr) Melange agissant de maniere synergique et inhibant la croissance pileuse
EP1213025A1 (fr) Composition cosmétique et/ou dermopharmaceutique conténant un extrait obtenu à partir de feuilles d'Argania spinosa
EP1213024A1 (fr) Composition cosmétique et/ou dermopharmaceutique conténant de protéines natives de Argania spinosa
EP1272155A1 (fr) Utilisation de matieres naturelles pour produire des preparations cosmetiques
EP1253906B1 (fr) Preparations cosmetiques contenant des extraits de waltheria indica et de l'acide ferulique
EP1294355A1 (fr) Utilisation d'inulines et de derives d'inulines
DE10059239A1 (de) Kosmetische und/oder pharmazeutische Emulsionen
EP1276460B1 (fr) Utilisation de preparations contenant un extrait de la plante argania spinosa dans des produits de soin cosmetiques pour les cheveux et la peau
EP1138313A1 (fr) Proliposomes
WO2003096998A1 (fr) Shampooings antipelliculaires
EP1138310A1 (fr) Proliposomes
EP1239814A2 (fr) Utilisation de residus de la fabrication du vin
WO2001039738A2 (fr) Utilisation de flavones et/ou d'isoflavones tirees d'extraits de plantes
EP1138311A1 (fr) Proliposomes
EP1283854B1 (fr) Agent de solubilisation
WO2001006995A1 (fr) Produits cosmetiques contenant de l'hydroxychavicole
DE10207919A1 (de) Anti-Ageingmittel
WO2001052809A1 (fr) Preparations cosmetiques ou pharmaceutiques contenant une quantite efficace d'un extrait d'arrabidaea chica
DE10021167A1 (de) Kosmetische Zubereitungen
WO2001097771A2 (fr) Preparations renfermant un extrait de plantes pistia stratiotes
WO2001006996A1 (fr) Produit cosmetique avec extraits de plantes de la famille des piperacees
WO2002013778A2 (fr) Preparations cosmetiques
EP1138312A1 (fr) Proliposomes
WO2003043646A1 (fr) Melanges de substances actives contenant de l'escine

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase