WO2000066171A1 - Agregat de granules d'alcool de sucre, et procede de preparation correspondant - Google Patents

Agregat de granules d'alcool de sucre, et procede de preparation correspondant Download PDF

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Publication number
WO2000066171A1
WO2000066171A1 PCT/JP1999/002809 JP9902809W WO0066171A1 WO 2000066171 A1 WO2000066171 A1 WO 2000066171A1 JP 9902809 W JP9902809 W JP 9902809W WO 0066171 A1 WO0066171 A1 WO 0066171A1
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WO
WIPO (PCT)
Prior art keywords
sugar alcohol
aggregate
weight
granule
less
Prior art date
Application number
PCT/JP1999/002809
Other languages
English (en)
Japanese (ja)
Inventor
Ikuo Tanai
Hisayoshi Kato
Original Assignee
Freund Industrial Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Freund Industrial Co., Ltd. filed Critical Freund Industrial Co., Ltd.
Publication of WO2000066171A1 publication Critical patent/WO2000066171A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A23L29/37—Sugar alcohols
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/20—Agglomerating; Granulating; Tabletting
    • A23P10/22—Agglomeration or granulation with pulverisation of solid particles, e.g. in a free-falling curtain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals

Definitions

  • the present invention relates to a sugar alcohol granule suitable for direct compression processing and a method for producing the same.
  • the present invention relates to an orally rapidly disintegrating tablet-type drug and food containing the sugar alcohol granule.
  • lactose is an excipient with low reactivity with drugs, but has a reaction activity like a Maillard reaction and may be poorly compoundable with specific drugs.
  • crystalline cellulose is an excellent excipient, it has a light brown color and may impair the aesthetics of tablets.
  • chewable tablets are used in terms of texture (mouthfeel). May not be possible.
  • mannitol one of the sugar alcohols, has excellent compatibility with drugs, has very few contraindications to other drugs, and has an energy of 2 kca 1 Zg, which is half that of sucrose. It is also highly stable because it has no hygroscopicity and retains almost no water, and is widely used as chewable tablets for vitamins, antibiotics, antacids, analgesics, antipyretics, etc. ing. And, because of its refreshing coolness and sweetness, it has recently been used for oral fast-disintegrating tablets.
  • Japanese Unexamined Patent Publication No. 7-170669 states that a lactose solution having a high content of / 3 lactose, before drying, has a content of 1 to 15% by weight based on the solid content of the solution. It describes an excipient for direct compression, consisting of a homogenous mass consisting of a dried product with the addition of sugar alcohols.
  • Japanese Patent Application Laid-Open Publication No. 8-291501 discloses that a binder such as polyvinylpyrrolidone is added to a sugar alcohol excipient, the tablet is compressed under low pressure, and then the obtained tablet is humidified. Thus, there is described a method of appropriately exerting the function of the binder in the step of drying.
  • Japanese Patent Application Laid-Open No. 9-143100 discloses that, when a tablet containing mannitol and lactose as an excipient is produced, a tablet is prepared by adding polyvinylpyrrolidone and the like. And that a fast dissolving tablet was produced.
  • these sugar alcohol-containing excipients or tablets containing sugar alcohol as an excipient can be prepared by using a binder such as hydroxypropyl cellulose, polyvinylpyridone, etc.
  • a binder such as hydroxypropyl cellulose, polyvinylpyridone, etc.
  • An excipient that imparts a predetermined mechanical strength is composed of sugar alcohol alone without a binder function, such as mannitol sorbitol, and can be tableted by direct compression molding. I can't say it.
  • An object of the present invention is to solve the above-mentioned problems and to provide a novel directly granulated granule consisting of only a sugar alcohol, which can be directly compression-molded, and a method for producing the same.
  • the present inventors have improved the fluidity, disintegration, and suitability of direct compression of granules substantially composed of only sugar alcohols, and manufactured them with a centrifugal tumbling granulator without mixing a binder.
  • the present invention has been completed by establishing a production method of drying a wet granulated product in a fluidized bed.
  • the present invention includes the following inventions.
  • a granulated aggregate containing sugar alcohol in an amount of 95% by weight or more wherein the aggregate is particles having a particle size of not less than 95% by weight and not more than 70 ⁇ m and not less than 70% by weight of not more than 75%.
  • the above-mentioned sugar alcohol granule aggregate contains 1 to 30% by weight, preferably 5 to 20% by weight of particles having a particle size of less than 75 ⁇ , (1).
  • the sugar alcohol granule aggregate contains a sugar alcohol granule containing 1 to 30% by weight, preferably 5 to 20% by weight of sugar alcohol particles having a particle size of less than 75 ⁇ m.
  • the pharmaceutical according to (4) which is an aggregate.
  • the pharmaceutical product is obtained by adding a drug component to the sugar alcohol granule aggregate.
  • the medicament according to (6) which is an orally rapidly disintegrating tablet produced by direct compression.
  • the sugar alcohol in the sugar alcohol granule aggregate is one or more selected from D-mannitol, erythritol and maltitol, (4) to (4).
  • the pharmaceutical according to any one of the above items 7).
  • a food characterized by comprising:
  • the sugar alcohol granule aggregate contains 1 to 30% by weight, preferably 5 to 20% by weight, of sugar alcohol particles less than 75 ⁇ ⁇ 1.
  • the sugar alcohol in the sugar alcohol granule aggregate is one or more kinds selected from D-mannitol, erythritol and maltitol, (9) ) Or (10).
  • the food is characterized in that it is a rapidly disintegrating tablet in the oral cavity which is produced by directly tableting the sugar alcohol granule aggregate with a drug component added thereto, (9) to (9).
  • the food according to any one of the above items 12).
  • a mixture of particles containing sugar alcohol of 95% by weight or more is charged on a rotating disk in a processing container of a centrifugal tumbling granulator, and the rotating disk is supplied while a slither is supplied into the container.
  • a sugar alcohol granule aggregate composed of particles of the following formula, wherein the bulk density of the aggregate is 0.5 g / ml or more, and the angle of repose is A method for producing a sugar alcohol granulated aggregate having a temperature of 40 ° or less.
  • the granulated product aggregate containing 95% by weight or more of the sugar alcohol is 1 to 30% by weight, preferably 5 to 20% by weight, of sugar alcohol particles having a particle size of less than 75 ⁇ .
  • a water-soluble binder such as a water-soluble polymer, for example, hydroxypropylcellulose, or polyvinylpyrrolidone, is capable of producing a sugar alcohol granule having good flowability. Since the granules contain binder components other than sugar alcohols, they not only adversely affect the ease of disintegration after tableting, but also affect the chewability of chewable tablets. It is a matter of concern.
  • the granulated product of the present invention comprising only mannitol or erythritol having excellent compression moldability and fluidity is extremely useful as an excipient when directly tableting with tablet-type drugs and food materials. It is.
  • the sugar alcohol granules substantially consist of the sugar alcohol itself. Therefore, “containing 95% or more of sugar alcohol” means that it is substantially composed of only sugar alcohol.
  • “D-mannitol” that meets the standards of the Japanese Pharmacopoeia (for example, the 13th revised pharmacopeia) conforms to the standards of the present invention.
  • “sugar alcohol” refers not only to a pure single chemical, but also to a mixture of substances known to be of the same type, such as D-mannitol and erythritol. .
  • sugar alcohol those which do not interact with a drug and can be used as a raw material for a medicament, and which have no Maillard reaction and can be used as a raw material for food are preferable.
  • a granulated material aggregate containing sugar alcohol of 95% by weight or more is supplied to a centrifugal tumbling granulator, in which sugar alcohol powder is supplied onto a rotating disk of a processing vessel, and the slurry is slipped into the vessel. It is manufactured by spraying water, an aqueous alcohol solution, an aqueous sugar alcohol solution, or an aqueous alcohol alcohol solution of sugar alcohol while wet rotating the rotating disk while supplying air.
  • sugar alcohol used in the present invention may contain a normal binder and other substances other than Z or saccharides as long as the amount does not exceed 5% by weight.
  • the binder means a water-soluble binder mainly, for example, polyvinylpyrrolidone, hydroxypropylcellulose, hydroxypropyl propylmethylcellulose, polyvinylanolecol, methisollecellulose, This includes pullulan, sodium alginate, agar, and gelatin.
  • the particles contained in the aggregate of granules containing 95% by weight or more of the sugar alcohol are particles of 95% by weight or more of 70% or less and 70% by weight or more of the particles. Are particles in the range of 75 to 71 O ⁇ m.
  • the granulated product aggregate of the present invention contains sugar alcohol particles having a size of less than 75 ⁇ in an amount of up to 30% by weight, preferably in an amount of 5 to 20% by weight. Can be. The presence of such fine particles is preferable because the surface of the obtained granulated material becomes smooth and there is no problem in mottling.
  • the sugar alcohol granule aggregate of the present invention has a kaza density of 0.5 g Z ml or more. If the bulk density is less than 0.5 g1, particles with good fluidity will not be obtained, which is not preferable.
  • the bulk density was measured by placing the granulated material lightly on a heap of 100 m1 of female cylinder (weight W), and then weighing the weighed weight Wb and weighing (Wb—W) / 100. 5 times It is shown by the average value of
  • the angle of repose of the aggregate of granulated sugar alcohols of the present invention is 40 ° or less.
  • the angle of repose exceeds 40 degrees, the fluidity becomes poor, the filling of the mortar during tableting becomes uneven, and the weight deviation of the tablet becomes large. It is not preferable because it occurs.
  • the angle of repose was measured by the Nogami-Sugihara method described in Japanese Patent Application Laid-Open No. Hei 6-20959, and the average value of the five measurements was taken.
  • the device shown in Fig. 2 was prepared by bonding four glass plates together, and the measurement of the angle of repose by the device was about 200 samples along the A wall. Gently pour m1 into the glass floor using a funnel onto surface B, and continue to flow from the front open end of surface B until the sample starts to flow. The angle between the inclined upper surface of the sample layer on the B surface and the B surface (horizontal plane) is read by the protractor C.
  • the granulated product is produced by a centrifugal tumbling granulator.
  • the granule has a somewhat rounded and heavy particle shape, and as a result, can be compressed with a small amount of lubricant.
  • the sugar alcohol granules may contain a drug appropriately selected from various drugs (various substances having a medicinal effect) such as water-soluble vitamins and antipyretic analgesics in a range of less than 5%. Can be.
  • Drugs are pharmaceutically active ingredients that show medicinal properties, such as antipyretic analgesics, rhinitis drugs, cardiovascular drugs, digestive drugs, antibiotics, chemotherapeutics, vitamins, narcotic analgesics, and hormonal drugs. , Antidepressants, anti-inflammatory drugs, antipsychotics and the like.
  • the centrifugal rolling device used for producing the sugar alcohol granule aggregate of the present invention comprises: a smooth rotating disk that rotates substantially horizontally on the bottom of the processing container; and a rotating shaft that rotates the rotating disk.
  • a slit which is an annular gap formed between an inner wall portion of the processing container and an edge located at a circumferential portion of the rotating disk, and a slit in the slit processing container.
  • Water and sugar alcohol to the slit air supply device to supply the sugar and the sugar alcohol powder in the processing vessel It has a spray nozzle for spraying an aqueous solution or an aqueous solution obtained by adding an alcohol to them.
  • CF device CF durable heater manufactured by Freund Corporation as shown in FIG. (However, the slit air supply device is not shown).
  • the above-mentioned CF device falls into a category called a granulation coating device, but the granulation coating device that can be used in the method of the present invention is not limited to the above-mentioned specific CF device, Various granulation coating apparatuses can be used as long as the apparatus has a general configuration. Examples of the CF device that can be variously deformed include a rotating shaft that stands on a rotating disk, a type in which the edge of the rotating disk is warped upward, and a horizontal type.
  • the upper surface of the rotating disk must be smooth at least in contact with the powder, but there may be protrusions at the center of the disk, causing various deformations. Needless to say, this is possible.
  • the shape is a “mortar” -shaped rotating plate having the lowest center portion and the higher outer portion. In this case, there is an advantage that the centrifugal force can be effectively used and the throughput of the granulated material is increased.
  • a drying function may be provided as an addition to the apparatus.
  • the fluidized bed in the granulating apparatus of the present invention refers to a fluidized bed that is supplied by a fluidized air supply device to flow the granulated material into a storage container into which the wet granulated material manufactured by the centrifugal rolling device is charged.
  • the fluidized bed can be formed, for example, by using a flow coater (trade name, “FL device”) manufactured by Freund Corporation.
  • FL device trade name, “FL device” manufactured by Freund Corporation.
  • This apparatus falls into the category of a fluidized bed granulation coating apparatus, and the present invention is not limited to the above-mentioned specific FL apparatus as long as the apparatus has the above-mentioned basic configuration.
  • Fluidized bed apparatus for example, FL apparatus equipped with a rotor container manufactured by Freund Corporation
  • a tumbling fluidized bed granulation coating apparatus for example, a tumbling fluidized bed granulation coating apparatus, and a product name “Spiraf Kuchiichi”. Can be.
  • the liquid to be sprayed in the centrifugal rolling device used for producing the sugar alcohol granule aggregate of the present invention may be water alone, Further, an alcohol such as ethanol may be added as required, or a small amount of a coloring agent or the like may be added thereto.
  • Addition of alcohol, especially ethanol, to the water or the aqueous solution of sugar alcohol may make the particle size distribution of the formed granules sharper, which may be more preferable.
  • foods and food additives appropriately selected from water-soluble vitamins, flavors and the like can be contained in the sugar alcohol granules in a range of less than 5%.
  • FIG. 1 is a diagram showing an example of a granulation coating device that can be used in the present invention.
  • FIG. 2 is a diagram illustrating a method of measuring the angle of repose of a sugar alcohol granule.
  • reference numeral 1 is a granulation container
  • 2 is a rotating disk
  • 2a is a disk ⁇
  • 3 is a rotating shaft
  • 4 is a slit
  • 4a is a slit air
  • 5 is an air chamber
  • 7 is a heat exchanger
  • 8 is a sugar alcohol powder
  • 9 is a powder feeder
  • 10 is a spray liquid
  • 11 is a tank
  • 12 is a constant flow pump
  • 13 is a spray nozzle
  • 1 Numeral 4 denotes atomizing air
  • numeral 15 denotes a product discharging device
  • numeral 16 denotes a stator cover
  • numeral 17 denotes slit air.
  • the rotating shaft 3 is rotated by a drive mechanism such as a motor (not shown), and while the rotating disk 2 is rotating, the air 17 for the slit air is dehumidified by the dehumidifier 6 and the heat exchanger 7.
  • the slit alcohol 4 is supplied from the slit 4 into the granulation container 1 through the air chamber 5 as slit air 4a, and a certain amount of the sugar alcohol powder 8 is rotated by opening the valve V of the supply device 9
  • the valve V is closed when the fixed amount is charged on the disk.
  • the spray liquid 10 is sprayed from the tank 11 through the respray nozzle 13 onto the sugar alcohol powder on the rotating disk near the slit 4, and granulation is performed to produce the wet sugar alcohol granules. Manufactured.
  • the wet sugar alcohol granules thus produced are then sent (not shown) to an FL unit (not shown), where they are dried by fluidizing air with fluidized air. As a result, a sugar alcohol granulated aggregate having the above properties, which is a final product, is produced.
  • the wet sugar alcohol granules may be dried on a rotating disk by sending drying air into the granulator shown in FIG.
  • any form that can be formulated can be used as long as the above-mentioned sugar alcohol granule aggregate is contained therein, but preferably, tablets and granules are used. Or fine granules.
  • the drug may be present inside or outside the granulated substance, but is preferably present outside.
  • the content of the granulated product varies depending on the type of the preparation using the granulated product. For example, in the case of granules, it is usually about 5 to 90% by weight, preferably about 20% by weight, based on the whole preparation. ⁇ 70% by weight.
  • the sugar alcohol constituting the granules is composed of D-mannitol as a main ingredient and other components such as erythritol and maltitol from the viewpoint of the stability with the drug. It may contain a sugar alcohol.
  • magnesium stearate 0.5% is added to the granulated product, and a tablet of 8 mm 0, 10 R, 18 mg / T is used in a single-shot tableting machine [(manufactured by Fuji Pharmaceutical Machinery Co., Ltd.)].
  • tableting was performed under a tableting pressure of 700 kgc in 2 , tableting was possible without causing tableting troubles such as sticking and cabbing. It was 4.8 k, as measured by Freund Corporation.
  • magnesium stearate 0.5% was added to the granulated product, and a tablet of 8 mm 0, 10 R, 18 mg ZT was punched with a single-shot tableting machine (manufactured by Fuji Pharmaceutical Machinery Co., Ltd.). It was tabletted Jo ⁇ 7 0 0 kg condition Z cm 2 However, tableting was possible without causing tableting troubles such as stateing and cabbing. The hardness of the tablet was measured with a tablet hardness tester (manufactured by Freund Corporation) to be 4.8 kg.
  • the sugar alcohol granule aggregate of the present invention described above contains substantially only sugar alcohol as a main component, it is said that the sugar alcohol granule is low in strength or non-caloric compared to conventional granules. There are advantages.
  • the rapidly disintegrating tablet in the oral cavity which is produced by directly compressing the sugar alcohol granules of the present invention for direct compression processing, disintegrates quickly in the oral cavity and can be taken without water. With. In the case of a rapidly disintegrating tablet in the mouth using D-mannitol, there is an advantage that it can be easily taken by children with a cool texture.
  • the granulated sugar alcohol of the present invention is advantageous in that the sugar alcohol alone or the sugar alcohol has an extremely high ratio, so that there is little reaction with the drug and the drug can be put in the granulated product.
  • the sugar alcohol granules of the present invention are characterized in that a sugar alcohol alone or a granule having a very high ratio of sugar alcohol has no Maillard reaction. It has the advantage of being able to incorporate food and food additives into granules.
  • the granule-containing drug provided by the present invention has excellent storage stability.
  • tablets, granules, fine granules, and powders containing granules mainly composed of D-mannitol have extremely low hygroscopicity, excellent storage stability, and low reactivity with drugs. It is good.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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Abstract

L'invention concerne un granule d'alcool de sucre destiné à un traitement par compression directe, un procédé de préparation dudit granule, et un médicament et un produit alimentaire renfermant ledit granule, lequel peut se désagréger rapidement dans la bouche. L'invention concerne, en particulier, un agrégat de granules renfermant de l'alcool de sucre à raison de 95 % en poids au moins, lequel agrégat est caractérisé en ce que 95 % au moins dudit agrégat se présente sous la forme de particules d'une granulométrie inférieure ou égale à 710 νm et en ce que 70 % en poids au moins dudit agrégat est constitué de particules d'une granulométrie comprise entre 75 et 710 νm. L'agrégat a une densité apparente de 0,5g/ml au moins et un angle de repos inférieur ou égal à 40°. L'invention concerne donc un agrégat de granules d'alcool de sucre, ainsi qu'un procédé permettant de préparer cet agrégat de granules, lequel procédé consiste à charger une poudre d'alcool de sucre sur une plaque circulaire tournant à l'intérieur d'une chambre de traitement d'un appareil de granulation à mouvement centrifuge ; à pulvériser une solution aqueuse tout en alimentant ladite chambre en air par une fente et en faisant tourner la plaque circulaire de manière à effectuer une granulation par voie humide ; et à sécher les granules humides obtenus dans un lit fluidisé.
PCT/JP1999/002809 1999-04-28 1999-05-27 Agregat de granules d'alcool de sucre, et procede de preparation correspondant WO2000066171A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP12156599 1999-04-28
JP11/121565 1999-04-28

Publications (1)

Publication Number Publication Date
WO2000066171A1 true WO2000066171A1 (fr) 2000-11-09

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004080439A1 (fr) * 2003-03-12 2004-09-23 Takeda Pharmaceutical Company Limited Composition de medicament comportant un principe actif adhere en concentration elevee a un noyau spherique
CN108553645A (zh) * 2018-03-27 2018-09-21 天津信诚康达药业有限公司 一种创新型辅料蔗糖及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61155343A (ja) * 1984-10-03 1986-07-15 ロケツト　フレ−ル　ソシエテ　アノニム 直接圧縮加工用粒状マンニトールおよびその製造方法
JPH06205959A (ja) * 1993-01-12 1994-07-26 Freunt Ind Co Ltd 球形顆粒、その製造方法およびそれを用いた医薬品
JPH09263589A (ja) * 1996-01-24 1997-10-07 Freunt Ind Co Ltd 乳糖の球形粒及びその製造方法
JPH1036291A (ja) * 1996-04-16 1998-02-10 Takeda Chem Ind Ltd Ｄ−マンニトールおよびその製造法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61155343A (ja) * 1984-10-03 1986-07-15 ロケツト　フレ−ル　ソシエテ　アノニム 直接圧縮加工用粒状マンニトールおよびその製造方法
JPH06205959A (ja) * 1993-01-12 1994-07-26 Freunt Ind Co Ltd 球形顆粒、その製造方法およびそれを用いた医薬品
JPH09263589A (ja) * 1996-01-24 1997-10-07 Freunt Ind Co Ltd 乳糖の球形粒及びその製造方法
JPH1036291A (ja) * 1996-04-16 1998-02-10 Takeda Chem Ind Ltd Ｄ−マンニトールおよびその製造法

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004080439A1 (fr) * 2003-03-12 2004-09-23 Takeda Pharmaceutical Company Limited Composition de medicament comportant un principe actif adhere en concentration elevee a un noyau spherique
US8449911B2 (en) 2003-03-12 2013-05-28 Takeda Pharmaceutical Company Limited Drug composition having active ingredient adhered at high concentration to spherical core
CN108553645A (zh) * 2018-03-27 2018-09-21 天津信诚康达药业有限公司 一种创新型辅料蔗糖及其制备方法

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