WO2000059796A1 - Stopper - Google Patents

Stopper Download PDF

Info

Publication number
WO2000059796A1
WO2000059796A1 PCT/EP1999/002271 EP9902271W WO0059796A1 WO 2000059796 A1 WO2000059796 A1 WO 2000059796A1 EP 9902271 W EP9902271 W EP 9902271W WO 0059796 A1 WO0059796 A1 WO 0059796A1
Authority
WO
WIPO (PCT)
Prior art keywords
stopper
vial
membrane
active product
closing
Prior art date
Application number
PCT/EP1999/002271
Other languages
English (en)
French (fr)
Inventor
Franck Moisio
Franz A. Klug
Original Assignee
Pentapharm Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pentapharm Ag filed Critical Pentapharm Ag
Priority to PCT/EP1999/002271 priority Critical patent/WO2000059796A1/en
Priority to AU38124/99A priority patent/AU3812499A/en
Priority to PL350603A priority patent/PL201020B1/pl
Priority to IL14514600A priority patent/IL145146A0/xx
Priority to EP00914170A priority patent/EP1169238A1/en
Priority to CA002368154A priority patent/CA2368154A1/en
Priority to JP2000609321A priority patent/JP2002541029A/ja
Priority to KR1020017012418A priority patent/KR20020028868A/ko
Priority to PCT/EP2000/002738 priority patent/WO2000059797A1/en
Priority to CN00805645A priority patent/CN1345284A/zh
Priority to AU35582/00A priority patent/AU3558200A/en
Priority to CZ20013393A priority patent/CZ294054B6/cs
Priority to HU0200428A priority patent/HU228739B1/hu
Publication of WO2000059796A1 publication Critical patent/WO2000059796A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/14—Rigid discs or spherical members adapted to be held in sealing engagement with mouth of container, e.g. closure plates for preserving jars
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1406—Septums, pierceable membranes

Definitions

  • the present invention concerns an elastic stopper for closing a vial in a system for preparing ready to use suspensions or solutions of an active product stored in said vial .
  • Such systems usually comprise two hermetically closed vials, one containing an active product generally in the form of a lyophilized or otherwise dried powder or granulate and the second containing the liquid in which the active product is dissolved or suspended.
  • the system further comprises a connecting piece for temporary connection of the two vials.
  • the active product is usually contained in a glass vial which is closed by an elastic stopper inserted in the neck of the vial.
  • the stopper has in its axis a channel which is covered by a thin, per- forable airtight membrane, such as aluminum, which is glued or welded onto the top surface of the stopper.
  • the second vial containing the liquid is more often made of plastic material and is closed by a dropper with a tip having a diameter smaller than the said channel through the stopper.
  • the dropper perforates the membrane in such a way that airtightness is provided between the two vials.
  • the presently known stoppers have the disadvantage that they consist of two pieces namely the stopper as such and the membrane affixed to it. To produce such a stopper several consecutive manufacturing steps are necessary resulting in a relatively expensive product.
  • the aim of the present invention is to provide a stopper whose manufacture is less complicated and which is, thus, less expensive.
  • a stopper consisting of one piece of elastic material which has a concentrical portion whose axial thickness is reduced to a membrane which has radially arranged cuts constituting defined breakage lines during perforation.
  • the figure shows a top view and a cross-section along line A - A of a stopper 1 made of elastic material such as rubber.
  • the stopper is generally cylindrical and has an upper flange-shaped portion 2 and a lower skirt-shaped portion 3. In its interior it is provided with a coaxial cavity 4 extending from the lower surface 5 up almost to the top surface 6 leaving a thin membrane-like layer 7 of the stopper material to keep the closing capability of the stopper.
  • the membrane-like layer 7 is provided with four radially arranged cuts 8 which meet in the stopper axis and which extend partially through the layer 7 without entirely perforating it to keep the airtightness of the stopper.
  • the cuts constitute predefined breakage lines which guarantee tight attachment of the membrane-like layer flaps to the dropper to keep airtightness during connection. After removal of the other vial the flaps close the perforation to essentially retain tightness.
  • the stopper is particularly useful in connection with the dual vial connector described in PCT/EP 97/04660 and PCT/EP 04290 in which however the membrane and the sealing rings would be eliminated. This combination would be a preferable alternative for the user who due to habit or in view of manufacturing restrictions intends to remain with a stopper solution.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Closures For Containers (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
PCT/EP1999/002271 1999-04-01 1999-04-01 Stopper WO2000059796A1 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
PCT/EP1999/002271 WO2000059796A1 (en) 1999-04-01 1999-04-01 Stopper
AU38124/99A AU3812499A (en) 1999-04-01 1999-04-01 Stopper
PL350603A PL201020B1 (pl) 1999-04-01 2000-03-28 Korek
IL14514600A IL145146A0 (en) 1999-04-01 2000-03-28 Stopper
EP00914170A EP1169238A1 (en) 1999-04-01 2000-03-28 Stopper
CA002368154A CA2368154A1 (en) 1999-04-01 2000-03-28 Stopper
JP2000609321A JP2002541029A (ja) 1999-04-01 2000-03-28 ストッパ
KR1020017012418A KR20020028868A (ko) 1999-04-01 2000-03-28 스토퍼
PCT/EP2000/002738 WO2000059797A1 (en) 1999-04-01 2000-03-28 Stopper
CN00805645A CN1345284A (zh) 1999-04-01 2000-03-28 瓶塞
AU35582/00A AU3558200A (en) 1999-04-01 2000-03-28 Stopper
CZ20013393A CZ294054B6 (cs) 1999-04-01 2000-03-28 Zátka
HU0200428A HU228739B1 (hu) 1999-04-01 2000-03-28 Záróelem

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP1999/002271 WO2000059796A1 (en) 1999-04-01 1999-04-01 Stopper

Publications (1)

Publication Number Publication Date
WO2000059796A1 true WO2000059796A1 (en) 2000-10-12

Family

ID=8167258

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/EP1999/002271 WO2000059796A1 (en) 1999-04-01 1999-04-01 Stopper
PCT/EP2000/002738 WO2000059797A1 (en) 1999-04-01 2000-03-28 Stopper

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/002738 WO2000059797A1 (en) 1999-04-01 2000-03-28 Stopper

Country Status (11)

Country Link
EP (1) EP1169238A1 (ja)
JP (1) JP2002541029A (ja)
KR (1) KR20020028868A (ja)
CN (1) CN1345284A (ja)
AU (2) AU3812499A (ja)
CA (1) CA2368154A1 (ja)
CZ (1) CZ294054B6 (ja)
HU (1) HU228739B1 (ja)
IL (1) IL145146A0 (ja)
PL (1) PL201020B1 (ja)
WO (2) WO2000059796A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6551944B1 (en) 1999-04-07 2003-04-22 Stmicroelectronics S.R.L. Process for manufacturing a semiconductor material wafer comprising single-Crystal regions separated by insulating material regions

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0413438D0 (en) * 2004-06-16 2004-07-21 Sanders Mark J Anti spike devcies
EP4253276A1 (de) * 2022-03-30 2023-10-04 Datwyler Pharma Packaging Belgium Verschlussstopfen für medizinische oder pharmazeutische substanzen enthaltende behälter

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2906423A (en) * 1956-07-18 1959-09-29 American Cyanamid Co Closure puncturable by polyethylene needle
DE2040072A1 (de) * 1969-08-23 1971-03-04 Philips Nv Elastisch verformbarer Stopfen fuer eine Injektionsspritze
US4545497A (en) * 1984-11-16 1985-10-08 Millipore Corporation Container cap with frangible septum
EP0509281A2 (de) * 1991-04-13 1992-10-21 BEHRINGWERKE Aktiengesellschaft Behälterverschluss mit durchstossbarem Verschlusskörper
WO1994003373A1 (en) * 1992-08-07 1994-02-17 The West Company, Incorporated Needleless access stopper

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5829939U (ja) * 1981-08-24 1983-02-26 武田薬品工業株式会社 バイアル用ゴム栓
JPH0746242Y2 (ja) * 1991-11-02 1995-10-25 株式会社ニッショー 真空採血管用密封栓体
US5484566A (en) * 1994-03-07 1996-01-16 Wheaton Inc. Method of manufacture of a partially laminated rubber closure
JP3464827B2 (ja) * 1994-07-04 2003-11-10 株式会社鳥羽合成樹脂製作所 サンプルバイアル
JPH1147234A (ja) * 1997-07-29 1999-02-23 Naniwa Rubber Kogyo Kk 医療用ゴム栓

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2906423A (en) * 1956-07-18 1959-09-29 American Cyanamid Co Closure puncturable by polyethylene needle
DE2040072A1 (de) * 1969-08-23 1971-03-04 Philips Nv Elastisch verformbarer Stopfen fuer eine Injektionsspritze
US4545497A (en) * 1984-11-16 1985-10-08 Millipore Corporation Container cap with frangible septum
EP0509281A2 (de) * 1991-04-13 1992-10-21 BEHRINGWERKE Aktiengesellschaft Behälterverschluss mit durchstossbarem Verschlusskörper
WO1994003373A1 (en) * 1992-08-07 1994-02-17 The West Company, Incorporated Needleless access stopper

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6551944B1 (en) 1999-04-07 2003-04-22 Stmicroelectronics S.R.L. Process for manufacturing a semiconductor material wafer comprising single-Crystal regions separated by insulating material regions

Also Published As

Publication number Publication date
KR20020028868A (ko) 2002-04-17
IL145146A0 (en) 2002-06-30
HUP0200428A3 (en) 2002-11-28
HU228739B1 (hu) 2013-05-28
PL201020B1 (pl) 2009-02-27
CZ294054B6 (cs) 2004-09-15
AU3558200A (en) 2000-10-23
CA2368154A1 (en) 2000-10-12
WO2000059797A1 (en) 2000-10-12
HUP0200428A2 (hu) 2002-05-29
CN1345284A (zh) 2002-04-17
AU3812499A (en) 2000-10-23
EP1169238A1 (en) 2002-01-09
PL350603A1 (en) 2003-01-13
JP2002541029A (ja) 2002-12-03

Similar Documents

Publication Publication Date Title
US4986322A (en) System of packaging for ready to use preparations
US4950237A (en) Dual chambered mixing and dispensing vial
EP1098821B1 (en) An enclosure cap for multiple piercing
JP3564032B2 (ja) 複数種類の異なる物質を分離収納する容器デバイス
CA2497664A1 (en) Sealed containers and methods of making and filling same
US4301799A (en) Non-collapsible medical fluid container with air vent filter
US6571971B1 (en) Hermetically sealed container with pierceable entry port
US6387073B1 (en) Hermetically sealed container with medicament storing and dispensing insert
US8800759B2 (en) Bushing for receiving a dropper neck, and corresponding package and kit
EP0229847A1 (en) Suction pipe
IL134356A (en) Two-plate connection system for freeze-dried products
WO2003057583A1 (fr) Structure de fermeture d'un recipient, recipient comprenant cette structure de fermeture et procede de fabrication de cette structure de fermeture
JP6854781B2 (ja) 接続及び容器システム
CN105905422A (zh) 分配封盖、具有分配封盖的容器以及用于制造分配封盖的方法
JPH05270560A (ja) 閉鎖キャップ
US4569456A (en) Sealed container with replaceable plug insert
US2568029A (en) Unitary container for hypodermic injection ingredients
WO2000059796A1 (en) Stopper
US5234001A (en) Container for immunoassay with frangible nipple
EP2773571A1 (en) Bottle including a hollow removable closure
CN104755380A (zh) 带盖吸嘴
JPS60193855A (ja) 液状物飲用容器
JP2000062855A (ja) 用時開封ユニット及び排液ユニットを所定の順序でユニット換装による切換え実行型の溶液等の製造装置
MX2008000681A (en) Perforable closure for a container, mould and method for manufacturing said closure
JPS6086483U (ja) 小型デイスペンサ−

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

NENP Non-entry into the national phase

Ref country code: CA

122 Ep: pct application non-entry in european phase