US2906423A - Closure puncturable by polyethylene needle - Google Patents

Closure puncturable by polyethylene needle Download PDF

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Publication number
US2906423A
US2906423A US59861356A US2906423A US 2906423 A US2906423 A US 2906423A US 59861356 A US59861356 A US 59861356A US 2906423 A US2906423 A US 2906423A
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Prior art keywords
stopper
needle
closure
bottle
tear
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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Sandhage Ellsworth Roland
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Wyeth Holdings LLC
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Wyeth Holdings LLC
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00Closures not otherwise provided for
    • B65D51/002Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61DVETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00Medical syringes, e.g. enemata; Irrigators

Description

Sept. 29, 1959 E. R. SANDHAGE CLOSURE PUNCTURABLE BY POLYETHYLENE NEEDLE Filed July 18, 1956 o v 1 I 1 Dust "@om 25 A Sealing 26 Wafer Retaining Stopper /4/% 1 IN VEN TOR jj ELLSWORTH R. .SANDHAGE,

A TTORNE 7.

United States Patent i 2,906,423 CLOSURE PUNCTURABLE BY POLYETHYLENE NEEDLE Ellsworth Roland Sandhage, Pearl River, N.Y., amignor to American Cyanamid Company, New York, N.Y., a corporation of Maine Application July '18, 1956, Serial No. 598,613 1 Claim. 01. 215-47 This invention relates to a container for liquid pharmaceutical preparations and includes a bottle comprising a resilient closure puncturable by a polyethylene needle, and the closure itself.

It is an object of this invention to provide a closure of a resilient rubber-like material which is retained in position in a bottle and is moisture-proof and contamination-proof before use, which may be easily punctured by a plastic needle and which is self-reclosing and contamination-resistant when in use, and is easily reopened, economical and tamper-proof. Additionally, the closure is easily attached with conventional sealing machinery.

With recent improvements in molding techniques it has been possible to produce inexpensive syringes in which the nose of the syringe in itself serves as a needle. Among other uses for such syringes is in the treatment of mastitis. With such syringes, the needle is inserted in the milk orifice of the cows teat. Obviously, the needle must be smooth and rounded for such use. Such a rounded needle is too dull to puncture a conventional rubber stopper, but none the less, it is convenient to have the closure resemble an ordinary closure for use with hypodermic needles. One solution is, of course, to use an auxiliary pointed needle for the opening operation and change to a separate injection needle for the treatment of the cow.

Such a procedure is inconvenient.

Prior art closures using a solid membrane, such as disclosed in a U.S. Patent to Biehn, 1,413,703, April 25, 1922, Closure for Hypodermic Solution Containers, would be suitable with a sharp needle. Other types of closures such as shown by McElroy, 1,180,665, April 25, 1916, Closure or Stopper for Serum Containers, etc., are also usable except that the lumen through the stopper can easily allow contamination of the contents and may require too long a needle, and induce an undue amount of friction.

I have now found that a stopper formed of a low tearresistant rubber, with a conical well in the top face extending partway into the plug portion of the stopper, and which has a cut slit extending partway from the apex of the conical well towards the bottom face of the stopper provides a moisture-proof closure; and a closure which is easily opened by forcing a polyethylene needle therethrough.

Many materials are more easily torn after an initial line of weakness has been formed. For instance, conventional cellophane is extremely difiicult to tear up until a tear is started, but once a tear is started, the cellophane tears extremely easy. Similarly, in rubber or rubberlike materials, it is easier to extend-a tear than to start one, and by using a rubber of low tear resistance, as for example, synthetic rubber of the GRS type, there may be provided a resilient closure in which a slit once started is very easy to extend. Even with material conventionally used in preparing resilient rubber stoppers a tear once started by a cut slit is easy to extend when using a rounded point polyethylene needle.

Patented Sept. 29, 1959 ICC Certain embodiments of the invention are more clearly illustrated in connection with specific improvements thereof shown in the drawings:

,Figure 1 is an exploded view of the preferred form of the closure.

Figure 2 is a sectional view through the top of the closed container.

l Figure 3 shows an elliptical cone with a longitudinal s it.

Figure 4 shows a circular cone with a point slit.

Figures 5, 6, 7 and 8 show the progress of a polyethylene needle as it is forced through the stopper.

, As shown in Figure 1, the bottle may be any size bottle 11 with a neck 12, having a rim 13= thereon. In the neck of the bottle is the stopper 14 itself. The stopper may be of conventional material such as rubber but preferably is of a grade of rubber having a low tear resistance. Many of the new synthetic rubbers, such as GRS are conventionally compounded to have a low tear resistance by methods known in the trade. This stopper 14 conveniently consists of the plug 15, which is the portion that extends into the neck of the bottle, above which is a flange 16 which fits against the rim of the bottle and may be used to retain the stopper in position. Preferably, but not necessarily, the lower portion of the plug has a recess 17 therein which extends partway up into the plug. The upper face 18 has therein a conical well 19. As shown in Figure 4 the conical well may be a right circular cone, or it may be elliptical in cross section as shown in Figure 3, and rather than terminating at an apex it may have a conoidal shape terminating in an apex line 20. At the apex 21 or the apex line 20 is a cut slit 22. The cut slit is cut in the stopper, after it has been molded, by a sharp instrument so that there is an actual tear started into the stopper itself. By having an actual tear started it is easier to extend the tear. This would not be the case if the slit were molded and had a rounded edge. The cut slit extends partway but not completely through the stopper. An unpunctured membrane 23 remains between the bottom of the cut slit and the top of the recess, so that the stopper forms an unperforated closure for the bottle.

By thus being unperforated, the stopper prevents the passage of moisture. Additionally, by inspection, it can be determinated that the contents of the bottle have not been used. Once this slit is extended through the stopper the evidence of entry remains.

The stopper may have a thin lubricant coat 24 on the surface thereof which may be of a silicone fluid, such as disclosed in U.S. Patent 2,649,090, Parsons et a1., Rubber Closure for Pharmaceutical Vials, August 18, 1953. In addition to lubricating the stopper for ease of insertion, the lubricant tends to fill up the cut slit thereby preventing the entry of contaminating microorganisms and also lubricating the entry of the vpolyethylene needle through the conical well into the interior of the bottle.

In use the stopper may be held in the bottle by any convenient means but conveniently may be retained by a retaining ring 25 of a ductile material, such as aluminum, which may be spun or otherwise drawn under the rim of the bottle. The retaining ring holds the stopper in position during use and protects the bottle and its contents from tampering. Preferably, a resilient sealing wafer 26 is placed over the stopper and the retaining ring and held in place by dust disc 27. The lower side of the sealing wafer may have an adhesive coat which unites it to the retaining ring and aids in preventing contamination of the face of the stopper. The dust disc and the sealing wafer are held in position by a tear off cover 28. The tear off cover, the dust disc, the sealing Wafer and the retaining ring maybe preassembled andplaced over the stopper in the bottle by conventional closing machines. When so closed, the top face of the closure-is protectedagainstcontarninationand tampering. The closure is opened-by'ripping'the tearoff cover, andremoving the dust disc and sealing waferthus exposing the face-ofthe 'stopperin Which-there-is the conical well.

As shown in Figures to 8, the rounded end of apolyethylene needle 29 slides smoothly on the lubricant coat, separates the sides of the slit, and extends-the tear from bottom of the cutslit to the bottom surface 30 of the stopper. Stages in this process are shown. After the partial withdrawal of the contents into the syringe attached to the polyethylene needle, the needle may be withdrawn, permitting theclosure of the now extended slit which thus protects the contents of the bottle until the next usage.-

The exact proportions suchas the relative depth of:

the'conicalwell, and the recess, the-relative length of the plug, and the thickness of the flange may be-varied-d'e-- pending upon the size of the bottle and manufacturing convenience. Conveniently, proportions are chosen such:

that the standard stoppering procedures may be used to place an aluminum seal thereon. Obviously, the bottle does not need to be glass and the retaining ring, dust disc,.

andthe tear off cover neednot be of aluminum, although conveniently a glass bottle and an aluminum seal are usually used.

Having thus described certain embodiments thereof, as my invention, I claim:

A closure for liquid pharmaceutical preparations comprising: a resilient-stopper comprisinga plug, a flange, an

upperfa'ce li'avinga conical well therein, a cut slit, termi- ReferenceszCited: in. the; file, of this, patent:

UNITED STATES PATENTS 1,180,665- McElroy Apr; 25,1916 2,108,583: Falk -Feb. 15, 1938 2,334,905 Cherkin Nov 23,. 1943 2,649,090 Parsonset al; Aug. 18,1953

US2906423A 1956-07-18 1956-07-18 Closure puncturable by polyethylene needle Expired - Lifetime US2906423A (en)

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Cited By (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3088615A (en) * 1960-07-25 1963-05-07 Owens Illinois Glass Co Closure caps
US3161310A (en) * 1960-10-14 1964-12-15 Baxter Don Inc Parenteral solution container
EP0097591A1 (en) * 1982-06-18 1984-01-04 Miramanda Fernando Xalabarder A stopper for containers for use in analyses
FR2598137A1 (en) * 1986-05-05 1987-11-06 Astraplastique Sa Tamperproof screwing sealing plug device and its method of assembly
DE9006079U1 (en) * 1990-05-30 1990-09-13 Bethkenhagen, Juergen, 5223 Nuembrecht, De
US5060812A (en) * 1990-09-06 1991-10-29 International Medication Systems, Limited Medication container stopper which can be punctured by nozzle of a hypodermic syringe
EP0480196A1 (en) * 1990-10-12 1992-04-15 Pohl GmbH & Co. KG Closure cap for an infusion bottle
US5111946A (en) * 1990-11-30 1992-05-12 Elliot Glanz Safety bottle
US5202093A (en) * 1991-05-20 1993-04-13 Medical Robotics, Inc. Sealing cap with a one way valve having semi-cylindrical valve closure springs
WO1994003373A1 (en) * 1992-08-07 1994-02-17 The West Company, Incorporated Needleless access stopper
EP0634339A1 (en) * 1993-06-29 1995-01-18 Becton Dickinson and Company Combination stopper-shield closure
US5540674A (en) * 1993-09-28 1996-07-30 Abbott Laboratories Solution container with dual use access port
DE19514521A1 (en) * 1995-04-12 1996-10-17 Schulz Hans Joachim Dr Laboratory equipment for simultaneous manual performance of chemical reactions
WO1996041649A1 (en) * 1995-06-09 1996-12-27 Migada, Inc. Blunt cannula construction for multiple applications
US5588547A (en) * 1993-12-09 1996-12-31 Carl Freudenberg Covering developed for infusion bottle
US5795784A (en) * 1996-09-19 1998-08-18 Abbott Laboratories Method of performing a process for determining an item of interest in a sample
US5856194A (en) * 1996-09-19 1999-01-05 Abbott Laboratories Method for determination of item of interest in a sample
EP0917882A1 (en) * 1997-11-19 1999-05-26 Arzneimittel GmbH Apotheker Vetter & Co. Ravensburg Syringe particularly a prefilled syringe or ampoule
US5983770A (en) * 1994-08-03 1999-11-16 Abbott Laboratories Reseal with a partial perforation and method and apparatus for creating a partial perforation in a reseal
EP0960616A3 (en) * 1998-05-16 2000-04-26 Bracco International B.V. Multiple use universal stopper
US6123469A (en) * 1983-10-13 2000-09-26 Seiko Epson Corporation Ink-supply wire dot matrix printer head
WO2000059797A1 (en) * 1999-04-01 2000-10-12 Pentapharm Ag Stopper
US6391014B1 (en) * 1996-12-20 2002-05-21 David G. Silverman Strong diaphragm/safe needle/converting device combinations and their individual components
US20020127147A1 (en) * 2001-03-09 2002-09-12 Kacian Daniel L. Penetrable cap
US20030052074A1 (en) * 2001-09-17 2003-03-20 Chang Min Shuan Closure for container for holding biological samples
US20030083606A1 (en) * 1998-06-03 2003-05-01 Epstein Gordon Howard Direct dual filling device for sealing agents
US20030194349A1 (en) * 1991-03-04 2003-10-16 Glen Carey Fluid handling apparatus for an automated analyzer
US6716396B1 (en) 1999-05-14 2004-04-06 Gen-Probe Incorporated Penetrable cap
JP2004290473A (en) * 2003-03-27 2004-10-21 Jms Co Ltd Medical purpose rubber stopper and container
US20080148872A1 (en) * 2000-05-12 2008-06-26 Gen-Probe Incorporated Method for accessing the contents of an assembly
US20100089862A1 (en) * 2008-10-10 2010-04-15 Friedrich Sanner Gmbh & Co. Kg Closure to be pressed and latched onto a container
US20100264148A1 (en) * 2009-04-20 2010-10-21 Mackay Kathy Stainless steel beverage container
US20100310817A1 (en) * 2009-06-09 2010-12-09 Hirofumi Imai Support plate, method for producing the same, and method for processing substrate
US20110303670A1 (en) * 2008-12-10 2011-12-15 Raymond John Baker Secure closure
US20130174937A1 (en) * 2011-07-26 2013-07-11 Hainan Weikang Pharmaceutical (Qianshan) Co.,Ltd Puncture Free Bottle Cork and the Application Thereof
US9656786B2 (en) 2011-12-22 2017-05-23 Toppan Printing Co., Ltd. Plug
WO2018060333A1 (en) * 2016-09-28 2018-04-05 Fresenius Kabi Deutschland Gmbh Sealing cap for a container for holding a medical liquid

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1180665A (en) * 1915-11-29 1916-04-25 Randall Faichney Company Inc Closure or stopper for serum-containers, &c.
US2108583A (en) * 1936-02-26 1938-02-15 Baxter Laboratories Inc Container
US2334905A (en) * 1942-02-09 1943-11-23 Baxter Don Inc Closure for containers
US2649090A (en) * 1950-09-29 1953-08-18 American Cyanamid Co Rubber closure for pharmaceutical vials

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1180665A (en) * 1915-11-29 1916-04-25 Randall Faichney Company Inc Closure or stopper for serum-containers, &c.
US2108583A (en) * 1936-02-26 1938-02-15 Baxter Laboratories Inc Container
US2334905A (en) * 1942-02-09 1943-11-23 Baxter Don Inc Closure for containers
US2649090A (en) * 1950-09-29 1953-08-18 American Cyanamid Co Rubber closure for pharmaceutical vials

Cited By (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3088615A (en) * 1960-07-25 1963-05-07 Owens Illinois Glass Co Closure caps
US3161310A (en) * 1960-10-14 1964-12-15 Baxter Don Inc Parenteral solution container
EP0097591A1 (en) * 1982-06-18 1984-01-04 Miramanda Fernando Xalabarder A stopper for containers for use in analyses
US6224275B1 (en) 1983-10-13 2001-05-01 Seiko Epson Corporation Ink-supply tank for a printer
US6123469A (en) * 1983-10-13 2000-09-26 Seiko Epson Corporation Ink-supply wire dot matrix printer head
US6176629B1 (en) 1983-10-13 2001-01-23 Seiko Epson Corporation Ink supply tank for a printer
US6231248B1 (en) 1983-10-13 2001-05-15 Seiko Epson Corporation Ink supply tank for a printer
FR2598137A1 (en) * 1986-05-05 1987-11-06 Astraplastique Sa Tamperproof screwing sealing plug device and its method of assembly
DE9006079U1 (en) * 1990-05-30 1990-09-13 Bethkenhagen, Juergen, 5223 Nuembrecht, De
US5060812A (en) * 1990-09-06 1991-10-29 International Medication Systems, Limited Medication container stopper which can be punctured by nozzle of a hypodermic syringe
EP0480196A1 (en) * 1990-10-12 1992-04-15 Pohl GmbH & Co. KG Closure cap for an infusion bottle
US5111946A (en) * 1990-11-30 1992-05-12 Elliot Glanz Safety bottle
US7182912B2 (en) 1991-03-04 2007-02-27 Bayer Corporation Fluid handling apparatus for an automated analyzer
US20030194349A1 (en) * 1991-03-04 2003-10-16 Glen Carey Fluid handling apparatus for an automated analyzer
US5202093A (en) * 1991-05-20 1993-04-13 Medical Robotics, Inc. Sealing cap with a one way valve having semi-cylindrical valve closure springs
US5433330A (en) * 1992-08-07 1995-07-18 The West Company, Incorporated Needleless access stopper
WO1994003373A1 (en) * 1992-08-07 1994-02-17 The West Company, Incorporated Needleless access stopper
EP0634339A1 (en) * 1993-06-29 1995-01-18 Becton Dickinson and Company Combination stopper-shield closure
US5540674A (en) * 1993-09-28 1996-07-30 Abbott Laboratories Solution container with dual use access port
US5588547A (en) * 1993-12-09 1996-12-31 Carl Freudenberg Covering developed for infusion bottle
EP0773776B1 (en) * 1994-08-03 2000-04-19 Abbott Laboratories A reseal with a partial perforation and method and apparatus for creating a partial perforation in a reseal
US5983770A (en) * 1994-08-03 1999-11-16 Abbott Laboratories Reseal with a partial perforation and method and apparatus for creating a partial perforation in a reseal
DE19514521A1 (en) * 1995-04-12 1996-10-17 Schulz Hans Joachim Dr Laboratory equipment for simultaneous manual performance of chemical reactions
WO1996041649A1 (en) * 1995-06-09 1996-12-27 Migada, Inc. Blunt cannula construction for multiple applications
US5856194A (en) * 1996-09-19 1999-01-05 Abbott Laboratories Method for determination of item of interest in a sample
US5795784A (en) * 1996-09-19 1998-08-18 Abbott Laboratories Method of performing a process for determining an item of interest in a sample
US6562298B1 (en) 1996-09-19 2003-05-13 Abbott Laboratories Structure for determination of item of interest in a sample
US6391014B1 (en) * 1996-12-20 2002-05-21 David G. Silverman Strong diaphragm/safe needle/converting device combinations and their individual components
US5989227A (en) * 1997-11-11 1999-11-23 Arzneimittel Gmbh Apotheker Vetter & Co. Prefilled syringe with sterility-preserving cap
EP0917882A1 (en) * 1997-11-19 1999-05-26 Arzneimittel GmbH Apotheker Vetter & Co. Ravensburg Syringe particularly a prefilled syringe or ampoule
EP0960616A3 (en) * 1998-05-16 2000-04-26 Bracco International B.V. Multiple use universal stopper
US7081103B2 (en) * 1998-06-03 2006-07-25 Baxter International Inc. Direct dual filling device for sealing agents
US20030083606A1 (en) * 1998-06-03 2003-05-01 Epstein Gordon Howard Direct dual filling device for sealing agents
WO2000059796A1 (en) * 1999-04-01 2000-10-12 Pentapharm Ag Stopper
WO2000059797A1 (en) * 1999-04-01 2000-10-12 Pentapharm Ag Stopper
US7648680B2 (en) 1999-05-14 2010-01-19 Gen-Probe Incorporated Method for accessing the contents of a closed vessel containing a specimen retrieval device
US6806094B2 (en) 1999-05-14 2004-10-19 Gen-Probe Incorporated Method for removing a fluid substance from a collection device
US8535621B2 (en) 1999-05-14 2013-09-17 Gen-Probe Incorporated Penetrable cap having rib structures
US8211710B2 (en) 1999-05-14 2012-07-03 Dickey Kathleen A Method for accessing the contents of a closed collection device
US8206662B2 (en) 1999-05-14 2012-06-26 Gen-Probe Incorporated Collection device including a penetrable cap having an absorbent pile fabric
US8573072B2 (en) 1999-05-14 2013-11-05 Gen-Probe Incorporated Method for removing a fluid substance from a sealed collection device
US7795036B2 (en) 1999-05-14 2010-09-14 Gen-Probe Incorporated Method for accessing the contents of a closed collection device
US7276383B2 (en) 1999-05-14 2007-10-02 Gen-Probe Incorporated Method for obtaining the contents of a fluid-holding vessel
US8038967B2 (en) 1999-05-14 2011-10-18 Gen-Probe Incorporated Method for accessing the contents of a closed vessel containing a specimen retrieval device
US7309469B2 (en) 1999-05-14 2007-12-18 Gen-Probe Incorporated Collection device
US7927549B2 (en) 1999-05-14 2011-04-19 Gen-Probe Incorporated Method for accessing the contents of a closed collection device with a modified pipette tip
US7435389B2 (en) 1999-05-14 2008-10-14 Gen-Probe Incorporated Sealed collection device having striated cap
US8334145B2 (en) 1999-05-14 2012-12-18 Gen-Probe Incorporated Pierceable cap having spaced-apart grooves
US6716396B1 (en) 1999-05-14 2004-04-06 Gen-Probe Incorporated Penetrable cap
US20080148872A1 (en) * 2000-05-12 2008-06-26 Gen-Probe Incorporated Method for accessing the contents of an assembly
US20050079633A1 (en) * 2001-03-09 2005-04-14 Gen-Probe Incorporated Method for transferring a substance to or from a closed system
US7691332B2 (en) 2001-03-09 2010-04-06 Gen-Probe Incorporated Penetrable cap
USRE45194E1 (en) 2001-03-09 2014-10-14 Gen-Probe Incorporated Penetrable cap
US7824922B2 (en) 2001-03-09 2010-11-02 Gen-Probe Incorporated Method for removing a fluid substance from a closed system
US8685347B2 (en) 2001-03-09 2014-04-01 Gen-Probe Incorporated Penetrable cap
US7294308B2 (en) 2001-03-09 2007-11-13 Gen-Probe Incorporated Penetrable cap
US8052944B2 (en) 2001-03-09 2011-11-08 Gen-Probe Incorporated Penetrable cap
US8057762B2 (en) 2001-03-09 2011-11-15 Gen-Probe Incorporated Penetrable cap
US20020127147A1 (en) * 2001-03-09 2002-09-12 Kacian Daniel L. Penetrable cap
US6893612B2 (en) 2001-03-09 2005-05-17 Gen-Probe Incorporated Penetrable cap
US20030052074A1 (en) * 2001-09-17 2003-03-20 Chang Min Shuan Closure for container for holding biological samples
JP2004290473A (en) * 2003-03-27 2004-10-21 Jms Co Ltd Medical purpose rubber stopper and container
US20100089862A1 (en) * 2008-10-10 2010-04-15 Friedrich Sanner Gmbh & Co. Kg Closure to be pressed and latched onto a container
US20110303670A1 (en) * 2008-12-10 2011-12-15 Raymond John Baker Secure closure
US20100264148A1 (en) * 2009-04-20 2010-10-21 Mackay Kathy Stainless steel beverage container
US20100310817A1 (en) * 2009-06-09 2010-12-09 Hirofumi Imai Support plate, method for producing the same, and method for processing substrate
US8354157B2 (en) * 2009-06-09 2013-01-15 Tokyo Ohka Kogyo Co., Ltd. Support plate, method for producing the same, and method for processing substrate
US20130174937A1 (en) * 2011-07-26 2013-07-11 Hainan Weikang Pharmaceutical (Qianshan) Co.,Ltd Puncture Free Bottle Cork and the Application Thereof
US9656786B2 (en) 2011-12-22 2017-05-23 Toppan Printing Co., Ltd. Plug
WO2018060333A1 (en) * 2016-09-28 2018-04-05 Fresenius Kabi Deutschland Gmbh Sealing cap for a container for holding a medical liquid

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