WO2000018295A1 - Dispositif de mesure d'au moins une propriete ou une caracteristique d'une zone d'un tissu - Google Patents

Dispositif de mesure d'au moins une propriete ou une caracteristique d'une zone d'un tissu Download PDF

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Publication number
WO2000018295A1
WO2000018295A1 PCT/EP1999/006907 EP9906907W WO0018295A1 WO 2000018295 A1 WO2000018295 A1 WO 2000018295A1 EP 9906907 W EP9906907 W EP 9906907W WO 0018295 A1 WO0018295 A1 WO 0018295A1
Authority
WO
WIPO (PCT)
Prior art keywords
torque motor
area
measuring
magnetic
torque
Prior art date
Application number
PCT/EP1999/006907
Other languages
German (de)
English (en)
Inventor
Gilles Pauly
Original Assignee
Laboratoires Serobiologiques (Societe Anonyme)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Serobiologiques (Societe Anonyme) filed Critical Laboratoires Serobiologiques (Societe Anonyme)
Priority to AU59790/99A priority Critical patent/AU5979099A/en
Publication of WO2000018295A1 publication Critical patent/WO2000018295A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/442—Evaluating skin mechanical properties, e.g. elasticity, hardness, texture, wrinkle assessment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0048—Detecting, measuring or recording by applying mechanical forces or stimuli
    • A61B5/0057—Detecting, measuring or recording by applying mechanical forces or stimuli by applying motion other than vibrations, e.g. rolling, rubbing, applying a torque, tribometry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • A61B5/7207—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise induced by motion artifacts

Definitions

  • the present invention relates to the determination and analysis of certain physical features of soft or deformable materials, such as in particular those of human skin, by non-invasive measuring methods, and is particularly concerned with a device for measuring or determining at least one mechanical feature of a deformable area Substance that may have elastic properties and / or viscosity.
  • a known method for determining such features is that a longitudinal force on an element such as e.g. a pin is attached, which is firmly connected (e.g. by gluing) to an area of the substance to be tested, and that the deflection caused by this force is measured.
  • the applied force is generated with the aid of an electromagnet or a linear motor which consists of a movable coil or winding, which is arranged in a radial magnetic field generated by a fixed magnet (as in a loudspeaker).
  • the stroke of the moving part is measured with the help of an LVDT (Linear Variable Differential Transformer) inductive sensor.
  • LVDT Linear Variable Differential Transformer
  • this device or this device with a small stroke (2 to 4 mm) is difficult to adjust in reality, because of the involuntary movements of the test subject, which are of the same order of magnitude as said stroke.
  • the movable unit since the movable unit has only one degree of freedom in translation, it is very difficult to adjust the position of the device with respect to the test person to H mm exactly in the transverse direction and in height.
  • each movement of the test person in a plane perpendicular to the direction of the application of the force causes deformations and friction which distort the measurements.
  • the guidance of the movable unit on air cushions causes not inconsiderable friction and restoring forces, in particular due to the mass to be guided and the surfaces involved, which add to the force of the electromagnet and likewise falsify the measurement results.
  • the problem underlying the present invention is, in particular, to provide a simply constructed device which allows the above-described method to be used easily in vivo, in particular in humans, and this independently of at least certain involuntary movements of the test person and when achieving precise and reliable measurements.
  • the invention relates to a device for measuring at least one / a mechanical property or feature of a region of a deformable material, which may have elastic and / or viscous properties, such as skin, by applying a controlled force to an element firmly connected to said area of the material, characterized in that it essentially consists on the one hand of a torque motor coupled to an angular displacement sensor or tachometer module and on the other hand of a linkage for transmitting the said Torque motor delivered torque on the element firmly connected to said area of the substance to be measured in the form of a tangential tensile and / or compressive force, said linkage permitting at least one degree of freedom of rotation of the element with respect to the torque motor.
  • Figure 1 a simplified schematic representation illustrating the principle of the method used
  • Figure 2 is a schematic representation of a measuring device according to the invention.
  • FIGS. 3A and 3B an elevation view from the front and a plan view, in section, of a preferred embodiment of the torque motor / encoder module unit, which is part of the device shown in FIG. 2;
  • Figure 4 is a perspective view showing the attachment of the device of the invention to an adjustable support frame;
  • Figure 5 is a sectional side view of a first embodiment of the articulation of the linkage, which is part of the device shown in Figure 2;
  • Figure 6 is a perspective view of a second embodiment of the linkage of the linkage, which is part of the device shown in Figure 2;
  • FIG. 7 a schematic representation showing the functional connections between the torque motor / Represents donor module and the latter controlling administrative unit;
  • FIGS. 8A and 8B compare the curves obtained as measurement results of the dynamic elasticity coefficient (DSR) of a piece of human skin, in each case before and after the application of an active substance (hydrogel with 5% Vegeseryl® HGP LS 8572 (Laboratoires Serobiiquess), 4 ⁇ l / cm 2 ), achieved on the one hand in vitro using a device according to the prior art of the GBE type (FIG. 8A) and on the other hand achieved in vivo using the measuring device according to the invention (FIG. 8B); and
  • DSR dynamic elasticity coefficient
  • FIG. 9 schematically shows a measurement setup according to the invention formed by a combined parallel arrangement of two measuring devices mentioned above.
  • the measuring device 1 consists mainly of a rotatable torque motor 4, which is coupled to an angle or tachometer encoder module 5, and a linkage 6, 7, 8 for reshaping the one Torque motor 4 delivered torque into a linearly applied force m in the form of a tangential tensile and / or compressive force on an element 3 which is firmly connected to said area of the material 2 to be measured, said linkage at least one degree of freedom of rotation of the element 3 compared to the torque motor 4.
  • the transmission linkage includes a first element 6 forming a lever or crank, one end of which is fixed to the axis 4 'of the Torque motor 4 or the movable part 4 "thereof, and a second, a transmission rod or a connecting rod-forming element 7, one end of which is connected to the element 3 which is fixedly connected to the material zone to be tested, said first and second elements 6 and 7 at their ends opposite the above lying ends are connected to each other via an articulated connection 8, which has at least two degrees of freedom of rotation, but no degree of translation freedom.
  • the latter arrangement allows slight movements of the material area 2 to be tested, which e.g. for measurements of the skin in vivo result from involuntary movements of the test subject or the patient in the y and z directions, without this interfering with or distorting the measurement.
  • the forces applied to the element 3 are preferably alternating tensile and compressive forces in the same linear direction.
  • the linkage element 6 can be designed, for example, either as a straight lever fixed at one end to the axis 4 'and / or the rotor 14, so that he / it himself extends perpendicular to the longitudinal direction of the axis 4 '(FIG
  • crank which, on the one hand, has a first part fixedly attached to the end of the axis 4 'longitudinally and coaxially thereto and in an extension thereof, which may merge into the end section of said axis 4', and on the other hand a second part which forms a lever arm Part that extends perpendicular to said first part ( Figure 2).
  • the element 3 which is firmly connected to the area 2 of the substance to be tested is preferably designed in the form of a pin which is detachably attached to the end of the second part 7 and is glued at its base to the surface of the area 2, e.g. by means of a cyanoacrylate adhesive ( Figure 2).
  • the end of the second element 7 can e.g. be bent and pressed into an opening of said pin 3, possibly with the possibility of rotating about the axis of said opening.
  • the element of the linkage 6 that forms a lever arm or a crank is dimensioned and the measuring device 1 is positioned relative to the element 3 that is firmly connected to the area 2 of the substance to be tested such that the tensile and / or compressive force one direction is applied, which runs essentially parallel to a plane which is tangential to zone 2 of the substance to be tested, and that the magnitude of the translational movement of the connecting rod element 7 which forms a connecting rod is small compared to the length of the
  • Lever 6 or the part of the crank connected to the joint 8 said lever or the latter part of the crank forming a lever arm being arranged substantially perpendicular to the surface of the area of the substance 2 to be tested.
  • the length of the element of the linkage 6 is sufficient so that the angular movements (produced by the applied force and by the involuntary movements of the test subject) in the course of the measuring processes are such that they do not incline by more than 10 ° with respect to its neutral position (vertical to area 2).
  • the torque motor or the unit torque motor 4 / transmitter module 5 is mounted on a support frame 18, the position of which can be adjusted in the three orthogonal directions of a space cross , namely via means 18 ', 18 ", 18'" for controlled translation adjustment, said support frame 18 being releasably locked in a given position.
  • the hinge connection 8 is preferably made by means of a ball joint, a universal joint or a flexible connection.
  • the articulated connection 8 which is designed in the form of a ball joint, can be formed by a joint head 9 fixed to the connecting rod 7 and a ball 9 'enclosed and enclosed therein are fixedly connected to the end of the crank 6, the ball 9 'being mounted in the joint head 9 by caulking or pressing in with play.
  • a Such assembly of the articulation 8 allows three degrees of freedom of rotation.
  • the universal joint forming the articulated connection 8 can consist of an angular part 10, which is formed by rigid connection of two flat parts 10 ', 10 ", which each have at least one ball bearing 11, 11 'integrated therein, and in each of which (for example by gluing, pressing, etc.) the corresponding end of the crank or lever 6 is inserted, and on the other hand a shaft part 12, which is on the right An angle is rigidly connected to the corresponding end of the connecting rod 7.
  • Such an embodiment of the articulated connection 8 allows two degrees of freedom of rotation, in order to reduce the friction on the support bearings, the moving parts of the torque motor 4 and the encoder module 5 are mounted on a common axis 4 'on which the transmission linkage 6, 7, 8 may also be attached.
  • the common axis 4 ' can be supported with an adjustment option for the preload or the play between two pivot bearings 13 in the form of ball bearings, rubies or the like, in which the respectively opposite ends of the said axis 4 'run, the installation clearance of said axis 4' eg can be adjusted by means of a screw 13 'which is blocked in its rotation by a lock nut.
  • the common axis 4 ' can also be mounted in a floating manner, for example being magnetically levitated or supported locally on an air cushion, preferably only at the two opposite ends of the common axis 4' , which is axially blocked.
  • the torque motor 4 can either be formed by a movable coil or winding 14 ′ mounted on a rotor 14 O
  • the rotor 14 of the torque motor 4 carrying the movable winding 14 ' is made of a non-magnetic and non-conductive material, whereby any hysteresis and eddy currents can be avoided, said torque motor 4 preferably consisting of an electric DC motor.
  • the angle sensor 5 'present in the sensor module 5 can advantageously be selected from the group formed by capacitive, optical, potentiometric and magnetic sensors. If said sensor 5 'is a magnetic sensor, the sensor module 5 can either contain a movable magnetic field sensor 5' running in a fixed magnetic field or a fixed magnetic field sensor 5 'generated in a movable magnet or electromagnet. According to a preferred embodiment of the invention, the magnetic angle sensor 5 'consists of a Hall effect sensor (eg of the type known under the designation 5594A1 from Honeywell), which is attached to the axis 4' of the torque motor 4 and responds to the direction of the magnetic field in which he moves.
  • a Hall effect sensor eg of the type known under the designation 5594A1 from Honeywell
  • the winding 14 'of the rotor 14 and the magnetic encoder 5' are supplied with very fine (for example in the range of approx. 0.1 mm) and very supple wires 21 manufactured, or by means that produce negligible small friction.
  • the magnets or electromagnets 15 and 16 which each generate the magnetic fields surrounding the rotor 14 and the magnetic transmitter 5 ', are installed in respective magnetic circuits, which, for example are formed by mild steel jackets 15 'and 16'.
  • the magnetic fields surrounding the rotor 14 and the magnetic transmitter 5 ' are perpendicular to one another, the two shells 15' and 16 'forming the magnetic circuits being separated from one another by a wall or a flat element 17 made of an amagnetic material.
  • Said magnetic circuits 15 'and 16' allow the magnetic fields generated by the magnets or electromagnets 15 and 16 to be amplified and equalized, the wall 17 making it possible to form a magnetic barrier between the two magnetic circuits 15 'and 16'.
  • the measuring device 1 is advantageously controlled by at least one administration unit 19, e.g. of the computer-supported type, in particular for controlling and monitoring the torque motor 4 and for recording and evaluating the measurement results, which unit is coupled to suitable interface circuits 20, 20 'and 20 ", in particular for power supply, control, conversion and amplification.
  • This management unit 19 allows in particular the definition of the characteristics of the applied forces as a function of time, and the measurement of the resulting movement.
  • the magnitude of the applied force can in particular be a periodic function of time, for example a sinusoidal, rectangular or triangular function is supplied, for example, by the output signal of a function generator.
  • the administration unit 19 includes, if necessary also divided into several parts,
  • Means for processing which on the one hand can carry out the statistical analysis of at least one relationship or correlation coefficient between the applied force / measured deformation, with the elimination of the faulty or fault values, and on the other hand the analysis and evaluation of the non- linear function applied force / measured deformation.
  • DSR dynamic coefficient of elasticity
  • FIGS. 8A and 8B of the accompanying drawings show in comparison that the measuring device according to the invention enables in vivo measurement results which are equivalent to those which could be achieved in vitro with measuring devices or devices according to the prior art.
  • the invention also relates to a structure for measuring at least one property or a characteristic of a region of a deformable, possibly elastic and / or viscous material, characterized in that it consists of two parallel measuring devices 1 which work in opposite phases and by an administrative unit 19 can be controlled, for example of the computer-aided type which controls the actuation of the torque motors and which collects and processes the signals and data supplied by said measuring devices 1.
  • the measuring device 1 and the measuring set-up as described above are preferred, but not exclusive, lent, for the assessment, in vivo and ex vivo, of the effect of cosmetic or pharmaceutical products on the skin, in particular on human skin.
  • the measuring device 1 and the above-mentioned measuring setup are particularly suitable for carrying out sensitive and precise measurements in the context of, in particular, tests of the effect of cosmetic or personal hygiene products, by making the effect or activity of these products visible, e.g. an exciting, smoothing, firming, softening or rehydrating effect, increasing elasticity, or the like.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Force Measurement Appropriate To Specific Purposes (AREA)

Abstract

Dispositif de mesure d'au moins une propriété mécanique ou d'une caractéristique d'une zone d'un tissu déformable qui présente éventuellement des propriétés élastiques et/ou visqueuses, comme par ex. la peau humaine, par application d'une force régulée sur un élément solidement fixé sur ladite zone du tissu. Ledit dispositif comporte principalement d'une part un moteur (4) couple combiné avec un module (5) capteur angulaire ou capteur tachymétrique et d'autre part des tiges (6, 7, 8) destinées à convertir le couple fourni par le moteur (4) couple en une force, appliquée sur l'élément (3) solidement fixé sur ladite zone (2) à examiner du tissu, sous forme de force tangentielle de traction et/ou de pression. Lesdites tiges permettent au moins un degré de liberté de rotation de l'élément (3) par rapport au moteur (4) couple.
PCT/EP1999/006907 1998-09-25 1999-09-17 Dispositif de mesure d'au moins une propriete ou une caracteristique d'une zone d'un tissu WO2000018295A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU59790/99A AU5979099A (en) 1998-09-25 1999-09-17 Device for measuring at least one characteristic or feature in an area of a material

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9812125A FR2783697B1 (fr) 1998-09-25 1998-09-25 Dispositif de mesure d'au moins une propriete ou caracteristique mecanique d'une zone d'un materiau
FR98/12125 1998-09-25

Publications (1)

Publication Number Publication Date
WO2000018295A1 true WO2000018295A1 (fr) 2000-04-06

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PCT/EP1999/006907 WO2000018295A1 (fr) 1998-09-25 1999-09-17 Dispositif de mesure d'au moins une propriete ou une caracteristique d'une zone d'un tissu

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AU (1) AU5979099A (fr)
FR (1) FR2783697B1 (fr)
WO (1) WO2000018295A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005064311A1 (fr) * 2003-12-27 2005-07-14 University Court Of The University Of Dundee Mesure de la deflexion de la peau

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2822672B1 (fr) 2001-03-29 2004-03-05 Cognis Deutschland Gmbh Appareil de mesure de proprietes mecaniques de surface

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2412299A1 (fr) * 1977-12-26 1979-07-20 Moeller J D Optik Generateur/mesureur de forces mecaniques
FR2485914A1 (fr) * 1980-07-01 1982-01-08 Oreal Appareil de mesure des caracteristiques elastiques d'une peau
WO1997025921A1 (fr) * 1996-01-16 1997-07-24 Hadasit Medical Research Services & Development Company Ltd. Dispositif pour etudier la viscoelasticite d'un tissu vivant ou artificiel

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2412299A1 (fr) * 1977-12-26 1979-07-20 Moeller J D Optik Generateur/mesureur de forces mecaniques
FR2485914A1 (fr) * 1980-07-01 1982-01-08 Oreal Appareil de mesure des caracteristiques elastiques d'une peau
WO1997025921A1 (fr) * 1996-01-16 1997-07-24 Hadasit Medical Research Services & Development Company Ltd. Dispositif pour etudier la viscoelasticite d'un tissu vivant ou artificiel

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005064311A1 (fr) * 2003-12-27 2005-07-14 University Court Of The University Of Dundee Mesure de la deflexion de la peau

Also Published As

Publication number Publication date
FR2783697B1 (fr) 2001-02-23
AU5979099A (en) 2000-04-17
FR2783697A1 (fr) 2000-03-31

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