WO2000016075A1 - Cuvettes de reaction, ensemble de telles cuvettes, appareil de dosage immunologique et procede mettant en oeuvre de tels ensembles de cuvettes - Google Patents
Cuvettes de reaction, ensemble de telles cuvettes, appareil de dosage immunologique et procede mettant en oeuvre de tels ensembles de cuvettes Download PDFInfo
- Publication number
- WO2000016075A1 WO2000016075A1 PCT/FR1999/002170 FR9902170W WO0016075A1 WO 2000016075 A1 WO2000016075 A1 WO 2000016075A1 FR 9902170 W FR9902170 W FR 9902170W WO 0016075 A1 WO0016075 A1 WO 0016075A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- light
- reaction
- cuvette
- cuvettes
- bowl
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/808—Automated or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
- Y10T436/114165—Automated chemical analysis with conveyance of sample along a test line in a container or rack with step of insertion or removal from test line
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
- Y10T436/114998—Automated chemical analysis with conveyance of sample along a test line in a container or rack with treatment or replacement of aspirator element [e.g., cleaning, etc.]
Definitions
- the present invention relates mainly to reaction cuvettes, to sets of such cuvettes for automatic immunoassay devices, to automatic immunoassay devices using such sets of cuvettes and to a method using sets of such bowls.
- automatic immunoassay devices essentially comprising means for supporting, guiding and moving stepwise reaction cuvettes on a path comprising a predetermined number of positions, a turntable for supporting samples to be analyzed, a turntable for supporting reagents, means for taking determined quantities of samples and reagents and injecting these samples into the reaction cuvettes, means for washing of cuvettes, means of optical reading of the assay results and a computer control system allowing the execution of previously programmed analysis cycles, corresponding to assays of the monoreactive or bi-reactive type, these known devices having a rate of operation of the order of 120 dosages per hour to 360 dosages per hour for the second.
- reaction modules which are molded parts of transparent plastic comprising several reaction cuvettes aligned and integral with each other , these reaction modules being mass produced at a very low cost price, which allows them to be discarded after a single use.
- reaction modules are stackable or stackable, which facilitates their packaging as well as their stacking in automatic feeding means of the device.
- FR-9612546 proposes an apparatus of the aforementioned type, comprising means for supporting, guiding and moving step by step sets of reaction cuvettes on a path comprising a predetermined number of positions, means for supporting samples to be analyzed , reagent support means, means for taking determined quantities of samples and reagents and for injecting these samples in the reaction cuvettes, as well as means for washing the cuvettes, means for reading the results and means for feeding sets of reaction cuvettes and for ejecting the used cuvette sets, characterized in that the path of the reaction cuvette sets is rectangular in shape and comprises two long sides defined by parallel rectilinear rails for supporting and guiding the cuvette sets and two short sides defined by means for transversely displacing the cuvette sets in three positions comprising two positions end on the long sides of the path and an intermediate position which constitutes the ejection position of a set of used cuvettes and the feeding position of a set of new cuvettes.
- the devices of known type include a dark room provided with photometric means for measuring brightness, means for transferring reaction mixtures from a cuvette in the dark room, means for washing the dark room and transfer means, darkroom decontamination means and transfer means.
- a dark room provided with photometric means for measuring brightness
- means for transferring reaction mixtures from a cuvette in the dark room means for washing the dark room and transfer means
- darkroom decontamination means and transfer means means for washing the dark room and transfer means.
- the sets of cuvettes according to the present invention are made of an opaque material.
- the light tightness test is carried out on each assembly formed by the photometric detection device associated with a cuvette filled with reaction mixture.
- the main object of the invention is a reaction cuvette for an automatic immunoassay device comprising cuvette-shaped walls for collecting a test sample, a test reagent and a substrate coupled with a chemiluminescent substance thus a filling opening characterized in that the walls are impermeable to the light capable of being emitted by the chemiluminescent substance with the exception of a window for reading the intensity of the light capable of being emitted by the mixture reaction formed by the test sample, the reagent and the substrate.
- the invention also relates to a bowl, characterized in that the reading window corresponds to the filling opening of the bowl.
- Another subject of the invention is a cuvette characterized in that the reading window is surrounded by a substantially flat area for applying a light-tight pad.
- the invention also relates to a monobloc assembly of multiple reaction cuvettes characterized in that it comprises a plurality of cuvettes.
- the invention also relates to an automatic immunoassay device, comprising means for supporting, guiding and moving step by step of cuvette or sets of reaction cuvettes on a path comprising a predetermined number of positions, means for supporting samples to be analyzed, means for supporting reagents, means for taking determined quantities of samples and reagents and for injecting these samples into the reaction cuvettes, as well as means for washing the cuvettes, means for reading the results and means for supplying sets of reaction cuvettes and ejecting sets of used cuvettes, characterized in that it comprises means forming a temporary dark room, impermeable to external light, said dark room including means photometric light intensity measurement and a cuvette or cuvette from a set of cuvettes.
- the invention also relates to an apparatus characterized in that it comprises an opaque application pad in a light-tight manner around a reading window of a reaction cuvette provided with a central opening for passage of the light between the cuvette and photometric means.
- the invention also relates to an apparatus characterized in that it comprises a plate for receiving the washing means and photometric means.
- the invention also relates to an apparatus characterized in that the photometric means comprise a movable assembly ensuring the application of the pad on the reading window of the reaction cuvette.
- the invention also relates to an apparatus characterized in that it comprises a shutter for optical isolation of a photoelectric detector, in particular a photomultiplier and means for measuring the electrical values delivered by the photoelectric detector when it is plunged into darkness, the shutter being closed.
- the invention also relates to an apparatus characterized in that the movement of the movable assembly ensures the closing or opening of the shutter.
- the invention also relates to an apparatus characterized in that it comprises a light source illuminating, on command, the outside of the dark room provisionally formed by the walls of the cuvette and the photometric means to allow a test of tightness to light of the dark room, the immunological test being rejected if the photometric means detect the light emitted by the light-tightness test source.
- the invention also relates to an apparatus characterized in that it performs a light-tightness test for each reaction cuvette undergoing an immunological test.
- the invention also relates to an automatic immunoassay method comprising a step of detecting a light possibly emitted by a substrate coupled with a luminescent chemical substance in the presence of a reagent and a sample to be tested, characterized in that it comprises a step for measuring the present light intensity . inside a reaction cuvette.
- the invention also relates to a method characterized in that a temporary dark room is formed with a reaction cuvette with an opaque wall and photometric means.
- FIG. 1 is a top view of the preferred assembly of the cuvettes according to the present invention.
- Figure 2 is a perspective view of the assembly of Figure 1;
- FIG. 3 is a schematic plan view of the preferred embodiment of an apparatus according to the present invention
- - Figure 4 is a schematic elevational view of a washing and detection device of the apparatus of Figure 3, sets of bowls being shown in plan on the same scale;
- FIG. 5 is a vertical sectional view of a photometric measurement device implemented by the apparatus according to the present invention in a condition of rest or calibration measurement of the photometric value of black;
- FIG. 6 is a view of the device of FIG. 5, in vertical section along a plane orthogonal to that of FIG. 5.
- FIGS. 1 to 6 the same references have been used to designate the same elements.
- the sets 26 of reaction cuvettes 28 are made in one piece by molding of opaque plastic, in particular filled polystyrene and each comprise eight reaction cuvettes 28 aligned along the longitudinal axis 45 of the set 26 and connected to each other. others, each assembly comprising two L-shaped upper longitudinal edges 30 extending above the open ends of the bowls 28.
- Each longitudinal edge 30 comprises, at each bowl 28, a frustoconical orifice 32 used for positioning accurate assembly 26 in certain positions of the device according to the invention.
- the outer lateral faces of the flanges 30 each comprise two vertical ribs 34 intended to cooperate with the drive means of the assemblies 26.
- the bowls 28 are sections of tube with rectangular section, closed at their lower end and widened at their upper end, which makes it possible to stack or stack vertically the assemblies 26 by partially nesting them in one another, the lower parts of cuvettes 28 of a set 26 penetrating into the enlarged upper ends of cuvettes 28 of a lower set of reaction cuvettes. This interlocking is facilitated by the fact that the inner faces of the longitudinal edges 30 diverge slightly from one another upwards from the open upper ends of the bowls 28.
- the sets 26 of bowls according to the present invention differ from those of FR-9612546 and WO-9614582 in that each opening 37 of a bowl 28 is surrounded by a substantially flat rim 39 allowing the application of an opaque pad 41 (FIGS. 4 to 6), preventing external light entering towards a photometric measuring device 43.
- the rim 39 is advantageously formed by, on the one hand by a space 39 'between bowls and, on the other hand, by two sidewalks 39 "situated between the walls 30' of the rim 30 and the longitudinal walls 28 'of the upper parts of the cuvettes 28. It is understood that the present invention is in no way limited to the shape or the material of the assemblies 26 of the reaction cuvettes 28.
- the photometric detection means comprise means for isolating the cell during reading, such as for example covers or a pad similar to pad 41.
- the apparatus comprises a chassis 10 on which are mounted a turntable 12 for supporting samples to be analyzed, a turntable 14 for supporting assay reagents , means 16, 18 for taking a given quantity of samples and a given quantity of reagents respectively and for depositing these taken quantities in a reaction cuvette, these means being of the same type as those which have been described in International Application WO-9614582 and FR-9612546, the contents of which are incorporated herein by reference.
- the reagents used are of the magnetic ball type and the apparatus according to the invention comprises means 20 for washing or rinsing these magnetic balls, which are of the same type as those already described in the aforementioned Applications and which include needles. suction and liquid injection, vertically moving, and permanent magnets 53 arranged on each side of the path of the reaction cuvettes 28 to attract, by magnetic attraction, the magnetic beads of the reagents and temporarily fix them on the walls of the cuvettes of reaction.
- the means 20 also comprise a needle for depositing a chemiluminescent substrate in the reaction cuvettes 28, arranged immediately downstream of the injection and suction needles for washing liquid.
- Photometric means 22 for optical reading comprise means 43 for measuring the light intensity corresponding to the wavelengths of the luminescence of the substrate used.
- a substrate containing the disodium salt of 4-methoxyr4- (3-phosphonatephenyl) -spiro [1, 2-dioxethane-3,2'-amandane] sold by the company LUMIGENE under the reference lumi-Phos 530 ® emitting in light visible and whose emission peak corresponds substantially to 530 nm.
- a visible light detector is used, the bandwidth of which can possibly be reduced by the use of a filter allowing only the frequencies likely to be transmitted to pass.
- the preferred embodiment of the apparatus according to the present invention uses a photomultiplier tube.
- the preferred example uses a photomultiplier sold by HAMAMATSU under the reference H 7155-20.
- This type of tube has the advantage of being able to work at ambient temperature, which makes it possible, in the preferred embodiment, to produce a machine devoid of cryostats.
- the apparatus according to the present invention advantageously performs, before each luminescence measurement of a reaction mixture, a measurement in the absence of light, in the dark, so as to calibrate the value, in particular the electrical voltage corresponding to complete darkness. This improves the reliability and repeatability of the measurements, all the more so that in order to promote the incubation of the reaction mixture, the circulation space of the assemblies 26 is thermostatically controlled, for example at 37 ° C.
- the output of the photomultiplier 43 is connected, via the interface and adaptation means, to a computer responsible for supervising the machine, exploiting the results and / or managing them.
- the output of the photomultiplier is connected, through analog adaptation means, in particular of the frequency amplifiers or adapters type, to an analog-digital converter whose output is connected to an acquisition, counting and control card installed in a microcomputer, for example of the PC type (not shown).
- a common plantine 47 comprising for example an upper plate 47.1 and a lower plate 47.2 (FIG. 4) carries the washing head 20 and the photometric means 22.
- the injection or sampling needles bear the references 49
- the indexing pins penetrating into the openings 32 bear the reference 51.
- the first two indexing pins 51 are connected by a spring 55.
- the assemblies 26 of the bowls 28 as well as the magnets 53 oriented North-South or South-North are shown in a plane in FIG. 4 to give the scale of the plate 47 comprising the means 20 and 22.
- the apparatus according to the invention also comprises means for moving sets of reaction cuvettes on a rectangular-shaped path, at one end of which are provided means 24 for automatically feeding sets of reaction and ejection cuvettes of these bowls.
- the device according to the present invention comprises an external bodywork and internal covers made of opaque or partially opaque material limiting the arrival of light at the reading window of the photometric means 22.
- the device according to the present invention includes a light source 57, for example a light emitting diode (LED in English terminology) making it possible to check the optical insulation of the measurement cavity formed by the cuvette being measured associated with the photometric means 22.
- a light source 57 for example a light emitting diode (LED in English terminology) making it possible to check the optical insulation of the measurement cavity formed by the cuvette being measured associated with the photometric means 22.
- the photometric means 22 comprise the photomultiplier 43 fixed relative to the lower plate 47.2 and a mobile assembly 59.
- the mobile assembly comprises for example a shutter 61, a light guide 63 housed in an opaque rigid tubular pipe 65 emerging at an opening 67 of the opaque pad 41.
- a rail 67 provides guidance between a low position shown in FIG. 5, in which the shutter 61 ensures the optical isolation of the photomultiplier 43 relative to the light guide 63 and a high position, illustrated in FIG. 6, in which the shutter 61 is erased so as to allow communication between the light guide 63 and the photomultiplier 43.
- Return means 69 for example a helical spring surrounding the rigid tubular pipe 65 ensure the return of the movable assembly 59 to the low position of FIG. 5.
- the shutter 61 is a rotary shutter around an axis of rotation 71 and comprises return means, for example a helical spring 73 working in tension ensuring the return to the closed position.
- the shutter 61 obstructs the end of the light guide 63 in the low position of the moving element 59 illustrated in FIG. 5 and disappears in the high position of the moving element 59 illustrated in FIG. 6.
- the apparatus 10 is loaded, on the one hand with the reagents and the substrate and, on the other hand, with the samples (serum) to be tested.
- the cuvettes 28 of the assemblies 26 receive, via the device 16, the samples to be tested.
- the assemblies 26 are driven by the belt 40.
- the cuvettes 28 receive the reagents from the device 18.
- the means 20 wash the magnetic beads and ensure the introduction of the luminescent substrate.
- a black level calibration is first of all carried out, that is to say a reading of the voltage available at the output of the photomultiplier 43 when the shutter 61 is closed (position bass illustrated in Figure 5); then an actuator (not shown) applies the movable assembly 59 to the inlet 37 of a bowl 28. More specifically, the pad 41 is applied to the periphery 39 of the bowl 28 to be read.
- the positioning pin 51 ensures precise positioning with superposition of the opening 67 of the shoe 41 with the inlet 37 of the bowl 28.
- the bowl assembly 26 rises and ensures the ascent of the mobile assembly.
- an actuator lowers the lower plate 47.2, which ensures the relative ascent of the moving element 59 relative to the plate 47.
- the movement of the moving element 59 ensures the opening of the shutter and allows the luminescence present in the bowl 28 to be measured.
- the moving element 59 descends relative to the plate 47.2 (as illustrated in FIG. 5), the light source is turned on 57, and a new measurement is carried out ensuring the tightness control to light of the dark room provisional formed by the photometric assembly 22 and the cuvette 28 during measurement. If the luminescence value obtained during the light-tightness test is greater than the value obtained during the measurement, it is considered that the measurement result is not reliable. The test result is rejected and, advantageously, the test is repeated using a new reaction mixture comprising the same sample and the same reagent deposited in a new cuvette 28.
- the measurement of the level of the voltage at the output of the photomultiplier 43, closed shutter 61 can be carried out periodically, but not necessarily for all the measurements.
- the present invention applies in particular to the detection of the presence of a chemical or biological substance in a sample.
- the present invention is mainly applicable to analysis and medical research.
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2310137A CA2310137C (fr) | 1998-09-11 | 1999-09-13 | Cuvettes de reaction, ensemble de telles cuvettes, appareil de dosage immunologique et procede mettant en oeuvre de tels ensembles de cuvettes |
EP99942955A EP1031025A1 (fr) | 1998-09-11 | 1999-09-13 | Cuvettes de reaction, ensemble de telles cuvettes, appareil de dosage immunologique et procede mettant en oeuvre de tels ensembles de cuvettes |
BR9906995-4A BR9906995A (pt) | 1998-09-11 | 1999-09-13 | Cubeta de reação, aparelho automático de dosagem imunológica, e, processo automático de dosagem imunológica |
AU56273/99A AU5627399A (en) | 1998-09-11 | 1999-09-13 | Reaction wells, assembly thereof, immunoassay apparatus and method using such well assemblies |
US09/554,167 US7097981B1 (en) | 1998-09-11 | 1999-09-13 | Reaction wells, assembly thereof, immunoassay apparatus and method using such well assemblies |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9811375A FR2783321B1 (fr) | 1998-09-11 | 1998-09-11 | Cuvettes de reaction, ensemble de telles cuvettes, appareil de dosage immunologique et procede mettant en oeuvre de tels ensembles de cuvettes |
FR98/11375 | 1998-09-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000016075A1 true WO2000016075A1 (fr) | 2000-03-23 |
Family
ID=9530348
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR1999/002170 WO2000016075A1 (fr) | 1998-09-11 | 1999-09-13 | Cuvettes de reaction, ensemble de telles cuvettes, appareil de dosage immunologique et procede mettant en oeuvre de tels ensembles de cuvettes |
Country Status (7)
Country | Link |
---|---|
US (1) | US7097981B1 (fr) |
EP (1) | EP1031025A1 (fr) |
AU (1) | AU5627399A (fr) |
BR (1) | BR9906995A (fr) |
CA (1) | CA2310137C (fr) |
FR (1) | FR2783321B1 (fr) |
WO (1) | WO2000016075A1 (fr) |
Cited By (2)
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US7497135B2 (en) | 2003-05-28 | 2009-03-03 | Biomerieux | Method for placing a receptacle containing a liquid in a device for sampling the liquid and sampling device for applying the method |
US8043559B2 (en) | 2003-05-28 | 2011-10-25 | Bio Merieux | System for temperature control within an automatic biological analyzer |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102654506A (zh) * | 2011-03-04 | 2012-09-05 | 苏州长光华医生物医学工程有限公司 | 一种全自动管式化学发光免疫检测仪用反应杯 |
EP2699889B1 (fr) * | 2011-04-22 | 2017-09-13 | 3M Innovative Properties Company | Procédé et ensemble pour la détection de substances à analyser par luminescence |
CN107083319A (zh) | 2012-03-16 | 2017-08-22 | 统计诊断与创新有限公司 | 具有集成传送模块的测试盒 |
CN110455787A (zh) * | 2019-09-19 | 2019-11-15 | 南京迪格诺斯生物技术有限公司 | 一种化学发光分析仪的测量室 |
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1998
- 1998-09-11 FR FR9811375A patent/FR2783321B1/fr not_active Expired - Fee Related
-
1999
- 1999-09-13 CA CA2310137A patent/CA2310137C/fr not_active Expired - Fee Related
- 1999-09-13 US US09/554,167 patent/US7097981B1/en not_active Expired - Fee Related
- 1999-09-13 EP EP99942955A patent/EP1031025A1/fr not_active Withdrawn
- 1999-09-13 BR BR9906995-4A patent/BR9906995A/pt not_active Application Discontinuation
- 1999-09-13 AU AU56273/99A patent/AU5627399A/en not_active Abandoned
- 1999-09-13 WO PCT/FR1999/002170 patent/WO2000016075A1/fr active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5482839A (en) * | 1990-03-30 | 1996-01-09 | Ashihara; Yoshihiro | Automatic immunological measuring system |
JPH05157699A (ja) * | 1991-12-09 | 1993-06-25 | Hamamatsu Photonics Kk | 発光サンプルの試験器具 |
US5643535A (en) * | 1992-05-05 | 1997-07-01 | Chiron Corporation | Luminometer with reduced sample crosstalk |
EP0837331A1 (fr) * | 1996-10-15 | 1998-04-22 | Laboratoires Merck-Clevenot | Appareil automatique de dosage immunologique |
Non-Patent Citations (1)
Title |
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PATENT ABSTRACTS OF JAPAN vol. 017, no. 553 (P - 1625) 5 October 1993 (1993-10-05) * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7497135B2 (en) | 2003-05-28 | 2009-03-03 | Biomerieux | Method for placing a receptacle containing a liquid in a device for sampling the liquid and sampling device for applying the method |
US8043559B2 (en) | 2003-05-28 | 2011-10-25 | Bio Merieux | System for temperature control within an automatic biological analyzer |
Also Published As
Publication number | Publication date |
---|---|
AU5627399A (en) | 2000-04-03 |
FR2783321B1 (fr) | 2000-11-24 |
EP1031025A1 (fr) | 2000-08-30 |
CA2310137A1 (fr) | 2000-03-23 |
US7097981B1 (en) | 2006-08-29 |
BR9906995A (pt) | 2000-09-26 |
FR2783321A1 (fr) | 2000-03-17 |
CA2310137C (fr) | 2010-11-16 |
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