WO1999044528A1 - Marknagel mit verriegelungsloch - Google Patents

Marknagel mit verriegelungsloch Download PDF

Info

Publication number
WO1999044528A1
WO1999044528A1 PCT/CH1998/000087 CH9800087W WO9944528A1 WO 1999044528 A1 WO1999044528 A1 WO 1999044528A1 CH 9800087 W CH9800087 W CH 9800087W WO 9944528 A1 WO9944528 A1 WO 9944528A1
Authority
WO
WIPO (PCT)
Prior art keywords
intramedullary nail
locking hole
longitudinal axis
opening
bore
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CH1998/000087
Other languages
German (de)
English (en)
French (fr)
Inventor
Roman Ackeret
Peter Senn
Ruth HUNGERBÜHLER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AO Technology AG
Synthes USA LLC
Original Assignee
Synthes AG Chur
Synthes USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP98903983A priority Critical patent/EP1059888B8/de
Priority to DE59810423T priority patent/DE59810423D1/de
Priority to AT98903983T priority patent/ATE255856T1/de
Priority to PCT/CH1998/000087 priority patent/WO1999044528A1/de
Priority to JP2000534137A priority patent/JP4058238B2/ja
Priority to CA002323045A priority patent/CA2323045C/en
Priority to BR9815706-0A priority patent/BR9815706A/pt
Priority to ES98903983T priority patent/ES2210717T3/es
Application filed by Synthes AG Chur, Synthes USA LLC filed Critical Synthes AG Chur
Priority to AU62035/98A priority patent/AU729213B2/en
Priority to ZA9901741A priority patent/ZA991741B/xx
Priority to ARP990100949A priority patent/AR018319A1/es
Publication of WO1999044528A1 publication Critical patent/WO1999044528A1/de
Priority to US09/654,044 priority patent/US6319253B1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
    • A61B17/68Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/72Intramedullary devices, e.g. pins or nails
    • A61B17/7233Intramedullary devices, e.g. pins or nails with special means of locking the nail to the bone
    • A61B17/725Intramedullary devices, e.g. pins or nails with special means of locking the nail to the bone with locking pins or screws of special form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
    • A61B17/68Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/72Intramedullary devices, e.g. pins or nails

Definitions

  • the invention relates to an intramedullary nail with a locking hole according to the preamble of claim 1.
  • an intramedullary nail can be implanted into the thigh from the knee.
  • Such intramedullary nails are often implanted with a spiral blade that is inserted laterally medially to fix the intramedullary nail.
  • a hole with an elongated cross section is made in the intramedullary nail, for example in the form of a slot or in a shape similar to a keyhole.
  • the intramedullary nail can also be locked with locking screws, which are also inserted laterally medially, so that the intramedullary nail cannot move in the direction of its longitudinal axis.
  • the openings for the locking means are usually designed so that the intramedullary nail can be fixed axially either only with locking screws or only with a spiral blade. This creates a large assortment of intramedullary nails, each of which must be implanted with a specific locking device. 2
  • the invention seeks to remedy this.
  • the invention has for its object to provide an intramedullary nail with a locking hole penetrating the intramedullary nail, which allows the appropriate locking means to be used as required.
  • the shape of the locking hole is designed so that a spiral blade or several locking screws can be implanted laterally medially penetrating the intramedullary nail. Due to the special design of the locking hole in the intramedullary nail, the spiral blade or locking screws fulfill the task that after their implantation, the intramedullary nail can no longer be moved in the direction of its longitudinal axis. Instead of the intramedullary nail, another intramedullary implant is also conceivable.
  • the invention solves this problem with an intramedullary nail with a locking hole, which has the features of claim 1.
  • this locking hole runs transversely to the longitudinal axis of the intramedullary nail and penetrates the intramedullary nail.
  • the locking hole comprises a through-opening which runs transversely to the longitudinal axis of the intramedullary nail and penetrates the intramedullary nail, a bore which does not touch the through-opening and also runs transversely to the longitudinal axis of the intramedullary nail and penetrates the intramedullary nail and a slot which connects the through-opening and the bore and is not parallel to the through-opening.
  • the slot connects the passage opening 3
  • the locking hole is designed in such a way that a spiral blade can be passed through the locking hole from lateral to medial by executing a helical movement.
  • the shape of the locking hole is such that instead of the spiral blade, two screws can be implanted laterally medially penetrating the intramedullary nail.
  • the screws and the spiral blade run parallel with respect to their longitudinal axes in a plane containing the longitudinal axis of the intramedullary nail.
  • one of them must be installed through the hole to prevent the intramedullary nail from moving in the axial direction.
  • the other can be positioned in the passage opening. If the screw is placed in the through opening at the edge of the through opening that is distant from the slot, it additionally helps to prevent displacement in the longitudinal direction of the intramedullary nail.
  • Another embodiment of the intramedullary nail according to the invention with a locking hole differs from the above-described embodiment only in that the slot which connects the through opening and the bore across the intramedullary nail runs at an angle to the longitudinal axis of the intramedullary nail.
  • Yet another embodiment of the intramedullary nail according to the invention with a locking hole differs from the variant described first only in that the slot has a parallel cutting plane which contains the longitudinal axis of the intramedullary nail and a second straight line enclosing an angle with respect to the central axis of the bore.
  • the slot connecting the through opening and the bore runs at an angle to the aforementioned longitudinal axes of the bore and the through opening through the Intramedullary nail.
  • Another embodiment of the intramedullary nail according to the invention with a locking hole differs from the previously described variants only in that the slot runs parallel to a plane which contains the longitudinal axis of the intramedullary nail and a second straight line including an angle of 15 ° with respect to the central axis of the bore.
  • Another embodiment of the intramedullary nail according to the invention with a locking hole differs from the previously described variants only in that the through-opening belonging to the locking hole according to the invention and the bore likewise belonging to the locking hole according to the invention run at right angles to the longitudinal axis of the intramedullary nail.
  • Yet another embodiment of the intramedullary nail according to the invention with a locking hole differs from the variants described above in that the through opening is an elongated hole with a width b and a length a.
  • Yet another embodiment of the intramedullary nail according to the invention with a locking hole differs from the variant described above only in that the width b of the elongated hole belonging to the locking hole according to the invention corresponds to the diameter of the bore also counting to the locking hole according to the invention.
  • Another embodiment of the intramedullary nail according to the invention with a locking hole is distinguished from the variants described above in that the passage opening belonging to the locking hole according to the invention has an oval cross-section instead of an elongated hole with the large semi-axis a / 2 and the small semi-axis b / 2.
  • Yet another embodiment of the intramedullary nail according to the invention with a locking hole is distinguished from the variants described above in that the through-opening which is part of the locking hole according to the invention has a circular cross section. 6
  • a further embodiment of the intramedullary nail according to the invention with a locking hole is that the slot has a width c in a section perpendicular to the longitudinal axis of the intramedullary nail, which is between 10% and 90% of the width b of the elongated hole.
  • a further embodiment of the intramedullary nail according to the invention with a locking hole is that the slot has a width c in a section perpendicular to the longitudinal axis of the intramedullary nail, which is between 30% and 50% of the width b of the elongated hole.
  • the advantages achieved by the invention are essentially to be seen in the fact that, thanks to the locking hole according to the invention for locking means in intramedullary nails, the same intramedullary nail can be used for two different types of locking.
  • the shape of the locking hole is designed such that both the spiral blade and the locking screws are placed within the locking hole according to the invention in such a way that the intramedullary nail can no longer be displaced in the direction of its longitudinal axis.
  • the novelty of the locking hole according to the invention is that an intramedullary nail can be fixed with two different locking means.
  • the advantage for the user and the producer lies in the smaller range. The decision as to which interlock should be selected can therefore be made very quickly. 7
  • Figure 1 is an elevation of part of the intramedullary nail with the locking hole according to the invention and a cross section through the intramedullary nail perpendicular to the longitudinal axis.
  • FIG. 2 shows an elevation and a side elevation of a part of the intramedullary nail with the locking hole according to the invention and the spiral blade inserted therein;
  • FIG. 3 shows an elevation and a side elevation of part of the intramedullary nail with the locking hole according to the invention and locking screws inserted therein;
  • Fig. 5 is an elevation of part of the intramedullary nail with another variant of the locking hole and a cross section through the intramedullary nail perpendicular to the longitudinal axis. 8th
  • the embodiment of the intramedullary nail 2 according to the invention with locking hole 1 for various locking means in intramedullary nails 2 shows a section of the intramedullary nail 2 with the locking hole 1 in elevation and a cross section of the intramedullary nail 2.
  • the locking hole 1 according to the invention runs perpendicular to the longitudinal axis 3 of the Intramedullary nail 2 and penetrates the intramedullary nail 2 diametrically.
  • the locking hole 1 comprises a through-opening 4 which runs diametrically to the longitudinal axis 3 of the intramedullary nail 2, for example an elongated hole, a bore 5 with a central axis 7 and a slot which does not touch the through-opening 4 and also perpendicular to the longitudinal axis 3 of the intramedullary nail 2 and parallel to the through-opening 4 6.
  • the slot 6 connects the through opening 4 and the bore 5 in the direction of the longitudinal axis 3 of the intramedullary nail 2 over their entire length corresponding to the diameter of the intramedullary nail 2 and penetrates the intramedullary nail 2 transversely to the longitudinal axis 3 of the intramedullary nail 2.
  • the slot 6 runs in one Cross-section of the intramedullary nail 2 not parallel to the passage opening 4, but penetrates the intramedullary nail 2 diametrically. Furthermore, the slot 6 has a parallel cutting plane which contains the longitudinal axis 3 of the intramedullary nail 2 and a second straight line 9 enclosing an angle 8 with respect to the central axis 7 of the bore 5.
  • the angle between the central axis 7 of the bore 5 and a straight line 9 parallel to the slot 6 is an angle of 15 °.
  • the through opening 4 is designed as an elongated hole and has a length a and a width b, which corresponds to the diameter of the bore 5, which also belongs to the locking hole 1.
  • the cross section of the passage opening 4 can also be oval or round instead of an elongated hole 4.
  • Fig. 2 shows part of an intramedullary nail 2 with the locking hole 1, which corresponds to that described above.
  • a spiral blade 10 inserted into the locking hole 1 of the intramedullary nail 2 and a locking screw 11 inserted through a further bore 12 in the intramedullary nail 2 are shown here.
  • FIG. 3 shows part of an intramedullary nail 2 with the embodiment of the locking hole 1 described in FIG. 1.
  • two locking screws 11 inserted through the locking hole 1 of the intramedullary nail 2 and a further locking screw 11 inserted through the bore 12 in the intramedullary nail 2 are shown in FIG. 3.
  • FIG. 4 shows an embodiment of the intramedullary nail 2 according to the invention with a locking hole 1, which differs from the embodiment shown in FIG. 1 in that the slot 6, which comprises the through opening 4 designed as an elongated hole, and the bore 5 in the direction of the longitudinal axis 3 10
  • the intramedullary nail 2 connects between the elongated hole 4 and the bore 5 at an angle 15 with respect to the longitudinal axis 3 of the intramedullary nail 2.
  • the slot 6 also runs diametrically in this variant and forms an angle 8 to the central axis 7 of the bore 5.
  • the slot 16 consists of a bore with the diameter d, the central axis 9 of the bore 16 including an angle 8 with the central axis 7 of the bore 5.

Landscapes

  • Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)
  • Slide Fasteners, Snap Fasteners, And Hook Fasteners (AREA)
  • Prostheses (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
PCT/CH1998/000087 1998-03-05 1998-03-05 Marknagel mit verriegelungsloch Ceased WO1999044528A1 (de)

Priority Applications (12)

Application Number Priority Date Filing Date Title
BR9815706-0A BR9815706A (pt) 1998-03-05 1998-03-05 Pino medular com abertura de travamento
AT98903983T ATE255856T1 (de) 1998-03-05 1998-03-05 Marknagel mit verriegelungsloch
PCT/CH1998/000087 WO1999044528A1 (de) 1998-03-05 1998-03-05 Marknagel mit verriegelungsloch
JP2000534137A JP4058238B2 (ja) 1998-03-05 1998-03-05 ロック穴を備えた骨髄釘
CA002323045A CA2323045C (en) 1998-03-05 1998-03-05 Intramedullary nail with locking hole
ES98903983T ES2210717T3 (es) 1998-03-05 1998-03-05 Clavo de osteosintesis intramedular con orificio de enclavamiento.
AU62035/98A AU729213B2 (en) 1998-03-05 1998-03-05 Medullar pin with locking opening
EP98903983A EP1059888B8 (de) 1998-03-05 1998-03-05 Marknagel mit verriegelungsloch
DE59810423T DE59810423D1 (de) 1998-03-05 1998-03-05 Marknagel mit verriegelungsloch
ZA9901741A ZA991741B (en) 1998-03-05 1999-03-04 Intramedullary nail with locking hole.
ARP990100949A AR018319A1 (es) 1998-03-05 1999-03-05 Clavo para hueso con agujero de bloqueo
US09/654,044 US6319253B1 (en) 1998-03-05 2000-09-01 Intramedullary nail with locking hole

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CH1998/000087 WO1999044528A1 (de) 1998-03-05 1998-03-05 Marknagel mit verriegelungsloch

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/654,044 Continuation US6319253B1 (en) 1998-03-05 2000-09-01 Intramedullary nail with locking hole

Publications (1)

Publication Number Publication Date
WO1999044528A1 true WO1999044528A1 (de) 1999-09-10

Family

ID=4551309

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CH1998/000087 Ceased WO1999044528A1 (de) 1998-03-05 1998-03-05 Marknagel mit verriegelungsloch

Country Status (12)

Country Link
US (1) US6319253B1 (https=)
EP (1) EP1059888B8 (https=)
JP (1) JP4058238B2 (https=)
AR (1) AR018319A1 (https=)
AT (1) ATE255856T1 (https=)
AU (1) AU729213B2 (https=)
BR (1) BR9815706A (https=)
CA (1) CA2323045C (https=)
DE (1) DE59810423D1 (https=)
ES (1) ES2210717T3 (https=)
WO (1) WO1999044528A1 (https=)
ZA (1) ZA991741B (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6379360B1 (en) 1998-03-11 2002-04-30 Synthes (Usa) Spiral blade insertion instrument
US7776038B2 (en) 2004-09-15 2010-08-17 Stryker Trauma Gmbh Intramedullary locking nail
US8668695B2 (en) 2008-10-15 2014-03-11 Zimmer Gmbh Intramedullary nail
US9597129B2 (en) 2007-05-25 2017-03-21 Zimmer Gmbh Reinforced intramedullary nail

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US8070786B2 (en) * 1993-01-21 2011-12-06 Acumed Llc System for fusing joints
US9161793B2 (en) 1993-01-21 2015-10-20 Acumed Llc Axial tension screw
US6296645B1 (en) * 1999-04-09 2001-10-02 Depuy Orthopaedics, Inc. Intramedullary nail with non-metal spacers
US6527775B1 (en) 2000-09-22 2003-03-04 Piper Medical, Inc. Intramedullary interlocking fixation device for the distal radius
US6652529B2 (en) * 2001-09-12 2003-11-25 Todd V. Swanson Method and apparatus for treating supracondylar fractures of the femur
US6835197B2 (en) * 2001-10-17 2004-12-28 Christoph Andreas Roth Bone fixation system
US7655009B2 (en) 2003-12-01 2010-02-02 Smith & Nephew, Inc. Humeral nail
US7947043B2 (en) * 2004-01-20 2011-05-24 Depuy Products, Inc. Intramedullary nail and associated method
US20060015101A1 (en) 2004-07-15 2006-01-19 Wright Medical Technology, Inc. Intramedullary fixation assembly and devices and methods for installing the same
US7588577B2 (en) 2004-07-15 2009-09-15 Wright Medical Technology, Inc. Guide assembly for intramedullary fixation and method of using the same
US8425570B2 (en) 2004-08-09 2013-04-23 Si-Bone Inc. Apparatus, systems, and methods for achieving anterior lumbar interbody fusion
US8470004B2 (en) 2004-08-09 2013-06-25 Si-Bone Inc. Apparatus, systems, and methods for stabilizing a spondylolisthesis
US20070156241A1 (en) * 2004-08-09 2007-07-05 Reiley Mark A Systems and methods for the fixation or fusion of bone
US20180228621A1 (en) 2004-08-09 2018-08-16 Mark A. Reiley Apparatus, systems, and methods for the fixation or fusion of bone
US8414648B2 (en) 2004-08-09 2013-04-09 Si-Bone Inc. Apparatus, systems, and methods for achieving trans-iliac lumbar fusion
US8986348B2 (en) 2004-08-09 2015-03-24 Si-Bone Inc. Systems and methods for the fusion of the sacral-iliac joint
US20060036251A1 (en) 2004-08-09 2006-02-16 Reiley Mark A Systems and methods for the fixation or fusion of bone
US9949843B2 (en) 2004-08-09 2018-04-24 Si-Bone Inc. Apparatus, systems, and methods for the fixation or fusion of bone
US8444693B2 (en) 2004-08-09 2013-05-21 Si-Bone Inc. Apparatus, systems, and methods for achieving lumbar facet fusion
US9662158B2 (en) 2004-08-09 2017-05-30 Si-Bone Inc. Systems and methods for the fixation or fusion of bone at or near a sacroiliac joint
US7410488B2 (en) 2005-02-18 2008-08-12 Smith & Nephew, Inc. Hindfoot nail
US8961516B2 (en) 2005-05-18 2015-02-24 Sonoma Orthopedic Products, Inc. Straight intramedullary fracture fixation devices and methods
US9060820B2 (en) 2005-05-18 2015-06-23 Sonoma Orthopedic Products, Inc. Segmented intramedullary fracture fixation devices and methods
CN101208053A (zh) 2005-05-18 2008-06-25 索诺玛整形外科产品公司 微创可致动骨固定装置、系统和使用方法
JP4978906B2 (ja) * 2006-10-17 2012-07-18 周 中村 大腿骨転子部骨折に対する骨折内固定具
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DE102007029090A1 (de) 2007-06-21 2008-12-24 Plus Orthopedics Ag Vorrichtung zur Osteosynthese gelenknaher Knochenfrakturen
US8771283B2 (en) 2007-12-17 2014-07-08 Wright Medical Technology, Inc. Guide assembly for intramedullary fixation and method of using the same
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US8778026B2 (en) 2012-03-09 2014-07-15 Si-Bone Inc. Artificial SI joint
JP6091529B2 (ja) 2012-03-09 2017-03-08 エスアイ−ボーン・インコーポレイテッドSi−Bone, Inc. 一体化インプラント
US10363140B2 (en) 2012-03-09 2019-07-30 Si-Bone Inc. Systems, device, and methods for joint fusion
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US10492803B2 (en) 2016-09-22 2019-12-03 Globus Medical, Inc. Systems and methods for intramedullary nail implantation
US11083503B2 (en) 2016-09-22 2021-08-10 Globus Medical, Inc. Systems and methods for intramedullary nail implantation
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US11369419B2 (en) 2019-02-14 2022-06-28 Si-Bone Inc. Implants for spinal fixation and or fusion
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AU2020386985A1 (en) 2019-11-21 2022-06-02 Si-Bone Inc. Rod coupling assemblies for bone stabilization constructs
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JP2023504571A (ja) 2019-12-09 2023-02-03 エスアイ-ボーン・インコーポレイテッド 仙腸関節安定化インプラント及び埋込方法
JP2023553120A (ja) 2020-12-09 2023-12-20 エスアイ-ボーン・インコーポレイテッド 仙腸関節安定化インプラントおよびインプラント方法
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Citations (5)

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US3433220A (en) * 1966-12-30 1969-03-18 Robert E Zickel Intramedullary rod and cross-nail assembly for treating femur fractures
US4103683A (en) * 1977-06-03 1978-08-01 Neufeld John A Sub-trochanteric nail
DE3730570A1 (de) * 1987-09-11 1989-03-23 Kernforschungsz Karlsruhe Nagel zur fixierung proximaler femurfrakturen
EP0411273A1 (en) * 1989-08-03 1991-02-06 Synthes AG, Chur Osteosynthetic assembly with twist fixation plate
WO1998030164A1 (en) * 1997-01-13 1998-07-16 Synthes Ag Chur Helical osteosynthetic implant

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3433220A (en) * 1966-12-30 1969-03-18 Robert E Zickel Intramedullary rod and cross-nail assembly for treating femur fractures
US4103683A (en) * 1977-06-03 1978-08-01 Neufeld John A Sub-trochanteric nail
DE3730570A1 (de) * 1987-09-11 1989-03-23 Kernforschungsz Karlsruhe Nagel zur fixierung proximaler femurfrakturen
EP0411273A1 (en) * 1989-08-03 1991-02-06 Synthes AG, Chur Osteosynthetic assembly with twist fixation plate
WO1998030164A1 (en) * 1997-01-13 1998-07-16 Synthes Ag Chur Helical osteosynthetic implant

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6379360B1 (en) 1998-03-11 2002-04-30 Synthes (Usa) Spiral blade insertion instrument
US7776038B2 (en) 2004-09-15 2010-08-17 Stryker Trauma Gmbh Intramedullary locking nail
US9597129B2 (en) 2007-05-25 2017-03-21 Zimmer Gmbh Reinforced intramedullary nail
US8668695B2 (en) 2008-10-15 2014-03-11 Zimmer Gmbh Intramedullary nail
US9474557B2 (en) 2008-10-15 2016-10-25 Zimmer Gmbh Intramedullary nail

Also Published As

Publication number Publication date
CA2323045C (en) 2007-05-29
ZA991741B (en) 1999-09-27
DE59810423D1 (de) 2004-01-22
JP4058238B2 (ja) 2008-03-05
US6319253B1 (en) 2001-11-20
AU6203598A (en) 1999-09-20
AU729213B2 (en) 2001-01-25
BR9815706A (pt) 2000-11-14
ES2210717T3 (es) 2004-07-01
EP1059888B8 (de) 2004-03-03
EP1059888B1 (de) 2003-12-10
EP1059888A1 (de) 2000-12-20
AR018319A1 (es) 2001-11-14
JP2002505141A (ja) 2002-02-19
CA2323045A1 (en) 1999-09-10
ATE255856T1 (de) 2003-12-15

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