WO1999003754A1 - Emballage permettant de stocker un produit sous atmosphere controlee et son procede de fabrication - Google Patents
Emballage permettant de stocker un produit sous atmosphere controlee et son procede de fabrication Download PDFInfo
- Publication number
- WO1999003754A1 WO1999003754A1 PCT/GB1998/001869 GB9801869W WO9903754A1 WO 1999003754 A1 WO1999003754 A1 WO 1999003754A1 GB 9801869 W GB9801869 W GB 9801869W WO 9903754 A1 WO9903754 A1 WO 9903754A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- package
- atmosphere
- product
- layers
- strips
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B29/00—Packaging of materials presenting special problems
- B65B29/10—Packaging two or more different substances isolated from one another in the package but capable of being mixed without opening the package, e.g. forming packages containing a resin and hardener isolated by a frangible partition
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
- B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
- B65D81/266—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants
Definitions
- the present invention relates to a package and to a method for the manufacture thereof.
- the package is particularly well suited to storage of materials which need to 5 be kept in a controlled atmosphere environment, such as pharmaceutical products.
- FR-A-2660634 Airsec Industries discloses a packaging for pharmaceutical products comprising a half shell made from injected plastics material and having two chambers. One of the chambers contains a desiccant which is held in place by a semi- permeable membrane. The other chamber houses a pharmaceutical product and is connected to the first chamber by a passageway. Air passing through the passageway
- WO 96/07601 discloses a blister package for moisture sensitive pharmaceutical preparations.
- the rigid moulded construction of this package is expensive and inconvenient with respect to manufacture and use.
- GB 2246107 W R Grace
- WO 88/01592 Garwood
- WO 87/02965 Garwood
- the present invention seeks to provide a package which is more convenient to manufacture, store and use than the packs previously known in the art.
- a package for storing a product in a controlled atmosphere comprising a first pack layer of relatively lower puncture resistance, a second pack layer of gas/vapour permeable material and a third pack layer of relatively higher puncture resistance wherein the second layer is intercalated between the first and third layers such that the first and second layers define a first space suitable for housing a product and the second and third layers define a second space suitable for housing an atmosphere-modifying material, such that any gas or vapour trapped in the package is able to pass between the first and second spaces but wherein the product may be physically separated from the atmosphere-modifying material.
- the first space is adapted to house a product in the form of a pharmaceutical preparation such as a tablet or powder.
- the second space is adapted to house an atmosphere modifying material in the form of a desiccant such as silica gel powder.
- a desiccant such as silica gel powder.
- the first pack layer of lower puncture resistance is a multilayer laminate, preferably a paper/aluminium foil/polyethylene laminate.
- the second pack layer of gas/vapour permeable material is a semi- permeable membrane formed, for example, from spun bonded polythene.
- the third pack layer of relatively higher puncture resistance is a multilayer laminate, preferably a polyethylene terephthalate/aluminium foil/polyethylene laminate.
- the package takes the form of a sachet.
- the first, second and third pack layers are substantially conterminous.
- overlapping edges of the first, second and third pack layers are heat-sealed, and optionally crimped.
- an atmosphere-modifying material is contained within the interstices of the second pack layer of gas/vapour permeable material.
- the package comprises a packaged product comprising an atmosphere sensitive product in the first space and an atmosphere modifying material in the second space.
- the atmosphere sensitive product is a water-sensitive pharmaceutical product such as an effervescent tablet and the atmosphere modifying material is a desiccant.
- the atmosphere sensitive product may be an oxygen-sensitive pharmaceutical product and the atmosphere modifying material may be an oxygen-removing material such as iron filings.
- the present invention further provides a method for preparing a package as claimed in any one of the preceding claims by: a) combining strips of the first, second and third pack layers; b) introducing a product between the first and second layers and introducing an atmosphere modifying material between the second and third layers; and c) separating units of packaging from the combined strips.
- the strips are combined by heat sealing along their long edges. Preferably they are combined by passage over rollers. Suitably the finished packages are separated by heat sealing and, if necessary, cutting the combined strips across their width.
- all three of the strips are combined at substantially the same time.
- two of the strips are combined in a first operation and the remaining strip is combined with the strips combined from the first operation as part of a second operation .
- Figure 1 is a cut-away (schematic) representation of a package in accordance with the present invention with the three layers cut away in turn to show the internal construction (the layers are in fact conterminous and of substantially the same size in this embodiment);
- Figure 2 is a cross section (again in schematic form) through the package of Figure 1 along the line II-II of Figure 1 ;
- Figure 3 is a schematic representation of a first method of manufacture of the package of Figures 1 and 2;
- Figure 4 is a schematic representation of an alternative method of manufacture of the package of Figures 1 and 2.
- the package comprises three substantially square, conterminous and mutually overlaid pack layers in the form of sheets (1,2,3).
- the first sheet (1) provides a barrier of relatively lower puncture resistance and is a multilayer laminate consisting of paper (on the external face which forms part of the outside of the package) aluminium foil (in the middle) and polyethylene (on the internal face).
- This first sheet is adjacent to and overlays a second pack layer of gas/vapour permeable material which provides a semi-permeable barrier in the form of a membrane (2) having a relatively high puncture resistance compared to the first sheet.
- the membrane is formed of spun bonded polythene of the type sold under the trade name "Tyvek 1073B" by the Du Pont Corporation.
- a third pack layer (3) (again providing a barrier of relatively high puncture resistance compared to the first pack layer) in the form of a multilayer laminate consisting of polyethylene (on the internal face), aluminium foil (in the middle) and polyethyleneterephthalate (on the external face).
- the second sheet (2) is intercalated between the first sheet (1) and the third sheet (3)
- first sheet (1) and semi-permeable membrane (2) form a first space (4) suitable for housing a pharmaceutical product such as the effervescent tablet (5) shown.
- semi-permeable membrane (2) and the third sheet (3) form a second space (6) suitable for housing an atmosphere-modifying material such as the desiccant material (7) shown.
- the semi-permeable membrane is substantially impervious to the pharmaceutical and desiccant materials housed in the internal spaces (4 and 6) but is permeable to air and water vapour. Any water vapour present in space (4) is free to pass through the semi-permeable membrane (2) where it is absorbed by the desiccant material (7). This ensures the maintenance of a substantially water vapour-free atmosphere in the said first space (4) thus ensuring that the pharmaceutical tablet housed therein is kept dry and prevented from deteriorating during storage.
- the user To retrieve the product from the package the user simply punctures the first pack layer (1) (eg by tearing) and retrieves the product from the first space ready for use.
- the higher puncture resistance of the second and third pack sheets prevents the user from disturbing or releasing the atmosphere modifying material in the second space during this operation.
- FIG 3 is a schematic illustration of apparatus suitable for manufacturing the package of Figures 1 and 2 above. It will be appreciated that this is based on generally conventional strip packaging equipment.
- the apparatus comprises two mutually opposing rollers (9 A, 9), over the first of which is suspended a tablet feeding device (10) and over the second of which is suspended a desiccant feeding device (11).
- a long strip (12) about 5cm wide (or as appropriate to the intended size of the pack) of the semi-permeable membrane material is fed continuously between the two rollers (9,9 A) to emerge along a line substantially tangential to both rollers.
- a similar sized strip (13) about 5cm wide of the laminate material forming the barrier of lower puncture resistance making up the first barrier ( 1 ) of the package is fed over the first roller (9 A) such that the strip follows the circumference of the roller up to the point where the rollers meet and then continues parallel with and adjacent to the strip of semi-permeable material.
- a 5cm strip (14) of the laminate material forming the barrier of higher puncture resistance is fed over the second roller (9) to emerge from the roller parallel with and adjacent to the semi- permeable material, but on the opposite side to the lower puncture resistance strip (13).
- the tablet feeding device (10) is operable to introduce individual tablets between the lower puncture resistance strip (13) and the semi-permeable strip (12) and the desiccant feeding device (11) is operable to introduce measured quantities of desiccant material between the semi-permeable strip (14) and the higher puncture resistance strip (14).
- the tablets are introduced at a rate of about one tablet per 5cm of strip length (corresponding to one tablet per finished package; although it will be appreciated that more than one tablet per package could be included if desired, and if so the rate of introduction would be correspondingly increased).
- the desiccant material in the form of silica gel powder
- the strips pass between the two rollers (8,9) their long edges are heated to bond the strips together along their length.
- the strips are bonded together by heat-sealing in a direction transverse to the direction of movement (ie across their widths) to seal individual sachets of about 5cm by 5cm. These are then separated by a cutting tool (not shown) to provide the final sealed sachets.
- FIG 4 shows a schematic representation of an alternative apparatus for manufacturing the package of Figures 1 and 2.
- This alternative apparatus has two sets of mutually opposing rollers (15, 16 and 17, 18).
- a desiccant feeding device (19) is positioned immediately above the meeting point of the first pair of rollers (15, 16) and a tablet feeding device (20) is positioned immediately above the meeting point of the second pair of rollers (17, 18).
- the strip follows a path around approximately a quarter of the circumference of the roller until it reaches the meeting point with roller (16) at which point the strip is fed off along a line substantially tangential to both of the said rollers.
- a similar strip (22), about 5cm wide (or again as appropriate to the intended size of the pack), of the laminate material used for the barrier of higher puncture resistance is fed in a similar way over the second roller (16) but in the converse direction.
- the desiccant feeding device (19) introduces measured quantities of silica gel desiccant (eg approximately 0.1 g per 5 cm of strip length) between the strips.
- silica gel desiccant eg approximately 0.1 g per 5 cm of strip length
- the strips pass between the rollers they are heated from the laminate material side only (the Tyvek® material should not normally be heated directly) to bond the strips together along their length.
- the strips are bound together by heat-sealing in a direction transverse to the direction of movement (ie across their widths) to seal individual sachets of about 5cm by 5cm (each sachet thereby containing eg about 0.1 g of desiccant material).
- the bonded strips are then passed through the second set of rollers (17,18).
- the combined strips follow a path around approximately a quarter of the circumference of the first roller (17) until they reach the meeting point with roller (18) at which point the strips are fed off along a line substantially tangential to both of the said rollers.
- a similar strip, (23) about 5cm wide, of the laminate material used for the barrier of lower puncture resistance is fed in a similar way over the second roller (18) but in the converse direction.
- the tablet feeding device (20) introduces individual tablets between the remaining strip (23) and the previously bonded strips which are the output from the first set of rollers.
- the tablets are suitably introduced at a rate of about one tablet per 5cm of strip length.
- the strips are heated to bond the three strips together along their length.
- the strips are bond together by heat-sealing in a direction transverse to the direction of movement (ie across their widths) to seal individual sachets of about 5cm by 5cm in a continuous strip (24).
- the seals from the second set of rollers are contrived to be coincident with the seals from the first set. These sachets are then separated by a cutting tool (not shown) to provide the final sealed sachets.
- machinery used for the purpose of making strip packs sometimes uses reciprocating jaws instead of rollers, and such machinery may also be used to manufacture the packs of the present invention.
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Food Science & Technology (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Packages (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU82241/98A AU8224198A (en) | 1997-07-15 | 1998-07-14 | Package for storing a product in a controlled atmosphere and method of making it |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9714738.3 | 1997-07-15 | ||
GBGB9714738.3A GB9714738D0 (en) | 1997-07-15 | 1997-07-15 | Novel package |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999003754A1 true WO1999003754A1 (fr) | 1999-01-28 |
Family
ID=10815784
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1998/001869 WO1999003754A1 (fr) | 1997-07-15 | 1998-07-14 | Emballage permettant de stocker un produit sous atmosphere controlee et son procede de fabrication |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU8224198A (fr) |
GB (1) | GB9714738D0 (fr) |
WO (1) | WO1999003754A1 (fr) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009155387A2 (fr) * | 2008-06-20 | 2009-12-23 | Boston Scientific Scimed, Inc. | Ensemble de conditionnement |
US20100268187A1 (en) * | 2009-04-17 | 2010-10-21 | Ranbaxy Laboratories Limited | Packaging for sirolimus and composition thereof |
US8235209B2 (en) | 2010-08-11 | 2012-08-07 | Boston Scientific Scimed, Inc. | Medical device packaging and methods for preparing and packaging medical devices |
EP2341008B1 (fr) * | 1999-03-10 | 2013-04-24 | Biogaia Ab | Dispositif destiné a l'ajout d'un composant a un paquet |
JP2014189311A (ja) * | 2013-03-27 | 2014-10-06 | Fujimori Kogyo Co Ltd | 帯状フィルムを用いた製袋充填方法および製袋充填装置 |
US8973748B2 (en) | 2011-01-19 | 2015-03-10 | Boston Scientific Scime, Inc. | Medical device packaging and methods for preparing and packaging medical devices |
US9096368B2 (en) | 2011-01-19 | 2015-08-04 | Boston Scientific Scimed, Inc. | Medical device packaging and methods for preparing and packaging medical devices |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1140952A (fr) * | 1956-01-04 | 1957-08-22 | Emballage protecteur contre l'humidité | |
GB1073786A (en) * | 1964-03-26 | 1967-06-28 | Participations Et Procedes Ind | Containers incorporating dehydrating devices |
US3391047A (en) * | 1965-12-13 | 1968-07-02 | Schweizeerische Ind Ges | Apparatus for manufacturing dual-compartment sachets |
WO1996008424A1 (fr) * | 1994-09-14 | 1996-03-21 | Sealed Air (Nz) Limited | Conditionnement de la viande et d'autres produits alimentaires |
-
1997
- 1997-07-15 GB GBGB9714738.3A patent/GB9714738D0/en not_active Ceased
-
1998
- 1998-07-14 AU AU82241/98A patent/AU8224198A/en not_active Abandoned
- 1998-07-14 WO PCT/GB1998/001869 patent/WO1999003754A1/fr active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1140952A (fr) * | 1956-01-04 | 1957-08-22 | Emballage protecteur contre l'humidité | |
GB1073786A (en) * | 1964-03-26 | 1967-06-28 | Participations Et Procedes Ind | Containers incorporating dehydrating devices |
US3391047A (en) * | 1965-12-13 | 1968-07-02 | Schweizeerische Ind Ges | Apparatus for manufacturing dual-compartment sachets |
WO1996008424A1 (fr) * | 1994-09-14 | 1996-03-21 | Sealed Air (Nz) Limited | Conditionnement de la viande et d'autres produits alimentaires |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2341008B1 (fr) * | 1999-03-10 | 2013-04-24 | Biogaia Ab | Dispositif destiné a l'ajout d'un composant a un paquet |
WO2009155387A2 (fr) * | 2008-06-20 | 2009-12-23 | Boston Scientific Scimed, Inc. | Ensemble de conditionnement |
WO2009155387A3 (fr) * | 2008-06-20 | 2010-03-04 | Boston Scientific Scimed, Inc. | Ensemble de conditionnement |
US9095324B2 (en) | 2008-06-20 | 2015-08-04 | Boston Scientific Scimed, Inc. | Package assembly |
US20100268187A1 (en) * | 2009-04-17 | 2010-10-21 | Ranbaxy Laboratories Limited | Packaging for sirolimus and composition thereof |
US8235209B2 (en) | 2010-08-11 | 2012-08-07 | Boston Scientific Scimed, Inc. | Medical device packaging and methods for preparing and packaging medical devices |
US8973748B2 (en) | 2011-01-19 | 2015-03-10 | Boston Scientific Scime, Inc. | Medical device packaging and methods for preparing and packaging medical devices |
US9096368B2 (en) | 2011-01-19 | 2015-08-04 | Boston Scientific Scimed, Inc. | Medical device packaging and methods for preparing and packaging medical devices |
JP2014189311A (ja) * | 2013-03-27 | 2014-10-06 | Fujimori Kogyo Co Ltd | 帯状フィルムを用いた製袋充填方法および製袋充填装置 |
Also Published As
Publication number | Publication date |
---|---|
GB9714738D0 (en) | 1997-09-17 |
AU8224198A (en) | 1999-02-10 |
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