WO1998056387A1 - Method of treatment of liver tumours and pharmaceutical compositions for use therein - Google Patents

Method of treatment of liver tumours and pharmaceutical compositions for use therein Download PDF

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Publication number
WO1998056387A1
WO1998056387A1 PCT/AU1998/000440 AU9800440W WO9856387A1 WO 1998056387 A1 WO1998056387 A1 WO 1998056387A1 AU 9800440 W AU9800440 W AU 9800440W WO 9856387 A1 WO9856387 A1 WO 9856387A1
Authority
WO
WIPO (PCT)
Prior art keywords
vitamin
compound
cancer
liver
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/AU1998/000440
Other languages
English (en)
French (fr)
Inventor
David Lawson Morris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Unisearch Ltd
Original Assignee
Unisearch Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unisearch Ltd filed Critical Unisearch Ltd
Priority to HK01100738.6A priority Critical patent/HK1030144B/xx
Priority to AU76316/98A priority patent/AU735676B2/en
Priority to EP98923934A priority patent/EP1003523A4/en
Priority to US09/445,688 priority patent/US6486144B1/en
Priority to JP50114299A priority patent/JP2002504100A/ja
Publication of WO1998056387A1 publication Critical patent/WO1998056387A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Definitions

  • TAE transarterial chemoembolisation
  • chemotherapeutic agents are emulsified with or dissolved in the contrast agent Lipiodol, which is an iodised poppy seed oil fatty acid ethylester. Uptake of iodised oil into tumours is thought to prolong contact of the chemotherapeutic agent with tumour, and the radioopaque nature of the medium enables progress of the infusion to be monitored by radiography.
  • Vitamin D is an isoprenoid compound made up of activated 5 -carbon units. The most abundant form of vitamin D is vitamin D 3 , or cholecalciferol. Vitamin D 3 arises from biosynthesis of 7-dehydrocholesterol, an intermediate in cholesterol biosynthesis.
  • Vitamin D 3 is metabolised in the liver to 25- hydroxycholocalciferol [25(OH)D 3 ] which is a major form of Vitamin D circulating in the blood compartment. 25(OH)D 3 is converted by the kidney to produce two principal dihydroxylated metabolites, namely, 1,25- dihydroxycholecalciferol [l,25(OH) 2 D 3 ] and 24,25-dihydroxycholocalciferol [24R,25(OH) 2 D 3 ].
  • 1.25(OH) 2 D 3 is the most biologically active naturally occurring form of vitamin D 3 and is transported in the bloodstream to its major site of action in the mucosal cells of the intestine, where calcium absorption is stimulated.
  • vitamin D 3 may be regarded as a prohormone because it is converted to a metabolite that acts analogously to a steroid hormone. It regulates calcium and phosphorous metabolism particularly in the synthesis of the inorganic matrix of bones.
  • Vitamin D 3 analogues are in the treatment of the cutaneous disease psoriasis.
  • the effect of the vitamin D compound on tumours is very dose dependent and there is therefore advantage in delivering high concentrations of the vitamin D compound to the tumour.
  • the limited solubility of vitamin D compounds in a conventional carrier such as aqueous media places an upper limit on the amount of compound that can be delivered to the tumour.

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
PCT/AU1998/000440 1997-06-10 1998-06-10 Method of treatment of liver tumours and pharmaceutical compositions for use therein Ceased WO1998056387A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
HK01100738.6A HK1030144B (en) 1997-06-10 1998-06-10 Method for treatment of liver tumours and pharmaceutical compositions for use therein
AU76316/98A AU735676B2 (en) 1997-06-10 1998-06-10 Method of treatment of liver tumours and pharmaceutical compositions for use therein
EP98923934A EP1003523A4 (en) 1997-06-10 1998-06-10 Method of treatment of liver tumours and pharmaceutical compositions for use therein
US09/445,688 US6486144B1 (en) 1997-06-10 1998-06-10 Method of treatment of liver tumors and pharmaceutical compositions for use therein
JP50114299A JP2002504100A (ja) 1997-06-10 1998-06-10 肝腫瘍の治療方法およびそれに使用するための医薬組成物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPO7270A AUPO727097A0 (en) 1997-06-10 1997-06-10 Method of treatment of hepatoma and pharmaceutical compositions for use therein
AUPO7270 1997-06-10

Publications (1)

Publication Number Publication Date
WO1998056387A1 true WO1998056387A1 (en) 1998-12-17

Family

ID=3801562

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU1998/000440 Ceased WO1998056387A1 (en) 1997-06-10 1998-06-10 Method of treatment of liver tumours and pharmaceutical compositions for use therein

Country Status (8)

Country Link
US (1) US6486144B1 (enExample)
EP (1) EP1003523A4 (enExample)
JP (1) JP2002504100A (enExample)
KR (1) KR100382219B1 (enExample)
CN (1) CN1154497C (enExample)
AU (1) AUPO727097A0 (enExample)
WO (1) WO1998056387A1 (enExample)
ZA (1) ZA985028B (enExample)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999056697A3 (en) * 1998-05-04 2001-06-21 Unisearch Ltd Pharmaceutical composition
WO2001034199A3 (en) * 1999-11-11 2002-03-07 Lilly Co Eli Oncolytic combinations for the treatment of cancer
US6503893B2 (en) 1996-12-30 2003-01-07 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
US6538037B2 (en) 1991-01-08 2003-03-25 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2
EP1226823A3 (en) * 2001-01-26 2003-04-16 Pfizer Products Inc. Method of treating certain cancers using an estrogen agonist/antagonist
US6559139B1 (en) 1997-08-29 2003-05-06 University Of Pittsburgh Of The Commonwealth System Of Higher Education Combination chemotherapy
US6566353B2 (en) 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US6573256B2 (en) 1996-12-30 2003-06-03 Bone Care International, Inc. Method of inhibiting angiogenesis using active vitamin D analogues
AU765846B2 (en) * 1998-05-04 2003-10-02 Mrc Holdings Pty Limited Pharmaceutical composition
JP2004026811A (ja) * 2002-04-30 2004-01-29 Kiyoshi Hashizume ビタミンｄ３誘導体を含有する抗癌作用を増強させるための薬剤
JP2004525140A (ja) * 2001-03-26 2004-08-19 ユニサーチ リミテッド ガンの治療方法及び該治療方法に使用する組成物
US6815415B2 (en) * 1999-11-08 2004-11-09 Rhode Island Hospital Diagnosis and treatment of malignant neoplasms
US7094775B2 (en) 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
KR100758620B1 (ko) * 2000-07-05 2007-09-13 바이엘 크롭사이언스 아게 4-알콕시 사이클로헥산-1 아미노 카복실산 에스테르 및그의 제조방법
US10238667B2 (en) 2013-04-24 2019-03-26 Salk Institute For Biological Studies Vitamin D receptor/SMAD genomic circuit gates fibrotic response
US11305016B2 (en) 2009-08-14 2022-04-19 Berg Llc Vitamin D3 and analogs thereof for treating alopecia
US11376264B2 (en) 2017-07-24 2022-07-05 Salk Institute For Biological Studies Use of bromodomain-containing protein 9 antagonists in combination with vitamin D receptor agonists in diabetes treatment

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002330482A1 (en) 2002-09-04 2004-03-29 Perseus Proteomics Inc. Method of diagnosing cancer by detecting gpc3
WO2004047673A2 (en) * 2002-11-21 2004-06-10 Novacea, Inc. Treatment of liver disease with active vitamin d compounds
WO2005027922A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. 2-alkylidene-19-nor-vitamin d derivatives for the treatment of hypogonadism or andropause
WO2005027916A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and aromatase inhibitors
CA2539361A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and an estrogen agonist/antagonist
WO2005027918A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a cyclooxgenase-2 inhibitor
WO2005027928A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. 2-alkylidene-19-nor-vit amin d derivatives for the treatment of hypocalcemic tetany or hyproparathyroidism
JP4248544B2 (ja) * 2005-12-19 2009-04-02 株式会社椿本チエイン 伝動装置用可動ガイド
CN105451818A (zh) * 2013-06-05 2016-03-30 萨克生物研究学院 治疗涉及cxcl12活性的疾病的维生素d受体激动剂
JP2016124818A (ja) * 2014-12-26 2016-07-11 日本化薬株式会社 転移性肝癌治療薬及び転移性肝癌の治療方法
WO2016167977A1 (en) 2015-04-14 2016-10-20 Mayo Foundation For Medical Education And Research Methods and materials for delivering agents to liver tissue
CN116059364B (zh) * 2021-11-04 2025-07-11 上海健康医学院 Dhcr7下调剂在减弱酒精诱导的肝脏肿瘤中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0296800A1 (en) * 1987-06-23 1988-12-28 Yamanouchi Pharmaceutical Co. Ltd. Vitamin D3 derivatives
WO1995001960A1 (en) * 1993-07-09 1995-01-19 Laboratoire Theramex S.A. Novel structural analogues of vitamin d
WO1996040153A1 (en) * 1995-06-07 1996-12-19 Bone Care International, Inc. Use of vitamin d4 derivatives for treating cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4927815A (en) * 1988-04-29 1990-05-22 Wisconsin Alumni Research Foundation Compounds effective in inducing cell differentiation and process for preparing same
US5856189A (en) * 1997-01-07 1999-01-05 The Regents Of The University Of Michigan Cell culture model for drug bioavailability

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0296800A1 (en) * 1987-06-23 1988-12-28 Yamanouchi Pharmaceutical Co. Ltd. Vitamin D3 derivatives
US4897387A (en) * 1987-06-23 1990-01-30 Yamanouchi Pharmaceutical Co., Ltd. Novel vitamin D3 derivatives
WO1995001960A1 (en) * 1993-07-09 1995-01-19 Laboratoire Theramex S.A. Novel structural analogues of vitamin d
WO1996040153A1 (en) * 1995-06-07 1996-12-19 Bone Care International, Inc. Use of vitamin d4 derivatives for treating cancer

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CREMOUX DE P, ET AL.: "1,25-DIHYDROXYCHOLECALCIFEROL INDUCES AN INCREASES IN PGE,- AND FORSKOLIN-STIMULATED CYCLIC-AMP PRODUCTION IN T47D HUMAN BREAST CANCER CELL LINE", FUNDAMENTAL & CLINICAL PHARMACOLOGY., ELSEVIER, PARIS., FR, vol. 01, no. 05, 1 January 1987 (1987-01-01), FR, pages 347 - 355, XP001000187, ISSN: 0767-3981 *
DILWORTH F J, ET AL.: "THE VITAMIN D ANALOG, KH1060, IS RAPIDLY DEGRADED BOTH IN VIVO AND IN VITRO VIA SEVERAL PATHWAYS: PRINCIPAL METABOLITES GENERATED RETAIN SIGNIFICANT BIOLOGICAL ACTIVITY", ENDOCRINOLOGY, THE ENDOCRINE SOCIETY, US, vol. 138, no. 12, 1 December 1997 (1997-12-01), US, pages S485 - S496, XP001000185, ISSN: 0013-7227, DOI: 10.1210/en.138.12.5485 *
HABENER J F, MAHAFFEY J E: "OSTEOMALACIA AND DISORDERS OF VITAMIN D METABOLISM", ANNUAL REVIEW OF MEDICINE : SELECTED TOPICS IN THE CLINICALSCIENCES, ANNUAL REVIEWS INC., US, vol. 29, 1 January 1978 (1978-01-01), US, pages 327 - 342, XP001000186, ISSN: 0066-4219, DOI: 10.1146/annurev.me.29.020178.001551 *
JONES G., CALVERLY M. J.: "A DIALOGUE ON ANALOGUES. ÖNEWER VITAMIN-D DRUGS FOR USE IN BONE DISEASE, PSORIASIS, AND CANCER.", TRENDS IN ENDOCRINOLOGY AND METABOLISM., ELSEVIER SCIENCE PUBLISHING, NEW YORK, NY., US, vol. 04., no. 09., 1 November 1993 (1993-11-01), US, pages 297 - 303., XP000575585, ISSN: 1043-2760, DOI: 10.1016/1043-2760(93)90049-K *
REYNOLDS J. E. F.: "MARTINDALE - THE EXTRA PHARMACOPOEIA.", vol. ED. 30, 1 January 1993, LONDON, PHARMACEUTICAL PRESS., GB, ISBN: 978-0-85369-300-0, article MARTINDALE: "0itamin D Substances", pages: 1058 - 1060, XP002966209, 021204 *
See also references of EP1003523A4 *

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6538037B2 (en) 1991-01-08 2003-03-25 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2
US6503893B2 (en) 1996-12-30 2003-01-07 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
US6680309B2 (en) 1996-12-30 2004-01-20 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
US6566353B2 (en) 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US6573256B2 (en) 1996-12-30 2003-06-03 Bone Care International, Inc. Method of inhibiting angiogenesis using active vitamin D analogues
US6559139B1 (en) 1997-08-29 2003-05-06 University Of Pittsburgh Of The Commonwealth System Of Higher Education Combination chemotherapy
AU765846B2 (en) * 1998-05-04 2003-10-02 Mrc Holdings Pty Limited Pharmaceutical composition
WO1999056697A3 (en) * 1998-05-04 2001-06-21 Unisearch Ltd Pharmaceutical composition
US6815415B2 (en) * 1999-11-08 2004-11-09 Rhode Island Hospital Diagnosis and treatment of malignant neoplasms
WO2001034199A3 (en) * 1999-11-11 2002-03-07 Lilly Co Eli Oncolytic combinations for the treatment of cancer
KR100758620B1 (ko) * 2000-07-05 2007-09-13 바이엘 크롭사이언스 아게 4-알콕시 사이클로헥산-1 아미노 카복실산 에스테르 및그의 제조방법
EP1226823A3 (en) * 2001-01-26 2003-04-16 Pfizer Products Inc. Method of treating certain cancers using an estrogen agonist/antagonist
US6821989B2 (en) 2001-01-26 2004-11-23 Pfizer Inc. Method of treating certain cancers using an estrogen agonist/antagonist
JP2004525140A (ja) * 2001-03-26 2004-08-19 ユニサーチ リミテッド ガンの治療方法及び該治療方法に使用する組成物
JP2004026811A (ja) * 2002-04-30 2004-01-29 Kiyoshi Hashizume ビタミンｄ３誘導体を含有する抗癌作用を増強させるための薬剤
US7094775B2 (en) 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
US11305016B2 (en) 2009-08-14 2022-04-19 Berg Llc Vitamin D3 and analogs thereof for treating alopecia
US10238667B2 (en) 2013-04-24 2019-03-26 Salk Institute For Biological Studies Vitamin D receptor/SMAD genomic circuit gates fibrotic response
US11376264B2 (en) 2017-07-24 2022-07-05 Salk Institute For Biological Studies Use of bromodomain-containing protein 9 antagonists in combination with vitamin D receptor agonists in diabetes treatment

Also Published As

Publication number Publication date
ZA985028B (en) 1999-01-25
AUPO727097A0 (en) 1997-07-03
US6486144B1 (en) 2002-11-26
CN1261800A (zh) 2000-08-02
KR100382219B1 (ko) 2003-04-26
HK1030144A1 (en) 2001-04-27
JP2002504100A (ja) 2002-02-05
EP1003523A4 (en) 2001-08-22
EP1003523A1 (en) 2000-05-31
KR20010013651A (ko) 2001-02-26
CN1154497C (zh) 2004-06-23

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