WO1998043990A1 - Derives d'esters d'acide gallique et medicaments contenant ces derniers en tant que principes actifs - Google Patents

Derives d'esters d'acide gallique et medicaments contenant ces derniers en tant que principes actifs Download PDF

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Publication number
WO1998043990A1
WO1998043990A1 PCT/JP1998/001258 JP9801258W WO9843990A1 WO 1998043990 A1 WO1998043990 A1 WO 1998043990A1 JP 9801258 W JP9801258 W JP 9801258W WO 9843990 A1 WO9843990 A1 WO 9843990A1
Authority
WO
WIPO (PCT)
Prior art keywords
acid ester
gallic acid
ester derivative
compound
derivative according
Prior art date
Application number
PCT/JP1998/001258
Other languages
English (en)
Japanese (ja)
Inventor
Masamichi Ueno
Izumi Takai
Hiroshi Ohi
Masakazu Adachi
Masatoshi Noda
Original Assignee
Japan Immunoresearch Laboratories Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Immunoresearch Laboratories Co., Ltd. filed Critical Japan Immunoresearch Laboratories Co., Ltd.
Publication of WO1998043990A1 publication Critical patent/WO1998043990A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/88—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Definitions

  • the present invention provides the use of the gallic acid ester derivative as a medicament.
  • the compound (4) is subjected to catalytic hydrogen transfer reduction in a mixed solution of methanol and ethyl acetate. Is preferred.
  • the dose of the medicament of the present invention varies depending on symptoms, age, body weight, etc., but usually 5 to 200 mg / day as the compound (1) of the present invention is preferable, and the compound is administered once or several times a day. Is preferred.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

Dérivés d'esters d'acide gallique préparés par substitution d'un ou plusieurs atomes d'hydrogène des groupes hydroxyle de composés polyhydroxylés par le galloyle. Ces composés permettent de traiter efficacement des infections intestinales provoquées par des bactéries du type biotoxine, notamment les Escherichia coli toxigènes, les salmonelles, les vibrions pathogènes (Vibrio cholerae, V. parahaemolyticus), les Shigella et les campylobacters.
PCT/JP1998/001258 1997-03-31 1998-03-24 Derives d'esters d'acide gallique et medicaments contenant ces derniers en tant que principes actifs WO1998043990A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9080296A JPH10273495A (ja) 1997-03-31 1997-03-31 ガリック酸エステル誘導体及びこれを有効成分とする医薬
JP9/80296 1997-03-31

Publications (1)

Publication Number Publication Date
WO1998043990A1 true WO1998043990A1 (fr) 1998-10-08

Family

ID=13714320

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1998/001258 WO1998043990A1 (fr) 1997-03-31 1998-03-24 Derives d'esters d'acide gallique et medicaments contenant ces derniers en tant que principes actifs

Country Status (2)

Country Link
JP (1) JPH10273495A (fr)
WO (1) WO1998043990A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001072596A (ja) * 1999-09-03 2001-03-21 Hayashibara Biochem Lab Inc 抗菌作用の増強方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010059057A (ja) * 2006-12-28 2010-03-18 Microbiotech:Kk 蛋白質毒素の分泌阻害剤

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02297484A (ja) * 1989-02-07 1990-12-07 Sanyo Chem Ind Ltd 感熱記録用材料

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02297484A (ja) * 1989-02-07 1990-12-07 Sanyo Chem Ind Ltd 感熱記録用材料

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BHIMANI R.S. et al., "Inhibition of Oxidative Stress in Hel a Cells by Chemopreventive Agents", CANCER RESEARCH, Vol. 53, (1 October 1993), p. 4528-4533. *
HAGENAH S. et al., "Biosynthesis of 1,2,3,6-Tetra-O-Galloyl-beta-D-Glucose", PHYTOCHEMISTRY, Vol. 32, No. 3, (1993), p. 637-641. *
HATANO T. et al., "Gallotannins Having a 1,5-Anhydro-D-Glucitol Core and Some Ellagitannins from Acer Species", CHEM. PHARM. BULL., Vol. 38, No. 7, (1990), p. 1902-1905. *
KIMURA Y. et al., "Effects of Cafferoyl- and Galloyl-Tannins on Arachidonate Metabolism in Rat Peritoneal Macrophage Homogenates", JOURNAL OF TRADITIONAL MEDICINES, Vol. 12, (1995), p. 180-186. *
SAWADA H. et al., "Inhibition of Human Placenta Aldose Reductase by Tannic Acid", CHEM. PHARM. BULL., Vol. 37, No. 6, (1989), p. 1662-1664. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001072596A (ja) * 1999-09-03 2001-03-21 Hayashibara Biochem Lab Inc 抗菌作用の増強方法
JP4542644B2 (ja) * 1999-09-03 2010-09-15 株式会社林原生物化学研究所 抗菌作用の増強方法

Also Published As

Publication number Publication date
JPH10273495A (ja) 1998-10-13

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