WO1998043685A3 - Ciment osseux pateux contenant un antibiotique - Google Patents

Ciment osseux pateux contenant un antibiotique Download PDF

Info

Publication number
WO1998043685A3
WO1998043685A3 PCT/EP1998/001546 EP9801546W WO9843685A3 WO 1998043685 A3 WO1998043685 A3 WO 1998043685A3 EP 9801546 W EP9801546 W EP 9801546W WO 9843685 A3 WO9843685 A3 WO 9843685A3
Authority
WO
WIPO (PCT)
Prior art keywords
bone
antibiotic
cement paste
bone cement
hardened
Prior art date
Application number
PCT/EP1998/001546
Other languages
German (de)
English (en)
Other versions
WO1998043685A2 (fr
Inventor
Robert Wenz
Berthold Nies
Original Assignee
Merck Patent Gmbh
Robert Wenz
Berthold Nies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh, Robert Wenz, Berthold Nies filed Critical Merck Patent Gmbh
Priority to US09/402,120 priority Critical patent/US6485754B1/en
Priority to EP98919106A priority patent/EP0973561B1/fr
Priority to AU72075/98A priority patent/AU7207598A/en
Priority to JP54110498A priority patent/JP2001516264A/ja
Priority to DE59809723T priority patent/DE59809723D1/de
Priority to AT98919106T priority patent/ATE250433T1/de
Publication of WO1998043685A2 publication Critical patent/WO1998043685A2/fr
Publication of WO1998043685A3 publication Critical patent/WO1998043685A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Materials Engineering (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un ciment osseux pâteux durcissable qui peut être injecté, à base de composés contenant du phosphate d calcium de type hydroxyapatite biorésorbable, qui contient un antibiotique cationique sous forme de sel, de préférence son sulfate. Le ciment osseux biodégradable libère l'antibiotique avec une action de type dépôt, sur une longue période, dans des concentrations efficaces sur le plan biologique. Les ciments osseux produits selon l'invention s'utilisent pour traiter des inflammations infectieuses de l'os et de la moelle, en particulier suite à des anomalies osseuses et à des fractures osseuses.
PCT/EP1998/001546 1997-04-01 1998-03-17 Ciment osseux pateux contenant un antibiotique WO1998043685A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US09/402,120 US6485754B1 (en) 1997-04-01 1998-03-17 Bone cement paste containing an antibiotic
EP98919106A EP0973561B1 (fr) 1997-04-01 1998-03-17 Ciment osseux pateux contenant un antibiotique
AU72075/98A AU7207598A (en) 1997-04-01 1998-03-17 Bone cement paste containing an antibiotic
JP54110498A JP2001516264A (ja) 1997-04-01 1998-03-17 抗生物質含有骨用セメントペースト
DE59809723T DE59809723D1 (de) 1997-04-01 1998-03-17 Antibiotikumhaltige knochenzementpaste
AT98919106T ATE250433T1 (de) 1997-04-01 1998-03-17 Antibiotikumhaltige knochenzementpaste

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19713229.4 1997-04-01
DE19713229A DE19713229A1 (de) 1997-04-01 1997-04-01 Antibiotikumhaltige Knochenzementpaste

Publications (2)

Publication Number Publication Date
WO1998043685A2 WO1998043685A2 (fr) 1998-10-08
WO1998043685A3 true WO1998043685A3 (fr) 1999-01-07

Family

ID=7825002

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/001546 WO1998043685A2 (fr) 1997-04-01 1998-03-17 Ciment osseux pateux contenant un antibiotique

Country Status (9)

Country Link
US (1) US6485754B1 (fr)
EP (1) EP0973561B1 (fr)
JP (1) JP2001516264A (fr)
AR (1) AR010912A1 (fr)
AT (1) ATE250433T1 (fr)
AU (1) AU7207598A (fr)
DE (2) DE19713229A1 (fr)
ES (1) ES2207827T3 (fr)
WO (1) WO1998043685A2 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19918295C2 (de) * 1999-04-22 2003-09-25 Coripharm Medizinprodukte Gmbh Kompatibles Implantat-Baustein-System in Form eines Baukastensystems für Implantationsmaterialien, Verfahren zur Herstellung derselben und ihre Verwendung
WO2002009783A1 (fr) * 2000-08-01 2002-02-07 Coripharm Medizinprodukte Gmbh & Co. Kg Systeme modulaire d'implant contenant des agents actifs et son procede de fabrication
DE10114364A1 (de) * 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Verfahren zur Herstellung von antibiotischen Kompositen
DE10114244A1 (de) * 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Antibiotikum-/Antibiotika-Zubereitung mit retardierender Wirkstofffreisetzung
FR2850282B1 (fr) 2003-01-27 2007-04-06 Jerome Asius Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation
WO2004071543A1 (fr) * 2003-02-13 2004-08-26 Synthes Ag Chur Melange injectable de remplacement d'os
NZ550667A (en) * 2004-04-15 2010-10-29 Etex Corp Delayed-setting calcium phosphate pastes for the treatment of orthopedic conditions
JP5323354B2 (ja) 2004-09-21 2013-10-23 トーマス ジョセフ ラリー， 多目的生体材料組成物
ATE419019T1 (de) * 2005-01-14 2009-01-15 Eska Implants Gmbh & Co Verfahren zur herstellung einer osteoinduktiv- antiseptischen implantatbeschichtung
US20070015685A1 (en) * 2005-04-04 2007-01-18 Naomi Balaban Bone cement compositions and the like comprising an RNAIII-inhibiting peptide
US20070092572A1 (en) * 2005-04-04 2007-04-26 Naomi Balaban Bone cement compositions and the like comprising an RNAIII-inhibiting peptide
FR2896057A1 (fr) * 2006-01-12 2007-07-13 St Microelectronics Sa Procede et dispositif de generation d'un nombre aleatoire dans un peripherique usb
US20100233225A1 (en) * 2007-02-09 2010-09-16 Bingyun Li Method of surface coating devices to incorporate bioactive molecules
US20080241795A1 (en) * 2007-03-26 2008-10-02 Block James C Prevention and treatment of alveolar osteitis
EP2421559B1 (fr) 2009-04-24 2016-07-20 Vanderbilt University Induction anti-tgf-beta de la fonction de la croissance osseuse
US8529933B2 (en) 2009-07-27 2013-09-10 Warsaw Orthopedic, Inc. Biphasic calcium phosphate cement for drug delivery
JP5095034B2 (ja) * 2009-12-18 2012-12-12 ハウメディカ・オステオニクス・コーポレイション 照射後貯蔵安定性の直接注入可能なデュアルペースト型骨セメントを製造するシステムおよびリン酸カルシウム組成物
US10182973B2 (en) 2010-11-10 2019-01-22 Stryker European Holdings I, Llc Polymeric bone foam composition and method
US8834772B2 (en) 2011-12-07 2014-09-16 Biomet Manufacturing, Llc Antimicrobial methacrylate cements
US9278002B2 (en) * 2013-06-07 2016-03-08 Gregory Merrell Elbow antibiotic spacer implant
US11285190B2 (en) 2015-04-20 2022-03-29 The Board Of Regents Of The University Of Texas System CLEC11a is a bone growth agent
WO2017011448A1 (fr) 2015-07-13 2017-01-19 Bone Solutions, Inc. Composition de bio-matériau et ses méthodes d'utilisation
CN115893892B (zh) * 2022-11-30 2024-05-28 济南大学 一种二维高铝型铝钙石微纳米箔状材料及其制备工艺与应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4291013A (en) * 1978-10-09 1981-09-22 Merck Patent Gesellschaft Mit Beschrankter Haftung Medicinally useful, shaped mass of collagen resorbable in the body
EP0147021A1 (fr) * 1983-10-20 1985-07-03 Ed. Geistlich Söhne Ag Für Chemische Industrie Composition pharmaceutique
EP0242672A2 (fr) * 1986-04-18 1987-10-28 MERCK PATENT GmbH Phosphate tricalcique pour implants

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1190855A (fr) * 1980-09-03 1985-07-23 Rolf W. Pfirrmann Traitement de l'osteite
DK154260C (da) * 1981-02-20 1989-05-22 Mundipharma Gmbh Fremgangsmaade til fremstilling af et knogleimplantat af braendt tricalciumphosphat, specielt til udfyldning af hulrum eller til sammensaetning af knogledele efter fraktur.
DE3542972A1 (de) * 1985-12-05 1987-06-11 Merck Patent Gmbh Pharmakadepot
US5676976A (en) * 1995-05-19 1997-10-14 Etex Corporation Synthesis of reactive amorphous calcium phosphates

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4291013A (en) * 1978-10-09 1981-09-22 Merck Patent Gesellschaft Mit Beschrankter Haftung Medicinally useful, shaped mass of collagen resorbable in the body
EP0147021A1 (fr) * 1983-10-20 1985-07-03 Ed. Geistlich Söhne Ag Für Chemische Industrie Composition pharmaceutique
EP0242672A2 (fr) * 1986-04-18 1987-10-28 MERCK PATENT GmbH Phosphate tricalcique pour implants

Also Published As

Publication number Publication date
WO1998043685A2 (fr) 1998-10-08
ES2207827T3 (es) 2004-06-01
DE59809723D1 (de) 2003-10-30
ATE250433T1 (de) 2003-10-15
DE19713229A1 (de) 1998-10-08
AR010912A1 (es) 2000-07-12
US6485754B1 (en) 2002-11-26
EP0973561B1 (fr) 2003-09-24
JP2001516264A (ja) 2001-09-25
AU7207598A (en) 1998-10-22
EP0973561A2 (fr) 2000-01-26

Similar Documents

Publication Publication Date Title
WO1998043685A3 (fr) Ciment osseux pateux contenant un antibiotique
AR034347A1 (es) Vehiculo para la liberacion de fosfato de calcio para proteinas osteoinductivas
ATE234124T1 (de) Verfahren zur herstellung von wirkstoffhaltigen knochenzementen
CA2157890A1 (fr) Phosphate de calcium, precurseur d'hydroxyapatite; methode de preparation et utilisation
EP0339607A3 (en) Composition for repair of cartilage and bone and method for their preparation as skeletal tissue implant
AU2000261892A1 (en) Calcium phosphate artificial bone as osteoconductive and biodegradable bone substitute material
ATE221393T1 (de) Resorbierbare, bioaktive phospat-zemente
ATE378075T1 (de) Biologisch resorbierbare kalzium phosphate zement-zusammensetzungen
AU1615695A (en) Method for forming bone cement to an implant
HK1068640A1 (en) Time release calcium sulfate matrix for bone augmentation
GB2361878B (en) Bone cement mixer and method
AU2002231355A1 (en) Injectable vertebral augmentation composition and method
AU2759397A (en) Resorbable implant biomaterial made of condensed calcium phosphate particles
AU1331302A (en) Biocompatible cement containing reactive calcium phosphate nanoparticles and methods for making and using such cement
ZA872762B (en) Tricalcium phosphate for implant materials
WO2005074453A3 (fr) Compositions de ciment de phosphate de calcium a durcissement rapide
WO1998021972A3 (fr) Composes a action inductrice amelioree sur les cartilages et les os
ATE353677T1 (de) Material zur knochenrekonstruktion
TW200518767A (en) Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins
DE69732282D1 (de) Zusammensetzung zur beschleunigung der düngemittelabsorption und düngemittelzusammensetzungen
WO1998051354A3 (fr) Compositions pour osteogenese induite par des agents morphogenetiques
AU2725299A (en) Calcium salts of lipopeptide antibiotics, method for producing same and their use
EP1184352A4 (fr) Clinker de ciment, composition de ciment, procede de production d'un clinker de ciment et procede de traitement de dechets contenant un composant alcalin
ZA9610169B (en) Mixing bone cement
PL361626A1 (en) Use, method and composition of organic acids in gypsum producing desulphurising plants

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV GH

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 1998919106

Country of ref document: EP

ENP Entry into the national phase

Ref country code: JP

Ref document number: 1998 541104

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 09402120

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 1998919106

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

NENP Non-entry into the national phase

Ref country code: CA

WWG Wipo information: grant in national office

Ref document number: 1998919106

Country of ref document: EP