WO1998021343B1 - Genes codant des proteines de telomerase - Google Patents
Genes codant des proteines de telomeraseInfo
- Publication number
- WO1998021343B1 WO1998021343B1 PCT/US1997/021248 US9721248W WO9821343B1 WO 1998021343 B1 WO1998021343 B1 WO 1998021343B1 US 9721248 W US9721248 W US 9721248W WO 9821343 B1 WO9821343 B1 WO 9821343B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- seq
- polypeptide
- nucleic acid
- acid molecule
- vector
- Prior art date
Links
- 102000004591 Telomerase Human genes 0.000 title claims abstract 4
- 108010017842 Telomerase Proteins 0.000 title claims abstract 4
- 229920001184 polypeptide Polymers 0.000 claims abstract 50
- 108020004707 nucleic acids Proteins 0.000 claims abstract 48
- 150000007523 nucleic acids Chemical class 0.000 claims abstract 48
- 235000001014 amino acid Nutrition 0.000 claims 13
- 150000001413 amino acids Chemical class 0.000 claims 13
- 102100014244 TERT Human genes 0.000 claims 12
- 239000002773 nucleotide Substances 0.000 claims 7
- 125000003729 nucleotide group Chemical group 0.000 claims 7
- 102100009725 EIF3I Human genes 0.000 claims 5
- 101700046349 EIF3I Proteins 0.000 claims 5
- 101710018053 PSMC5 Proteins 0.000 claims 5
- 229960005261 Aspartic Acid Drugs 0.000 claims 2
- 108020004705 Codon Proteins 0.000 claims 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-Methionine Natural products CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 2
- 235000004279 alanine Nutrition 0.000 claims 2
- 235000003704 aspartic acid Nutrition 0.000 claims 2
- 230000000295 complement Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 102100018596 TEP1 Human genes 0.000 claims 1
- 101700004103 TEP1 Proteins 0.000 claims 1
- 230000003247 decreasing Effects 0.000 claims 1
- 229920003013 deoxyribonucleic acid Polymers 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
Abstract
L'invention concerne des molécules d'acide nucléique, qui codent des polypeptides du complexe télomérase. L'invention se rapporte également à des procédés de préparation desdites molécules d'acide nucléique et desdits polypeptides et à des procédés d'utilisation desdites molécules.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP52294198A JP2001527385A (ja) | 1996-11-15 | 1997-11-13 | テロメラーゼ蛋白質をコードする遺伝子 |
AU52644/98A AU5264498A (en) | 1996-11-15 | 1997-11-13 | Genes encoding telomerase proteins |
EP97947600A EP0939823A1 (fr) | 1996-11-15 | 1997-11-13 | Genes codant des proteines de telomerase |
CA002271718A CA2271718A1 (fr) | 1996-11-15 | 1997-11-13 | Genes codant des proteines de telomerase |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/751,189 | 1996-11-15 | ||
US08/751,189 US5919656A (en) | 1996-11-15 | 1996-11-15 | Genes encoding telomerase protein 1 |
US87303997A | 1997-06-11 | 1997-06-11 | |
US08/873,039 | 1997-10-16 | ||
US08/951,733 US7390891B1 (en) | 1996-11-15 | 1997-10-16 | Polynucleotides encoding a telomerase component TP2 |
US08/951,733 | 1997-10-16 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO1998021343A1 WO1998021343A1 (fr) | 1998-05-22 |
WO1998021343B1 true WO1998021343B1 (fr) | 1998-07-30 |
WO1998021343A8 WO1998021343A8 (fr) | 2002-01-31 |
Family
ID=27419411
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/021248 WO1998021343A1 (fr) | 1996-11-15 | 1997-11-13 | Genes codant des proteines de telomerase |
Country Status (5)
Country | Link |
---|---|
US (1) | US7390891B1 (fr) |
EP (1) | EP0939823A1 (fr) |
AU (1) | AU5264498A (fr) |
CA (1) | CA2271718A1 (fr) |
WO (1) | WO1998021343A1 (fr) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6808880B2 (en) | 1996-10-01 | 2004-10-26 | Geron Corporation | Method for detecting polynucleotides encoding telomerase |
US6093809A (en) | 1996-10-01 | 2000-07-25 | University Technology Corporation | Telomerase |
US7585622B1 (en) | 1996-10-01 | 2009-09-08 | Geron Corporation | Increasing the proliferative capacity of cells using telomerase reverse transcriptase |
US6261836B1 (en) | 1996-10-01 | 2001-07-17 | Geron Corporation | Telomerase |
US6777203B1 (en) | 1997-11-19 | 2004-08-17 | Geron Corporation | Telomerase promoter driving expression of therapeutic gene sequences |
US6475789B1 (en) | 1996-10-01 | 2002-11-05 | University Technology Corporation | Human telomerase catalytic subunit: diagnostic and therapeutic methods |
US6610839B1 (en) | 1997-08-14 | 2003-08-26 | Geron Corporation | Promoter for telomerase reverse transcriptase |
ATE245194T1 (de) * | 1996-10-01 | 2003-08-15 | Geron Corp | Katalytische untereinheit der menschlichen telomerase |
WO1998037181A2 (fr) * | 1997-02-20 | 1998-08-27 | Whitehead Institute For Biomedical Research | Gene de sous-unite catalytique de telomerase et proteine codee |
US7622549B2 (en) * | 1997-04-18 | 2009-11-24 | Geron Corporation | Human telomerase reverse transcriptase polypeptides |
US7413864B2 (en) | 1997-04-18 | 2008-08-19 | Geron Corporation | Treating cancer using a telomerase vaccine |
AU745420B2 (en) * | 1997-06-20 | 2002-03-21 | Bayer Aktiengesellschaft | Human catalytic telomerase sub-unit and its diagnostic and therapeutic use |
IL133830A0 (en) * | 1997-07-01 | 2001-04-30 | Cambia Biosystems Llc | Vertebrate tolomerase genes and proteins and uses thereof |
EP1571215A3 (fr) * | 1997-07-01 | 2007-10-31 | Cambia Biosystems LLC | Gènes et protéines de télomérases de vertèbres et leurs utilisations |
US7378244B2 (en) | 1997-10-01 | 2008-05-27 | Geron Corporation | Telomerase promoters sequences for screening telomerase modulators |
AU1606999A (en) * | 1997-11-26 | 1999-06-15 | Albert Einstein College Of Medicine Of Yeshiva University | Mouse telomerase reverse transcriptase |
US6337200B1 (en) | 1998-03-31 | 2002-01-08 | Geron Corporation | Human telomerase catalytic subunit variants |
JP2002509716A (ja) | 1998-03-31 | 2002-04-02 | ユニバーシティ テクノロジー コーポレイション | テロメラーゼ抗原に対する免疫応答を惹起するための方法および組成物 |
US7402307B2 (en) | 1998-03-31 | 2008-07-22 | Geron Corporation | Method for identifying and killing cancer cells |
US7030211B1 (en) | 1998-07-08 | 2006-04-18 | Gemvax As | Antigenic peptides derived from telomerase |
US6995145B1 (en) | 1999-06-04 | 2006-02-07 | Au Jessie L-S | Methods and compositions for modulating drug activity through telomere damage |
US6492171B2 (en) | 2000-05-16 | 2002-12-10 | Isis Pharmaceuticals, Inc. | Antisense modulation of TERT expression |
US6331399B1 (en) | 2000-05-16 | 2001-12-18 | Isis Pharmaceuticals, Inc. | Antisense inhibition of tert expression |
AUPR769701A0 (en) * | 2001-09-14 | 2001-10-11 | Li, He | Telomerase inhibitory peptides and uses thereof |
US7294708B2 (en) * | 2002-05-31 | 2007-11-13 | Beijing Institute Of Biotechnology | Telomerase reverse transcriptase fragments and uses thereof |
ES2376010T3 (es) * | 2006-10-12 | 2012-03-08 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.R.L. | Prote�?na de fusión de transcriptasa inversa de la telomerasa, nucleótidos que la codifican y usos de la misma. |
KR20130024888A (ko) | 2010-02-16 | 2013-03-08 | 오슬로 유니버시티 하스피탈 에이치에프 | 폴리펩티드 |
JP6517692B2 (ja) * | 2012-09-19 | 2019-05-22 | ジェムバックス アンド カエル カンパニー,リミティド | 細胞透過性ペプチド、それを含んだコンジュゲート、及びそれを含んだ組成物 |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
DE3169595D1 (en) | 1980-11-10 | 1985-05-02 | Gersonde Klaus | Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application |
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
EP0088046B1 (fr) | 1982-02-17 | 1987-12-09 | Ciba-Geigy Ag | Lipides en phase aqueuse |
US4452747A (en) | 1982-03-22 | 1984-06-05 | Klaus Gersonde | Method of and arrangement for producing lipid vesicles |
DE3218121A1 (de) | 1982-05-14 | 1983-11-17 | Leskovar, Peter, Dr.-Ing., 8000 München | Arzneimittel zur tumorbehandlung |
HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
EP0143949B1 (fr) | 1983-11-01 | 1988-10-12 | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION | Composition pharmaceutique contenant de l'urokinase |
EP0154316B1 (fr) | 1984-03-06 | 1989-09-13 | Takeda Chemical Industries, Ltd. | Lymphokine chimiquement modifiée et son procédé de préparation |
ATE135370T1 (de) | 1988-12-22 | 1996-03-15 | Kirin Amgen Inc | Chemisch modifizierte granulocytenkolonie erregender faktor |
US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
US5639613A (en) | 1992-05-13 | 1997-06-17 | Board Of Regents, University Of Texas System | Methods for cancer diagnosis and prognosis |
US5489508A (en) | 1992-05-13 | 1996-02-06 | University Of Texas System Board Of Regents | Therapy and diagnosis of conditions related to telomere length and/or telomerase activity |
US5648215A (en) | 1992-05-13 | 1997-07-15 | Board Of Regents, The University Of Texas System | Telomerase diagnostic methods |
US5645986A (en) | 1992-05-13 | 1997-07-08 | Board Of Reagents, The University Of Texas System | Therapy and diagnosis of conditions related to telomere length and/or telomerase activity |
US5629154A (en) | 1993-11-12 | 1997-05-13 | Geron Corporation | Telomerase activity assays |
US5489743A (en) | 1993-01-19 | 1996-02-06 | Amgen Inc. | Transgenic animal models for thrombocytopenia |
JPH08509870A (ja) | 1993-05-26 | 1996-10-22 | オンタリオ キャンサー インスティテュート | 特定のcd45イソ型タンパク質の発現を遮断するトランスジェニック哺乳動物 |
US6664107B1 (en) | 1993-05-26 | 2003-12-16 | Ontario Cancer Institute, University Health Network | CD45 disrupted nucleic acid |
WO1995013382A1 (fr) | 1993-11-12 | 1995-05-18 | Geron Corporation | Diagnostic et traitement de desordres lies a la longueur de telomeres et/ou l'activite de la telomerase |
US5972605A (en) | 1994-07-07 | 1999-10-26 | Geron Corporation | Assays for regulators of mammalian telomerase expression |
PL181019B1 (pl) | 1994-07-07 | 2001-05-31 | Geron Corp | Składnik RNA ssaczej telomerazy i sposób wytwarzania rekombinowanego enzymu telomerazy |
US5583016A (en) | 1994-07-07 | 1996-12-10 | Geron Corporation | Mammalian telomerase |
US5635349A (en) | 1994-12-02 | 1997-06-03 | Tularik, Inc. | High-throughput screening assay for inhibitors of nucleic acid polymerases |
WO1996019580A2 (fr) | 1994-12-19 | 1996-06-27 | Cold Spring Harbor Laboratory | Fraction proteinique de la telomerase |
US6054442A (en) | 1995-07-06 | 2000-04-25 | Board Of Regents, University Of Texas System | Methods and compositions for modulation and inhibition of telomerase in vitro |
WO1997035967A2 (fr) | 1996-03-28 | 1997-10-02 | Cold Spring Harbor Laboratory | Organismes transgeniques presentant une alteration de l'activite de la telomerase |
WO1997037691A1 (fr) | 1996-04-10 | 1997-10-16 | Lynx Therapeutics, Inc. | Inhibiteurs de la telomerase |
US5770422A (en) | 1996-07-08 | 1998-06-23 | The Regents Of The University Of California | Human telomerase |
US5747317A (en) | 1996-07-08 | 1998-05-05 | Tularik Inc. | Human telomerase RNA interacting protein gene |
AU3798997A (en) | 1996-07-17 | 1998-02-09 | David E. Burstein | Telomerase assay for precancerous lesions of the uterine cervix |
JPH1028600A (ja) | 1996-07-17 | 1998-02-03 | Kyowa Hakko Kogyo Co Ltd | テロメラーゼ活性の測定法 |
WO1998007838A1 (fr) | 1996-08-21 | 1998-02-26 | Mitsubishi Chemical Corporation | Proteine de telomerase d'animaux superieurs et gene codant pour elle |
WO1998008938A1 (fr) | 1996-08-28 | 1998-03-05 | Shonen Yoshida | Proteines ayant une activite de telomerase |
JP2001500379A (ja) | 1996-09-13 | 2001-01-16 | ジェロン コーポレイション | テロメア長およびテロメア活性を調節するための方法および試薬 |
US6475789B1 (en) * | 1996-10-01 | 2002-11-05 | University Technology Corporation | Human telomerase catalytic subunit: diagnostic and therapeutic methods |
US6093809A (en) * | 1996-10-01 | 2000-07-25 | University Technology Corporation | Telomerase |
ATE245194T1 (de) | 1996-10-01 | 2003-08-15 | Geron Corp | Katalytische untereinheit der menschlichen telomerase |
US6261836B1 (en) * | 1996-10-01 | 2001-07-17 | Geron Corporation | Telomerase |
US6337200B1 (en) * | 1998-03-31 | 2002-01-08 | Geron Corporation | Human telomerase catalytic subunit variants |
-
1997
- 1997-10-16 US US08/951,733 patent/US7390891B1/en not_active Expired - Fee Related
- 1997-11-13 CA CA002271718A patent/CA2271718A1/fr not_active Abandoned
- 1997-11-13 WO PCT/US1997/021248 patent/WO1998021343A1/fr not_active Application Discontinuation
- 1997-11-13 EP EP97947600A patent/EP0939823A1/fr not_active Withdrawn
- 1997-11-13 AU AU52644/98A patent/AU5264498A/en not_active Abandoned
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1998021343B1 (fr) | Genes codant des proteines de telomerase | |
CA2087261A1 (fr) | Clonage de peptides dans un but de purification | |
JP4189035B2 (ja) | 溶解性を向上させた組換えヒトインターフェロン−β | |
KR960704038A (ko) | 세포 표면 수용체 Hek와 결합하는 사이토킨(Cytokines That Bind the Cell Surface Receptor Hek) | |
WO1998056927A3 (fr) | Acides nucleiques codant des polypeptides a fonction protease | |
EP0889133A3 (fr) | Procédé de préparation de transglutaminase microbienne | |
CA2249233A1 (fr) | Codage des apotose proteases mch4 et mch5 par des acides nucleiques, et methodes d'utilisation | |
CA2180103A1 (fr) | Gene codant par les adseverines | |
KR20110106286A (ko) | 친화성 태그가 결합된 융합 콜라게나제 및 그의 제조방법 | |
WO2006042719A3 (fr) | Polypeptide presentant une activite de phytase et sequence nucleotidique codant ce polypeptide | |
CA2252493A1 (fr) | Gene de la .beta.-galactoside - .alpha. 2,6-sialyltransferase | |
AU653526B2 (en) | Novel signal sequences | |
EP0857789A3 (fr) | Acide férulique décarboxylase | |
WO2000000607B1 (fr) | Acide nucleique codant pour une proteine de liaison du retinoblastome (rbp-7) et marqueurs polymorphes associes a cet acide nucleique | |
AU8649698A (en) | Cell cycle-regulating proteins | |
US7771970B2 (en) | Process for preparation of polypeptides of interest from fusion polypeptides | |
CA2241786A1 (fr) | Nouvelles proteines kinases activees par l'amp | |
CA2384122A1 (fr) | Synthases de depsipeptides cycliques, genes correspondants et systeme de production de masse de ces depsipeptides cycliques | |
CA2253006A1 (fr) | Gene hydroxylase de beta-carotene | |
WO2002010384A1 (fr) | Genes codant des proteines capables de regenerer la luciferine, adn recombine et methode de production de proteines capables de regenerer la luciferine | |
WO1999054436A3 (fr) | Acides nucleiques et proteines de genes de type insuline derives de c. elegans, et leurs utilisations | |
KR920000932A (ko) | 효소 및 이를 암호화하는 dna | |
CA2374513A1 (fr) | Adn et polypeptides il-1 eta | |
CA2348732A1 (fr) | Proteines humaines h37 et adnc les codant | |
Zhao et al. | Ruminant brain ribonucleases: expression and evolution |