WO1998019701B1 - Procedes pour promouvoir la cicatrisation et pour traiter les vasculopathies associees a des transplantations - Google Patents

Procedes pour promouvoir la cicatrisation et pour traiter les vasculopathies associees a des transplantations

Info

Publication number
WO1998019701B1
WO1998019701B1 PCT/US1997/020388 US9720388W WO9819701B1 WO 1998019701 B1 WO1998019701 B1 WO 1998019701B1 US 9720388 W US9720388 W US 9720388W WO 9819701 B1 WO9819701 B1 WO 9819701B1
Authority
WO
WIPO (PCT)
Prior art keywords
inos
graft
wound
region
cells
Prior art date
Application number
PCT/US1997/020388
Other languages
English (en)
Other versions
WO1998019701A1 (fr
Filing date
Publication date
Priority claimed from US08/745,375 external-priority patent/US5830461A/en
Application filed filed Critical
Priority to AU51992/98A priority Critical patent/AU5199298A/en
Priority to EP97946907A priority patent/EP0963204A1/fr
Priority to JP52181598A priority patent/JP2001503432A/ja
Priority to CA002270619A priority patent/CA2270619A1/fr
Publication of WO1998019701A1 publication Critical patent/WO1998019701A1/fr
Publication of WO1998019701B1 publication Critical patent/WO1998019701B1/fr

Links

Abstract

Cette invention se rapporte à un procédé permettant de promouvoir la fermeture d'une plaie dans le corps d'un patient. Ce procédé consiste à transférer l'enzyme sous forme exogène oxyde nitrique synthase inductible (ONSi) dans la région de la plaie, pour qu'un produit de cette enzyme ONSi soit généré dans la région de la plaie, afin de promouvoir sa fermeture. Cette invention se rapporte également à un procédé permettant de transplanter une greffe dans le corps d'un patient, ce procédé consistant à transférer un vecteur comprenant une cassette d'expression d'ONSi dans des cellules associées à la greffe et à incorporer par voie chirurgicale les tissus de la greffe dans le corps du patient. Après expression de l'enzyme ONSi dans le corps du patient, un produit de cette enzyme est généré dans la région de la greffe, de façon à atténuer la vasculopathie dans la région de la greffe. Pour réaliser ce procédé, cette invention présente également des compositions pharmaceutiques permettant d'acheminer l'enzyme ONSi et/ou la bioptérine BH4 dans les cellules associées aux plaies ou aux greffes.
PCT/US1997/020388 1996-11-08 1997-11-07 Procedes pour promouvoir la cicatrisation et pour traiter les vasculopathies associees a des transplantations WO1998019701A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU51992/98A AU5199298A (en) 1996-11-08 1997-11-07 Methods for promoting wound healing and treating transplant-associated vasculopathy
EP97946907A EP0963204A1 (fr) 1996-11-08 1997-11-07 Promotion de la cicatrisation et traitement des vasculopathies associees a des transplantations
JP52181598A JP2001503432A (ja) 1996-11-08 1997-11-07 創傷治癒の促進方法および移植に関連する血管症の治療方法
CA002270619A CA2270619A1 (fr) 1996-11-08 1997-11-07 Procedes pour promouvoir la cicatrisation et pour traiter les vasculopathies associees a des transplantations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/745,375 US5830461A (en) 1992-11-25 1996-11-08 Methods for promoting wound healing and treating transplant-associated vasculopathy
US08/745,375 1996-11-08

Publications (2)

Publication Number Publication Date
WO1998019701A1 WO1998019701A1 (fr) 1998-05-14
WO1998019701B1 true WO1998019701B1 (fr) 1998-07-23

Family

ID=24996422

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/020388 WO1998019701A1 (fr) 1996-11-08 1997-11-07 Procedes pour promouvoir la cicatrisation et pour traiter les vasculopathies associees a des transplantations

Country Status (6)

Country Link
US (2) US5830461A (fr)
EP (1) EP0963204A1 (fr)
JP (1) JP2001503432A (fr)
AU (1) AU5199298A (fr)
CA (1) CA2270619A1 (fr)
WO (1) WO1998019701A1 (fr)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830461A (en) * 1992-11-25 1998-11-03 University Of Pittsburgh Of The Commonwealth System Of Higher Education Methods for promoting wound healing and treating transplant-associated vasculopathy
US10028851B2 (en) 1997-04-15 2018-07-24 Advanced Cardiovascular Systems, Inc. Coatings for controlling erosion of a substrate of an implantable medical device
US8172897B2 (en) 1997-04-15 2012-05-08 Advanced Cardiovascular Systems, Inc. Polymer and metal composite implantable medical devices
US6240616B1 (en) 1997-04-15 2001-06-05 Advanced Cardiovascular Systems, Inc. Method of manufacturing a medicated porous metal prosthesis
US6890726B1 (en) 1999-04-06 2005-05-10 Oklahoma Medical Research Foundation Method for selecting recombinase variants with altered specificity
EP1114862A3 (fr) * 1999-11-17 2003-08-06 Switch Biotech Aktiengesellschaft Utilitsation des polypeptides ou leurs acids nucléiques pour la diagnose ou traitement des maladies de la peau et leurs utilisation pour l'identification des substances pharmacologiquement actives
US8109994B2 (en) 2003-01-10 2012-02-07 Abbott Cardiovascular Systems, Inc. Biodegradable drug delivery material for stent
US7875283B2 (en) 2000-04-13 2011-01-25 Advanced Cardiovascular Systems, Inc. Biodegradable polymers for use with implantable medical devices
US6527801B1 (en) 2000-04-13 2003-03-04 Advanced Cardiovascular Systems, Inc. Biodegradable drug delivery material for stent
EP1176200A3 (fr) * 2000-06-20 2005-01-12 Switch Biotech Aktiengesellschaft Utilisation des polypeptides ou leurs acides nucléiques pour le diagnose ou traitement des maladies de la peau ou de la cicatrisation de blessures et leurs utilisations pour l'identification des substances pharmacologiquement actives
US7989018B2 (en) 2001-09-17 2011-08-02 Advanced Cardiovascular Systems, Inc. Fluid treatment of a polymeric coating on an implantable medical device
US7285304B1 (en) 2003-06-25 2007-10-23 Advanced Cardiovascular Systems, Inc. Fluid treatment of a polymeric coating on an implantable medical device
US6863683B2 (en) 2001-09-19 2005-03-08 Abbott Laboratoris Vascular Entities Limited Cold-molding process for loading a stent onto a stent delivery system
US8435550B2 (en) 2002-12-16 2013-05-07 Abbot Cardiovascular Systems Inc. Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
US7758881B2 (en) 2004-06-30 2010-07-20 Advanced Cardiovascular Systems, Inc. Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
SE525036C2 (sv) * 2003-04-04 2004-11-16 Born To Run Design Hb Anordning och metod för sterilisering, fyllning och försegling av en förpackning
US7186789B2 (en) 2003-06-11 2007-03-06 Advanced Cardiovascular Systems, Inc. Bioabsorbable, biobeneficial polyester polymers for use in drug eluting stent coatings
US7198675B2 (en) 2003-09-30 2007-04-03 Advanced Cardiovascular Systems Stent mandrel fixture and method for selectively coating surfaces of a stent
MXPA06004687A (es) * 2003-10-31 2006-06-27 Altana Pharma Ag Uso de bh4 para el tratamiento de enfermedades respiratorias.
JP2007511536A (ja) 2003-11-17 2007-05-10 バイオマリン ファーマシューティカル インコーポレイテッド 代謝障害の処置のための方法及び組成物
US20050214339A1 (en) 2004-03-29 2005-09-29 Yiwen Tang Biologically degradable compositions for medical applications
US8568469B1 (en) 2004-06-28 2013-10-29 Advanced Cardiovascular Systems, Inc. Stent locking element and a method of securing a stent on a delivery system
US8241554B1 (en) 2004-06-29 2012-08-14 Advanced Cardiovascular Systems, Inc. Method of forming a stent pattern on a tube
US7971333B2 (en) 2006-05-30 2011-07-05 Advanced Cardiovascular Systems, Inc. Manufacturing process for polymetric stents
US8778256B1 (en) 2004-09-30 2014-07-15 Advanced Cardiovascular Systems, Inc. Deformation of a polymer tube in the fabrication of a medical article
US8747878B2 (en) 2006-04-28 2014-06-10 Advanced Cardiovascular Systems, Inc. Method of fabricating an implantable medical device by controlling crystalline structure
US8747879B2 (en) 2006-04-28 2014-06-10 Advanced Cardiovascular Systems, Inc. Method of fabricating an implantable medical device to reduce chance of late inflammatory response
US7731890B2 (en) 2006-06-15 2010-06-08 Advanced Cardiovascular Systems, Inc. Methods of fabricating stents with enhanced fracture toughness
US9283099B2 (en) 2004-08-25 2016-03-15 Advanced Cardiovascular Systems, Inc. Stent-catheter assembly with a releasable connection for stent retention
US7229471B2 (en) 2004-09-10 2007-06-12 Advanced Cardiovascular Systems, Inc. Compositions containing fast-leaching plasticizers for improved performance of medical devices
US8173062B1 (en) 2004-09-30 2012-05-08 Advanced Cardiovascular Systems, Inc. Controlled deformation of a polymer tube in fabricating a medical article
US8043553B1 (en) 2004-09-30 2011-10-25 Advanced Cardiovascular Systems, Inc. Controlled deformation of a polymer tube with a restraining surface in fabricating a medical article
US7875233B2 (en) 2004-09-30 2011-01-25 Advanced Cardiovascular Systems, Inc. Method of fabricating a biaxially oriented implantable medical device
EP2436379A1 (fr) * 2004-11-17 2012-04-04 BioMarin Pharmaceutical Inc. Formule de comprimé stable
US7632307B2 (en) * 2004-12-16 2009-12-15 Advanced Cardiovascular Systems, Inc. Abluminal, multilayer coating constructs for drug-delivery stents
US7381048B2 (en) 2005-04-12 2008-06-03 Advanced Cardiovascular Systems, Inc. Stents with profiles for gripping a balloon catheter and molds for fabricating stents
AU2006245770A1 (en) * 2005-05-11 2006-11-16 Nycomed Gmbh Combination of the PDE4 inhibitor roflumilast and a tetrahydrobiopterin derivative
US7658880B2 (en) 2005-07-29 2010-02-09 Advanced Cardiovascular Systems, Inc. Polymeric stent polishing method and apparatus
US20070042003A1 (en) * 2005-08-19 2007-02-22 Webber Robert J Method of effecting a mammalian model of sepsis, severe sepsis, or septic shock
US9248034B2 (en) 2005-08-23 2016-02-02 Advanced Cardiovascular Systems, Inc. Controlled disintegrating implantable medical devices
US7867547B2 (en) 2005-12-19 2011-01-11 Advanced Cardiovascular Systems, Inc. Selectively coating luminal surfaces of stents
US20070156230A1 (en) 2006-01-04 2007-07-05 Dugan Stephen R Stents with radiopaque markers
US7951185B1 (en) 2006-01-06 2011-05-31 Advanced Cardiovascular Systems, Inc. Delivery of a stent at an elevated temperature
KR100853761B1 (ko) * 2006-02-13 2008-08-22 주식회사 알엔에이 노각나무 추출물 및 그 용도
US7964210B2 (en) 2006-03-31 2011-06-21 Abbott Cardiovascular Systems Inc. Degradable polymeric implantable medical devices with a continuous phase and discrete phase
US8003156B2 (en) 2006-05-04 2011-08-23 Advanced Cardiovascular Systems, Inc. Rotatable support elements for stents
US7761968B2 (en) 2006-05-25 2010-07-27 Advanced Cardiovascular Systems, Inc. Method of crimping a polymeric stent
US7951194B2 (en) 2006-05-26 2011-05-31 Abbott Cardiovascular Sysetms Inc. Bioabsorbable stent with radiopaque coating
US20130331926A1 (en) 2006-05-26 2013-12-12 Abbott Cardiovascular Systems Inc. Stents With Radiopaque Markers
US8343530B2 (en) 2006-05-30 2013-01-01 Abbott Cardiovascular Systems Inc. Polymer-and polymer blend-bioceramic composite implantable medical devices
US7842737B2 (en) 2006-09-29 2010-11-30 Abbott Cardiovascular Systems Inc. Polymer blend-bioceramic composite implantable medical devices
US20070282434A1 (en) * 2006-05-30 2007-12-06 Yunbing Wang Copolymer-bioceramic composite implantable medical devices
US7959940B2 (en) 2006-05-30 2011-06-14 Advanced Cardiovascular Systems, Inc. Polymer-bioceramic composite implantable medical devices
US8486135B2 (en) 2006-06-01 2013-07-16 Abbott Cardiovascular Systems Inc. Implantable medical devices fabricated from branched polymers
US8034287B2 (en) 2006-06-01 2011-10-11 Abbott Cardiovascular Systems Inc. Radiation sterilization of medical devices
US8603530B2 (en) 2006-06-14 2013-12-10 Abbott Cardiovascular Systems Inc. Nanoshell therapy
US8048448B2 (en) 2006-06-15 2011-11-01 Abbott Cardiovascular Systems Inc. Nanoshells for drug delivery
US8535372B1 (en) 2006-06-16 2013-09-17 Abbott Cardiovascular Systems Inc. Bioabsorbable stent with prohealing layer
US8333000B2 (en) 2006-06-19 2012-12-18 Advanced Cardiovascular Systems, Inc. Methods for improving stent retention on a balloon catheter
US8017237B2 (en) 2006-06-23 2011-09-13 Abbott Cardiovascular Systems, Inc. Nanoshells on polymers
US9072820B2 (en) 2006-06-26 2015-07-07 Advanced Cardiovascular Systems, Inc. Polymer composite stent with polymer particles
US8128688B2 (en) 2006-06-27 2012-03-06 Abbott Cardiovascular Systems Inc. Carbon coating on an implantable device
US7794776B1 (en) 2006-06-29 2010-09-14 Abbott Cardiovascular Systems Inc. Modification of polymer stents with radiation
US7740791B2 (en) 2006-06-30 2010-06-22 Advanced Cardiovascular Systems, Inc. Method of fabricating a stent with features by blow molding
US7823263B2 (en) 2006-07-11 2010-11-02 Abbott Cardiovascular Systems Inc. Method of removing stent islands from a stent
US7757543B2 (en) 2006-07-13 2010-07-20 Advanced Cardiovascular Systems, Inc. Radio frequency identification monitoring of stents
US7998404B2 (en) 2006-07-13 2011-08-16 Advanced Cardiovascular Systems, Inc. Reduced temperature sterilization of stents
US7794495B2 (en) 2006-07-17 2010-09-14 Advanced Cardiovascular Systems, Inc. Controlled degradation of stents
US7886419B2 (en) 2006-07-18 2011-02-15 Advanced Cardiovascular Systems, Inc. Stent crimping apparatus and method
US8016879B2 (en) 2006-08-01 2011-09-13 Abbott Cardiovascular Systems Inc. Drug delivery after biodegradation of the stent scaffolding
US9173733B1 (en) 2006-08-21 2015-11-03 Abbott Cardiovascular Systems Inc. Tracheobronchial implantable medical device and methods of use
US7923022B2 (en) 2006-09-13 2011-04-12 Advanced Cardiovascular Systems, Inc. Degradable polymeric implantable medical devices with continuous phase and discrete phase
US8099849B2 (en) 2006-12-13 2012-01-24 Abbott Cardiovascular Systems Inc. Optimizing fracture toughness of polymeric stent
US8262723B2 (en) 2007-04-09 2012-09-11 Abbott Cardiovascular Systems Inc. Implantable medical devices fabricated from polymer blends with star-block copolymers
US7829008B2 (en) 2007-05-30 2010-11-09 Abbott Cardiovascular Systems Inc. Fabricating a stent from a blow molded tube
US7959857B2 (en) 2007-06-01 2011-06-14 Abbott Cardiovascular Systems Inc. Radiation sterilization of medical devices
US8293260B2 (en) 2007-06-05 2012-10-23 Abbott Cardiovascular Systems Inc. Elastomeric copolymer coatings containing poly (tetramethyl carbonate) for implantable medical devices
US8202528B2 (en) 2007-06-05 2012-06-19 Abbott Cardiovascular Systems Inc. Implantable medical devices with elastomeric block copolymer coatings
US8425591B1 (en) 2007-06-11 2013-04-23 Abbott Cardiovascular Systems Inc. Methods of forming polymer-bioceramic composite medical devices with bioceramic particles
US8048441B2 (en) 2007-06-25 2011-11-01 Abbott Cardiovascular Systems, Inc. Nanobead releasing medical devices
US7901452B2 (en) 2007-06-27 2011-03-08 Abbott Cardiovascular Systems Inc. Method to fabricate a stent having selected morphology to reduce restenosis
US7955381B1 (en) 2007-06-29 2011-06-07 Advanced Cardiovascular Systems, Inc. Polymer-bioceramic composite implantable medical device with different types of bioceramic particles
US8568471B2 (en) 2010-01-30 2013-10-29 Abbott Cardiovascular Systems Inc. Crush recoverable polymer scaffolds
US8808353B2 (en) 2010-01-30 2014-08-19 Abbott Cardiovascular Systems Inc. Crush recoverable polymer scaffolds having a low crossing profile
US8726483B2 (en) 2011-07-29 2014-05-20 Abbott Cardiovascular Systems Inc. Methods for uniform crimping and deployment of a polymer scaffold
US9216178B2 (en) 2011-11-02 2015-12-22 Biomarin Pharmaceutical Inc. Dry blend formulation of tetrahydrobiopterin
US9999527B2 (en) 2015-02-11 2018-06-19 Abbott Cardiovascular Systems Inc. Scaffolds having radiopaque markers
US9700443B2 (en) 2015-06-12 2017-07-11 Abbott Cardiovascular Systems Inc. Methods for attaching a radiopaque marker to a scaffold

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4840940A (en) * 1987-10-21 1989-06-20 Sottiurai Vikrom S Method for reducing the occurrence of distal anastomotic intimal hyperplasia using fractionated heparin
US5328470A (en) * 1989-03-31 1994-07-12 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
US5580722A (en) * 1989-07-18 1996-12-03 Oncogene Science, Inc. Methods of determining chemicals that modulate transcriptionally expression of genes associated with cardiovascular disease
US5304121A (en) * 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
ES2115662T3 (es) * 1990-10-31 1998-07-01 Cell Genesys Inc Modificacion genetica de celulas endoteliales.
US5268465A (en) * 1991-01-18 1993-12-07 The Johns Hopkins University Purification and molecular cloning of nitric oxide synthase
US5132407A (en) * 1991-09-26 1992-07-21 Cornell Research Foundation, Inc. Purified inducible nitric oxide synthase flavoprotein
US5252479A (en) * 1991-11-08 1993-10-12 Research Corporation Technologies, Inc. Safe vector for gene therapy
US5266594A (en) * 1992-05-12 1993-11-30 Dawson Valina L Inhibitors of nitric oxide synthase and use thereof to prevent glutamate neurotoxicity
US5830461A (en) * 1992-11-25 1998-11-03 University Of Pittsburgh Of The Commonwealth System Of Higher Education Methods for promoting wound healing and treating transplant-associated vasculopathy
US5658565A (en) * 1994-06-24 1997-08-19 University Of Pittsburgh Of The Commonwealth System Of Higher Education Inducible nitric oxide synthase gene for treatment of disease
CA2150125A1 (fr) * 1992-11-25 1994-06-09 Timothy R. Billiar Clone d'adnc pour l'oxide nitrique synthase inductible humaine et procede de preparation
GB9306386D0 (en) * 1993-03-26 1993-05-19 Wellcome Found Gene expression
DK43393D0 (da) * 1993-04-16 1993-04-16 Novo Nordisk As Dna-sekvens, der koder for et enzym
US5428070A (en) * 1993-06-11 1995-06-27 The Board Of Trustees Of The Leland Stanford Junior University Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production of activity
US6103226A (en) * 1994-08-12 2000-08-15 Arch Development Corporation Genetically engineered cells that produce produce L. Dopa
WO1997033980A1 (fr) * 1996-03-15 1997-09-18 The General Hospital Corporation Animaux transgeniques comportant un gene interrompu de synthase d'oxyde nitrique endotheliale, et procedes d'utilisation

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