CA2150125A1 - Clone d'adnc pour l'oxide nitrique synthase inductible humaine et procede de preparation - Google Patents

Clone d'adnc pour l'oxide nitrique synthase inductible humaine et procede de preparation

Info

Publication number
CA2150125A1
CA2150125A1 CA002150125A CA2150125A CA2150125A1 CA 2150125 A1 CA2150125 A1 CA 2150125A1 CA 002150125 A CA002150125 A CA 002150125A CA 2150125 A CA2150125 A CA 2150125A CA 2150125 A1 CA2150125 A1 CA 2150125A1
Authority
CA
Canada
Prior art keywords
nitric oxide
oxide synthase
leu
inducible nitric
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002150125A
Other languages
English (en)
Inventor
Timothy R. Billiar
David A. Geller
Richard L. Simmons
Andreas K. Nussler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pittsburgh
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2150125A1 publication Critical patent/CA2150125A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • C12N9/0075—Nitric-oxide synthase (1.14.13.39)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/13—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
    • C12Y114/13039—Nitric-oxide synthase (NADPH dependent) (1.14.13.39)
CA002150125A 1992-11-25 1993-11-23 Clone d'adnc pour l'oxide nitrique synthase inductible humaine et procede de preparation Abandoned CA2150125A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98134492A 1992-11-25 1992-11-25
US981,344 1992-11-25

Publications (1)

Publication Number Publication Date
CA2150125A1 true CA2150125A1 (fr) 1994-06-09

Family

ID=25528300

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002150125A Abandoned CA2150125A1 (fr) 1992-11-25 1993-11-23 Clone d'adnc pour l'oxide nitrique synthase inductible humaine et procede de preparation

Country Status (5)

Country Link
US (2) US5468630A (fr)
EP (1) EP0670902A1 (fr)
JP (1) JPH08503852A (fr)
CA (1) CA2150125A1 (fr)
WO (1) WO1994012645A2 (fr)

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JPH08503852A (ja) * 1992-11-25 1996-04-30 ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブハイヤー エデュケーション ヒト誘導性一酸化窒素シンターゼのｃＤＮＡクローンおよびその作製方法
US5658565A (en) * 1994-06-24 1997-08-19 University Of Pittsburgh Of The Commonwealth System Of Higher Education Inducible nitric oxide synthase gene for treatment of disease
US5830461A (en) * 1992-11-25 1998-11-03 University Of Pittsburgh Of The Commonwealth System Of Higher Education Methods for promoting wound healing and treating transplant-associated vasculopathy
DE4411402A1 (de) * 1994-03-31 1995-10-05 Juergen Schrader DNA-Expressionsvektoren zur Verwendung in der gentherapeutischen Behandlung von Gefäßerkrankungen
US5744340A (en) * 1995-06-09 1998-04-28 Schering Corporation Expression of human inducible nitric oxide synthase
US5908842A (en) * 1995-12-08 1999-06-01 Merck & Co., Inc. Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase
WO1997034014A1 (fr) * 1996-03-15 1997-09-18 Yale University Procedes et moyen de detection d'une synthase d'oxyde nitrique
GB9607440D0 (en) * 1996-04-10 1996-06-12 Medical Res Council Analysis of DNA
US7198904B1 (en) * 1996-04-12 2007-04-03 Robert Webber Immunoassay method employing monoclonal antibody reactive to human iNOS
WO1997042965A1 (fr) * 1996-05-10 1997-11-20 Gonzalez Cadavid Nestor F Amelioration de la dyserection
US5856158A (en) * 1996-07-05 1999-01-05 University Of Iowa Research Foundation Purified nitric oxide synthase from rat brain
US20020076782A1 (en) * 1996-07-05 2002-06-20 John P.N. Rosazza Purified nitric oxide synthase
US6150500A (en) 1996-07-12 2000-11-21 Salerno; John C. Activators of endothelial nitric oxide synthase
US5789395A (en) * 1996-08-30 1998-08-04 The Research Foundation Of State University Of New York Method of using tetracycline compounds for inhibition of endogenous nitric oxide production
WO1998012313A1 (fr) * 1996-09-20 1998-03-26 Suntory Limited Procede de tri de composes regulateurs de l'expression de la synthase induisant chez l'homme la production d'acide nitrique
US6160000A (en) * 1996-12-23 2000-12-12 Merck & Co., Inc. Antidiabetic agents based on aryl and heteroarylacetic acids
US6090839A (en) * 1996-12-23 2000-07-18 Merck & Co., Inc. Antidiabetic agents
JP4117911B2 (ja) * 1997-04-11 2008-07-16 ロバート ウェバー ヒトｉＮＯＳに反応するモノクロナール抗体を用いる免疫学的検定法
AU3775799A (en) 1998-05-01 1999-11-23 University Of Pittsburgh Muscle-derived cell mediated gene delivery for treating muscle- and bone-relatedinjury or dysfunction
US20040043068A1 (en) * 1998-09-29 2004-03-04 Eugene Tedeschi Uses for medical devices having a lubricious, nitric oxide-releasing coating
AUPQ577700A0 (en) * 2000-02-22 2000-03-16 K. King & Co Pty Limited Method of treatment of anorectal disorders
US6270779B1 (en) 2000-05-10 2001-08-07 United States Of America Nitric oxide-releasing metallic medical devices
US6620616B1 (en) 2000-09-13 2003-09-16 The Cleveland Clinic Foundation Nucleic acids encoding nitric oxide synthase variants
EP1436018A1 (fr) * 2001-09-26 2004-07-14 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Dispositifs medicaux revetus a liberation d'oxyde nitrique et leur procede de preparation
US6703046B2 (en) 2001-10-04 2004-03-09 Medtronic Ave Inc. Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and use
CA2545584C (fr) 2003-11-17 2012-10-23 Biomarin Pharmaceutical Inc. Methodes et compositions destinees au traitement de troubles metaboliques
BRPI0517088A (pt) * 2004-11-17 2008-09-30 Biomarin Pharm Inc formulação de comprimido estável
US8021679B2 (en) 2005-08-25 2011-09-20 Medtronic Vascular, Inc Nitric oxide-releasing biodegradable polymers useful as medical devices and coatings therefore
US20070053952A1 (en) * 2005-09-07 2007-03-08 Medtronic Vascular, Inc. Nitric oxide-releasing polymers derived from modified polymers
WO2007053292A2 (fr) * 2005-10-31 2007-05-10 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Diazeniumdiolates lies par un carbone, liberant de l'oxyde nitrique et derives de polysaccharides
US8241619B2 (en) * 2006-05-15 2012-08-14 Medtronic Vascular, Inc. Hindered amine nitric oxide donating polymers for coating medical devices
US7811600B2 (en) * 2007-03-08 2010-10-12 Medtronic Vascular, Inc. Nitric oxide donating medical devices and methods of making same
US8273828B2 (en) 2007-07-24 2012-09-25 Medtronic Vascular, Inc. Methods for introducing reactive secondary amines pendant to polymers backbones that are useful for diazeniumdiolation
US8852732B2 (en) * 2008-01-08 2014-10-07 Johns Manville Fiber-reinforced composite articles made from fibers having coupling-initiator compounds and methods of making the articles
US20090232863A1 (en) * 2008-03-17 2009-09-17 Medtronic Vascular, Inc. Biodegradable Carbon Diazeniumdiolate Based Nitric Oxide Donating Polymers
US20090232868A1 (en) * 2008-03-17 2009-09-17 Medtronic Vascular, Inc. Nitric Oxide Releasing Polymer Composition
US8158187B2 (en) * 2008-12-19 2012-04-17 Medtronic Vascular, Inc. Dry diazeniumdiolation methods for producing nitric oxide releasing medical devices
US8709465B2 (en) * 2009-04-13 2014-04-29 Medtronic Vascular, Inc. Diazeniumdiolated phosphorylcholine polymers for nitric oxide release
US20110301299A1 (en) 2010-06-08 2011-12-08 Medtronic Vascular, Inc. Medical Devices and Polymers Therefor Having PTFE Surfaces Modified With Nitric Oxide-Releasing Polymers
US9216178B2 (en) 2011-11-02 2015-12-22 Biomarin Pharmaceutical Inc. Dry blend formulation of tetrahydrobiopterin
CN109837594A (zh) * 2017-11-27 2019-06-04 上海欧易生物医学科技有限公司 一种提高表达文库阳性率的建库方法

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US4652639A (en) * 1982-05-06 1987-03-24 Amgen Manufacture and expression of structural genes
US4882282A (en) * 1985-08-16 1989-11-21 Immunex Corporation DNA sequences encoding bovine interleukin-2
US5017691A (en) * 1986-07-03 1991-05-21 Schering Corporation Mammalian interleukin-4
US5239060A (en) * 1986-07-25 1993-08-24 The Children's Medical Center Corporation Muscular dystrophy protein, dystrophin
US5223425A (en) * 1987-04-02 1993-06-29 The Beth Israel Hospital Association DNA encoding human adipsin with complement D activity
US5171674A (en) * 1988-07-13 1992-12-15 Brigham And Women's Hospital Polynucleotides that encode the human proteoglycan peptide core of the effector cells of the immune response
US5216131A (en) * 1989-02-23 1993-06-01 Genentech, Inc. Lymphocyte homing receptors
DE4012928C2 (de) * 1990-04-24 1997-01-09 Roland Man Druckmasch Bogentransporttrommel für Schrägregisterkorrektur
GB2250993B (en) * 1990-11-21 1995-02-15 Inst Nat Sante Rech Med Stromelysin-3 and its application in the diagnosis and treatment of malignant breast cancer
US5268465A (en) * 1991-01-18 1993-12-07 The Johns Hopkins University Purification and molecular cloning of nitric oxide synthase
US5278299A (en) * 1991-03-18 1994-01-11 Scripps Clinic And Research Foundation Method and composition for synthesizing sialylated glycosyl compounds
US5268295A (en) * 1991-05-31 1993-12-07 W. Alton Jones Cell Science Center, Inc. Mammalian adipocyte protein p154, nucleic acids coding therefor and uses thereof
US5132407A (en) * 1991-09-26 1992-07-21 Cornell Research Foundation, Inc. Purified inducible nitric oxide synthase flavoprotein
JPH08503852A (ja) * 1992-11-25 1996-04-30 ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブハイヤー エデュケーション ヒト誘導性一酸化窒素シンターゼのｃＤＮＡクローンおよびその作製方法

Also Published As

Publication number Publication date
US5468630A (en) 1995-11-21
JPH08503852A (ja) 1996-04-30
US5882908A (en) 1999-03-16
WO1994012645A2 (fr) 1994-06-09
EP0670902A1 (fr) 1995-09-13
WO1994012645A3 (fr) 1994-07-21

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued