WO1998004521B1 - Inhibiteurs du canal de potassium - Google Patents
Inhibiteurs du canal de potassiumInfo
- Publication number
- WO1998004521B1 WO1998004521B1 PCT/US1997/012559 US9712559W WO9804521B1 WO 1998004521 B1 WO1998004521 B1 WO 1998004521B1 US 9712559 W US9712559 W US 9712559W WO 9804521 B1 WO9804521 B1 WO 9804521B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- optionally substituted
- alkyl
- methyl
- group
- carbocycloalkyl
- Prior art date
Links
- 230000002401 inhibitory effect Effects 0.000 title claims abstract 3
- 102000004257 potassium channel family Human genes 0.000 title claims abstract 3
- 108020001213 potassium channel family Proteins 0.000 title claims abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 claims abstract 18
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 8
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 7
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 7
- 125000003107 substituted aryl group Chemical group 0.000 claims abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 6
- 239000001257 hydrogen Substances 0.000 claims abstract 6
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims abstract 6
- 150000001875 compounds Chemical class 0.000 claims abstract 5
- 239000000651 prodrug Substances 0.000 claims abstract 5
- 229940002612 prodrugs Drugs 0.000 claims abstract 5
- 150000003839 salts Chemical class 0.000 claims abstract 5
- 239000011780 sodium chloride Substances 0.000 claims abstract 5
- 150000002500 ions Chemical class 0.000 claims abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- -1 β-naphthyl Chemical group 0.000 claims 1
- 206010007521 Cardiac arrhythmias Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 235000019256 formaldehyde Nutrition 0.000 abstract 1
- 230000002062 proliferating Effects 0.000 abstract 1
Abstract
Composés représentés par la formule (I) dans laquelle R1 représente H, alkyle ou est sélectionné dans le groupe constitué par un aryle éventuellement substitué, un hétéroaryle éventuellement substitué, un hétérocyclyle éventuellement substitué et un carbocycloalkyle éventuellement substitué; R2 est sélectionné dans le groupe constitué par alkyle, un aryle éventuellement substitué, un hétéroaryle éventuellement substitué, un hétérocyclyle éventuellement substitué et un carbocycloalkyle éventuellement substitué; R3 représente hydrogène ou méthyle; R4 représente hydrogène ou méthyle; X1 représente C=O; C=S ou SO¿2; X?2 représente C=O ou SO¿2; Y?1 représente O, (CH¿2?)p, CH2O, HC=CH ou NH; dans laquelle p est 0, 1 ou 2; Y?2¿ représente O, (CH¿2?)q, HC=CH ou NH dans laquelle q est 0 ou 1; Z représente H, OR?5 ou NR6R7¿, dans laquelle R5 représente H, (CH¿2)m-R?6 ou C(O)-(CH¿2)m-R?8, m = 1 à 5; R8 représente N(R9)2, N(R9)3L ou CO2R9, dans laquelle chaque R9 est indépendamment sélectionné dans H ou alkyle; et L représente un contre-ion; R6 représente H ou alkyle; R7 représente H, alkyle ou CO¿2R?10, dans laquelle R10 représente alkyle; ou leurs sels ou promédicaments acceptables sur le plan pharmaceutique, utiles en tant qu'inhibiteurs des canaux de potassium, ainsi que pour le traitement de l'arythmie cardiaque et les maladies prolifératives des cellules.
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU38035/97A AU734711B2 (en) | 1996-07-26 | 1997-07-23 | Potassium channel inhibitors |
IL12820597A IL128205A (en) | 1996-07-26 | 1997-07-23 | Indane derivatives and pharmaceutical compositions containing the same |
AT97934996T ATE250571T1 (de) | 1996-07-26 | 1997-07-23 | Kaliumkanal-blocker |
EP97934996A EP0923543B1 (fr) | 1996-07-26 | 1997-07-23 | Inhibiteurs du canal de potassium |
JP50888498A JP2002513385A (ja) | 1996-07-26 | 1997-07-23 | カリウムチャンネル阻害剤 |
HU0003250A HUP0003250A3 (en) | 1996-07-26 | 1997-07-23 | Potassium channel inhibitor indane derivatives and pharmaceutical compositions containing the same |
DE69725153T DE69725153T2 (de) | 1996-07-26 | 1997-07-23 | Kaliumkanal-blocker |
CA002261814A CA2261814A1 (fr) | 1996-07-26 | 1997-07-23 | Inhibiteurs du canal de potassium |
BR9710587-2A BR9710587A (pt) | 1996-07-26 | 1997-07-23 | Inibidores de canal de potássio |
HK99105493A HK1020334A1 (en) | 1996-07-26 | 1999-11-26 | Potassium channel inhibitors |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2254796P | 1996-07-26 | 1996-07-26 | |
US60/022,547 | 1996-07-26 | ||
US08/893,160 US6083986A (en) | 1996-07-26 | 1997-07-15 | Potassium channel inhibitors |
US08/893,160 | 1997-07-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998004521A1 WO1998004521A1 (fr) | 1998-02-05 |
WO1998004521B1 true WO1998004521B1 (fr) | 1998-03-26 |
Family
ID=26696048
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/012559 WO1998004521A1 (fr) | 1996-07-26 | 1997-07-23 | Inhibiteurs du canal de potassium |
Country Status (13)
Country | Link |
---|---|
US (1) | US6083986A (fr) |
EP (1) | EP0923543B1 (fr) |
JP (1) | JP2002513385A (fr) |
KR (1) | KR20000029605A (fr) |
AT (1) | ATE250571T1 (fr) |
AU (1) | AU734711B2 (fr) |
BR (1) | BR9710587A (fr) |
CA (1) | CA2261814A1 (fr) |
DE (1) | DE69725153T2 (fr) |
HK (1) | HK1020334A1 (fr) |
HU (1) | HUP0003250A3 (fr) |
IL (1) | IL128205A (fr) |
WO (1) | WO1998004521A1 (fr) |
Families Citing this family (76)
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CA2297906A1 (fr) * | 1997-07-22 | 1999-02-04 | Bret Eugene Huff | Composes pharmaceutiques |
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WO2000012077A1 (fr) | 1998-09-01 | 2000-03-09 | Bristol-Myers Squibb Company | Inhibiteurs de canaux potassium et leur methode d'utilisation |
US6632836B1 (en) | 1998-10-30 | 2003-10-14 | Merck & Co., Inc. | Carbocyclic potassium channel inhibitors |
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EP1214293A1 (fr) | 1999-09-08 | 2002-06-19 | Guilford Pharmaceuticals Inc. | Composes non-peptidiques de liaison cyclophiline et leur utilisation |
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CN104011028A (zh) | 2011-11-18 | 2014-08-27 | 艾伯维德国有限责任两合公司 | N-取代的氨基苯并环庚烯、氨基四氢化萘、氨基茚满和苯烷基胺衍生物、包含所述衍生物的药物组合物及其在治疗中的用途 |
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CN105992764A (zh) | 2013-10-17 | 2016-10-05 | 艾伯维德国有限责任两合公司 | 氨基色满、氨基硫代色满及氨基-1,2,3,4-四氢喹啉衍生物,包含其的药物组合物及其在治疗中的用途 |
US10835533B2 (en) | 2014-05-15 | 2020-11-17 | Array Biopharma Inc. | 1 -((3S,4R)-4-(3-fluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1H-pyrazol-5-yl)urea as a TrkA kinase inhibitor |
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1997
- 1997-07-15 US US08/893,160 patent/US6083986A/en not_active Expired - Lifetime
- 1997-07-23 CA CA002261814A patent/CA2261814A1/fr not_active Abandoned
- 1997-07-23 IL IL12820597A patent/IL128205A/xx not_active IP Right Cessation
- 1997-07-23 HU HU0003250A patent/HUP0003250A3/hu unknown
- 1997-07-23 WO PCT/US1997/012559 patent/WO1998004521A1/fr active IP Right Grant
- 1997-07-23 AT AT97934996T patent/ATE250571T1/de not_active IP Right Cessation
- 1997-07-23 JP JP50888498A patent/JP2002513385A/ja not_active Ceased
- 1997-07-23 DE DE69725153T patent/DE69725153T2/de not_active Expired - Fee Related
- 1997-07-23 AU AU38035/97A patent/AU734711B2/en not_active Ceased
- 1997-07-23 EP EP97934996A patent/EP0923543B1/fr not_active Expired - Lifetime
- 1997-07-23 BR BR9710587-2A patent/BR9710587A/pt not_active Application Discontinuation
- 1997-07-23 KR KR1019997000669A patent/KR20000029605A/ko active IP Right Grant
-
1999
- 1999-11-26 HK HK99105493A patent/HK1020334A1/xx not_active IP Right Cessation
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