WO1997048430A1 - Improvements relating to injection devices - Google Patents

Improvements relating to injection devices Download PDF

Info

Publication number
WO1997048430A1
WO1997048430A1 PCT/GB1997/001614 GB9701614W WO9748430A1 WO 1997048430 A1 WO1997048430 A1 WO 1997048430A1 GB 9701614 W GB9701614 W GB 9701614W WO 9748430 A1 WO9748430 A1 WO 9748430A1
Authority
WO
WIPO (PCT)
Prior art keywords
capsule
needle
injection device
spring means
trigger
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1997/001614
Other languages
English (en)
French (fr)
Inventor
Jeremy Marshall
David Danvers Crossman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Owen Mumford Ltd
Original Assignee
Owen Mumford Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Owen Mumford Ltd filed Critical Owen Mumford Ltd
Priority to JP50248798A priority Critical patent/JP4559541B2/ja
Priority to EP97926127A priority patent/EP0906131B1/en
Priority to US09/202,687 priority patent/US6077247A/en
Priority to DE69718468T priority patent/DE69718468T2/de
Publication of WO1997048430A1 publication Critical patent/WO1997048430A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033Spring-loaded one-shot injectors with or without automatic needle insertion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/206With automatic needle insertion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
    • A61M2005/208Release is possible only when device is pushed against the skin, e.g. using a trigger which is blocked or inactive when the device is not pushed against the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M2005/3103Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3104Caps for syringes without needle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2066Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically comprising means for injection of two or more media, e.g. by mixing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202Devices for protection of the needle before use, e.g. caps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202Devices for protection of the needle before use, e.g. caps
    • A61M5/3204Needle cap remover, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices

Definitions

  • This invention relates to injection devices and is particularly but not exclusively concerned with those for capsules where two ingredients are initially separated, but which are mixed immediately prior to injection. These are well known, and will not be described in detail. But a typical arrangement is to have liquid in a rear chamber of the capsule and powder in a forward chamber, the two being connected by a narrow bypass passage. The first stage is to compress the liquid so it forces its way through the bypass gradually to infiltrate and mix with the powder. Then, in the second stage, the plunger is urged forwards and the mixture is injected through the needle at the leading end.
  • an injection device comprising a two-part barrel, the parts being mutually telescoped and containing spring means to act in a forward direction on a capsule housed therein, the forward part providing a passage at its leading end through which a needle at the leading end of the capsule can be projected, wherein for operation the parts of the barrel have their telescopic overlap increased, which exposes for operation a trigger that holds the capsule in a needle retracted position, actuation of the trigger then releasing the capsule for that to be urged forwardly by the spring means to project the needle.
  • the spring means may also be arranged, after urging the capsule forwards, to have residual energy to act on the contents of the capsule to eject a dose through the needle.
  • the forward part of the barrel telescopes into the rearward part.
  • the trigger is integrally formed with the part that telescopes into the other one.
  • the spring means will conveniently be a coil spring acting between the rear end of the rearward barrel part and the rear end of the capsule.
  • the travel of the plunger within the capsule during the mixing operation will preferably be less than the mutual movement of the two barrel parts when the overlap is increased, whereby the spring means will have residual energy after the components have been mixed, first, when the trigger is activated, to shoot the capsule forwards to a limit, acting on the plunger, this projecting the needle, and then to press the plunger further into the capsule and thereby eject a dose through the needle.
  • Figures 1-5 are axial sections of an injection device in progressive stages of operation
  • Figure 6 is a perspective view of the injection device prior to use
  • Figure 7 is a perspective view of the injection device almost ready for use.
  • the injection device is a two part barrel which contains a capsule 1 with a needle 2 at its leading end This will have a two component dose which will be mixed and injected during the course of operation. It can be of known type and will not be described in detail.
  • the rear part 3 of the barrel is of stepped cylindrical form having a closed rear end 4 and a shoulder 5 at about its mid-length where the diameter increases.
  • This enlarged section 6 is not completely cylindrical but has a longitudi ⁇ nal slot 7 extending from the shoulder 5 to an enlargement 8 stepped further out from the section 6.
  • this section 6 has an internal rim 9.
  • the forward part 10 of the barrel is also generally cylindrical but it has an integral trigger 11. This extends in the longitudinal direction and is joined at its mid- length to the main barrel part 10 by bridging webs 12, as best seen in figures 6 and 7.
  • the trigger is proud of the part 10 and extends into the enlargement 8 where initially it terminates just short of the slot 7. Forward of its pivot, the trigger steps inwardly at 13 and then continues forwardly to terminate in an inwardly projecting lug 14. The step 13 and the lug 14 bear on a shoulder of the capsule 1 and the forward end of the needle assembly respectively.
  • the part 10 has two circumferential ribs 15 and 16, the rearmost one 15 initially cooperating with the rim 9 to retain the two barrel parts together.
  • the barrel part 10 narrows to form a passage 17 through which the needle 2 will be projected, this initially being covered by a cap 18 which plugs into the passage. There, it cooperates with a sheath 19 protecting the needle 2.
  • the parts 3 and 10 are telescoped further together to the Figure 2 position where the rim 9 snaps over the rib 16 to retain the parts there.
  • the spring 20 is com- pressed and initiates the- component mixing as described. This further telescoping also exposes the rear end of the trigger 11 in the slot 7.
  • the cap 18 is then removed as shown in Figure 3 and this pulls away the sheath 19.
  • the mouth of the passage 17 is then held against the skin and the rear end of the trigger 11 is depressed as shown in Figure 4.
  • This pivots the trigger so that the step 13 and the lug 14 release the capsule and needle.
  • the spring 20 therefore shoots the capsule 1 and needle 2 forwards until the needle is arrested by the entrance to the passage 17.
  • the capsule 1 continues to move forwards so that a membrane at its front end is pierced by the rear end of the double ended needle, and then the final expansion of the spring ejects the dose through the needle 2.
  • the detents formed by the ribs 15 and 16 do allow the rim 9 to snap past them in either direction, so that the barrel can be dismantled and put together again for replace ⁇ ment of a capsule. But of course they are sufficient to stop the two barrel parts simply falling apart.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
PCT/GB1997/001614 1996-06-18 1997-06-16 Improvements relating to injection devices Ceased WO1997048430A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP50248798A JP4559541B2 (ja) 1996-06-18 1997-06-16 注射装置
EP97926127A EP0906131B1 (en) 1996-06-18 1997-06-16 Improvements relating to injection devices
US09/202,687 US6077247A (en) 1996-06-18 1997-06-16 Injection devices
DE69718468T DE69718468T2 (de) 1996-06-18 1997-06-16 Verbesserte injektionsvorrichtung

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9612724.6 1996-06-18
GBGB9612724.6A GB9612724D0 (en) 1996-06-18 1996-06-18 Improvements relating to injection devices

Publications (1)

Publication Number Publication Date
WO1997048430A1 true WO1997048430A1 (en) 1997-12-24

Family

ID=10795478

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1997/001614 Ceased WO1997048430A1 (en) 1996-06-18 1997-06-16 Improvements relating to injection devices

Country Status (6)

Country Link
US (1) US6077247A (enExample)
EP (1) EP0906131B1 (enExample)
JP (1) JP4559541B2 (enExample)
DE (1) DE69718468T2 (enExample)
GB (1) GB9612724D0 (enExample)
WO (1) WO1997048430A1 (enExample)

Cited By (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6391003B1 (en) 1999-10-25 2002-05-21 Antares Pharma, Inc. Locking mechanism for a jet injector
US6428528B2 (en) 1998-08-11 2002-08-06 Antares Pharma, Inc. Needle assisted jet injector
EP1759728A1 (en) * 2005-09-05 2007-03-07 JCR Pharmaceuticals Co., Ltd. Injection device for two-compartment syringes
EP1790366A1 (en) * 2005-11-29 2007-05-30 JCR Pharmaceuticals Co., Ltd. Injection device
WO2007138296A1 (en) * 2006-06-01 2007-12-06 Cilag Gmbh International Cap for injection device
WO2011131997A1 (en) * 2010-04-23 2011-10-27 Barry Peter Liversidge Needle safety devices
GB2486748A (en) * 2011-03-24 2012-06-27 Owen Mumford Ltd Autoinjector devices
US8277414B2 (en) 2004-05-28 2012-10-02 Cilag Gmbh International Injection device
US8298171B2 (en) 2002-07-02 2012-10-30 Panasonic Corporation Automatic administration instrument for medical use
US8313463B2 (en) 2004-05-28 2012-11-20 Cilag Gmbh International Injection device
US8313464B2 (en) 2004-05-28 2012-11-20 Cilag Gmbh International Injection device
US8313465B2 (en) 2004-05-28 2012-11-20 Cilag Gmbh International Injection device
US8317751B2 (en) 2005-04-06 2012-11-27 Cilag Gmbh International Injection device
US8343110B2 (en) 2004-05-28 2013-01-01 Cilag Gmbh International Injection device
US8366669B2 (en) 2005-04-06 2013-02-05 Cilag Gmbh International Injection device
EP2596822A1 (en) * 2011-11-24 2013-05-29 Sanofi-Aventis Deutschland GmbH Autoinjector
US8529518B2 (en) 2009-06-12 2013-09-10 Novo Nordisk A/S Drug delivery device with cap functions for needle assembly
US8834419B2 (en) 2008-06-19 2014-09-16 Cilag Gmbh International Reusable auto-injector
US8845594B2 (en) 2008-06-19 2014-09-30 Cilag Gmbh International Auto-injector with filling means
US8915889B2 (en) 2008-08-05 2014-12-23 Antares Pharma, Inc. Multiple dosage injector
US8939958B2 (en) 2008-06-19 2015-01-27 Cilag Gmbh International Fluid transfer assembly for a syringe
US8945063B2 (en) 2009-03-20 2015-02-03 Antares Pharma, Inc. Hazardous agent injection system
US8968236B2 (en) 2005-04-06 2015-03-03 Cilag Gmbh International Injection device
US9028453B2 (en) 2008-06-19 2015-05-12 Cilag Gmbh International Reusable auto-injector
US9072833B2 (en) 2006-06-01 2015-07-07 Cilag Gmbh International Injection device
US9180259B2 (en) 2005-01-24 2015-11-10 Antares Pharma, Inc. Prefilled syringe jet injector
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
US9333309B2 (en) 2002-02-11 2016-05-10 Antares Pharma, Inc. Intradermal injector
US9358346B2 (en) 2005-08-30 2016-06-07 Cilag Gmbh International Needle assembly for a prefilled syringe system
US9364610B2 (en) 2012-05-07 2016-06-14 Antares Pharma, Inc. Injection device with cammed ram assembly
US9446195B2 (en) 2011-07-15 2016-09-20 Antares Pharma, Inc. Injection device with cammed ram assembly
US9649441B2 (en) 2005-04-06 2017-05-16 Cilag Gmbh International Injection device (bayonet cap removal)
US9675757B2 (en) 2004-05-28 2017-06-13 Cilag Gmbh International Injection device
US9675758B2 (en) 2004-05-28 2017-06-13 Cilag Gmbh International Injection device
US9682194B2 (en) 2008-06-19 2017-06-20 Cilag Gmbh International Re-useable auto-injector with filling means
US9707354B2 (en) 2013-03-11 2017-07-18 Antares Pharma, Inc. Multiple dosage injector with rack and pinion dosage system
US9731080B2 (en) 2005-04-06 2017-08-15 Cilag Gmbh International Injection device
US9744302B2 (en) 2013-02-11 2017-08-29 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
US9757520B2 (en) 2006-06-01 2017-09-12 Cilag Gmbh International Injection device
US9770558B2 (en) 2005-09-27 2017-09-26 Cilag Gmbh International Auto-injection device with needle protecting cap having outer and inner sleeves
US9808582B2 (en) 2006-05-03 2017-11-07 Antares Pharma, Inc. Two-stage reconstituting injector
US9895493B2 (en) 2004-05-28 2018-02-20 Cilag Gmbh International Injection device
US9950125B2 (en) 2012-04-06 2018-04-24 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
US10709849B2 (en) 2013-06-11 2020-07-14 Cilag Gmbh International Guide for an injection device
US10799646B2 (en) 2013-06-11 2020-10-13 Cilag Gmbh International Injection device
US11123492B2 (en) 2013-06-11 2021-09-21 Cilag Gmbh International Injection device
US11173255B2 (en) 2013-06-11 2021-11-16 Cilag Gmbh International Injection device
US20230022361A1 (en) * 2020-03-30 2023-01-26 Ypsomed Ag Autoinjector with multichamber product container

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9817662D0 (en) * 1998-08-13 1998-10-07 Crocker Peter J Substance delivery
US6958055B2 (en) * 1998-09-04 2005-10-25 Nmt Group Plc Retractable needle syringe including a sheath and an intravenous adapter
GB2359754B (en) * 2000-03-03 2004-04-28 Nmt Group Plc Needle sheath
ES2605353T3 (es) * 2000-08-02 2017-03-14 Becton, Dickinson And Company Sistema de aguja de pluma y pantalla protectora de seguridad
US6986760B2 (en) * 2000-08-02 2006-01-17 Becton, Dickinson And Company Pen needle and safety shield system
US6912417B1 (en) * 2002-04-05 2005-06-28 Ichor Medical Systmes, Inc. Method and apparatus for delivery of therapeutic agents
CN1723053A (zh) * 2002-09-12 2006-01-18 儿童医院医疗中心 无痛药物注射的方法和设备
US6997904B2 (en) * 2002-12-24 2006-02-14 Robert David Sculati Viscous fluid injection system
US7500963B2 (en) * 2003-07-22 2009-03-10 Safety Syringes, Inc. Systems and methods for automatic medical injection with safeguard
US8932264B2 (en) * 2003-08-11 2015-01-13 Becton, Dickinson And Company Medication delivery pen assembly with needle locking safety shield
US7708732B2 (en) * 2003-10-16 2010-05-04 Nps Pharmaceuticals, Inc. Methods of administering therapeutic injections
WO2005058396A1 (de) * 2003-12-18 2005-06-30 Tecpharma Licensing Ag Auslösbares injektionsgerät
US7896841B2 (en) * 2004-02-17 2011-03-01 Children's Hospital Medical Center Injection device for administering a vaccine
EP1729848B1 (en) 2004-03-08 2015-04-29 Ichor Medical Systems Inc. Improved apparatus for electrically mediated delivery of therapeutic agents
US20050222539A1 (en) * 2004-03-30 2005-10-06 Pediamed Pharmaceuticals, Inc. Automatic injection device
GB2414404B (en) 2004-05-28 2009-06-03 Cilag Ag Int Injection device
GB2414405B (en) * 2004-05-28 2009-01-14 Cilag Ag Int Injection device
GB0414054D0 (en) 2004-06-23 2004-07-28 Owen Mumford Ltd Improvements relating to automatic injection devices
US20060106342A1 (en) * 2004-06-28 2006-05-18 Michael Cox Injection applicator for a hypodermic syringe
US7297136B2 (en) * 2004-12-06 2007-11-20 Wyrick Ronald E Medicine injection devices and methods
US8372044B2 (en) 2005-05-20 2013-02-12 Safety Syringes, Inc. Syringe with needle guard injection device
US20070173770A1 (en) 2006-01-23 2007-07-26 The Medical House Plc Injection device
WO2007131025A1 (en) 2006-05-03 2007-11-15 Antares Pharma, Inc. Injector with adjustable dosing
US7909842B2 (en) * 2006-06-15 2011-03-22 Abbott Diabetes Care Inc. Lancing devices having depth adjustment assembly
CN103316402A (zh) 2006-06-30 2013-09-25 艾伯维生物技术有限公司 自动注射装置
MX2009009494A (es) * 2007-03-09 2009-09-15 Lilly Co Eli Mecanismo de retardo para dispositivo de inyeccion automatica.
US8012120B2 (en) * 2007-09-13 2011-09-06 Avant Medical Corp. Device and method for the automatic initiation of an injection
GB0801874D0 (en) * 2008-02-01 2008-03-12 Liversidge Barry P Injection device
US8814834B2 (en) 2008-03-10 2014-08-26 Antares Pharma, Inc. Injector safety device
GB0900930D0 (en) * 2009-01-20 2009-03-04 Future Injection Technologies Ltd Injection device
GB0901801D0 (en) * 2009-02-05 2009-03-11 Medical House Plc The Improved autoinjector
TWI391154B (zh) * 2009-04-27 2013-04-01 Shl Group Ab 藥物輸送裝置
CN102458517B (zh) 2009-04-29 2014-07-23 阿布维生物技术有限公司 自动注射装置
NZ600069A (en) 2009-12-15 2015-02-27 Abbvie Biotechnology Ltd Improved firing button for automatic injection device
PT2542280E (pt) 2010-03-01 2014-09-12 Lilly Co Eli Dispositivo automático de injecção com mecanismo de atraso que inclui um membro de pressionar de dupla função
JP2013523202A (ja) 2010-03-25 2013-06-17 ニュー インジェクション システムズ リミテッド 注射器
NZ702172A (en) 2010-04-21 2016-03-31 Abbvie Biotechnology Ltd Wearable automatic injection device for controlled delivery of therapeutic agents
EP3187216B1 (en) 2011-01-24 2019-08-21 AbbVie Biotechnology Ltd. Automatic injection devices having overmolded gripping surfaces
AU2012209222B2 (en) * 2011-01-24 2015-07-09 Abbvie Biotechnology Ltd Removal of needle shields from syringes and automatic injection devices
US8992477B2 (en) 2011-01-24 2015-03-31 Elcam Agricultural Cooperative Association Ltd. Injector
ES2713007T3 (es) 2011-05-18 2019-05-17 Becton Dickinson Co Inyector de un único uso de bajo coste
FI2822618T3 (fi) 2012-03-06 2024-03-21 Antares Pharma Inc Esitäytetty injektioruisku laukeamisvoimaominaisuuden kera
AU2013349611B2 (en) 2012-11-23 2018-05-31 Sensile Medical Ag Auto-injector assembly
WO2014165136A1 (en) 2013-03-12 2014-10-09 Antares Pharma, Inc. Constant volume prefilled syringes and kits thereof
ES2927108T3 (es) 2013-03-14 2022-11-02 Lilly Co Eli Mecanismo de retardo adecuado para dispositivo de inyección automática compacto
HUE033629T2 (en) 2013-03-14 2017-12-28 Lilly Co Eli Release mechanism for automatic injection device
KR20170097020A (ko) 2014-12-23 2017-08-25 오토메드 피티와이 리미티드 딜리버리 장치, 시스템 및 관련 방법
CN108290000B (zh) * 2015-08-13 2021-03-19 温德加普医疗股份有限公司 具有无菌特征部的混合和注射装置
KR102535764B1 (ko) 2016-03-28 2023-05-30 아이커 메디칼 시스템스 인코포레이티드 치료제를 전달하기 위한 장치
US12569620B2 (en) 2018-01-19 2026-03-10 Birya Biotech, Inc. Tool for servicing an auto-injector
US11957542B2 (en) 2020-04-30 2024-04-16 Automed Patent Holdco, Llc Sensing complete injection for animal injection device

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE511524A (enExample) *
FR505931A (fr) * 1919-11-11 1920-08-10 Richard Heller Appareil pour injections hypodermiques et autres
DE378714C (de) * 1923-07-30 Charles De Montet Dr Selbsttaetiger Injektionsapparat
FR1014881A (fr) * 1950-03-21 1952-08-25 Appareil automatique pour injections parentérales
FR2506161A1 (fr) * 1981-05-20 1982-11-26 Alsetex Armement Seringue auto-injectante
DE8813938U1 (de) * 1988-11-08 1989-12-07 Nothdurft, Klaus, 7000 Stuttgart Injektionsgerät
WO1995019194A1 (fr) * 1994-01-17 1995-07-20 Laboratoire Aguettant Injecteur automatique de medicament

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894054A (en) * 1988-06-20 1990-01-16 Miskinyar Shir A Preloaded automatic disposable syringe
US5358489A (en) * 1993-05-27 1994-10-25 Washington Biotech Corporation Reloadable automatic or manual emergency injection system

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE511524A (enExample) *
DE378714C (de) * 1923-07-30 Charles De Montet Dr Selbsttaetiger Injektionsapparat
FR505931A (fr) * 1919-11-11 1920-08-10 Richard Heller Appareil pour injections hypodermiques et autres
FR1014881A (fr) * 1950-03-21 1952-08-25 Appareil automatique pour injections parentérales
FR2506161A1 (fr) * 1981-05-20 1982-11-26 Alsetex Armement Seringue auto-injectante
DE8813938U1 (de) * 1988-11-08 1989-12-07 Nothdurft, Klaus, 7000 Stuttgart Injektionsgerät
WO1995019194A1 (fr) * 1994-01-17 1995-07-20 Laboratoire Aguettant Injecteur automatique de medicament

Cited By (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6428528B2 (en) 1998-08-11 2002-08-06 Antares Pharma, Inc. Needle assisted jet injector
US6565553B2 (en) 1998-08-11 2003-05-20 Antares Pharma, Inc. Needle assisted jet injector
US6746429B2 (en) 1998-08-11 2004-06-08 Antares Pharma, Inc. Needle assisted jet injector
US6391003B1 (en) 1999-10-25 2002-05-21 Antares Pharma, Inc. Locking mechanism for a jet injector
US9737670B2 (en) 2002-02-11 2017-08-22 Antares Pharma, Inc. Intradermal injector
US9333309B2 (en) 2002-02-11 2016-05-10 Antares Pharma, Inc. Intradermal injector
US8298171B2 (en) 2002-07-02 2012-10-30 Panasonic Corporation Automatic administration instrument for medical use
US9731074B2 (en) 2002-07-02 2017-08-15 Panasonic Healthcare Holdings, Co., Ltd. Automatic administration instrument for medical use
US10363368B2 (en) 2002-07-02 2019-07-30 Phc Holdings Corporation Automatic administration instrument for medical use
US10814064B2 (en) 2002-07-02 2020-10-27 Phc Holdings Corporation Automatic administration instrument for medical use
US8679055B2 (en) 2002-07-02 2014-03-25 Panasonic Corporation Automatic administration instrument for medical use
US10821230B2 (en) 2002-07-02 2020-11-03 Phc Holdings Corporation Automatic administration instrument for medical use
US10828420B2 (en) 2002-07-02 2020-11-10 Phc Holdings Corporation Automatic administration instrument for medical use
US10881794B2 (en) 2002-07-02 2021-01-05 Phc Holdings Corporation Automatic administration instrument for medical use
US10912887B2 (en) 2002-07-02 2021-02-09 Phc Holdings Corporation Automatic administration instrument for medical use
US8313465B2 (en) 2004-05-28 2012-11-20 Cilag Gmbh International Injection device
US8313464B2 (en) 2004-05-28 2012-11-20 Cilag Gmbh International Injection device
US8313463B2 (en) 2004-05-28 2012-11-20 Cilag Gmbh International Injection device
US9675757B2 (en) 2004-05-28 2017-06-13 Cilag Gmbh International Injection device
US8343110B2 (en) 2004-05-28 2013-01-01 Cilag Gmbh International Injection device
US9895493B2 (en) 2004-05-28 2018-02-20 Cilag Gmbh International Injection device
US8277414B2 (en) 2004-05-28 2012-10-02 Cilag Gmbh International Injection device
US9675758B2 (en) 2004-05-28 2017-06-13 Cilag Gmbh International Injection device
US10478560B2 (en) 2005-01-24 2019-11-19 Antares Pharma, Inc. Prefilled syringe injector
US11446441B2 (en) 2005-01-24 2022-09-20 Antares Pharma, Inc. Prefilled syringe injector
US9180259B2 (en) 2005-01-24 2015-11-10 Antares Pharma, Inc. Prefilled syringe jet injector
US12576210B2 (en) 2005-01-24 2026-03-17 Antares Pharma, Inc. Prefilled syringe injector
US9629959B2 (en) 2005-01-24 2017-04-25 Antares Pharma, Inc. Prefilled syringe jet injector
US8968236B2 (en) 2005-04-06 2015-03-03 Cilag Gmbh International Injection device
US8366669B2 (en) 2005-04-06 2013-02-05 Cilag Gmbh International Injection device
US9649441B2 (en) 2005-04-06 2017-05-16 Cilag Gmbh International Injection device (bayonet cap removal)
US9731080B2 (en) 2005-04-06 2017-08-15 Cilag Gmbh International Injection device
US8317751B2 (en) 2005-04-06 2012-11-27 Cilag Gmbh International Injection device
US9358346B2 (en) 2005-08-30 2016-06-07 Cilag Gmbh International Needle assembly for a prefilled syringe system
US7402150B2 (en) 2005-09-05 2008-07-22 Jcr Pharmaceuticals Co., Ltd. Injection device
EP1759728A1 (en) * 2005-09-05 2007-03-07 JCR Pharmaceuticals Co., Ltd. Injection device for two-compartment syringes
US9770558B2 (en) 2005-09-27 2017-09-26 Cilag Gmbh International Auto-injection device with needle protecting cap having outer and inner sleeves
EP1790366A1 (en) * 2005-11-29 2007-05-30 JCR Pharmaceuticals Co., Ltd. Injection device
US11547808B2 (en) 2006-05-03 2023-01-10 Antares Pharma, Inc. Two-stage reconstituting injector
US10688250B2 (en) 2006-05-03 2020-06-23 Antares Pharma, Inc. Two-stage reconstituting injector
US9808582B2 (en) 2006-05-03 2017-11-07 Antares Pharma, Inc. Two-stage reconstituting injector
US9028451B2 (en) 2006-06-01 2015-05-12 Cilag Gmbh International Injection device
US9072833B2 (en) 2006-06-01 2015-07-07 Cilag Gmbh International Injection device
AU2007266882B2 (en) * 2006-06-01 2011-05-26 Cilag Gmbh International Cap for injection device
EA014264B1 (ru) * 2006-06-01 2010-10-29 Цилаг Гмбх Интернэшнл Устройство для инъекций
US9757520B2 (en) 2006-06-01 2017-09-12 Cilag Gmbh International Injection device
WO2007138296A1 (en) * 2006-06-01 2007-12-06 Cilag Gmbh International Cap for injection device
US9682194B2 (en) 2008-06-19 2017-06-20 Cilag Gmbh International Re-useable auto-injector with filling means
US8845594B2 (en) 2008-06-19 2014-09-30 Cilag Gmbh International Auto-injector with filling means
US8834419B2 (en) 2008-06-19 2014-09-16 Cilag Gmbh International Reusable auto-injector
US9028453B2 (en) 2008-06-19 2015-05-12 Cilag Gmbh International Reusable auto-injector
US8939958B2 (en) 2008-06-19 2015-01-27 Cilag Gmbh International Fluid transfer assembly for a syringe
US8915889B2 (en) 2008-08-05 2014-12-23 Antares Pharma, Inc. Multiple dosage injector
US11497753B2 (en) 2009-03-20 2022-11-15 Antares Pharma, Inc. Hazardous agent injection system
US10555954B2 (en) 2009-03-20 2020-02-11 Antares Pharma, Inc. Hazardous agent injection system
US12357642B2 (en) 2009-03-20 2025-07-15 Antares Pharma, Inc. Hazardous agent injection system
US9750881B2 (en) 2009-03-20 2017-09-05 Antares Pharma, Inc. Hazardous agent injection system
US8945063B2 (en) 2009-03-20 2015-02-03 Antares Pharma, Inc. Hazardous agent injection system
US8529518B2 (en) 2009-06-12 2013-09-10 Novo Nordisk A/S Drug delivery device with cap functions for needle assembly
US10058660B2 (en) 2010-04-23 2018-08-28 Tip-Top.Com Ltd Needle safety devices
WO2011131996A1 (en) * 2010-04-23 2011-10-27 Barry Peter Liversidge Safety needle device
US10195362B2 (en) 2010-04-23 2019-02-05 Tip-Top.Com Ltd Safety needle device
WO2011131997A1 (en) * 2010-04-23 2011-10-27 Barry Peter Liversidge Needle safety devices
US9814839B2 (en) 2011-03-24 2017-11-14 Owen Mumford Limited Autoinjector device
GB2486748A (en) * 2011-03-24 2012-06-27 Owen Mumford Ltd Autoinjector devices
GB2486748B (en) * 2011-03-24 2013-04-10 Owen Mumford Ltd Autoinjector devices
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
US10279131B2 (en) 2011-07-15 2019-05-07 Antares Pharma, Inc. Injection device with cammed RAM assembly
US12179007B2 (en) 2011-07-15 2024-12-31 Antares Pharma, Inc. Injection device with cammed ram assembly
US9446195B2 (en) 2011-07-15 2016-09-20 Antares Pharma, Inc. Injection device with cammed ram assembly
US10568809B2 (en) 2011-07-15 2020-02-25 Ferring B.V. Liquid-transfer adapter beveled spike
US9849242B2 (en) 2011-11-24 2017-12-26 Sanofi-Aventis Deutschland Gmbh Autoinjector
EP2596822A1 (en) * 2011-11-24 2013-05-29 Sanofi-Aventis Deutschland GmbH Autoinjector
CN104066466A (zh) * 2011-11-24 2014-09-24 赛诺菲-安万特德国有限公司 自我注射器
CN104066466B (zh) * 2011-11-24 2016-12-28 赛诺菲-安万特德国有限公司 自我注射器
JP2014533564A (ja) * 2011-11-24 2014-12-15 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 自動注射器
WO2013076246A1 (en) * 2011-11-24 2013-05-30 Sanofi-Aventis Deutschland Gmbh Autoinjector
US11771646B2 (en) 2012-04-06 2023-10-03 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
US10821072B2 (en) 2012-04-06 2020-11-03 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
US9950125B2 (en) 2012-04-06 2018-04-24 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
US12171986B2 (en) 2012-05-07 2024-12-24 Antares Pharma, Inc. Injection device with cammed ram assembly
US9364610B2 (en) 2012-05-07 2016-06-14 Antares Pharma, Inc. Injection device with cammed ram assembly
US10357609B2 (en) 2012-05-07 2019-07-23 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
US9364611B2 (en) 2012-05-07 2016-06-14 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
US10905827B2 (en) 2012-05-07 2021-02-02 Antares Pharma, Inc. Injection device with cammed ram assembly
US12220560B2 (en) 2012-05-07 2025-02-11 Antares Pharma, Inc. Needle assisted injection device having reduced trigger force
US11446440B2 (en) 2012-05-07 2022-09-20 Antares Pharma, Inc. Needle assisted injection device having reduced trigger force
US12318581B2 (en) 2013-02-11 2025-06-03 Antares Pharma, Inc. Needle assisted injection device having reduced trigger force
US10881798B2 (en) 2013-02-11 2021-01-05 Antares Pharma, Inc. Needle assisted injection device having reduced trigger force
US9744302B2 (en) 2013-02-11 2017-08-29 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
US11813435B2 (en) 2013-02-11 2023-11-14 Antares Pharma, Inc. Needle assisted injection device having reduced trigger force
US9707354B2 (en) 2013-03-11 2017-07-18 Antares Pharma, Inc. Multiple dosage injector with rack and pinion dosage system
US11628260B2 (en) 2013-03-11 2023-04-18 Antares Pharma, Inc. Multiple dosage injector with rack and pinion dosage system
US12576213B2 (en) 2013-03-11 2026-03-17 Antares Pharma, Inc. Multiple dosage injector with rack and pinion dosage system having ram that includes a lockout protrusion
US10610649B2 (en) 2013-03-11 2020-04-07 Antares Pharma, Inc. Multiple dosage injector with rack and pinion dosage system
US10799646B2 (en) 2013-06-11 2020-10-13 Cilag Gmbh International Injection device
US11173255B2 (en) 2013-06-11 2021-11-16 Cilag Gmbh International Injection device
US11123492B2 (en) 2013-06-11 2021-09-21 Cilag Gmbh International Injection device
US10709849B2 (en) 2013-06-11 2020-07-14 Cilag Gmbh International Guide for an injection device
US12558483B2 (en) * 2020-03-30 2026-02-24 Ypsomed Ag Autoinjector with multichamber product container
US20230022361A1 (en) * 2020-03-30 2023-01-26 Ypsomed Ag Autoinjector with multichamber product container

Also Published As

Publication number Publication date
US6077247A (en) 2000-06-20
EP0906131A1 (en) 1999-04-07
EP0906131B1 (en) 2003-01-15
JP4559541B2 (ja) 2010-10-06
DE69718468D1 (de) 2003-02-20
JP2000512523A (ja) 2000-09-26
GB9612724D0 (en) 1996-08-21
DE69718468T2 (de) 2003-10-02

Similar Documents

Publication Publication Date Title
EP0906131B1 (en) Improvements relating to injection devices
JP6110433B2 (ja) 自動注射器
US6159181A (en) Injection device
CA2509323C (en) Injection device
US7695453B2 (en) Injection devices
US5300030A (en) Injection devices
CN101784297B (zh) 注射设备
EP1071488B1 (en) Improvements relating to injection devices
JP5275031B2 (ja) 内側スリーブおよび外側スリーブを有する針保護キャップを備えた自動注射装置
US6149608A (en) Skin prickers
EP2670458B1 (en) Medicament delivery device
EP1003580B1 (en) Injection device
MXPA06013893A (es) Dispositivo de acoplamiento e inyeccion que se puede liberar.
EP1174158A1 (en) Safety syringe
HK1154219A (en) Injection device having a release mechanism to delay release of the syringe
HK1173397B (en) Injection device

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 09202687

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 1997926127

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1997926127

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 1997926127

Country of ref document: EP