WO1997046585A3 - Fragments de leptine (proteine ob) - Google Patents
Fragments de leptine (proteine ob) Download PDFInfo
- Publication number
- WO1997046585A3 WO1997046585A3 PCT/EP1997/002968 EP9702968W WO9746585A3 WO 1997046585 A3 WO1997046585 A3 WO 1997046585A3 EP 9702968 W EP9702968 W EP 9702968W WO 9746585 A3 WO9746585 A3 WO 9746585A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- leptin
- compound
- fragments
- protein
- analogue
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR9709529A BR9709529A (pt) | 1996-06-06 | 1997-06-04 | Fragmentos de leptina (proteína ob) |
CA002257240A CA2257240A1 (fr) | 1996-06-06 | 1997-06-04 | Fragments de leptine (proteine ob) |
NZ332879A NZ332879A (en) | 1996-06-06 | 1997-06-04 | Use of fragments of leptin (ob protein) in medicaments for treating obesity or diabetes |
IL12715397A IL127153A0 (en) | 1996-06-06 | 1997-06-04 | Fragments of leptin (ob protein) |
AU33372/97A AU3337297A (en) | 1996-06-06 | 1997-06-04 | Fragments of leptin (ob protein) |
HU0001774A HUP0001774A3 (en) | 1997-02-20 | 1997-06-04 | Fragments of leptin (ob protein) |
JP10500240A JP2000512137A (ja) | 1996-06-06 | 1997-06-04 | レプチン(obタンパク質)のフラグメント |
EP97929156A EP0912609A2 (fr) | 1996-06-06 | 1997-06-04 | Fragments de leptine (proteine ob) |
NO985683A NO985683L (no) | 1996-06-06 | 1998-12-04 | Fragmenter av leptin (ob protein) |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9611775.9A GB9611775D0 (en) | 1996-06-06 | 1996-06-06 | Novel compounds |
GB9611775.9 | 1996-06-06 | ||
GBGB9618540.0A GB9618540D0 (en) | 1996-09-05 | 1996-09-05 | Novel compounds |
GB9618540.0 | 1996-09-05 | ||
GBGB9703493.8A GB9703493D0 (en) | 1997-02-20 | 1997-02-20 | Novel compounds |
GB9703493.8 | 1997-02-20 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09194866 A-371-Of-International | 1998-12-04 | ||
US09/844,774 Continuation US20020037553A1 (en) | 1996-06-06 | 2001-04-27 | Fragments of leptin (ob protein) |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1997046585A2 WO1997046585A2 (fr) | 1997-12-11 |
WO1997046585A3 true WO1997046585A3 (fr) | 1998-04-23 |
Family
ID=27268305
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1997/002968 WO1997046585A2 (fr) | 1996-06-06 | 1997-06-04 | Fragments de leptine (proteine ob) |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0912609A2 (fr) |
JP (1) | JP2000512137A (fr) |
KR (1) | KR20000016402A (fr) |
CN (1) | CN1221426A (fr) |
AR (1) | AR008765A1 (fr) |
AU (1) | AU3337297A (fr) |
BR (1) | BR9709529A (fr) |
CA (1) | CA2257240A1 (fr) |
CZ (1) | CZ397898A3 (fr) |
IL (1) | IL127153A0 (fr) |
NO (1) | NO985683L (fr) |
NZ (1) | NZ332879A (fr) |
PL (1) | PL330361A1 (fr) |
TR (1) | TR199802534T2 (fr) |
WO (1) | WO1997046585A2 (fr) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU756617B2 (en) | 1998-07-28 | 2003-01-16 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Leptin-mediated gene-induction |
US6777388B1 (en) * | 1998-08-21 | 2004-08-17 | Clf Medical Technology Acceleration Program, Inc. | Leptin-related peptides |
US7208572B2 (en) * | 1998-08-21 | 2007-04-24 | Albany Medical College | Leptin-related peptides |
US6420339B1 (en) | 1998-10-14 | 2002-07-16 | Amgen Inc. | Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility |
AU782230B2 (en) * | 1999-09-22 | 2005-07-14 | Serono Genetics Institute S.A. | Methods of screening for compounds that modulate the LSR-leptin interaction and their use in the prevention and treatment of obesity-related diseases |
AU8178401A (en) | 2000-05-22 | 2001-12-03 | Vlaams Interuniv Inst Biotech | Receptor-based interaction trap |
PL214862B1 (pl) | 2001-10-22 | 2013-09-30 | Amgen | Sposób in vitro do okreslania predyspozycji pacjenta ludzkiego z lipoatrofia do reagowania na leczenie bialkiem leptyny, kompozycje farmaceutyczne do zastosowania do leczenia lipoatrofii i kompozycje farmaceutyczne zawierajace bialko leptyny |
ATE390144T1 (de) | 2003-09-08 | 2008-04-15 | Serono Lab | Behandlung von fibrosen |
WO2005077072A2 (fr) | 2004-02-11 | 2005-08-25 | Amylin Pharmaceuticals, Inc. | Polypeptides hybrides presentant des proprietes pouvant etre choisies |
EP1812038A1 (fr) | 2004-11-18 | 2007-08-01 | VIB vzw | Domaine de fibronectine iii servant d'antagonistes de recepteurs de la leptine |
WO2007022123A2 (fr) | 2005-08-11 | 2007-02-22 | Amylin Pharmaceuticals, Inc. | Polypeptides hybrides presentant des proprietes selectionnables |
EP2390264A1 (fr) | 2005-02-11 | 2011-11-30 | Amylin Pharmaceuticals Inc. | Analogues de GIP et polypeptides hybrides de GIP aux propriétés sélectionnables |
US7629315B2 (en) | 2005-03-09 | 2009-12-08 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Compositions for blocking the inhibitory effect of human CRP on human leptin |
BRPI0614649A2 (pt) | 2005-08-11 | 2011-04-12 | Amylin Pharmaceuticals Inc | polipeptìdeos hìbridos com propriedades selecionáveis |
ES2319048B1 (es) * | 2007-06-20 | 2010-02-10 | Universitat De Les Illes Balears | Uso de leptina en el tratamiento de alteraciones en los habitos alimentarios. |
US8889622B2 (en) | 2007-07-25 | 2014-11-18 | Washington University | Methods of inhibiting seizure in a subject |
GB2451858A (en) * | 2007-08-15 | 2009-02-18 | Sergiy Konovchuk | Methods of reducing body fat and treating obesity |
AU2008333173A1 (en) | 2007-12-05 | 2009-06-11 | Astrazeneca Ab | Piperazines as anti-obesity agents |
CN102015668A (zh) | 2007-12-05 | 2011-04-13 | 阿斯利康(瑞典)有限公司 | 用作瘦蛋白受体调节剂的哌嗪衍生物及其用途 |
KR20110015446A (ko) * | 2008-06-04 | 2011-02-15 | 아스트라제네카 아베 | 렙틴 수용체 조절제 유사체로서의 신규한 피리딘 유도체 |
MX2010013355A (es) * | 2008-06-04 | 2010-12-21 | Astrazeneca Ab | Nuevos compuestos v. |
JP2012523434A (ja) | 2009-04-10 | 2012-10-04 | アミリン・ファーマシューティカルズ,インコーポレイテッド | エストロゲン欠乏哺乳類のためのアミリンアゴニスト化合物 |
ES2602436T3 (es) * | 2010-05-11 | 2017-02-21 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Inhibidor basado en péptido de la activación de interleucina 10 o STAT-3 |
ES2641869T3 (es) | 2010-09-28 | 2017-11-14 | Aegerion Pharmaceuticals, Inc. | Polipéptidos de fusión de leptina-ABD con duración de acción aumentada |
CN104829707B (zh) * | 2015-05-06 | 2017-12-19 | 广东省生物资源应用研究所 | 一条cd环和e螺旋区突变的瘦素活性肽及其编码基因和应用 |
CN110183530A (zh) * | 2019-06-21 | 2019-08-30 | 深圳市亚辉龙生物科技股份有限公司 | 瘦素免疫原、杂交瘤细胞、单克隆抗体、多克隆抗体及应用 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996005309A2 (fr) * | 1994-08-17 | 1996-02-22 | The Rockefeller University | Modulateurs de masse corporelle, proteines et acides nucleiques correspondants, et utilisations a des fins therapeutiques et diagnostiques |
WO1996023815A1 (fr) * | 1995-01-31 | 1996-08-08 | Eli Lilly And Company | Anticorps contre les produits du gene ob |
WO1996023519A1 (fr) * | 1995-01-31 | 1996-08-08 | Eli Lilly And Company | Proteines agissant contre l'obesite |
WO1996023514A1 (fr) * | 1995-01-31 | 1996-08-08 | Eli Lilly And Company | Proteines anti-obesite |
WO1996031526A1 (fr) * | 1995-04-06 | 1996-10-10 | Amylin Pharmaceuticals, Inc. | Agents antiobesite |
WO1996034885A2 (fr) * | 1995-05-05 | 1996-11-07 | Smithkline Beecham Plc | Fragments peptidiques biologiquement actifs de proteines ob |
-
1997
- 1997-06-04 WO PCT/EP1997/002968 patent/WO1997046585A2/fr not_active Application Discontinuation
- 1997-06-04 JP JP10500240A patent/JP2000512137A/ja active Pending
- 1997-06-04 IL IL12715397A patent/IL127153A0/xx unknown
- 1997-06-04 CA CA002257240A patent/CA2257240A1/fr not_active Abandoned
- 1997-06-04 PL PL97330361A patent/PL330361A1/xx unknown
- 1997-06-04 EP EP97929156A patent/EP0912609A2/fr not_active Withdrawn
- 1997-06-04 CN CN97195311A patent/CN1221426A/zh active Pending
- 1997-06-04 TR TR1998/02534T patent/TR199802534T2/xx unknown
- 1997-06-04 NZ NZ332879A patent/NZ332879A/xx not_active IP Right Cessation
- 1997-06-04 CZ CZ983978A patent/CZ397898A3/cs unknown
- 1997-06-04 KR KR1019980709976A patent/KR20000016402A/ko not_active Application Discontinuation
- 1997-06-04 AU AU33372/97A patent/AU3337297A/en not_active Abandoned
- 1997-06-04 BR BR9709529A patent/BR9709529A/pt not_active Application Discontinuation
- 1997-06-04 AR ARP970102432A patent/AR008765A1/es unknown
-
1998
- 1998-12-04 NO NO985683A patent/NO985683L/no not_active Application Discontinuation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996005309A2 (fr) * | 1994-08-17 | 1996-02-22 | The Rockefeller University | Modulateurs de masse corporelle, proteines et acides nucleiques correspondants, et utilisations a des fins therapeutiques et diagnostiques |
WO1996023815A1 (fr) * | 1995-01-31 | 1996-08-08 | Eli Lilly And Company | Anticorps contre les produits du gene ob |
WO1996023519A1 (fr) * | 1995-01-31 | 1996-08-08 | Eli Lilly And Company | Proteines agissant contre l'obesite |
WO1996023514A1 (fr) * | 1995-01-31 | 1996-08-08 | Eli Lilly And Company | Proteines anti-obesite |
WO1996031526A1 (fr) * | 1995-04-06 | 1996-10-10 | Amylin Pharmaceuticals, Inc. | Agents antiobesite |
WO1996034885A2 (fr) * | 1995-05-05 | 1996-11-07 | Smithkline Beecham Plc | Fragments peptidiques biologiquement actifs de proteines ob |
Non-Patent Citations (2)
Title |
---|
DATABASE TOXLIT AN 1970:3841 * |
K.C. SAXENA ET AL.: "Hydrolysis of Peptides containing D-amino acids by Rabbit Tissues", INDIAN JOURNAL OF BIOCHEMISTRY, vol. 6, no. 4, 1969, pages 226 - 227 * |
Also Published As
Publication number | Publication date |
---|---|
PL330361A1 (en) | 1999-05-10 |
AR008765A1 (es) | 2000-02-23 |
CZ397898A3 (cs) | 1999-04-14 |
NO985683D0 (no) | 1998-12-04 |
AU3337297A (en) | 1998-01-05 |
CA2257240A1 (fr) | 1997-12-11 |
JP2000512137A (ja) | 2000-09-19 |
CN1221426A (zh) | 1999-06-30 |
EP0912609A2 (fr) | 1999-05-06 |
BR9709529A (pt) | 1999-08-10 |
TR199802534T2 (xx) | 1999-03-22 |
WO1997046585A2 (fr) | 1997-12-11 |
NZ332879A (en) | 2000-09-29 |
KR20000016402A (ko) | 2000-03-25 |
IL127153A0 (en) | 1999-09-22 |
NO985683L (no) | 1998-12-04 |
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