WO1997036553A1 - Copolymeres cristallins et procede de production de ces copolymeres - Google Patents

Copolymeres cristallins et procede de production de ces copolymeres Download PDF

Info

Publication number
WO1997036553A1
WO1997036553A1 PCT/US1997/005294 US9705294W WO9736553A1 WO 1997036553 A1 WO1997036553 A1 WO 1997036553A1 US 9705294 W US9705294 W US 9705294W WO 9736553 A1 WO9736553 A1 WO 9736553A1
Authority
WO
WIPO (PCT)
Prior art keywords
glycolide
crystalline
copolymer
lactide
added
Prior art date
Application number
PCT/US1997/005294
Other languages
English (en)
Inventor
Andrew M. Lichkus
Hildegard I. Kramer
Original Assignee
American Cyanamid Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Company filed Critical American Cyanamid Company
Priority to AU26004/97A priority Critical patent/AU2600497A/en
Priority to JP9535530A priority patent/JP2000508017A/ja
Priority to EP97917758A priority patent/EP0907338A4/fr
Priority to BR9710651A priority patent/BR9710651A/pt
Publication of WO1997036553A1 publication Critical patent/WO1997036553A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/78—Preparation processes
    • C08G63/82—Preparation processes characterised by the catalyst used
    • C08G63/823—Preparation processes characterised by the catalyst used for the preparation of polylactones or polylactides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06—At least partially resorbable materials
    • A61L17/10—At least partially resorbable materials containing macromolecular materials
    • A61L17/12—Homopolymers or copolymers of glycolic acid or lactic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Surgery (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

Cette invention concerne des copolymères cristallins de glycolide et de dl-lactide inactif sur la plan optique, lesquels copolymères comprennent 62 % en poids, ou moins, de glycolide. Cette invention concerne également des procédés de production de ces copolymères, ainsi que des dispositifs médicaux pouvant être absorbés qui sont fabriqués à partir de ces copolymères, et qui possèdent de meilleures propriétés.
PCT/US1997/005294 1996-04-01 1997-03-31 Copolymeres cristallins et procede de production de ces copolymeres WO1997036553A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU26004/97A AU2600497A (en) 1996-04-01 1997-03-31 Crystalline copolymers and methods of producing such copolymers
JP9535530A JP2000508017A (ja) 1996-04-01 1997-03-31 結晶コポリマー及びその製造方法
EP97917758A EP0907338A4 (fr) 1996-04-01 1997-03-31 Copolymeres cristallins et procede de production de ces copolymeres
BR9710651A BR9710651A (pt) 1996-04-01 1997-03-31 Copol¡meros cristalinos e processos de produ-Æo de tais copol¡meros

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1468196P 1996-04-01 1996-04-01
US60/014,681 1996-04-01

Publications (1)

Publication Number Publication Date
WO1997036553A1 true WO1997036553A1 (fr) 1997-10-09

Family

ID=21767008

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/005294 WO1997036553A1 (fr) 1996-04-01 1997-03-31 Copolymeres cristallins et procede de production de ces copolymeres

Country Status (6)

Country Link
EP (1) EP0907338A4 (fr)
JP (1) JP2000508017A (fr)
AU (1) AU2600497A (fr)
BR (1) BR9710651A (fr)
CA (1) CA2250760A1 (fr)
WO (1) WO1997036553A1 (fr)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1032310A1 (fr) * 1997-09-05 2000-09-06 United States Surgical Corporation Copolymeres sequences absorbables et articles chirurgicaux fabriques avec ces derniers
EP1034806A2 (fr) * 1999-03-05 2000-09-13 Stryker Technologies Corporation Matériaux bioabsorbables et articles médicaux
US6747121B2 (en) 2001-09-05 2004-06-08 Synthes (Usa) Poly(L-lactide-co-glycolide) copolymers, methods for making and using same, and devices containing same
DE102007036101A1 (de) 2007-08-01 2009-02-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue glycolidreiche Copolymere
US7494950B2 (en) 2003-09-05 2009-02-24 Synthes (U.S.A.) Bone cement compositions having fiber-reinforcement and/or increased flowability
US7700819B2 (en) 2001-02-16 2010-04-20 Kci Licensing, Inc. Biocompatible wound dressing
US7763769B2 (en) 2001-02-16 2010-07-27 Kci Licensing, Inc. Biocompatible wound dressing
WO2010085608A1 (fr) * 2009-01-23 2010-07-29 Surmodics Pharmaceuticals, Inc. Mélanges de polymères comprenant des polymères ayant différentes unités non répétitives et leurs procédés de fabrication et d'utilisation
EP2308517A2 (fr) 2004-06-10 2011-04-13 Synthes USA Os composite flexible
CN113788938A (zh) * 2021-09-15 2021-12-14 杭州锐健马斯汀医疗器材有限公司 一种医用丙交酯聚合物及其制备方法
RU2818268C1 (ru) * 2023-11-15 2024-04-26 Общество с ограниченной ответственностью "ТВС" (ООО "ТВС") Способ получения (со)полимера гликолида и/или лактида для изготовления рассасывающихся хирургических изделий

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4137921A (en) * 1977-06-24 1979-02-06 Ethicon, Inc. Addition copolymers of lactide and glycolide and method of preparation
US4243775A (en) * 1978-11-13 1981-01-06 American Cyanamid Company Synthetic polyester surgical articles
US4443430A (en) * 1982-11-16 1984-04-17 Ethicon, Inc. Synthetic absorbable hemostatic agent
US5320624A (en) * 1991-02-12 1994-06-14 United States Surgical Corporation Blends of glycolide and/or lactide polymers and caprolactone and/or trimethylene carbonate polymers and absorbable surgical devices made therefrom

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1123984A (fr) * 1977-11-16 1982-05-18 Yuzi Okuzumi Copolymeres sequences de lactide et de glycolide et protheses chirurgicales
JPH0613602B2 (ja) * 1987-07-14 1994-02-23 三井東圧化学株式会社 ｄ▲ｌ▼−乳酸−グリコール酸共重合物の製造方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4137921A (en) * 1977-06-24 1979-02-06 Ethicon, Inc. Addition copolymers of lactide and glycolide and method of preparation
US4157437A (en) * 1977-06-24 1979-06-05 Ethicon, Inc. Addition copolymers of lactide and glycolide and method of preparation
US4243775A (en) * 1978-11-13 1981-01-06 American Cyanamid Company Synthetic polyester surgical articles
US4443430A (en) * 1982-11-16 1984-04-17 Ethicon, Inc. Synthetic absorbable hemostatic agent
US5320624A (en) * 1991-02-12 1994-06-14 United States Surgical Corporation Blends of glycolide and/or lactide polymers and caprolactone and/or trimethylene carbonate polymers and absorbable surgical devices made therefrom

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP0907338A4 *

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1032310A1 (fr) * 1997-09-05 2000-09-06 United States Surgical Corporation Copolymeres sequences absorbables et articles chirurgicaux fabriques avec ces derniers
EP1032310A4 (fr) * 1997-09-05 2003-03-12 United States Surgical Corp Copolymeres sequences absorbables et articles chirurgicaux fabriques avec ces derniers
EP1034806A2 (fr) * 1999-03-05 2000-09-13 Stryker Technologies Corporation Matériaux bioabsorbables et articles médicaux
EP1034806A3 (fr) * 1999-03-05 2000-11-22 Stryker Technologies Corporation Matériaux bioabsorbables et articles médicaux
US6206883B1 (en) 1999-03-05 2001-03-27 Stryker Technologies Corporation Bioabsorbable materials and medical devices made therefrom
US6716957B2 (en) 1999-03-05 2004-04-06 Stryker Technologies Corporation Bioabsorbable materials and medical devices made therefrom
US7700819B2 (en) 2001-02-16 2010-04-20 Kci Licensing, Inc. Biocompatible wound dressing
US8084664B2 (en) 2001-02-16 2011-12-27 Kci Licensing, Inc. Biocompatible wound dressing
US8735644B2 (en) 2001-02-16 2014-05-27 Kci Licensing, Inc. Biocompatible wound dressing
US8163974B2 (en) 2001-02-16 2012-04-24 Kci Licensing, Inc. Biocompatible wound dressing
US7763769B2 (en) 2001-02-16 2010-07-27 Kci Licensing, Inc. Biocompatible wound dressing
US6747121B2 (en) 2001-09-05 2004-06-08 Synthes (Usa) Poly(L-lactide-co-glycolide) copolymers, methods for making and using same, and devices containing same
EP1591132A3 (fr) * 2001-09-05 2014-04-30 Synthes GmbH Terpolymères de poly(lactide-co-glycolide) et articles médicaux contenant ces terpolymères
US8057595B2 (en) 2003-09-05 2011-11-15 Synthes Usa, Llc Bone cement compositions having fiber-reinforcement and/or increased flowability
US7628851B2 (en) 2003-09-05 2009-12-08 Synthes Usa, Llc Bone cement compositions having fiber-reinforcement and/or increased flowability
US7494950B2 (en) 2003-09-05 2009-02-24 Synthes (U.S.A.) Bone cement compositions having fiber-reinforcement and/or increased flowability
EP3498312A1 (fr) 2003-09-05 2019-06-19 Synthes GmbH Composition de ciment osseux à renfort de fibres et/ou à fluidité améliorée
EP2308517A2 (fr) 2004-06-10 2011-04-13 Synthes USA Os composite flexible
US8771721B2 (en) 2004-06-10 2014-07-08 DePuy Synthes Products, LLC Flexible bone composite
DE102007036101A1 (de) 2007-08-01 2009-02-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue glycolidreiche Copolymere
WO2010085608A1 (fr) * 2009-01-23 2010-07-29 Surmodics Pharmaceuticals, Inc. Mélanges de polymères comprenant des polymères ayant différentes unités non répétitives et leurs procédés de fabrication et d'utilisation
CN113788938A (zh) * 2021-09-15 2021-12-14 杭州锐健马斯汀医疗器材有限公司 一种医用丙交酯聚合物及其制备方法
RU2818268C1 (ru) * 2023-11-15 2024-04-26 Общество с ограниченной ответственностью "ТВС" (ООО "ТВС") Способ получения (со)полимера гликолида и/или лактида для изготовления рассасывающихся хирургических изделий

Also Published As

Publication number Publication date
CA2250760A1 (fr) 1997-10-09
EP0907338A4 (fr) 1999-09-01
BR9710651A (pt) 1999-08-17
EP0907338A1 (fr) 1999-04-14
AU2600497A (en) 1997-10-22
JP2000508017A (ja) 2000-06-27

Similar Documents

Publication Publication Date Title
US4157437A (en) Addition copolymers of lactide and glycolide and method of preparation
US4118470A (en) Normally-solid, bioabsorbable, hydrolyzable, polymeric reaction product
US4122129A (en) Normally-solid, bioabsorbable, hydrolyzable, polymeric reaction product
JPH06122Y2 (ja) 合成コポリマー外科用縫合糸
US4095600A (en) Normally-solid, bioabsorbable, hydrolyzable, polymeric reaction product
EP0440448B1 (fr) Copolyesters cristallins de (lactide/glycolide) amorphe et de p-dioxanone
US4048256A (en) Normally-solid, bioabsorbable, hydrolyzable, polymeric reaction product
US4800219A (en) Polylactide compositions
US4766182A (en) Polylactide compositions
US5133739A (en) Segmented copolymers of ε-caprolactone and glycolide
JP3218055B2 (ja) 生吸収性セグメント化コポリマー
US4719246A (en) Polylactide compositions
EP2285863B1 (fr) Copolyesters résorbables de poly(éthoxyéthylène diglycolate) et de glycolide
US20040082755A1 (en) Monomer addition techniques to control manufacturing of bioabsorbable copolymers
WO1997036553A1 (fr) Copolymeres cristallins et procede de production de ces copolymeres
JP2001106772A (ja) 吸収性コポリラクチドおよびその使用
US7652127B2 (en) Absorbable copolyesters of poly(ethoxyethylene diglycolate) and glycolide
EP0441322B1 (fr) Copolymères segmentés d'epsilon-caprolactone et de glycolide
KR20150132318A (ko) 2개 이상의 카르복실산 기를 갖는 모놀 및 다이올 중합 개시제로부터 제조된 폴리락톤 중합체
MXPA98008072A (en) Crystalline copolymers and methods to produce such copolime
KR100817905B1 (ko) 생체적합성이 우수한 생분해성 지방족 폴리에스테르 수지 조성물 및 그 제조방법
US9200112B2 (en) Semi-crystalline, fast absorbing polymer formulation
KR960012437B1 (ko) 혼합촉매를 이용한 고점도 폴리에스테르의 제조방법
US8298260B2 (en) Compliant, long-lasting absorbable monofilament sutures
KR100894007B1 (ko) 필름용 생분해성 고점도 지방족 폴리에스테르 수지 및이의 제조방법

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE HU IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG US UZ VN AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH KE LS MW SD SZ UG AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
ENP Entry into the national phase

Ref document number: 2250760

Country of ref document: CA

Kind code of ref document: A

Ref document number: 2250760

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: PA/a/1998/008072

Country of ref document: MX

Ref document number: 1997917758

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 1997917758

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1997917758

Country of ref document: EP