WO1996018592A1 - Sels de phosphonium lies par la resine et leur utilisation dans la synthese organique - Google Patents

Sels de phosphonium lies par la resine et leur utilisation dans la synthese organique Download PDF

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Publication number
WO1996018592A1
WO1996018592A1 PCT/EP1995/004691 EP9504691W WO9618592A1 WO 1996018592 A1 WO1996018592 A1 WO 1996018592A1 EP 9504691 W EP9504691 W EP 9504691W WO 9618592 A1 WO9618592 A1 WO 9618592A1
Authority
WO
WIPO (PCT)
Prior art keywords
resin
polymer
phosphonium salt
bound
optionally substituted
Prior art date
Application number
PCT/EP1995/004691
Other languages
English (en)
Inventor
Ian Hughes
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Priority to JP8518181A priority Critical patent/JPH10510854A/ja
Priority to EP95941043A priority patent/EP0796233A1/fr
Publication of WO1996018592A1 publication Critical patent/WO1996018592A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B80/00—Linkers or spacers specially adapted for combinatorial chemistry or libraries, e.g. traceless linkers or safety-catch linkers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/40—Introducing phosphorus atoms or phosphorus-containing groups
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/18—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support using a particular method of attachment to the solid support
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Structural Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention se rapporte à la réalisation d'un procédé de chimie organique sur support solide, et notamment à l'utilisation d'un sel de phosphonium en tant qu'agent de liaison pour la synthèse en phase solide.
PCT/EP1995/004691 1994-12-10 1995-11-23 Sels de phosphonium lies par la resine et leur utilisation dans la synthese organique WO1996018592A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP8518181A JPH10510854A (ja) 1994-12-10 1995-11-23 樹脂結合ホスホニウム塩およびその有機合成における使用
EP95941043A EP0796233A1 (fr) 1994-12-10 1995-11-23 Sels de phosphonium lies par la resine et leur utilisation dans la synthese organique

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9424972.9A GB9424972D0 (en) 1994-12-10 1994-12-10 Process
GB9424972.9 1994-12-10

Publications (1)

Publication Number Publication Date
WO1996018592A1 true WO1996018592A1 (fr) 1996-06-20

Family

ID=10765747

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1995/004691 WO1996018592A1 (fr) 1994-12-10 1995-11-23 Sels de phosphonium lies par la resine et leur utilisation dans la synthese organique

Country Status (4)

Country Link
EP (1) EP0796233A1 (fr)
JP (1) JPH10510854A (fr)
GB (1) GB9424972D0 (fr)
WO (1) WO1996018592A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999028356A1 (fr) * 1997-11-28 1999-06-10 Active Materials Inc. Polymeres fonctionnels portant des derives oxacides non metalliques sur des bras dimethylene
WO2001079213A2 (fr) * 2000-04-13 2001-10-25 E.I. Dupont De Nemours And Company Synthese sur supports polymeres de ligands bidentes heteroatomiques convenant pour la catalyse
WO2002030558A2 (fr) * 2000-10-11 2002-04-18 Kalibrant Limited Groupe de liaison et procede de synthese chimique

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1148933A (en) * 1965-04-23 1969-04-16 Ferrania Spa The use of polymeric compound containing quaternary phosphonium recurring units as mordants for acid dyes
DE2052813A1 (en) * 1970-10-28 1972-05-10 Merck Patent Gmbh Polymeric triphenylphosphine reagents and their phosphonium - salts - used in olefin synthesis by wittig reaction
US3725365A (en) * 1971-04-08 1973-04-03 Dow Chemical Co Resins with phosphorane pendant groups and process for preparing same
US3919126A (en) * 1973-08-23 1975-11-11 Dow Chemical Co Insoluble polyalkyl phosphonium salt resins having crosslinked backbone
EP0096647A2 (fr) * 1982-05-28 1983-12-21 The Goodyear Tire & Rubber Company Procédé de préparation de polymères renfermant des groupes insaturés pendants
EP0216640A2 (fr) * 1985-09-25 1987-04-01 Toa Nenryo Kogyo Kabushiki Kaisha Composé catalytique et procédé pour la production de silanes
WO1994010214A1 (fr) * 1992-11-02 1994-05-11 Exxon Chemical Patents Inc. Ionomeres polymeres de phosphonium

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1148933A (en) * 1965-04-23 1969-04-16 Ferrania Spa The use of polymeric compound containing quaternary phosphonium recurring units as mordants for acid dyes
DE2052813A1 (en) * 1970-10-28 1972-05-10 Merck Patent Gmbh Polymeric triphenylphosphine reagents and their phosphonium - salts - used in olefin synthesis by wittig reaction
US3725365A (en) * 1971-04-08 1973-04-03 Dow Chemical Co Resins with phosphorane pendant groups and process for preparing same
US3919126A (en) * 1973-08-23 1975-11-11 Dow Chemical Co Insoluble polyalkyl phosphonium salt resins having crosslinked backbone
EP0096647A2 (fr) * 1982-05-28 1983-12-21 The Goodyear Tire & Rubber Company Procédé de préparation de polymères renfermant des groupes insaturés pendants
EP0216640A2 (fr) * 1985-09-25 1987-04-01 Toa Nenryo Kogyo Kabushiki Kaisha Composé catalytique et procédé pour la production de silanes
WO1994010214A1 (fr) * 1992-11-02 1994-05-11 Exxon Chemical Patents Inc. Ionomeres polymeres de phosphonium

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J. CASTELLS ET AL: "Reaction of dialdehydes with conventional and polymer-supported Wittig reagents", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS I, pages 1 - 6 *
M. BERNARD ET AL: "Wittig reagents bound to cross-linked polystyrenes", JOURNAL OF ORGANIC CHEMISTRY, vol. 48, pages 326 - 332 *
S. D. CLARKE ET AL: "Phase transfer catalysed polymer-supported Wittig reactions", TETRAHEDRON LETTERS, vol. 21, pages 1375 - 1378 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999028356A1 (fr) * 1997-11-28 1999-06-10 Active Materials Inc. Polymeres fonctionnels portant des derives oxacides non metalliques sur des bras dimethylene
US6448344B1 (en) 1997-11-28 2002-09-10 Active Materials, Inc. Functional polymers bearing non-metal oxyacid derivatives on dimethylene spaces
WO2001079213A2 (fr) * 2000-04-13 2001-10-25 E.I. Dupont De Nemours And Company Synthese sur supports polymeres de ligands bidentes heteroatomiques convenant pour la catalyse
WO2001079213A3 (fr) * 2000-04-13 2002-02-07 Du Pont Synthese sur supports polymeres de ligands bidentes heteroatomiques convenant pour la catalyse
WO2002030558A2 (fr) * 2000-10-11 2002-04-18 Kalibrant Limited Groupe de liaison et procede de synthese chimique
WO2002030558A3 (fr) * 2000-10-11 2002-09-06 Kalibrant Ltd Groupe de liaison et procede de synthese chimique

Also Published As

Publication number Publication date
EP0796233A1 (fr) 1997-09-24
GB9424972D0 (en) 1995-02-08
JPH10510854A (ja) 1998-10-20

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