WO1996006851A3 - D-xylofuranose-derivate, verfahren zu deren herstellung, deren verwendung und neue zwischenverbindungen für das verfahren - Google Patents
D-xylofuranose-derivate, verfahren zu deren herstellung, deren verwendung und neue zwischenverbindungen für das verfahren Download PDFInfo
- Publication number
- WO1996006851A3 WO1996006851A3 PCT/EP1995/003378 EP9503378W WO9606851A3 WO 1996006851 A3 WO1996006851 A3 WO 1996006851A3 EP 9503378 W EP9503378 W EP 9503378W WO 9606851 A3 WO9606851 A3 WO 9606851A3
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- WO
- WIPO (PCT)
- Prior art keywords
- group
- derivatives
- optionally substituted
- preparing
- intermediate compounds
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Saccharide Compounds (AREA)
Abstract
Die vorliegende Erfindung betrifft D-Xylofuranose-Derivate der Formel (VIa), worin R3 eine Hydroxyschutzgruppe, R4 eine Alkylgruppe mit 1-6 C-Atomen, R5 Wasserstoff, ein Halogenatom, ein Azid, ein Cyanid, ein Thiocyanat, eine Alkoxygruppe, eine gegebenenfalls substituierte Aryloxygruppe, eine gegebenenfalls substituierte Arylalkoxygruppe, eine gegebenenfalls substituierte Aroylgruppe, eine geradkettige oder verzweigte, gegebenenfalls substituierte Alkanoylgruppe und Z eine 1-Imidazolylgruppe, die Gruppe -CXxH3-x (worin X ein Halogenatom ist und x = 1 bis 3) oder Fluor bedeuten. Ferner betrifft die Erfindung Verfahren zur Herstellung dieser Derivate, neue Zwischenverbindungen, welche bei diesen Verfahren anfallen bzw. eingesetzt werden, sowie die Verwendung dieser Derivate zur Herstellung von 3-substituierten 2-Desoxy-2-fluor-D-pentofuranose-Derivaten.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4430401A DE4430401A1 (de) | 1994-08-26 | 1994-08-26 | D-Xylofuranose-Derivate, Verfahren zu deren Herstellung, deren Verwendung und neue Zwischenverbindungen für das Verfahren |
DEP4430401.3 | 1994-08-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1996006851A2 WO1996006851A2 (de) | 1996-03-07 |
WO1996006851A3 true WO1996006851A3 (de) | 1996-04-11 |
Family
ID=6526678
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1995/003378 WO1996006851A2 (de) | 1994-08-26 | 1995-08-25 | D-xylofuranose-derivate, verfahren zu deren herstellung, deren verwendung und neue zwischenverbindungen für das verfahren |
Country Status (2)
Country | Link |
---|---|
DE (1) | DE4430401A1 (de) |
WO (1) | WO1996006851A2 (de) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT400953B (de) | 1994-08-25 | 1996-05-28 | Joern Saischek | Pentofuranosid-derivate, deren herstellung und verwendung |
DE10006155B4 (de) * | 1999-06-24 | 2004-08-05 | Forschungszentrum Rossendorf E.V. | Verfahren zur Herstellung von 16α-[18F] Fluorestradiolsulfamaten |
US6277982B1 (en) * | 1999-08-20 | 2001-08-21 | Isis Pharmaceuticals, Inc. | Alkylation of alcohols, amines, thiols and their derivatives by cyclic sulfate intermediates |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0103877A1 (de) * | 1982-09-21 | 1984-03-28 | Fujisawa Pharmaceutical Co., Ltd. | Phosphat-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen |
EP0145978A2 (de) * | 1983-11-18 | 1985-06-26 | Bristol-Myers Company | Herstellung von Nukleosiden |
JPS62242693A (ja) * | 1986-04-15 | 1987-10-23 | Asahi Glass Co Ltd | フツ素含有リボフラノシド誘導体およびその製造法 |
JPH0634405A (ja) * | 1992-07-20 | 1994-02-08 | Oval Corp | 渦流量計 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH535757A (de) * | 1969-07-03 | 1973-04-15 | Ciba Geigy Ag | Verfahren zur Herstellung von Hexafuranoseverbindungen |
SE8802173D0 (sv) * | 1988-06-10 | 1988-06-10 | Astra Ab | Pyrimidine derivatives |
AT394564B (de) * | 1990-04-04 | 1992-05-11 | Chemprosa Chemische Produkte S | Verfahren zur herstellung von 2-desoxy-d-threopentose und 2,3-didesoxy-3-fluor-d-erythro-pentosesowie von substituierten und unsubstituierten 2,3-didesoxy-3-fluor-d-erythro-pentofuranosen und deren verwendung |
-
1994
- 1994-08-26 DE DE4430401A patent/DE4430401A1/de not_active Withdrawn
-
1995
- 1995-08-25 WO PCT/EP1995/003378 patent/WO1996006851A2/de active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0103877A1 (de) * | 1982-09-21 | 1984-03-28 | Fujisawa Pharmaceutical Co., Ltd. | Phosphat-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen |
EP0145978A2 (de) * | 1983-11-18 | 1985-06-26 | Bristol-Myers Company | Herstellung von Nukleosiden |
JPS62242693A (ja) * | 1986-04-15 | 1987-10-23 | Asahi Glass Co Ltd | フツ素含有リボフラノシド誘導体およびその製造法 |
JPH0634405A (ja) * | 1992-07-20 | 1994-02-08 | Oval Corp | 渦流量計 |
Non-Patent Citations (23)
Title |
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C.H. TANN ET AL.: "Fluorocarbohydrates in synthesis", J. ORG. CHEM., vol. 50, pages 3644 - 7 * |
C.H. WONG ET AL.: "Enzymes in carbohydrate synthesis", J. ORG. CHEM., vol. 53, pages 4939 - 45 * |
CHEMICAL ABSTRACTS, vol. 108, no. 19, Columbus, Ohio, US; abstract no. 167893, page 694; * |
DATABASE WPI Week 7140, Derwent World Patents Index; AN 71-64568S * |
E. MARQUEZ ET AL.: "A more expedient approach to the synthesis of anti-HIV-active 2,3-dideoxy-2-fluoro-beta-D-threo-pentofuranosyl nucleosides", SYNTHESIS, pages 1005 - 8 * |
E. MARQUEZ ET AL.: "Synthesis of a 2,3,-dideoxy-2,3-difluorofuranose with the D-lyxo configuration", CARBOHYDR. RES, vol. 262, 1 September 1994 (1994-09-01), pages 103 - 114 * |
J. KISS UND R. D'SOUZA: "A simple stereoselective synthesis of an alpha-D-fluorouridine derivative", J. CARBOHYDR. NUCLEOSIDES NUCLEOTIDES, vol. 7, pages 141 - 57 * |
J. LEROUX UND A.S. PERLIN: "Synthesis of glycosyl halides and glycosides via 1-O-sulfonyl derivatives", CARBOHYDR. RES., vol. 67, pages 163 - 78 * |
J. PRISBE: "Synthesis and anti-herpetic activity of a 2'-fluoroarabinosyl analog of trifluridine", NUCLEOSIDES, NUCLEOTIDES, vol. 7, pages 155 - 65 * |
J. YOSHIMURA ET AL.: "Synthesis of four stereoisomers of 4-amino-2-(hydroxymethyl)tetrahydrofuran-4-carboxylic acid", CARBOHYDR. RES., vol. 99, pages 129 - 42 * |
K. BOCK UND S. REFN: "A simple synthesis of alpha-D-ribofuranosides", ACTA CHEM. SCAND. SER. B, vol. B42, pages 324 - 7 * |
M. KAWANA ET AL.: "The use of Grignard reagents in the synthesis of carbohydrates", BULL. CHEM. SOC. JPN, vol. 54, pages 1492 - 1504 * |
M. VANDEWALLE ET AL.: "L-Ribulose: a novel chiral pool compound", TETRAHEDR. LETT., vol. 31, pages 2337 - 40 * |
M.F. JONES ET AL.: "Tetrahydrothiophene nucleosides as potential anti-HIV agents", TETRAHEDR. LETT., vol. 32, pages 247 - 250 * |
N.B. DYATKINA UND A.V. AZHAYEV: "Aminonucleosides and their derivatives; XII", SYNTHESIS, pages 961 - 3 * |
O.R. MARTIN ET AL.: "Unusual 1,5-hydride shifts in Lewis acid mediated reactions of benzylated sugars", J. ORG. CHEM., vol. 53, pages 3287 - 92 * |
O.R. MARTIN: "Multiple and long-range participation of benzyl groups in intramolecular C-arylation reactions of benzylated glycosides", CARBOHYDR. RES., vol. 202, pages 49 - 66 * |
R.D. GUTHRIE ET AL.: "Synthesis of some N-substituted methyl 2,3-dideoxy-2,3-epimino-beta-D-lyxofuranosides", J. CHEM. SOC. (C), pages 1385 - 90 * |
S. VELAZQUEZ UND M. CAMARASA: "Radical cyclizations on sugar templates", TETRAHEDRON: ASYMMETRIE, vol. 5, no. 11, 1 November 1994 (1994-11-01), pages 2141 - 54 * |
S.R. JENKINS UND E. WALTON: "Synthesis of 9-(3-deoxy-3-C-methyl-beta-D-xylofuranosyl)-adenine", CARBOHYDR. RES., vol. 26, pages 71 - 81 * |
T. MUKAIYAMA ET AL.: "A new method for the stereoselective synthesis of beta-xylofuranoside", CHEM. LETT., pages 1733 - 6 * |
V. NAIR ET AL.: "Novel isomeric dideoxynucleosides as potential antiviral agents", TETRAHEDRON, vol. 50, 27 June 1994 (1994-06-27), pages 7747 - 64 * |
W.G. OVEREND ET AL.: "Arylazo-glycenosides. Part IV", J.C.S. PERKIN I, pages 2163 - 77 * |
Also Published As
Publication number | Publication date |
---|---|
WO1996006851A2 (de) | 1996-03-07 |
DE4430401A1 (de) | 1996-02-29 |
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