WO1995019638A3 - Ion spray with intersecting flow - Google Patents
Ion spray with intersecting flow Download PDFInfo
- Publication number
- WO1995019638A3 WO1995019638A3 PCT/CA1995/000014 CA9500014W WO9519638A3 WO 1995019638 A3 WO1995019638 A3 WO 1995019638A3 CA 9500014 W CA9500014 W CA 9500014W WO 9519638 A3 WO9519638 A3 WO 9519638A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- flow
- orifice
- ions
- gas
- droplets
- Prior art date
Links
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
- H01J49/165—Electrospray ionisation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
- G01N30/724—Nebulising, aerosol formation or ionisation
- G01N30/7246—Nebulising, aerosol formation or ionisation by pneumatic means
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
- H01J49/044—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for preventing droplets from entering the analyzer; Desolvation of droplets
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
- H01J49/0477—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample using a hot fluid
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dispersion Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69509359T DE69509359T2 (en) | 1994-01-13 | 1995-01-09 | ARYL-SUBSTITUTED 5.5 CONDENSED AROMATIC NITROGEN COMPOUNDS AS AN ANTI-INFLAMMATORY AGENT |
CA002181040A CA2181040C (en) | 1994-01-13 | 1995-01-09 | Ion spray with intersecting flow |
EP95905498A EP0739533B1 (en) | 1994-01-13 | 1995-01-09 | Ion spray with intersecting flow |
AU14102/95A AU1410295A (en) | 1994-01-13 | 1995-01-09 | Ion spray with intersecting flow |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/181,529 US5412208A (en) | 1994-01-13 | 1994-01-13 | Ion spray with intersecting flow |
US08/181,529 | 1994-01-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1995019638A2 WO1995019638A2 (en) | 1995-07-20 |
WO1995019638A3 true WO1995019638A3 (en) | 1995-10-26 |
Family
ID=22664672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA1995/000014 WO1995019638A2 (en) | 1994-01-13 | 1995-01-09 | Ion spray with intersecting flow |
Country Status (6)
Country | Link |
---|---|
US (1) | US5412208A (en) |
EP (1) | EP0739533B1 (en) |
AU (1) | AU1410295A (en) |
CA (1) | CA2181040C (en) |
DE (1) | DE69509359T2 (en) |
WO (1) | WO1995019638A2 (en) |
Families Citing this family (102)
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US5750988A (en) * | 1994-07-11 | 1998-05-12 | Hewlett-Packard Company | Orthogonal ion sampling for APCI mass spectrometry |
DE19618323C2 (en) * | 1995-07-28 | 2001-10-18 | Agilent Technologies Inc | Device for self-generation of ions for the mass spectrometry of liquids |
DE19655220C2 (en) * | 1995-07-28 | 2003-02-27 | Agilent Technologies Inc | Self-generation ion device for mass spectrometry of liquids |
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US5868322A (en) * | 1996-01-31 | 1999-02-09 | Hewlett-Packard Company | Apparatus for forming liquid droplets having a mechanically fixed inner microtube |
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US5753910A (en) * | 1996-07-12 | 1998-05-19 | Hewlett-Packard Company | Angled chamber seal for atmospheric pressure ionization mass spectrometry |
US6207954B1 (en) * | 1997-09-12 | 2001-03-27 | Analytica Of Branford, Inc. | Multiple sample introduction mass spectrometry |
US6504149B2 (en) | 1998-08-05 | 2003-01-07 | National Research Council Canada | Apparatus and method for desolvating and focussing ions for introduction into a mass spectrometer |
US6177669B1 (en) * | 1998-09-28 | 2001-01-23 | Varian, Inc. | Vortex gas flow interface for electrospray mass spectrometry |
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US6687395B1 (en) | 1999-07-21 | 2004-02-03 | Surromed, Inc. | System for microvolume laser scanning cytometry |
US6486469B1 (en) | 1999-10-29 | 2002-11-26 | Agilent Technologies, Inc. | Dielectric capillary high pass ion filter |
US6528784B1 (en) | 1999-12-03 | 2003-03-04 | Thermo Finnigan Llc | Mass spectrometer system including a double ion guide interface and method of operation |
DE60133548T2 (en) * | 2000-05-22 | 2009-05-07 | The University Of British Columbia, Vancouver | A NORMAL PRESSURE LENS GENERATING A LARGER AND STABILIZED ION FLOW |
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US6484560B1 (en) | 2000-11-07 | 2002-11-26 | Agilent Technologies, Inc. | In Situ concentration of an analyte |
US6787761B2 (en) * | 2000-11-27 | 2004-09-07 | Surromed, Inc. | Median filter for liquid chromatography-mass spectrometry data |
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US7399961B2 (en) * | 2001-04-20 | 2008-07-15 | The University Of British Columbia | High throughput ion source with multiple ion sprayers and ion lenses |
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US6759650B2 (en) * | 2002-04-09 | 2004-07-06 | Mds Inc. | Method of and apparatus for ionizing an analyte and ion source probe for use therewith |
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Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4531056A (en) * | 1983-04-20 | 1985-07-23 | Yale University | Method and apparatus for the mass spectrometric analysis of solutions |
US4701419A (en) * | 1984-11-26 | 1987-10-20 | M-Scan Limited | Analysis of polymeric protein and protein products |
US4861988A (en) * | 1987-09-30 | 1989-08-29 | Cornell Research Foundation, Inc. | Ion spray apparatus and method |
WO1990014148A1 (en) * | 1989-05-19 | 1990-11-29 | Fenn John B | Multiply charged ions and a method for determining the molecular weight of large molecules |
EP0455892A1 (en) * | 1984-06-22 | 1991-11-13 | Georgia Tech Research Corporation | Monodisperse aerosol generator for use with infrared spectrometry |
US5122670A (en) * | 1991-05-17 | 1992-06-16 | Finnigan Corporation | Multilayer flow electrospray ion source using improved sheath liquid |
WO1992021138A1 (en) * | 1991-05-21 | 1992-11-26 | Analytica Of Brandford, Inc. | Method and apparatus for improving electrospray ionization of solute species |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4935624A (en) * | 1987-09-30 | 1990-06-19 | Cornell Research Foundation, Inc. | Thermal-assisted electrospray interface (TAESI) for LC/MS |
US5359196A (en) * | 1993-05-24 | 1994-10-25 | Hewlett-Packard Company | Mass spectrometry with gas counterflow for particle beam |
EP0655769A1 (en) * | 1993-11-17 | 1995-05-31 | Hewlett-Packard Company | Method and apparatus for preparing an electrospray ion source sample |
-
1994
- 1994-01-13 US US08/181,529 patent/US5412208A/en not_active Expired - Lifetime
-
1995
- 1995-01-09 CA CA002181040A patent/CA2181040C/en not_active Expired - Fee Related
- 1995-01-09 AU AU14102/95A patent/AU1410295A/en not_active Abandoned
- 1995-01-09 WO PCT/CA1995/000014 patent/WO1995019638A2/en active IP Right Grant
- 1995-01-09 EP EP95905498A patent/EP0739533B1/en not_active Expired - Lifetime
- 1995-01-09 DE DE69509359T patent/DE69509359T2/en not_active Expired - Lifetime
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4531056A (en) * | 1983-04-20 | 1985-07-23 | Yale University | Method and apparatus for the mass spectrometric analysis of solutions |
EP0455892A1 (en) * | 1984-06-22 | 1991-11-13 | Georgia Tech Research Corporation | Monodisperse aerosol generator for use with infrared spectrometry |
US4701419A (en) * | 1984-11-26 | 1987-10-20 | M-Scan Limited | Analysis of polymeric protein and protein products |
US4861988A (en) * | 1987-09-30 | 1989-08-29 | Cornell Research Foundation, Inc. | Ion spray apparatus and method |
WO1990014148A1 (en) * | 1989-05-19 | 1990-11-29 | Fenn John B | Multiply charged ions and a method for determining the molecular weight of large molecules |
US5122670A (en) * | 1991-05-17 | 1992-06-16 | Finnigan Corporation | Multilayer flow electrospray ion source using improved sheath liquid |
WO1992021138A1 (en) * | 1991-05-21 | 1992-11-26 | Analytica Of Brandford, Inc. | Method and apparatus for improving electrospray ionization of solute species |
Non-Patent Citations (1)
Title |
---|
R. FENG ET AL.: "stepwise refolding of acid-denaturated myoglobin - evidence from electrospray mass-spectrometry", JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, vol. 4, no. 8, August 1993 (1993-08-01), ISSN 1044-0305, pages 638 - 645, XP002095056 * |
Also Published As
Publication number | Publication date |
---|---|
US5412208A (en) | 1995-05-02 |
EP0739533A1 (en) | 1996-10-30 |
CA2181040C (en) | 2004-09-21 |
CA2181040A1 (en) | 1995-07-20 |
DE69509359T2 (en) | 1999-10-14 |
DE69509359D1 (en) | 1999-06-02 |
WO1995019638A2 (en) | 1995-07-20 |
EP0739533B1 (en) | 1999-04-28 |
AU1410295A (en) | 1995-08-01 |
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