WO1995017883A1 - Lotion eau dans huile contenant du corticosteroide - Google Patents
Lotion eau dans huile contenant du corticosteroide Download PDFInfo
- Publication number
- WO1995017883A1 WO1995017883A1 PCT/EP1994/004288 EP9404288W WO9517883A1 WO 1995017883 A1 WO1995017883 A1 WO 1995017883A1 EP 9404288 W EP9404288 W EP 9404288W WO 9517883 A1 WO9517883 A1 WO 9517883A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- water
- weight
- hydrocortisone
- propionate
- acetate
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Definitions
- the present invention relates to a new type of lotion comprising as active material a corticosteroid.
- Creams are often used as vehicles for therapy with corticosteroids. In the case of these creams, these are either oil in water or water in oil emulsion systems.
- oil-in-water cream comprising hydrocortisone diester is known, for example from document EP-A-0 217 146.
- oil-in-water creams play a minor role in the area of corticosteroid therapy, since most inflammatory processes arise in the case of dry skin.
- oil-in-water type emulsions containing water in the external phase of the emulsion
- Water in oil type creams are more often used (containing oil in the external phase of the emulsion). Because of their thick consistency and therefore their property to be difficult to spread, they have the disadvantage of being unsuitable for application on large surfaces. In addition, they leave a smooth film on the skin, which is unfavorable from a cosmetic point of view.
- a cream based on a water in oil emulsion comprising, as active material, hydrocortisone diesters is for example described in document EP-A-0 217 141; "stabilized" creams (water-in-oil emulsions) comprising corticosteroids are described, for example, in document US 4,284,630.
- a fifth basic type of corticosteroids is tinctures and tinctures solidified by gelling agents.
- these solutions most often based on ethanol, isopropanol / propylene glycol or polyethylene glycol / water. They are often called (mistakenly) lotions, although they do not represent emulsion systems. If these lotions additionally contain a surface-active substance, this only serves to dissolve the sparingly soluble corticosteroid.
- Such a dye is for example described (as "lotion") in document EP-A-0 292 893.
- Water in oil emulsifiers represent new types, particularly well suited to water in oil lotions. They are not identical to the emulsifiers commonly used for water-in-oil creams, such as sorbitanoleate and sorbitan tearate (Span ® products). The latter (see US 4,284,630) are only suitable for the preparation of water-in-oil creams.
- water-in-oil lotion comprising a corticosteroid as active material
- emulsifiers and stabilizers which can be taken into account for water-in-oil lotions tend to break down the corticosteroid contained therein.
- the storage stability of the active ingredient necessary for a therapeutic product is therefore questioned. It is understood by "necessary storage stability" that the water-in-oil lotion as well as the active material have the shelf life required for a medicament, therefore at least 3 years, and this also for high temperatures (above 30 ° C.) .
- DE-A-28 26 257 discloses the corticosteroid hydrocortisone-21-acetate-17-alpha-propionate.
- the object of the invention is to provide a water-in-oil lotion containing hydrocortisone-21-acetate-17-alpha-propionate, exhibiting good stability of the liquid emulsion, at the same time ensuring good preservability of the active ingredient during storage and ideally suited for therapy with corticosteroids in the case of dry skin and application to large areas.
- water in oil lotions having the following compositions A, B, C or D with the combinations of water in oil emulsifiers a) to d),
- .ai methoxypoiyethylene glycol-dodecyl glycol copolymer 1 - 10 .
- a 2 hydroxyoctacosanhylhydroxystéarate 0.5 - 10 .
- 3 polyethylene glycol / dodecylglycol copolymer 1 10
- esters of saturated fatty acids with glycerolsorbitane 0.5 - 10 .b 2 polyethoxylated fatty acids 1 7.5
- each of these compositions A to D possibly comprising, where appropriate, additives, and, in addition to the emulsifying combination indicated, one or more of the other components mentioned a 1 to d 2 or one or more of the emulsifying combinations a) to d) ci - above cited.
- the emulsifying combinations water in oil a) to d) are formed by the emulsifiers, stabilizers, thickeners and complex emulsifying systems a ⁇ a 2 etc. to d- t , d 2 as components.
- Component a- is preferably a water in oil nonionic emulsifier comprising about 22 units of ethylene glycol.
- emulsifiers are sold under the name Elfacos E 200 (Akzo Chemie, NL).
- Component a 2 acts as a consistency regulator.
- Such products are marketed under the name Elfacos C 26 (Akzo Chemie, NL).
- Component a 3 is preferably a water in oil nonionic emulsifier having approximately 20 to 45 ethylene glycol units and an HLB value of approximately 7.
- emulsifiers are marketed under the names Elfacos ST 9 and Elfacos ST 37 (Akzo Chemie, NL); in addition, they are described in the literature indicated above.
- Component b- is a water-in-oil nonionic emulsifier, preferably having a molecular weight of about 630, an HLB value of about 4.5 and a waxy consistency. Such products are sold in particular under the name Arlacel 986 (ICI Europa Ltd., Belgium).
- Component b 2 is preferably a nonionic saturated water-in-oil emulsifier having a molecular weight of about 1245 and an HLB value of about 6.4.
- Such products are sold in particular under the name Arlacel 989 (ICI) or Cremophor WO 7 (BASF).
- Component b 2 corresponds to components c 2 and d 2 .
- Component c 1 is an emulsifying water in saturated non-ionic oil. Such products are also marketed under the name Arlacel 780 (ICI).
- the preferred fatty acid esters are isopropylpalmitate, isopropylmyristate, isopropyl pylisostearate, myristylemyristate, 2-ketylhexylpalmitate (Cegesoft, Soc. Henkel), isooctylstearate (Cetiol 868, Soc. Henkel), l oleic ester of oleic acid (Cetiol V) and the cetyl ester of palmitic acid (Cutina CP, Soc. Henkel).
- the preferred fatty alcohols are myristic alcohol, cetyl alcohol, stearic alcohol, cetostearyl alcohol, behenyl alcohol and 2-octyldodecanol (Eutanol G).
- paraffin a very liquid paraffin is preferably used, if necessary in combination with a semi-solid paraffin (petroleum jelly), a solid paraffin or microcires. Particular preference is given to linear and branched paraffins.
- a suitable sorbitol solution is, for example, a 70% aqueous solution.
- Such products are sold in particular under the names "Karion F”, “Karion F fl ⁇ ssig SK” or “Karion F fl ⁇ ssig kosmetik” (E. Merck, Germany).
- the lotions preferably contain hydrocortisone-21-acetate-17-propionate in a concentration of 0.001 to 1% by weight, in particular from 0.01 to 0.3% by weight, always relative to the total weight.
- hydrocortisone-21-acetate-17-alpha-propionate in an amount of 0.025-0.2% by weight, in particular about 0.13% by weight, always relative to the total weight of the lotion .
- the lotions comprising the constituents and, where appropriate, the following additives:
- .a- ⁇ methoxypolyethylenegiycol-dodecylglycol copolymer 2 7.5 .
- a 2 hydroxyoctacossannylthydroxystéarate 1 5.
- a 3 polyethylene glycol / dodecyl glycol copolymer 2 7.5
- the lotion according to the invention may contain acid additives in small amounts, for example around 0.01 - 0.5% by weight.
- carboxylic acids such as succinic acid, lactic acid, citric acid or also phosphoric acid as well as their salts are very suitable as buffers.
- preservatives and stabilizers examples include parabens, benzalkonium chlorides, p-chloro-m-cresol, benzoic acid, sorbic acid, phenoxyethanol, benzyl alcohol, buthylhydroxyanisol and butylhydroxytoluene, tocopherolacetate, ascorbylpalmitate and their mixtures. These materials can be contained in an amount of 0.01 to 2.5% by weight.
- the emulsifiers suitable for water-in-oil lotions containing corticosteroids represent types having in part very complex compositions with low HLB values as well as their mixtures.
- the selection of emulsifiers has been carried out in order to obtain a stable water-in-oil lotion for several years - and this also at high temperatures - and compatible with the active ingredients respectively, to obtain stabilization of the active ingredients during the period indicated.
- the fatty phase of the water in oil lotion consists, for example, of a balanced mixture of liquid paraffins with straight or branched chain, natural and synthetic esters, fatty acids with straight or branched chain, saturated or unsaturated with monovalent or polyvalent alcohols (e.g. isopropylpalmitate, isopropylmyristate, isopropylstearate, isopropylisostearate, myristylmyristate, cetylpalmitate, oleyloleate, medium chain triglycerides, peanut oil, oil olive, castor oil, hydrogenated castor oil), fatty acids (e.g. linoleic acid, oleic acid) as well as fatty alcohols (e.g. myristic alcohol, cetostearyl alcohol), octyldodecanol and squalene, in an amount of 1 to 30% by weight, for example.
- monovalent or polyvalent alcohols e.g. isopropyl
- the lotions according to the invention may contain other additives.
- the aqueous phase contains for example polyvalent alcohols (for example glycerin, propylene glycol, 1, 3-butylene glycol, polyethylene glycols), saccharide alcohols (for example sorbitol, xylitol), lecithins (for example lecithin soy, ovolecithin) or phosphatidylchoiin-like compounds, dipalmitoylphosphatidylcholine, for example in an amount of 1 to 10% by weight.
- polyvalent alcohols for example glycerin, propylene glycol, 1, 3-butylene glycol, polyethylene glycols
- saccharide alcohols for example sorbitol, xylitol
- lecithins for example lecithin soy, ovolecithin
- phosphatidylchoiin-like compounds dipalmitoylphosphatidylcholine, for example in an amount of 1 to 10% by weight.
- a new water-in-oil lotion containing hydrocrotisone-17-propionate-21-acetate is distinguished which is distinguished by good activity, good dermatological acceptance and high storage stability.
- the water-in-oil lotion Compared with a water-in-oil cream, the water-in-oil lotion has the great advantage of being quickly absorbed by the skin and of not leaving a unctuous unctuous film - unlike the cream, despite the same type of emulsion.
- the constituents of the fatty phase such as paraffin, the isopropyl esters of fatty acids and the combination of emulsifiers are melted and brought to a high temperature, for example between 60 and 80 °, so known per se.
- Sorbitol, glycerin and magnesium sulfate and the constituents of the aqueous phase are dissolved in water at an elevated temperature.
- the phases are combined and emulsified.
- the active ingredient is added at a lower temperature, for example between 40 and 60 °. Then, the mass is allowed to cool with stirring.
- the active ingredient is very well absorbed from the lotion according to the invention which has excellent storage stability. It is for example used for the treatment of eczemas, dermatitides, psoriasis as well as inflammations.
- the lotion according to the invention can be applied topically to the injured parts.
- the amount of lotion applied varies depending on the concentration of the active ingredient. In general, an appropriate amount is applied to the injured part several times a day, depending on the severity of the disease to be treated.
- the preparation of the water-in-oil lotions is carried out in the following manner: the constituents of the fatty phase, such as paraffin, the fatty acid esters and the combination of the emulsifier are heated to approximately 80 ° C. in a mixer-homogenizer can be evacuated. Then, the constituents of the aqueous phase, such as sorbitol, glycerin and magnesium sulfate as well as the acids, the buffering agents are dissolved in a corresponding amount of water at a temperature of about 80 ° C. and the aqueous phase is added to the fatty phase in the mixer. Under vacuum, the mixture is cooled to about 40 ° C and homogenized with stirring.
- the constituents of the fatty phase such as paraffin, the fatty acid esters and the combination of the emulsifier are heated to approximately 80 ° C. in a mixer-homogenizer can be evacuated.
- the constituents of the aqueous phase such as sorbitol, glycer
- the active material is added and the preparation is cooled to approximately 25 ° C. with stirring and under vacuum.
- the preservatives are dissolved - depending on their physical and chemical properties respectively - either in the fatty phase at a temperature of about 80 ° C, or in the aqueous phase at about 80 ° C or added to the preparation at a temperature of about 40 ° C.
- the hydrocortisone-21-acetate-17-propionate is used as corticosteroid:
- a water-in-oil lotion is prepared using the constituents indicated below:
- the preparation is done in the manner indicated above.
- the preservative, phenoxyethanol, is dissolved in the aqueous phase
- the antioxidant, butylhydroxytoluene is dissolved in the fatty phase.
- the active ingredient, hydrocortisoneaceponate is dissolved in benzyl alcohol and added to the lotion at a temperature of about 40 ° C.
- EXAMPLE 2 A water in oil lotion is prepared by using the constituents indicated below:
- a water-in-oil lotion is prepared using the constituents indicated below:
- polyoxypropylene-polyoxyethylene-glycerol- sorbitanhydroxyisostearate 4.0 Polyethoxylated fatty acids 2.0 (Arlacel 989) isopropylmyristate 7.0 octyldodecanol 5.0 liquid paraffin 13.5 glycerin 2.5 sorbitol 70% (Karion F ) 2.5 hydrocortisone-21-acetate-17-propionate 0.127 phosphatidylcholine 3.0 benzalkonium chloride 0.25 lactic acid qs * ( * to adjust the pH to 4-5) demineralized water ad 100.0
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- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002179931A CA2179931C (fr) | 1993-12-27 | 1994-12-22 | Lotion eau dans huile contenant du corticosteroide |
JP51777595A JP3731607B2 (ja) | 1993-12-27 | 1994-12-22 | コルチコステロイドを含む油中水型ローション |
EP95904527A EP0737062B1 (fr) | 1993-12-27 | 1994-12-22 | Lotion eau dans huile contenant du corticosteroide |
US08/666,509 US5653989A (en) | 1993-12-27 | 1994-12-22 | Water-in oil lotion containing corticosteroid |
DE69410119T DE69410119T2 (de) | 1993-12-27 | 1994-12-22 | Wasser-in-oel-lotion, die ein corticosteroid enthaelt |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP4344697.3 | 1993-12-27 | ||
DE19934344697 DE4344697A1 (de) | 1993-12-27 | 1993-12-27 | Corticosteroide enthaltende W/O-Lotion |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1995017883A1 true WO1995017883A1 (fr) | 1995-07-06 |
Family
ID=6506382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1994/004288 WO1995017883A1 (fr) | 1993-12-27 | 1994-12-22 | Lotion eau dans huile contenant du corticosteroide |
Country Status (6)
Country | Link |
---|---|
US (1) | US5653989A (fr) |
EP (1) | EP0737062B1 (fr) |
JP (1) | JP3731607B2 (fr) |
AT (1) | ATE165733T1 (fr) |
DE (2) | DE4345186C2 (fr) |
WO (1) | WO1995017883A1 (fr) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19643238A1 (de) * | 1996-10-19 | 1998-04-23 | Beiersdorf Ag | Antitranspirant- und Deodorantstifte mit hohem Wassergehalt |
US5869075A (en) * | 1997-08-15 | 1999-02-09 | Kimberly-Clark Worldwide, Inc. | Soft tissue achieved by applying a solid hydrophilic lotion |
US6630152B2 (en) * | 1999-04-07 | 2003-10-07 | Shen Wei (Usa), Inc. | Aloe vera glove and manufacturing method |
DE10048125A1 (de) * | 2000-09-28 | 2002-04-18 | Beiersdorf Ag | Zubereitungen von Emulsionstyp W/O mit erhöhtem Wassergehalt, mit mittelpolaren und/oder unpolaren Lipiden und einem oder mehreren grenzflächenaktiven Polyethern vom Typ A-O-B-O-A |
DE10048427A1 (de) * | 2000-09-29 | 2002-04-11 | Beiersdorf Ag | Zubereitungen vom Emulsionstyp W/O mit erhöhtem Wassergehalt, mit mittelpolaren und/oder unpolaren Lipiden und einem oder mehreren grenzflächenaktiven Polyet hern vom Typ A-O-B-O-A sowie mindestens einer Substanz gewählt aus der Gruppe der anionischen und oder amphoteren Polymere |
DE10048366A1 (de) | 2000-09-29 | 2002-04-11 | Beiersdorf Ag | Zubereitungen vom Emulsionstyp W/O mit erhöhtem Wassergehalt, mit mittelpolaren und/oder unpolaren Lipiden und einem oder mehreren grenzflächenaktiven Polyethern vom Typ A-O-B-O-A sowie mit mindestens einer Substanz, gewählt aus der Gruppe der kationischen Polymere |
DE10048429A1 (de) * | 2000-09-29 | 2002-04-11 | Beiersdorf Ag | Zubereitungen vom Emulsionstyp W/O mit erhöhtem Wassergehalt, mit mittelpolaren und/oder unpolaren Lipiden und einem oder mehreren grenzflächenaktiven Polyethern von Typ A-O-B-O-A sowie einer Substanz gewählt aus der Gruppe der nichtionischen Polymere |
DE10049056A1 (de) * | 2000-10-04 | 2002-04-11 | Beiersdorf Ag | Zubereitungen vom Emulsionstyp W/O mit erhöhtem Wassergehalt enthaltend Polyetherpolester sowie mindestens einer Substanz gewählt aus der Gruppe der anionischen und/oder amphoteren Polymere |
JP2002265347A (ja) * | 2001-03-13 | 2002-09-18 | Shiseido Co Ltd | コーニファイドエンベロープの成熟を促す化粧料 |
AUPS158502A0 (en) * | 2002-04-08 | 2002-05-16 | Dermcare-Vet Pty Ltd | Allergic dermatitis composition and method of treatment |
US8734421B2 (en) | 2003-06-30 | 2014-05-27 | Johnson & Johnson Consumer Companies, Inc. | Methods of treating pores on the skin with electricity |
ES2665342T3 (es) * | 2004-03-15 | 2018-04-25 | Meda Ab | Formulaciones y métodos para modificadores de la respuesta inmune |
SG151334A1 (en) | 2004-04-01 | 2009-04-30 | Univ Nanyang | Addressable chem/bio chip array |
DE102006053360A1 (de) * | 2006-11-10 | 2008-05-15 | Evonik Stockhausen Gmbh | Hautreinigungsmittel, insbesondere Kälteschutzcreme |
US20120089232A1 (en) | 2009-03-27 | 2012-04-12 | Jennifer Hagyoung Kang Choi | Medical devices with galvanic particulates |
CA2804272A1 (fr) * | 2010-07-08 | 2012-01-12 | Johnson & Johnson Consumer Companies, Inc. | Composition de soins de la peau en emulsion |
US8685381B2 (en) | 2010-10-23 | 2014-04-01 | Joel Schlessinger | Topical base and active agent-containing compositions, and methods for improving and treating skin |
US8968755B2 (en) | 2010-10-23 | 2015-03-03 | Joel Schlessinger | Topical base and active agent-containing compositions, and methods for improving and treating skin |
US9205093B2 (en) * | 2012-09-11 | 2015-12-08 | Gary Marder | Hydrocortisone nanotechnological delivery system |
FR3039399B1 (fr) * | 2015-07-31 | 2018-08-24 | Idl International Drug Licensing | Creme pour l'admnistration de steroides et son procede de preparation |
WO2017197509A1 (fr) * | 2016-05-16 | 2017-11-23 | Joseph Gabriele | Formulations transdermiques pour l'administration de célécoxib et leur utilisation dans le traitement de maladies et de pathologies sensibles au celcoxib |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS58162516A (ja) * | 1982-03-20 | 1983-09-27 | Fujisawa Pharmaceut Co Ltd | ステロイド含有油中水型乳剤 |
Family Cites Families (10)
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---|---|---|---|---|
DE2826257C3 (de) * | 1978-06-15 | 1980-12-04 | Beiersdorf Ag, 2000 Hamburg | Hydrocortison-17,21-diester und Verfahren zu deren Herstellung, diese enthaltende Arzneimittel sowie Hydrocortison -17-propionat als Zwischenprodukt |
US4252796A (en) * | 1979-08-17 | 1981-02-24 | Yu Ruey J | Stable water-in-oil emulsions |
ATE6466T1 (de) * | 1979-10-26 | 1984-03-15 | Smith And Nephew Associated Companies P.L.C. | Autoklavierbare emulsionen. |
US4464389A (en) * | 1982-10-20 | 1984-08-07 | Sri International | Esters of retinoic acid and pentaerythritol and monobenzal acetals thereof |
JPS6272611A (ja) * | 1985-09-27 | 1987-04-03 | Kao Corp | 皮膚外用剤 |
DE3534743A1 (de) * | 1985-09-28 | 1987-04-02 | Beiersdorf Ag | Hydrocortisondiester enthaltende o/w-creme |
GB8821129D0 (en) * | 1988-09-09 | 1988-10-12 | Unilever Plc | Cosmetic composition |
DE3908047A1 (de) * | 1989-03-13 | 1990-09-20 | Desitin Arzneimittel Gmbh | Hochdisperse pharmazeutische zusammensetzung |
FR2648462B1 (fr) * | 1989-06-15 | 1994-01-28 | Oreal | Procede pour ameliorer l'efficacite therapeutique de corticosteroides liposolubles et composition pour la mise en oeuvre de ce procede |
US5196448A (en) * | 1991-01-22 | 1993-03-23 | Stiefel Laboratories, Inc. | Antiinflammatory compositions and method of use |
-
1993
- 1993-12-27 DE DE4345186A patent/DE4345186C2/de not_active Expired - Lifetime
-
1994
- 1994-12-22 JP JP51777595A patent/JP3731607B2/ja not_active Expired - Lifetime
- 1994-12-22 WO PCT/EP1994/004288 patent/WO1995017883A1/fr active IP Right Grant
- 1994-12-22 EP EP95904527A patent/EP0737062B1/fr not_active Expired - Lifetime
- 1994-12-22 US US08/666,509 patent/US5653989A/en not_active Expired - Lifetime
- 1994-12-22 AT AT95904527T patent/ATE165733T1/de not_active IP Right Cessation
- 1994-12-22 DE DE69410119T patent/DE69410119T2/de not_active Expired - Lifetime
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58162516A (ja) * | 1982-03-20 | 1983-09-27 | Fujisawa Pharmaceut Co Ltd | ステロイド含有油中水型乳剤 |
Non-Patent Citations (2)
Title |
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DATABASE WPI Week 4689, Derwent World Patents Index; AN 83-805363 * |
K.L. WATSKY ET AL.: "Water-in-oil emollients as steroid-sparing adjunctive therapy in the treatment of psoriasis.", CUTIS, vol. 50, no. 5, pages 383 - 386 * |
Also Published As
Publication number | Publication date |
---|---|
ATE165733T1 (de) | 1998-05-15 |
EP0737062B1 (fr) | 1998-05-06 |
US5653989A (en) | 1997-08-05 |
JP3731607B2 (ja) | 2006-01-05 |
DE4345186A1 (de) | 1995-06-29 |
DE4345186C2 (de) | 1997-08-14 |
JPH09510692A (ja) | 1997-10-28 |
DE69410119T2 (de) | 1998-09-03 |
DE69410119D1 (de) | 1998-06-10 |
EP0737062A1 (fr) | 1996-10-16 |
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