WO1993024167A1 - Dispositif indicateur de dose - Google Patents

Dispositif indicateur de dose Download PDF

Info

Publication number
WO1993024167A1
WO1993024167A1 PCT/GB1993/001064 GB9301064W WO9324167A1 WO 1993024167 A1 WO1993024167 A1 WO 1993024167A1 GB 9301064 W GB9301064 W GB 9301064W WO 9324167 A1 WO9324167 A1 WO 9324167A1
Authority
WO
WIPO (PCT)
Prior art keywords
housing
dispensing device
delivery system
medicament
indexing member
Prior art date
Application number
PCT/GB1993/001064
Other languages
English (en)
Inventor
Michael John Holroyd
Original Assignee
Norton Healthcare Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norton Healthcare Limited filed Critical Norton Healthcare Limited
Publication of WO1993024167A1 publication Critical patent/WO1993024167A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A61M15/0071—Mechanical counters having a display or indicator
    • A61M15/0073—Mechanical counters having a display or indicator on a ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0093—Inhalators mechanically breath-triggered without arming or cocking, e.g. acting directly on the delivery valve
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/04—Design features of general application for driving the stage of lowest order
    • G06M1/041—Design features of general application for driving the stage of lowest order for drum-type indicating means
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/08—Design features of general application for actuating the drive
    • G06M1/083—Design features of general application for actuating the drive by mechanical means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0096—Hindering inhalation before activation of the dispenser

Definitions

  • This invention relates to a dose indicating device for a dispensing device suitable for dispensing discrete amounts of fluid or particulate material entrained in an air stream.
  • Metered dose inhalers are well known in medicine for treatment, or alleviation of the effects of respiratory complaints, for example asthma. Breath-actuated devices are also known.
  • EP-0,269,496 describes a push button actuator for mounting on the neck of an aerosol dispenser, having a stroke counter comprising a counting ring with axially facing teeth which are engaged by an axially inclined flexible blade on the push button for actuating the aerosol valve.
  • actuating means which may be breath actuated, capable of actuating a pressurized aerosol container or a dry powder drug delivery system
  • a dose indicating means operated in association with the actuating means
  • the invention provides a dispensing device for use with a medicament delivery system which can be actuated to deliver discrete doses of medicament, the dispensing device comprising a housing for receiving the medicament delivery system, the housing having an inhalation nozzle and a dose indicating device comprising an annular or arcuate dose indicating element rotatably mounted in the housing with a section of the indicating element being visible from outside the housing, and an indexing member movable on discharge of a dose of medicament to index the indicating element incrementally, characterized in that actuating means are provided in the housing for acting on an end of a medicament delivery system remote from said nozzle, to cause dispensing of doses of medicament; in that the indicating element is located in the housing around a part associated with the actuating means and in that the indexing member is carried by said part for movement in one axial direction through the indicating element on actuation of the medicament delivery system and in the opposite axial direction for resetting the actuating means, with the indicating element being incrementally indexed on each movement of
  • Said actuating means are preferably breath-actuated on inhalation through the nozzle.
  • the indicating element may have internal teeth which are engaged by an indexing member which is resiliently mounted on the aforesaid part so that it can move inwardly of the teeth when it moves in said opposite direction, being the teeth and the engagement portion of said indexing member inclined with respect to the axis of rotation of the indicating element.
  • the release means are preferably breath actuated.
  • the actuation means may comprise means for applying a preload capable of actuating said drug delivery system.
  • the restraining means may comprise means for applying a resisting pneumatic force capable of preventing actuation of the actuation means.
  • the pneumatic resisting means may be provided by a gas, e.g. air, which is either held at a positive pressure greater than atmospheric or a negative pressure below atmospheric prior to release.
  • the release means will act to return the pressure to atmospheric or prior equilibrium, thus allowing the full force of the preload to act.
  • the means for applying a resisting pneumatic force may comprise an expandable gas tight chamber, the release means including valve means which can be opened to release a negative pressure prevailing in said low pressure chamber.
  • a device according to the invention is particularly suited for use with pressurized inhalation aerosols having valves which can be actuated to dispense a dose of medicament.
  • a device according to the invention can be used with a dry powder drug delivery system disposed within said housing, in which a dose of powdered medicament is dispensed by said system into an air flow in said housing created by inhalation at an outlet nozzle associated with the housing.
  • This inner sleeve is preferably arranged to form one end of a gas tight piston cylinder, bellows or diaphragm, such that movement of the inner sleeve will result in an increase in the enclosed volume within the piston cylinder, bellows or diaphragm producing a vacuum or low pressure volume to form the resisting force capable of preventing the actuation of the drug delivery system.
  • a preferred breath-actuating release means comprises a movable vane mechanism.
  • a valve seal is preferably attached to said vane, such that on inhalation the vane moves from its rest position closing said inlet means to its actuating position, thus moving the valve seal out of contact with the valve port, causing the opening of the valve to release the aforesaid resisting force.
  • the vane mechanism is preferably dynamically balanced, and may be biassed towards its closed position, e.g., by a spring.
  • Air inlets into the housing may take the form of slots in an upper end wall of said housing.
  • the actuating means act on the aforesaid inner sleeve, and are reset by causing the inner sleeve member to move in said opposite direction.
  • a cover for an outlet nozzle of the housing is movably mounted on the housing, and a cam formation on the cover cooperates with the lower end of at least one depending member associated with the inner sleeve such that, when the cover is closed, the depending member moves the inner sleeve to reset the actuating means.
  • Figure 1 is a diagrammatic sectional view through a metered dose inhaler having a dose indicating mechanism in accordance with the present invention
  • Figures 2A, 2B and 2C are sectional details of the inhaler showing the diaphragm in the pre-actuated, cocked, and actuated states, respectively;
  • Figure 3 is a diagrammatic perspective view of the dose counting mechanism of Figure 1;
  • Figure 4 is a diagrammatic perspective detail of parts of the mechanism of Figure 3.
  • an inhalation device consists of a main body 400 which is generally cylindrical in cross section, with a mouthpiece section 405 at one end and an end cap section 407 housing air inlets 419 at the other end.
  • a known type of aerosol dispensing container 25 of generally cylindrical shape is housed within the main body of the device.
  • the aerosol dispensing container has a stem 40 which contains an aerosol dispensing valve (not shown) .
  • the bore 15 of a pedestal 16 in the housing is such that it forms an airtight seal on the stem 40 of the aerosol dispensing container 25.
  • a shoulder 45 limits and locates the position of the stem 40, which in turn locates the aerosol dispensing container 25 in position in the main body 400.
  • a passage 50 extends from the bore 15, continuing from the shoulder 45 to interconnect with a dispensing nozzle 55.
  • the opposite end of the dispensing container is contained within a sleeve 420 of slightly smaller cross section to the main body 400.
  • the longitudinal axis of both the sleeve 420 and main body 400 is generally coaxial.
  • the sleeve is slidable within the inner wall of the main body to allow free passage of air in the main body past the sleeve.
  • the sleeve 420 may be held in place by connection with a diaphragm 440 held in connection with the top of the main body 400, as will now be described.
  • the sleeve 420 effectively hangs from the top of the main body.
  • moulded flexible diaphragm 440 (as indicated in Figure 2C) comprising a rigid disc-like section 441, a flexible generally cylindrical wall section 445 and a stiffer annular connector flange 447.
  • the sleeve 420 has a cooperating annular connection flange 450.
  • An annular U-section clip 470 snaps over the flanges 447 and 450 to hold them together in an air-tight manner.
  • a further lip 418 on the clip provides a snug fit for one end of a compression spring 460. The compression spring is thus located and free to act on the sleeve.
  • the other end of the compression spring is located by an annular flange of a predominantly cylindrical flanged insert 480 housed in the top section of the main body 400.
  • This insert includes a groove 485 into which the disc ⁇ like section 441 of the flexible diaphragm 440 is snap-fitted.
  • top surface 422 of the closed end of the sleeve to conform to the internal shape of the diaphragm such that in the rest (preactuated) position of the inhaler ( Figure 2A) the two surfaces are in close proximity, and the enclosed space between them very small.
  • the cylindrical insert 480 is retained in place by the end cap 407 comprising the upper part of the main body 400 of the device. This forms a chamber 590 between the air inlet slots 419 and the rigid part 441 of the diaphragm.
  • the chamber is provided with one or more air pathways 580 such that air may pass from the air inlet slots 419 to the mouthpiece 405.
  • the rigid disc-like section 441 of the diaphragm also includes a small valve port 495 which is normally covered by a diaphragm valve seal 540 housed in a vane 550 pivotally connected to the insert 480.
  • the vane 550 in its rest position divides the chamber 590 between the air inlets 419 and the air pathways 580 that link to the mouthpiece such that it may move from its rest position by means of a pressure drop between the air inlets and the mouthpiece.
  • the valve seal 540 On movement of the vane to the actuated position ( Figure 2C) the valve seal 540 is moved sufficiently to open the valve port 495.
  • the vane 550 may be biassed closed by a light spring flexure, a weight or a magnet not shown.
  • the lower end of the main body has a moulded section 500 beneath the mouthpiece 405 to which a dust cap is pivotally connected.
  • a cam 520 is integrally formed on each side of a dust cap 510, one on each side of the moulded section 500.
  • An annular yoke member 425 is secured to the lower end of the sleeve 420 and has a pair of downwardly depending legs 530, the lower ends of which act on the cams 520 such that when the dust cap is in the closed position the inner sleeve is forced by the cam follower to its uppermost position.
  • the dust cap is opened rotating the integral cam 520 allowing the cam follower 530 to drop by an initial amount of downward movement.
  • the inner sleeve is forced downwards under the action of the spring 460.
  • the enclosed volume between the diaphragm 440 and inner sleeve is increased. Since the valve port 495 is closed this creates a low pressure volume or near vacuum in the space 600 then defined between the upper surface 422 of the sleeve 420 and the diaphragm 440.
  • the effect of the pressure differential between the enclosed volume 600 and atmospheric pressure is such that the inner sleeve tends to resist the action of the spring 460.
  • a typical aerosol requires about 2ON force to actuate.
  • the spring 460 should accordingly provide a greater force, preferably 10% to 50% greater.
  • a small pressure differential is created across the vane 550 which is pivoted towards one end.
  • the pressure differential causes the vane to move from the rest position to the actuated position.
  • the vane and design of the air passageway 580 in the chamber 590 are such that in the actuated position air can flow freely from the air inlets 419 to the patient.
  • the movement of the vane 550 causes the valve seal 540 to be moved out of a sealing position with the valve port 495. Opening the valve port allows air into the space defined between the diaphragm 440 and inner sleeve 420 such that the enclosed space reaches atmospheric pressure. This causes an imbalance of forces acting on the sleeve 420 and the container 25. The sleeve and the container are thus forced downwards ( Figure 2C) by the spring 460 resulting in the release of a measured dose of medicament through the dispensing nozzle 55 and into the mouthpiece at the same time as the patient breathes in. Thus the patient inhales air with a metered dose of medicament.
  • the dust cap 510 is returned to its closed position. This rotates the cam 520 and causes the legs 530 of the yoke 425 to be forced upwards. This in turn acts on the inner sleeve 420 moving it upwards to compress the spring 460 and to close the space between the diaphragm 440 and the inner sleeve top surface 422. This forces air out of that space, which escapes through the valve port 495 lifting the valve seal 540. Since the valve seal is only lightly biassed to its closed position it presents little resistance to air flow out of the enclosed space. The aerosol can is free to return to the rest position under the action of its own aerosol valve spring.
  • the patient loads the aerosol dispensing container into the main body.
  • the aerosol container may be loaded by forming the main body 400 in two separable parts 350,360, which are joined by a threaded coupling.
  • the aerosol can be inserted.
  • the upper part 350 can then be replaced locating the inner sleeve 420 over the top end of the can, and the device is ready for use.
  • the device could be manufactured as a sealed unit.
  • the inhalation device is provided with a dose indicating mechanism in accordance with the present invention.
  • the upper part 407 of the main body 400 of the inhaler is formed with a viewing window 100 through which numbers or other dose indication markings provided on a rotary ring 101, can be viewed.
  • the ring 101 is located in annular recess defined in the upper body part 407.
  • the ring 101 is formed at its upper end with a set of internal, axially inclined ratchet teeth 103.
  • the ring 101 is rotationally indexed, in the direction of the arrow in Figure 3, by a predetermined amount, each time a dose is dispensed from the aerosol container 25.
  • This is achieved by providing an indexing member 109 on the sleeve 420 to cooperate with the internal teeth 103 on the ring 101.
  • the member 109 is made of a strip of a suitable resilient material, e.g., spring steel, and has a flat base portion 108 secured to the outer wall of the sleeve 420. The free edge of the strip is bent outwardly and shaped to form the indexing member 109 which is also inclined with respect to the axis of the ring 101.
  • a rectangular portion 107 is cut out of the flexible arm portion connecting the indexing member 109 to the base portion 108 so the connection is made by upper and lower limbs 105,106.
  • This construction produces a resilient support structure for the indexing member 109 which is torsionally relatively rigid but is relatively flexible along its length. In this way the indexing member can readily flex radially inwardly of the ring 101 during each return stroke, as described below.
  • the teeth 103 and the indexing face 110 of the member 109 are similarly inclined to the axis of the body part 400.
  • the indexing member 109 moves to its lower position as shown in Figure 4, thereby causing the indicating ring 101 to index by a predetermined increment to change the dose number displayed in the window 100.
  • the indexing member 109 completes its stroke of about 4.5 mm.
  • the indexing member 109 which has a height of about 8 mm, remains still engaged with the teeth 103, as indicated in Figure 4.
  • the indexing member 109 first engages the next inclined tooth 103, and then resiliently rides over that tooth to engage in the gap behind that tooth, ready for the next indexing operation.
  • the indexing member at the beginning of its stroke is engaged with the teeth 103, which have a depth of about 2 mm, over a distance of about 1.5 mm.
  • the indexing member 109 flexes radially inwardly of the ratchet teeth 103 on the ring 101 until, in its upper position, it engages in the next notch defined between the teeth 103 ready for a subsequent indexing operation.
  • the dose indicating mechanism is only actuated when the inner sleeve 420 moves downwards sufficiently to cause a dose to be dispensed from the aerosol 25. Therefore merely opening the mouthpiece cover 510 to reach the cocked position ( Figure 2B) will not cause the dose indicating mechanism to be indexed.
  • a gap 600' is formed in the set of teeth 103 so that after the maximum number of doses have been dispensed from the aerosol can 25 the indicating ring 101 is no longer indexed by the indexing member 109. At this point an "empty" indication could be shown in the window 100.
  • the device may also be provided with a means such that it will not operate below a certain predetermined air flow rate, e.g., 10 to 30 litres per minute.
  • a certain predetermined air flow rate e.g. 10 to 30 litres per minute.
  • the vane 550 will be biassed by a spring such that the predetermined minimum air flow is necessary for it to move to its actuated position and enable the valve seal to open.
  • the main body of a dispensing device is preferably manufactured from a plastic such as polypropylene, acetal or moulded polystyrene. It may however be manufactured from metal or other suitable material.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Nozzles (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention se rapporte à un dispositif distributeur de médicament qui comprend un boîtier (400) destiné à recevoir un système de distribution de médicament (25), par exemple, un flacon aérosol, que l'on peut actionner pour distribuer des doses individuelles de médicament. Un dispositif d'actionnement possède une boîte de glissement (420) chargée par ressort venant en contact avec le flacon aérosol au niveau de sa base, lorsque le dispositif d'actionnement est relâché lors de l'inhalation au niveau de l'embout (405) du boîtier. Un compteur de doses comprend une bague (101) rotative indicatrice de dose, entourant la boîte de glissement (420) à avancement incrémentiel, qui se déplace sous l'action d'un élément d'avancement élastique ménagé sur la boîte de glissement, lors de chaque actionnement du flacon aérosol (25) pour libérer une dose de médicament.
PCT/GB1993/001064 1992-05-29 1993-05-24 Dispositif indicateur de dose WO1993024167A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9211436.2 1992-05-29
GB929211436A GB9211436D0 (en) 1992-05-29 1992-05-29 Dose indicating device

Publications (1)

Publication Number Publication Date
WO1993024167A1 true WO1993024167A1 (fr) 1993-12-09

Family

ID=10716244

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1993/001064 WO1993024167A1 (fr) 1992-05-29 1993-05-24 Dispositif indicateur de dose

Country Status (8)

Country Link
CN (1) CN1079167A (fr)
AU (1) AU4083993A (fr)
GB (1) GB9211436D0 (fr)
IL (1) IL105735A0 (fr)
TR (1) TR26757A (fr)
TW (1) TW230751B (fr)
WO (1) WO1993024167A1 (fr)
ZA (1) ZA933639B (fr)

Cited By (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995026769A1 (fr) * 1994-03-30 1995-10-12 Norton Healthcare Limited Compteur isole destine a un inhalateur doseur
US5511540A (en) * 1992-08-18 1996-04-30 Minnesota Mining And Manufacturing Company Inhalation device
DE19549033C1 (de) * 1995-12-28 1997-05-28 Boehringer Ingelheim Int Mechanisches Zählwerk für ein Dosiergerät
WO1998056445A1 (fr) * 1997-06-10 1998-12-17 Glaxo Group Limited Distributeur pourvu d'un compte-doses
WO2000021593A1 (fr) 1998-10-08 2000-04-20 Pari GmbH Spezialisten für effektive Inhalation Moyen d'actionnement pour dispositifs compteurs et dispositif doseur distributeur d'aerosol dote dudit moyen
EP1010438A1 (fr) * 1998-12-11 2000-06-21 Bespak Plc Appareil d'inhalation
GB2360219A (en) * 2000-03-18 2001-09-19 Astrazeneca Uk Ltd Inhaler
WO2001070319A2 (fr) * 2000-03-21 2001-09-27 Iep Pharmaceutical Devices, Inc. Dispositif actionne par inhalation
US6553988B1 (en) * 2000-06-09 2003-04-29 Norton Healthcare, Inc. Medicament dispensing device with a multimaterial diaphragm bounding a pneumatic force chamber
EP1369139A1 (fr) * 2002-06-03 2003-12-10 3M Innovative Properties Company Indicateurs de dose et systèmes de dispension comprenants des nourrisses et des indicateurs
WO2004041339A2 (fr) 2002-11-04 2004-05-21 Cambridge Consultants Limited Inhalateurs pressurises
GB2398254A (en) * 2003-02-11 2004-08-18 Bespak Plc Dispensing apparatus
WO2005007226A1 (fr) * 2003-07-14 2005-01-27 Neolab Limited Inhalateur
WO2005084736A3 (fr) * 2004-03-08 2005-12-08 Sanner Friedr Gmbh Co Kg Pulverisateur destine a la delivrance d'une dose de matieres pulverisables, notamment a l'application de principes actifs pharmaceutiques pulverulents
WO2006027313A1 (fr) * 2004-09-04 2006-03-16 Alfred Von Schuckmann Inhalateur
WO2006054083A1 (fr) * 2004-11-19 2006-05-26 Clinical Designs Limited Distributeur de substance
WO2006115732A2 (fr) * 2005-04-28 2006-11-02 Kos Life Sciences, Inc. Aerosol active par la respiration
EP1787668A1 (fr) * 2005-11-22 2007-05-23 Bespak plc Distributeur d'aérosol
US7232043B2 (en) 2002-12-20 2007-06-19 Acrus Dds Pty Ltd Usage indicator
US7600512B2 (en) 2003-07-14 2009-10-13 Vortran Medical Technology 1, Inc. Inhaler with breath actuated dose counter
WO2011063067A1 (fr) 2009-11-23 2011-05-26 3M Innovative Properties Company Compteur de doses
WO2011071788A1 (fr) 2009-12-09 2011-06-16 3M Innovative Properties Company Indicateur de dose
US8157128B2 (en) 1998-01-16 2012-04-17 Trudell Medical International Indicating device
US8291898B2 (en) 2006-05-26 2012-10-23 Consort Medical Plc Dispensing apparatus
US8381719B1 (en) 2008-12-22 2013-02-26 Trudell Medical International Medicament delivery system with dose indicator and oversleeve actuator
US8567394B2 (en) 2006-12-22 2013-10-29 Almirall, S.A. Inhalation device for drugs in powder form
US8578934B2 (en) 2003-10-28 2013-11-12 Trudell Medical International Indicating device with warning dosage indicator
US8596265B2 (en) 2008-10-22 2013-12-03 Trudell Medical International Modular aerosol delivery system
US8662075B2 (en) 1998-05-05 2014-03-04 Trudell Medical International Dispensing device
WO2014039367A1 (fr) 2012-09-06 2014-03-13 3M Innovative Properties Company Améliorations pour des indicateurs de dose ou relatives à ceux-ci
US8689785B2 (en) 2006-05-26 2014-04-08 Consort Medical Plc Dispensing apparatus
US8869735B2 (en) 2003-12-15 2014-10-28 Trudell Medical International, Inc. Dose indicating device
US8936177B2 (en) 2003-05-15 2015-01-20 Aptar France Sas Fluid product dispenser
US8973784B2 (en) 2005-01-20 2015-03-10 Trudell Medical International Dispensing device
US9114221B2 (en) 2009-03-10 2015-08-25 Euro-Celtique S.A. Counter
WO2016000983A1 (fr) * 2014-06-30 2016-01-07 Chiesi Farmaceutici S.P.A. Inhalateur de poudre sèche et mécanisme actionné par inhalation correspondant
US9265901B2 (en) 2006-08-01 2016-02-23 Trudell Medical International Dispensing device
US9415178B2 (en) 2009-03-10 2016-08-16 Euro-Celtique S.A. Counter
US9592355B2 (en) 2005-09-09 2017-03-14 Raymond John Bacon Dispenser
EP4066874A1 (fr) * 2017-02-14 2022-10-05 Norton (Waterford) Limited Inhalateurs

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JP4805814B2 (ja) * 2003-03-04 2011-11-02 ノートン・ヘルスケアー リミテッド 内部医薬リザーバの状態を表すディスプレイを有する医薬分与装置
FR2857770B1 (fr) * 2003-07-18 2005-10-21 Valois Sas Indicateur de doses ameliore pour dispositif de distribution de produit fluide.
CN101247897B (zh) * 2005-08-24 2013-06-12 贝林格尔·英格海姆国际有限公司 雾化器
DE102014114462A1 (de) * 2013-10-15 2015-04-16 Alfred Von Schuckmann Zählwerk und Handgerät mit Zählwerk
CA2944282C (fr) * 2014-03-29 2021-09-21 Cipla Europe Nv Inhalateur dose comportant un mecanisme d'administration actionne par lesouffle
CN105031777B (zh) * 2015-07-30 2018-11-09 中山市美捷时包装制品有限公司 一种带缓冲装置的安全可计数定量给药促动器
CN105013051A (zh) * 2015-07-30 2015-11-04 中山市美捷时包装制品有限公司 一种带保险罩的可计数定量给药促动器装置
CN105013052B (zh) * 2015-07-30 2018-11-09 中山市美捷时包装制品有限公司 一种带缓冲罩的倒喷装配可计数定量给药促动器装置
CN106075677B (zh) * 2016-08-08 2022-06-10 中山市美捷时包装制品有限公司 一种干粉吸入装置的促动机构
EP3733233A1 (fr) * 2016-11-18 2020-11-04 Norton (Waterford) Limited Inhalateur
CN109529160B (zh) * 2018-12-27 2024-01-19 广东美捷时控股股份有限公司 一种带计数功能的气雾剂吸入给药促动器
CN115105695B (zh) * 2022-06-02 2023-05-16 宁波职业技术学院 一种哮喘呼吸器及哮喘呼吸器的使用方法

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Also Published As

Publication number Publication date
CN1079167A (zh) 1993-12-08
GB9211436D0 (en) 1992-07-15
TR26757A (tr) 1995-05-15
ZA933639B (en) 1993-12-20
IL105735A0 (en) 1993-09-22
TW230751B (fr) 1994-09-21
AU4083993A (en) 1993-12-30

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