WO1993023545A1 - Gene which codes for eicosapentaenoic acid synthetase group and process for producing eicosapentaenoic acid - Google Patents
Gene which codes for eicosapentaenoic acid synthetase group and process for producing eicosapentaenoic acid Download PDFInfo
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- WO1993023545A1 WO1993023545A1 PCT/JP1993/000641 JP9300641W WO9323545A1 WO 1993023545 A1 WO1993023545 A1 WO 1993023545A1 JP 9300641 W JP9300641 W JP 9300641W WO 9323545 A1 WO9323545 A1 WO 9323545A1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6432—Eicosapentaenoic acids [EPA]
Definitions
- SPECIFICATION Genes encoding icosapentaenoic acid synthase group and method for producing icosapentaenoic acid
- the present invention relates to a biosynthetic enzyme (hereinafter referred to as EPA) biosynthetic enzyme group gene, a plasmid containing the enzyme gene, an organism transformed with the plasmid, and an EPA using the organism.
- EPA biosynthetic enzyme
- EPA is useful as a raw material for pharmaceuticals, foods, feeds, etc.
- EPA icosapentaene
- Platelet aggregation inhibitory action [thrombolytic action] (2) Neutral fat lowering action in blood [3] VLDL-cholesterol, LDL-cholesterol lowering action in blood, HDL- (4) Blood viscosity lowering action (5) Blood pressure lowering action (6) Anti-inflammatory action (7) 'Anti-tumor action.
- EPA is important as a substrate for the generation of prostaglandins of type 3, has an inhibitory effect on platelet aggregation, and has application as a therapeutic and prophylactic agent for thrombosis.
- EPA is one of the most active polyunsaturated fatty acids that contributes to lowering plasma cholesterol levels and is far more active than linoleic acid found in normal vegetable oils. Effectiveness It is. It is also known as an essential nutrient for fish and the like.
- Fish oil extracted by the boiling method is a mixed dali cereide containing various kinds of fats as constituent fatty acids. Not only is it difficult to isolate and purify each component, but also EPA All are straight-chain polyunsaturated fatty acids having 20 carbon atoms and five cis double bonds, and are extremely susceptible to oxidation.
- EPA treats fish oil extracted by various methods under xeno- or alkaline conditions and hydrolyzes it to free fatty acids, or converts the free methyl or ethyl esters. After conversion to EPA, many of them are further purified by low-temperature fractional crystallization, urea addition, vacuum distillation, reverse phase chromatography, etc. to an EPA concentration of 90% or more.
- the EPA condensate obtained by using these methods uses many kinds of organic solvents during the process, Because it is heated nearby, there is a curiosity with residual organic solvents and alteration due to polymerization, isomerization or oxidation of EPA.
- fish oil is used as a raw material for EPA, it is difficult to remove docosenoic acid, etc., which is suspected as one of the causes of heart disease. The problem remains.
- the present inventors have developed an EPA-producing ability for the purpose of finding a fermentative production method of EPA-containing lipids using a bacterium that has a short culture time, facilitates culture control, and facilitates gene acquisition.
- a new Bacteria belonging to the genus Pseudomonas, Alteromonas, and Shewanel la produces EPA.
- the productivity of useful substances from wild strains that produce useful substances is generally low, and when the ability of those microorganisms is to be used industrially, microorganisms are improved by various methods, that is, productivity is improved. .
- the present invention uses ⁇ gene recombination methods to identify EPA biosynthetic enzymes that are unknown in the literature, and introduces them into other organisms to improve EPA productivity.
- the aim is to confer EPA biosynthesis capacity to non-functional organisms, thereby establishing an advantageous method of producing EPA.
- the present invention provides an EPA biosynthetic enzyme group gene, an expressed plasmid containing the gene, an organism transformed with the plasmid, and a method for producing EPA using the organism.
- FIG. 1 shows the structure of Brassmid PEPA which carries the gene group of the present invention.
- FIG. 2 shows a restriction map of a DNA fragment containing the gene group of the present invention.
- a gene encoding an EPA biosynthetic enzyme group is extracted by extracting DNA from a microorganism capable of producing EPA (a gene source microorganism) and cleaving the DNA with a restriction enzyme. Excision This is introduced into an appropriate vector to produce an expression type plasmid, and this plasmid is used to transform a host organism to produce an EPA-producing strain. This organism can produce EPA.
- Organisms that can be used as a gene source in the present invention are not particularly limited to genera, species or strains, but are usually those belonging to the genus Pseudomonas and Alteromonas. Microorganisms classified into the genus, genus Sewanella, etc. can be used.
- Pseudomonas putrefaciens is an example of a microorganism belonging to Pseudomonas that can be easily obtained from a public microorganism depositary institution.
- SCRC-2 18 1 (FE RM BP-29 17), SCRC-220 1 (FERMBP-29 16), SCRC-2 27 1 (FE RM BP-2
- Examples of microorganisms belonging to Arteromonas include Arteromonas putrefaciens SCRC-2871 (FE RM BP-1 ⁇ 24) and Arteromonas. 'Butance facilitance subspecies' Sagami facilitance I can do it.
- a heterologous host such as, for example, Escherichia coli or Bacillus subtilis (Baci 1 lus subtil is) or a host of the same species, such as a bacterium belonging to the genus Seawanella.
- Escherichia coli or Bacillus subtilis Bacillus subtilis (Baci 1 lus subtil is) or a host of the same species, such as a bacterium belonging to the genus Seawanella
- transforming yeast, filamentous fungi, etc. EPA-producing strains can be artificially created.
- EPA-producing strains can be artificially created.
- by introducing this gene into higher plants such as soybean, sunflower, rape, sesame and the like, it is possible to produce EPA-producing plants.
- the control region originally associated with these Xinyin genes can be used, but the expression level is It is preferable to prepare a separate promoter / operator system in order to improve the expression or enable the induction of expression.
- colon intestine is used as the host, trp, tac, lavUV5, PL,
- One set of promoter Z operators such as PR and 1 PP can be used, and SD sequences such as trp leader peptide, 1 ac Z, metapyroforce tecase or cII gene are used as SD sequences. be able to.
- a transcription terminator may be provided downstream of the coding region, for example, rrnBT1T2 terminator of liposome gene of E. coli.
- the expression of the gene involves the host z vector system of Saccharomyces cerev ⁇ si ae.
- the promoters include yeast alcohol dehydrogenase gene promoter, acid phosphatase gene promoter, and glyceraldehyde 1-3.
- a phosphate dehydrogenase promoter, an enolase gene promoter, and the like can be used, in which case the plasmid is a sequence for replication in yeast, and It preferably contains an auxotrophic marker as a selection marker for selecting a yeast containing the plasmid, for example, an auxotrophic sequence such as Leu, Trp, His and the like. No.
- Gene transfer into higher plants includes a method using vectors and a direct transfer method.
- Vectors include Ti Brass Midi, Power Reflex Moisture Virus (C a MV), Gemi Mini Virus, Casa Barentent Virus, Tomato Golden Mosai RNA viruses, such as DNA viruses such as viruses, bromozyme virus (BMV), and tandem mozy virus (TMV), can be used.
- promoters include the CaMV 35S promoter.
- the direct introduction method into the proto-platform includes the canoleic acid phosphate method, polyethylene glycol method, micro-injection method, and Cut mouth poration, ribosome method and the like.
- the particle gun method as a method for direct introduction into plant cells.
- the expression level of a specific protein in Escherichia coli is affected by the number of gene copies, transcription efficiency, mRNA stability, translation efficiency, protein stability, and the like.
- these control regions such as the promoter, SD region, and terminator
- the smaller the brassmid the better it is handled. Easy.
- the gene The number of copies is related to the size of the plasmid encoding the gene, and the smaller the size, the greater the number of copies. For this reason, a DNA fragment containing the EPA biosynthetic enzyme group gene described in Examples of the present invention is introduced into plasmid, and subcloning of this plasmid is repeated to repeat the gene.
- any strain derived from Escherichia coli 2 strain can be used.
- JM83, JM101, JM103, JM105, JM109, RR1, RB791, W3110, C600, HB101, DH1, AG 1, NM554 etc. can be used.
- Examples of the host yeast include AH22, DC5D-13-1A, and YNN140.
- the enzymes encoded by the gene of the present invention can induce higher fatty acids synthesized by the biosynthesis system inherent in the host organism into icosaventaenoic acid.
- the transformed organism having the gene of the present invention is cultured by a conventional method, for example, in the case of using a microorganism, by culturing in a medium to obtain a microorganism cell.
- a medium having the composition shown in Table 1 below can be prepared.
- EPA can be obtained by a conventional method, for example, by extraction using an organic solvent.
- the details will be exemplified in the following examples.
- Example 11-1 Synthesis ⁇ 3 ⁇ 4 Preparation of genome DNA
- the obtained cells were washed once with 1 M NaCl. After that, the cells were suspended in 20 ml of 1 M NaCl 1. The suspension was allowed to stand at 55'C for 30 minutes, and 0.1 MEDTA 20 ml was added thereto.
- the precipitated DNA was wound with a glass rod, washed in ethanol, dissolved in 1 O ml of TES buffer, and left at 4'C for a while.
- 0.5 mg of RNase A was added, and the mixture was shaken slowly at 37 with 3 hours, then 1 mg of proteinase K was added, and the mixture was further shaken for 4.5 hours.
- add 5 ml each of neutralized phenol and cross-hole form shake gently for 5 minutes, centrifuge, collect the upper layer, and add 10 ml of gross form. Shake gently for 5 minutes and centrifuge to obtain the upper layer.
- Example 1 The phage-infected Escherichia coli solution was subjected to LB agar medium containing 50 g / m1 of ambicilin [Tributon 1%, yeast extract 0.5%, NaC 1 1%, agar agar 2%) and cultured overnight at 37 ° C. The resulting colony was inoculated into 1.5 ml of LB medium containing 50 g / ml of ambicilin and incubated at 25 ° C. Shaking culture was performed for ⁇ 7 days. This is centrifuged to collect the cells, the medium is removed, suspended in 0.5 ml of methanol saturated with hydrogen chloride, sealed and kept at 80 ° C for 1 hour to remove fatty acids.
- Cosmid pEPA was prepared from the transformant AG-; LZpEPA. pEPA was digested with various restriction enzymes, and restriction enzyme cleavage maps were created (FIG. 1).
- SEQ ID NO: 1 The entire nucleotide sequence of the S au 3 AI fragment is shown in SEQ ID NO: 1. Eight oven reading frames 0 RF 2 to 9 are identified in this base sequence The respective nucleotide sequences and corresponding amino acid sequences are shown in SEQ ID NOs: 2 to 9. Table 2 shows the relationship between the entire nucleotide sequence [SEQ ID NO: 1) and 0RF 2 to 9 [SEQ ID NOs: 2 to 9]. Table 2
- FIG. 2 shows a restriction enzyme map of the genomic DNA insertion site and the corresponding positions of 0 R P 2 to 9.
- a mark indicates a site where mRNA forms a hair-bin structure (Stem and roop structure).
- the present invention provides a gene encoding the amino acid sequence shown in SEQ ID NOs: 2 to 9 and an amino acid sequence region having homology to the amino acid sequence of the known enzyme.
- the present invention also provides a DNA encoding an amino acid sequence containing the same.
- the present invention further provides a nucleotide sequence capable of hybridizing to the nucleotide sequence of SEQ ID NOS: 1 to 9 or a portion thereof, and encoding a useful activity, and a useful nucleotide sequence encoded by the nucleotide sequence. Includes polypeptides that have an effect.
- Example 2 Production of EPA by Transformed Ingredient AG—l Zp EPA Transformed Bacteria AG—1 Zp EPA was inoculated into 100 ml of LB medium containing 50 jtz 1 Zm1 of ampicillin, and The cells were cultured at 5 for 48 hours. The cells were obtained by centrifugation, washed once, suspended in 2 ml of pure water, and extracted three times with 12 ml of a 2-to-1 solvent consisting of chloroform and methanol. The solvent was evaporated to dryness, dissolved in 1.5 ⁇ 1 of methanol saturated with hydrogen chloride, placed in a closed container, and kept at 80 at room temperature for 1 hour to methylesterify the fatty acid.
- Example 3 Production of EPA by Transformant JM109 ZpEPA Escherichia coli K12 / JM109 strain was transformed by a conventional method using cosmid pEPA.
- JM109 nopEPA FREMBP-425
- Extraction and methyl esterification of bacterial lipids were performed in the same manner as in Example 2, and analysis by gas chromatography revealed an EPA peak.
- the ratio in the total fatty acid esters was calculated to be about 1.43% from the peak area ratio.
- the amount of EPA produced per culture was about 0.6 ml.
- GACGCAAACC TTATGGTTAA TAAAGCTGAC GTTAACCGCA TCTTACTTGG CCAAGTAACC 7980
- AAAATAGCCG ATAGCATGGT CGAGTTTACA CCTGACTTCG AAATCGTACC AACGCCTGTT 8100
- AAATGAGGCA TTAATCTCAA CAAGTGCAAG CTAGACATAA
- AAATTGACCC ATACCAAGCC GATATTGCCG CACCAGCGAA AAAGTCGCCA ATGAGCATTT 16800
- CTTAACAGCA CAGATAAAAT CTTAGTGACT GGTGGGGCAA AAGGGGTGAC ATTTGAATGT 20460
- 3GCCC 222C TATAAAC TGCGCCCTAATA ACCAGCG ATTAGCAAACTGA GTTGC CTGTTATCAAA
- GACACTCCTA TTCGTGTCGG TTGTGGTGGC GGTGTGGGTA CGCCTGATGC AGCGCTGGCA 31680 ACGTTTAACA TGGGCGCGGC GTATATTGTT ACCGGCTCTCTACACAAAGC TTGTGTTGAA 31740
- CTCAACACTA TCAAGTAAAA CTCTTGCATT AATACCTTGG TCCAACATTT TAGCAATACG 37260 CGGCAACTTA CCATCGGCAA TACCTACTGC ATAAATAATG TCTGTGTAAC CTTTAGATGC 37320
- Genomic DNA Origin Ziwanella Beautifaciens SC RC—2 8 7 4 CPE RM BP-1 6 25]
- VVO 961 ⁇ 2 VVO 190 100 000 OVV Oil 101 3V0 V13 IVD VU V01 OVI V3D 130 VVO
- CAC ATA GGC TCA ATG ACA ACT CAT GAC TTG AGC GCT ACA TAC TAC ATC 2784 H is lie G ly Ser Met Thr Thr His Asp leu Ser Ala Thr Tyr Tyr He
- GCT GftA GGC AAC GAT ACC AAG CAA CAC ATT GCG CTA GGT TCA GTT AAA 1200 Ala Glu Gly Asn Asp Thr Lys G in H is lie Ala Leu Gly Ser Val Lys
- GAC GCA GCC AAA TTT ACT AAA ACA AGC CGA
- GCT ATT CCG CAG CAA TAT GGT GAG ACG TTC ACT ACG CTG ATG ACC GAG 3312 Ala lie Pro Gin Gin Tyr Gly Glu Thr Phe Thr Thr Leu Met Thr Glu
- CAA GCT AAA CTG GCA AGT TCT GGT GTT GCA ATT CCA GAG AGT CTG CAA 3360 Gin Ala Lys Leu Ala Ser Ser Gly Val Ala He Pro Glu Ser Leu Gin
- GGC GAA ATC GTG ACT TAT ATG AAC TCT AAA
- CTC GCT GAC GGC TCT AAG 4656 Gly Glu lie Val Thr Tyr Met Asn Ser Lys Leu Ala Asp Gly Ser Lys
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Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU40881/93A AU673359B2 (en) | 1992-05-15 | 1993-05-14 | Gene which codes for eicosapentaenoic acid synthetase group and process for producing eicosapentaenoic acid |
NO940146A NO940146L (no) | 1992-05-15 | 1994-01-14 | Gen som koder for eikosapentaensyre-syntetasegruppe og fremgangsmåte for fremstilling av eikosapentaensyre |
FI940203A FI940203A (fi) | 1992-05-15 | 1994-01-14 | Geeni, joka koodaa eikosapeutaanihappoa syntetisoivia entsyymejä, ja menetelmä eikospentaanihapon valmistamiseksi |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14794592 | 1992-05-15 | ||
JP4/147945 | 1992-05-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1993023545A1 true WO1993023545A1 (en) | 1993-11-25 |
Family
ID=15441621
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP1993/000641 WO1993023545A1 (en) | 1992-05-15 | 1993-05-14 | Gene which codes for eicosapentaenoic acid synthetase group and process for producing eicosapentaenoic acid |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0594868A4 (ja) |
AU (1) | AU673359B2 (ja) |
CA (1) | CA2113557A1 (ja) |
FI (1) | FI940203A (ja) |
WO (1) | WO1993023545A1 (ja) |
Cited By (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996021735A1 (fr) * | 1995-01-13 | 1996-07-18 | Sagami Chemical Research Center | Genes codant un groupe d'enzymes de biosynthese pour l'acide icosapentaenoique (epa) et procede d'obtention dudit acide |
US6140486A (en) * | 1997-06-04 | 2000-10-31 | Calgene Llc | Production of polyunsaturated fatty acids by expression of polyketide-like synthesis genes in plants |
US6180602B1 (en) | 1992-08-04 | 2001-01-30 | Sagami Chemical Research Center | Human novel cDNA, TGF-beta superfamily protein encoded thereby and the use of immunosuppressive agent |
US6566583B1 (en) | 1997-06-04 | 2003-05-20 | Daniel Facciotti | Schizochytrium PKS genes |
US6600029B1 (en) | 1995-12-19 | 2003-07-29 | Regents Of The University Of Minnesota | Metabolic engineering of polyhydroxyalkanoate monomer synthases |
US7211418B2 (en) | 1999-01-14 | 2007-05-01 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
US7217856B2 (en) | 1999-01-14 | 2007-05-15 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
US7247461B2 (en) | 1999-01-14 | 2007-07-24 | Martek Biosciences Corporation | Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof |
US7271315B2 (en) | 1999-01-14 | 2007-09-18 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
US7759548B2 (en) | 2006-03-15 | 2010-07-20 | Martek Biosciences Corporation | Polyunsaturated fatty acid production in heterologous organisms using PUFA polyketide synthase systems |
US7807849B2 (en) | 2004-04-22 | 2010-10-05 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
US7834250B2 (en) | 2004-04-22 | 2010-11-16 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
US8003772B2 (en) | 1999-01-14 | 2011-08-23 | Martek Biosciences Corporation | Chimeric PUFA polyketide synthase systems and uses thereof |
US8816111B2 (en) | 2012-06-15 | 2014-08-26 | Commonwealth Scientific And Industrial Research Organisation | Lipid comprising polyunsaturated fatty acids |
US8940884B2 (en) | 2009-03-19 | 2015-01-27 | Dsm Ip Assets B.V. | Polyunsaturated fatty acid synthase nucleic acid molecules and polypeptides, compositions, and methods of making and uses thereof |
US9718759B2 (en) | 2013-12-18 | 2017-08-01 | Commonwealth Scientific And Industrial Research Organisation | Lipid comprising docosapentaenoic acid |
US9938486B2 (en) | 2008-11-18 | 2018-04-10 | Commonwealth Scientific And Industrial Research Organisation | Enzymes and methods for producing omega-3 fatty acids |
US10005713B2 (en) | 2014-06-27 | 2018-06-26 | Commonwealth Scientific And Industrial Research Organisation | Lipid compositions comprising triacylglycerol with long-chain polyunsaturated fatty acids at the sn-2 position |
US10513717B2 (en) | 2006-08-29 | 2019-12-24 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of fatty acids |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0223877A (ja) * | 1986-12-26 | 1990-01-26 | Sagami Chem Res Center | エイコサペンタエン酸含有脂質の製造方法 |
JPH0297393A (ja) * | 1988-10-03 | 1990-04-09 | Sagami Chem Res Center | エイコサペンタエン酸を含むリン脂質組成物の海洋微生物による製造法 |
JPH02286023A (ja) * | 1989-04-28 | 1990-11-26 | Sagami Chem Res Center | 稚魚用飼料としての生物の培養方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0324018A (ja) * | 1989-06-22 | 1991-02-01 | Tosoh Corp | 脂質代謝改善剤 |
-
1993
- 1993-05-14 AU AU40881/93A patent/AU673359B2/en not_active Ceased
- 1993-05-14 EP EP93910344A patent/EP0594868A4/en not_active Withdrawn
- 1993-05-14 CA CA002113557A patent/CA2113557A1/en not_active Abandoned
- 1993-05-14 WO PCT/JP1993/000641 patent/WO1993023545A1/ja not_active Application Discontinuation
-
1994
- 1994-01-14 FI FI940203A patent/FI940203A/fi unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0223877A (ja) * | 1986-12-26 | 1990-01-26 | Sagami Chem Res Center | エイコサペンタエン酸含有脂質の製造方法 |
JPH0297393A (ja) * | 1988-10-03 | 1990-04-09 | Sagami Chem Res Center | エイコサペンタエン酸を含むリン脂質組成物の海洋微生物による製造法 |
JPH02286023A (ja) * | 1989-04-28 | 1990-11-26 | Sagami Chem Res Center | 稚魚用飼料としての生物の培養方法 |
Non-Patent Citations (1)
Title |
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See also references of EP0594868A4 * |
Cited By (97)
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US6180602B1 (en) | 1992-08-04 | 2001-01-30 | Sagami Chemical Research Center | Human novel cDNA, TGF-beta superfamily protein encoded thereby and the use of immunosuppressive agent |
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US6600029B1 (en) | 1995-12-19 | 2003-07-29 | Regents Of The University Of Minnesota | Metabolic engineering of polyhydroxyalkanoate monomer synthases |
US6140486A (en) * | 1997-06-04 | 2000-10-31 | Calgene Llc | Production of polyunsaturated fatty acids by expression of polyketide-like synthesis genes in plants |
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Also Published As
Publication number | Publication date |
---|---|
FI940203A (fi) | 1994-03-14 |
CA2113557A1 (en) | 1993-11-25 |
FI940203A0 (fi) | 1994-01-14 |
EP0594868A1 (en) | 1994-05-04 |
AU4088193A (en) | 1993-12-13 |
EP0594868A4 (en) | 1997-01-02 |
AU673359B2 (en) | 1996-11-07 |
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