WO1990004420A1 - Instrument pourvu d'un ballon pour l'injection continue d'un medicament liquide - Google Patents

Instrument pourvu d'un ballon pour l'injection continue d'un medicament liquide Download PDF

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Publication number
WO1990004420A1
WO1990004420A1 PCT/JP1988/001055 JP8801055W WO9004420A1 WO 1990004420 A1 WO1990004420 A1 WO 1990004420A1 JP 8801055 W JP8801055 W JP 8801055W WO 9004420 A1 WO9004420 A1 WO 9004420A1
Authority
WO
WIPO (PCT)
Prior art keywords
tubular body
balloon
liquid medicine
resin
fluid resin
Prior art date
Application number
PCT/JP1988/001055
Other languages
English (en)
Japanese (ja)
Inventor
Osamu Tsukada
Original Assignee
Tsukada Medical Research Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tsukada Medical Research Co., Ltd. filed Critical Tsukada Medical Research Co., Ltd.
Priority to PCT/JP1988/001055 priority Critical patent/WO1990004420A1/fr
Publication of WO1990004420A1 publication Critical patent/WO1990004420A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
    • A61M5/152—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags pressurised by contraction of elastic reservoirs

Definitions

  • the present invention relates to a continuous drug injector with a balloon used for injecting a drug solution into a balloon and injecting a predetermined amount of drug solution into a human body within a predetermined time.
  • a method for injecting a drug solution into the human body for a relatively long time is to connect a syringe containing a drug solution to an injection needle or catheter and operate the injector manually, by a spring, or electrically to discharge the drug solution.
  • the drug solution was placed in a drip bottle or container, and the drug solution flowed out naturally or electrically.
  • the patient and the practitioner are restrained and fixed in the human body for a fixed period of time, causing great physical and mental pain.
  • the limit is one or two minutes.
  • a large amount of replenishment fluid is required in addition to the medicinal solution, and even a patient who does not need rehydration fluid will need to inject unnecessary fluid.
  • the IV bin or container must be located higher than the patient, and The need for a complex and long conduit between the catheter and the IV bottle restricted the patient's body movements and required practitioners to perform appropriate checks.
  • the continuous medicine injector with a balloon of this patent is provided with a tubular body having a drug solution flow path formed along a longitudinal axis, and a drug solution injection section having a check valve at one end of the tubular body.
  • a liquid injection section provided at the other end of the tubular main body; a member for blocking the chemical liquid flow path provided in the middle of the tubular main body;
  • Outflow holes or outflow holes to which a microporous membrane is adhered are formed on the side of the pouring part by penetrating the tube wall of the tubular body, and the inflow holes and the outflow holes are covered with a balloon made of an elastic material.
  • the structure is such that the circumference of the balloon is hermetically fixed to the outer circumference of the tubular body.
  • the applicant of the present application has proposed a “continuous infusion catheter for bladder” which has a simple structure, is easy to handle, and has high safety when infusing a medical solution into a human body for a relatively long time (Japanese Patent Application Laid-Open No. Sho 62). — No. 11464).
  • This catheter uses a conventional general bladder catheter
  • a concave portion is provided in a part of the outer periphery of the proximal end side of the catheter, the concave portion is surrounded by a balloon made of an elastic material, and the periphery of the balloon is airtightly fixed to the outer periphery of the catheter;
  • a thin tube is provided on the tube wall of the catheter along the axis, a base end of the thin tube is opened to form a drug solution outlet, and the base end of the thin tube is communicated with the recess, and a center of the balloon is formed.
  • the liquid medicine injection section is fixed in an airtight manner, a central passage is provided in the center of the liquid medicine injection section, a valve is provided on the inlet side of the central passage, and the outlet side is communicated with the recess. I have.
  • the above-mentioned injector or catheter is provided with pores or capillaries to control the outflow time of the drug solution.
  • pores or capillaries to control the outflow time of the drug solution.
  • An object of the present invention is to provide a continuous drug injector with a balloon having a structure capable of relatively easily forming a thin tube for controlling the outflow time of a drug solution and preventing clogging of the thin tube. .
  • the continuous drug injector according to the present invention includes a tubular body having a drug solution flow path formed along a longitudinal axis, a drug solution injector having a check valve at one end of the tubular body, The other end is provided with a chemical liquid injection section, and the other end of the tubular body is filled with a predetermined amount of a normal temperature or thermosetting fluid resin having no adhesive ability only to a specific material, and is specified in the fluid resin.
  • a thin wire made of a material having a predetermined diameter is embedded in a straight line, spiral shape, or meandering shape, and one end of the thin wire is connected to the tubular book.
  • Penetrating the body guiding the other end of the thin wire material to the outside through the chemical solution discharging portion, forming a hole through the tube wall of the tubular main body, and forming the hole with a balloon made of an elastic material. It surrounds the hole, and has a structure in which the periphery of the balun is air-tightly fixed to the outer periphery of the tubular body.
  • the room temperature or thermosetting fluid resin is of a type having an adhesive property to the tubular body, and examples thereof include a silicone resin, a polyurethane resin, and a butyl rubber resin.
  • the fine wire is one of a resin yarn, a metal yarn, a carbon fiber yarn, and a ceramic yarn.
  • the fine wire is pulled out of the tubular main body to form pores in the fluid resin, and a human body indwelling device can be attached to the chemical solution discharging section.
  • FIG. 1 is a longitudinal sectional view of a continuous drug solution injector of the present invention.
  • FIG. 2 is a cross-sectional view taken along line ⁇ —E in FIG. Fig. 3 is a cross-sectional view taken along the line H-IE in Fig. 1.
  • FIG. 4 is a side view showing an example of a human indwelling device connected to the continuous drug solution injector of the present invention.
  • FIG. 5 is a diagram illustrating the operation of the continuous drug injector according to the present invention.
  • FIG. 6 is a longitudinal sectional view of an example of a bladder catheter in which the continuous drug solution injector of the present invention is surrounded.
  • FIG. 7 is a longitudinal sectional view of a bladder force catheter to which the present invention is applied.
  • the continuous drug solution injector according to the present invention includes a tubular main body 1 and a balloon 2. .
  • the tubular main body 1 has a chemical liquid channel 11 formed along the longitudinal axis.
  • a chemical liquid injection section 12 is provided, and at the other end (the left end in the illustrated example), a chemical liquid discharge section 13 is provided.
  • the chemical liquid injection section 12 and the chemical liquid discharge section 13 may be formed integrally with the tubular body 1, but it is preferable to connect separate parts as shown in the figure in view of the convenience of manufacture and handling.
  • a conventional check valve 121 is provided in the liquid injector 12.
  • the check valve 121 may have a function of permitting the injection of the chemical solution in the direction of arrow 122 but not allowing the reverse flow.
  • Balloon 2 is preferably made of a wear-resistant, high-toughness material that is highly elastic and does not easily damage external action. In particular, transparent or translucent materials are preferred. As such a material, for example, a commercially available material such as silicon rubber or latex rubber is optimal.
  • the balloon 2 is in close contact with the outer periphery of the tubular main body 1 in a normal state before the injection of the drug solution, and as shown in FIG. 5 during operation after the injection of the drug solution.
  • the remaining portion expands apart from the outer periphery of the tubular body 1 except for the periphery 21.
  • the fluid resin 3 is filled in the chemical solution passage 11 inside the chemical solution discharge section 13.
  • the fine wire 4 is embedded by penetrating the fluid resin 3 in the pipe axis direction.
  • One end 41 of the fine wire 4 is guided into the chemical solution passage 11.
  • the other end 42 of the fine wire 4 penetrates the chemical solution discharge section 13 and goes out of the tubular body 1 Induce.
  • a ring 43 is connected to the tip of the other end 42.
  • the fluid resin 3 has a property of adhering to the inner surface of the chemical solution passage but not to the thin wire 4, for example, a resin such as a silicon resin, a polyvinyl resin, or a butyl rubber resin.
  • the fine wire 4 does not adhere to the flowable resin 3 and has a very small diameter of about 10 to 500 //, but relatively high tensile strength, for example, resin thread, metal thread, glass fiber thread, carbon Fibers such as textile yarns and ceramic yarns are preferred.
  • the filling amount of the fluid resin 3 defines the length of the pores 31 (FIG. 5 (c)) formed after the thin wire 4 is drawn.
  • the length of the pore 31 is an important factor that determines the outflow time of the chemical solution.
  • FIG. 4 shows a typical example of a human body indwelling device connected to the chemical solution discharging section 13 of the continuous chemical solution injector in one direction.
  • A shows an ordinary injection needle
  • B shows an injection needle having a flexible conduit
  • C shows an ordinary catheter.
  • Balloon 2 is basically spherical, but it can be formed into any shape according to the shape of the place where the human body is used. For example, it may be a flat ellipsoid.
  • FIG. 6 shows an example in which the continuous drug injector 100 of the present invention is connected to the drug injector 51 of the normal bladder catheter 5.
  • FIG. 7 shows an improved example in which the present invention is applied to a bladder catheter 5 similar to that of FIG.
  • the tip of the chemical liquid injection channel 52 is filled with the fluid resin 3 and the fine wire 4 is buried, and a hole 521 is provided in the middle of the channel 52, and the balloon 2 is attached to the outer periphery thereof. It is a thing.
  • an example of operation of the continuous drug solution injector according to the present invention will be described with reference to FIG.
  • a predetermined amount of the drug solution is injected from the drug solution injection section 12 of the continuous drug solution injector, and the drug solution flows into the balloon 2 through the drug solution flow path 11 and the hole 111 of the tubular main body 1, and the balloon 2 is inflated while the balloon 2 is inflated.
  • the liquid medicine filled in the balloon 2 does not flow backward by the check valve 121.
  • the same kind of chemical liquid or physiological saline is injected into the flow path 11 in advance, or as described later.
  • the wire 4 is pulled out to form a pore 31 (FIG. 5 (c)), and the pore 31 may be used as an air vent hole.
  • the user pulls the ring connected to the other end of the fine wire 4 with a finger (B). Since the fine wire 4 is not adhered to the hardened fluid resin 3, it can be removed from the hardened fluid resin 3 with a relatively small force. As a result, pores 31 are formed in the cured fluid resin 3 (C).
  • a necessary human indwelling device for example, an injection needle 6 is attached to the drug solution discharge section 13 (C).
  • the chemical liquid filled in the balun 2 flows into the injection needle 6 through the hole 11 1, the chemical liquid flow path 11, the fine hole 31, and the chemical liquid discharge section 13 due to the contraction force of the balun itself. I do.
  • the pouring time of the liquid medicine is determined by the injection amount and viscosity of the liquid medicine, the contraction characteristics of the balloon 2, the cross-sectional area and length of the pore 31, the internal pressure of the injection point, and the like. In practice, it is sufficient to actually measure the dispensing time for each continuous drug injector with a standard drug solution.
  • the target is three-way 'fore catering.
  • a fluorocarbon yarn with a diameter of 0.126 cm was passed through the drug solution injection channel in this catheter, and a room temperature-curable silicone RTV was injected and cured there.
  • the balloon is 150 urn thick and 2 cm long.
  • Table 1 shows the results of examining the pouring time under various conditions using water as the chemical.
  • a transparent cover over the outside of the balloon (not shown) to prevent the balloon from bursting by touching an external sharp object. May be removably attached to the tubular body 1.
  • the continuous drug solution injector of the present invention functions integrally as a drug solution container and a drug solution injecting device, so that its structure is simple and handling is easy. Therefore, the activity and body movement of the patient are not suppressed, and the operator's labor and restraint time are reduced. Also, once the air has been bleeded, no air will mix until the balloon is completely deflated.
  • the continuous drug injector of the present invention can very easily form pores that greatly affect the injection time, and the pores are formed immediately before use, so that the pores are formed immediately before use. There is no clogging problem. [Industrial applicability]

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

Cet instrument pour l'injection continue d'un médicament liquide possède un corps tubulaire (1) comportant un passage d'écoulement (11) de médicament liquide, s'étendant dans le sens de son axe longitudinal. Le corps tubulaire (1) présente à une extrémité une section d'injection de médicament liquide (12) contenant un clapet de non-retour (121), et à l'autre extrémité une section de déchargement de médicament liquide (13). Une quantité déterminée de résine fluide (3) ne possédant pas de pouvoir adhérant par rapport à un seul matériau spécifique est entassée dans l'extrémité avant du corps tubulaire (1). Une tige mince (4) en un matériau spécifique et possédant un diamètre déterminé est noyée linéairement dans la résine fluide, et une extrémité (41) de la tige mince traverse la résine fluide et pénètre à l'intérieur du corps tubulaire, alors que son autre extrémité (42) traverse la section de décharge de médicament liquide et aboutit à l'extérieur. Un passage (111) traverse la paroi du corps tubulaire et est enfermé dans un ballon (2) composé d'un matériau élastique, et les bords circonférentiels du ballon sont fixés de manière étanche sur la surface circonférentielle du corps tubulaire. Lors de l'utilisation, on injecte une quantité déterminée de médicament liquide dans le ballon par l'intermédiaire de la partie d'injection de médicament liquide, on retire la tige mince à l'extérieur du corps tubulaire, et on fixe ensuite un accessoire de montage à demeure sur la partie de décharge de médicament. Après l'extraction de la tige mince, le médicament liquide s'écoule en continu pendant longtemps à travers un petit passage aménagé dans la résine fluide.
PCT/JP1988/001055 1988-10-18 1988-10-18 Instrument pourvu d'un ballon pour l'injection continue d'un medicament liquide WO1990004420A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/JP1988/001055 WO1990004420A1 (fr) 1988-10-18 1988-10-18 Instrument pourvu d'un ballon pour l'injection continue d'un medicament liquide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP1988/001055 WO1990004420A1 (fr) 1988-10-18 1988-10-18 Instrument pourvu d'un ballon pour l'injection continue d'un medicament liquide

Publications (1)

Publication Number Publication Date
WO1990004420A1 true WO1990004420A1 (fr) 1990-05-03

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PCT/JP1988/001055 WO1990004420A1 (fr) 1988-10-18 1988-10-18 Instrument pourvu d'un ballon pour l'injection continue d'un medicament liquide

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002058739A (ja) * 2000-08-23 2002-02-26 Daiken Iki Kk 薬液のワンショット注入器および薬液注入装置
JP2018501053A (ja) * 2014-12-18 2018-01-18 マーク アンドリュー コスカ， 使い捨て注射システム

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56102252A (en) * 1980-01-18 1981-08-15 Alza Corp Medical syringe

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56102252A (en) * 1980-01-18 1981-08-15 Alza Corp Medical syringe

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002058739A (ja) * 2000-08-23 2002-02-26 Daiken Iki Kk 薬液のワンショット注入器および薬液注入装置
JP2018501053A (ja) * 2014-12-18 2018-01-18 マーク アンドリュー コスカ， 使い捨て注射システム

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