WO1990001323A1 - Procede et composition de traitement et de prevention des problemes de peau seche - Google Patents

Procede et composition de traitement et de prevention des problemes de peau seche Download PDF

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Publication number
WO1990001323A1
WO1990001323A1 PCT/US1989/003551 US8903551W WO9001323A1 WO 1990001323 A1 WO1990001323 A1 WO 1990001323A1 US 8903551 W US8903551 W US 8903551W WO 9001323 A1 WO9001323 A1 WO 9001323A1
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WO
WIPO (PCT)
Prior art keywords
concentrate
acid
weight
composition
cholesterol
Prior art date
Application number
PCT/US1989/003551
Other languages
English (en)
Inventor
Joel E. Bernstein
Original Assignee
Bernstein Joel E
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bernstein Joel E filed Critical Bernstein Joel E
Publication of WO1990001323A1 publication Critical patent/WO1990001323A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A61K8/553—Phospholipids, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • A61K8/985—Skin or skin outgrowth, e.g. hair, nails

Definitions

  • Dry skin also known as xerosis or Wintosis affects millions of Americans each year. Attempts to treat or prevent dry skin have led to the development of a large assortment of skin creams and lotions. All of these creams and lotions have been developed from either the point of view that applying an occlusive lipid such as petrolatum or mineral oil can retard moisture loss from the skin, or that the incorporation of water- soluble materials, such as free a ino acids, organic acids, inorganic ions or urea, into the cream, ointment, gel or lotion can trap or retain water in the skin.
  • an occlusive lipid such as petrolatum or mineral oil can retard moisture loss from the skin
  • water- soluble materials such as free a ino acids, organic acids, inorganic ions or urea
  • the stratum corneum of the skin contains certain lipids which may form complicated layers within the stratum corneum thus forming a "water barrier" which prevents water loss from the skin. It has been discovered that formulations may be prepared composed of components of the skin's natural water barrier forming lipid complex and that when these formulations are used by themselves or when they are incorporated into creams, ointments, gels and lotions, the resulting products provide unsurpassed protection against and treatment for dry skin conditions.
  • the present invention provides an improved method and composition for prophylaxis for or treatment of dry skin, consisting of preparing a formulation composed of representative lipids from the three classes of lipids naturally found in the stratum corneum. Such a formulation may be applied directly or may be incorporated into a cream, ointment, gel or lotion and the resulting product applied in order to prevent or treat dryness of the skin.
  • Fatty acids arachidonic, linoleic, linolenic, palmitic, stearic, oleic and docosanoic;
  • Sterols and sterol esters cholesterol and cholesterol sulfate
  • Phospholipids and glycolipids ceramides and lecithin.
  • lipid concentrate formulation may then be added to cream, ointment, gel or lotion vehicles in weight/weight concentrations ranging from about 1% to about 50%.
  • a therapeutic skin formula to treat and prevent dry skin was formulated by adding 15 gm of a lipid concentrate composed of 30% W/W cholesterol (obtained under the trade designation Loralan- CH from the Lanaetex Products, Inc., Elizabeth, New Jersey), 20% W/W lecithin [obtained from American Lecithin Company, Inc.
  • a therapeutic moisturizing formulation was prepared consisting of a lipid concentrate containing 10 ml of linoleic acid (obtained from Emery Industries, Cincinnati, Ohio) , 10 ml linolenic acid (obtained from Fluka Chemical Corporation, Ronkonkoma, New York) , 10 gm of a mixture of lecithin, cephalin and lipositol (obtained under the trade designation of Asolectin from Fluka Chemical Corporation, Ronkonkoma, New York) , and 10 gm of cholesterol (obtained under the trade designation of Loralan- CH from the Lanaetex Products, Inc. , Elizabeth, New Jersey) .
  • the resulting mixture was blended to make a cream composed as follows:
  • This formulation was applied to the very dry skin on the lower legs of a 43 year old woman. Within 24 hours of twice daily application the treated skin was noticeably softer, more moist and supple.
  • Tests were also performed to assess the efficacy of the present invention in preventing water loss. Baseline measurements of 15 healthy adult test subjects were performed to determine the barrier-forming properties of different formulations of the present invention, and to compare these properties with those of two commercially-available skin creams, Eucerin*, manufactured by Beiersdorf, Inc. , Norwalk, Connecicut, and Moisturel*, manufactured by Westwood
  • Lipid Concentrate I consisted of 30% w/w of cholesterol, 20% w/w of lecithin and ceramides, and 50% w/w of the linoleic, linolenic and arachidonic acid mix.
  • Lipid Concentrate II consisted of 15% w/w of cholesterol, 10% w/w lecithin and ceramides, and 75% w/w of the linoleic, linolenic and arachidonic acid mix.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Un procédé et une composition de traitement et de prévention de la peau sèche comprend un concentré lipidique mélangé provenant d'une combinaison de trois groupes de lipides se produisant naturellement trouvés dans la couche cornée. On peut appliquer le concentré localement tel qu'il est préparé, ou on peut le mélanger avec un véhicule thérapeutiquement acceptable adapté à une application locale.
PCT/US1989/003551 1988-08-12 1989-08-09 Procede et composition de traitement et de prevention des problemes de peau seche WO1990001323A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23184888A 1988-08-12 1988-08-12
US231,848 1988-08-12

Publications (1)

Publication Number Publication Date
WO1990001323A1 true WO1990001323A1 (fr) 1990-02-22

Family

ID=22870857

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1989/003551 WO1990001323A1 (fr) 1988-08-12 1989-08-09 Procede et composition de traitement et de prevention des problemes de peau seche

Country Status (3)

Country Link
AU (1) AU4216089A (fr)
CA (1) CA1336762C (fr)
WO (1) WO1990001323A1 (fr)

Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991019491A1 (fr) * 1988-12-13 1991-12-26 Le May David S Utilisation de savon de chaux pour le traitement de reactions inflammatoires de l'epiderme chez les chevaux et les poneys
EP0467218A2 (fr) * 1990-07-17 1992-01-22 Beiersdorf Aktiengesellschaft Combinaison d'agents actifs pour le soin de la peau
EP0542549A1 (fr) * 1991-11-15 1993-05-19 Unilever Plc Utilisation d'une composition cosmétique
EP0554897A2 (fr) * 1992-02-05 1993-08-11 Kao Corporation Nouveau dérivé de stérole, procédé pour sa préparation et les compositions dermatologique
EP0556957A1 (fr) * 1992-01-23 1993-08-25 Unilever Plc Composition cosmétique pour le traitement de dessèchement cutané
WO1994000127A1 (fr) * 1992-06-19 1994-01-06 The Regents Of The University Of California Lipides pour l'humidification de l'epiderme et la restauration de la fonction de barriere
EP0587288A1 (fr) * 1992-07-24 1994-03-16 Unilever Plc Composition cosmétique contenant un lipide et un acide hydroxy ou Ketocarboxylique
US5310556A (en) * 1993-06-09 1994-05-10 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Cosmetic composition
EP0612513A2 (fr) * 1994-05-02 1994-08-31 Shiseido Company Limited Preparation pour les soins de la peau à l'application externe
EP0646370A1 (fr) * 1993-09-30 1995-04-05 Roussel Uclaf Compositions cosmétiques et dermatologiques associant céramides et acide linoléique, leur préparation
DE4401102A1 (de) * 1994-01-17 1995-07-20 Henkel Kgaa Pseudoceramide
WO1996001637A1 (fr) * 1994-07-12 1996-01-25 Astra Aktiebolag Nouvelle preparation pharmaceutique pour le traitement des algies
WO1996012469A1 (fr) * 1994-10-20 1996-05-02 Unilever Plc Composition de soins d'hygiene corporelle
EP0716848A2 (fr) 1994-12-02 1996-06-19 Unilever Plc Les émulsions cosmétiques avec un système lipide de déclenchement de dépÔt
EP0716849A1 (fr) * 1994-12-14 1996-06-19 L'oreal Composition cosmetique ou dermatologique contenant un melange de ceramides, son utilisation pour hydrater la peau
US5552147A (en) * 1995-04-25 1996-09-03 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Petroleum jelly with alpha hydroxy carboxylic acids
US5552148A (en) * 1995-06-07 1996-09-03 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Petroleum jelly with inositol phosphates
WO1997027835A1 (fr) * 1996-02-02 1997-08-07 Unilever Plc Composition d'hygiene corporelle
US5662912A (en) * 1995-06-28 1997-09-02 Henkel Kommanditgesellschaft Auf Aktien Sugar monoacid amides in cosmetic preparations
WO1998017244A1 (fr) * 1996-10-17 1998-04-30 Henkel Kommanditgesellschaft Auf Aktien Utilisation de sterolsulfates comme substances actives pour la production de moyens destines a l'inhibition des serines proteases
WO1999018913A2 (fr) * 1997-10-10 1999-04-22 Cognis Deutschland Gmbh Utilisation de sterols esterifies comme reconstituants du film protecteur
DE19751550A1 (de) * 1997-11-20 1999-07-29 Kao Corp Zur kosmetischen Anwendung geeignete Wirkstoffzusammensetzung
EP0943324A2 (fr) * 1998-03-17 1999-09-22 Shiseido Company, Ltd. Composition pour un soin externe de la peau
EP1002524A1 (fr) * 1997-05-30 2000-05-24 Marie Pratt Sarl Composition ayant notamment une action anti-vieillissement de la peau
WO2000045786A1 (fr) * 1999-02-08 2000-08-10 Color Access, Inc. Compositions de sulfate de cholesterol destinees a ameliorer la fonction de la couche cornee
WO2001005388A2 (fr) * 1999-07-14 2001-01-25 Sucampo, A.G. Composition destinee au traitement des troubles de la secretion externe
WO2002100373A1 (fr) * 2001-06-13 2002-12-19 Knut Haadem Ab Preparation pour la peau
EP1420743A2 (fr) * 2001-01-31 2004-05-26 Color Access, Inc. Compositions de sulfate de cholesterol et de sucre amine permettant d'ameliorer la fonction de la couche cornee de l'epiderme
US6824785B1 (en) * 2000-02-09 2004-11-30 C. Neil Kitson Skin treatment composition and methods of use
WO2007020479A2 (fr) * 2005-08-19 2007-02-22 York Pharma Plc Ameliorations apportees a des compositions pharmaceutiques
US8710034B2 (en) 2000-04-04 2014-04-29 Color Access, Inc. Method and composition for improving skin barrier function
CN110179730A (zh) * 2019-06-19 2019-08-30 广东默默化妆品有限公司 一种无纹修护霜
WO2020190015A1 (fr) * 2019-03-21 2020-09-24 주식회사 리포바이오메드 Composition s'appliquant par voie cutanée présentant un point de fusion contrôlé et une température de transition de phase de molécules de graisse, son procédé de préparation et sa méthode d'application
WO2021008678A1 (fr) 2019-07-12 2021-01-21 Symrise Ag Utilisation d'ester d'acide n-acylhydroxyaminé pour induire l'expression de superoxyde dismutase et/ou d'hème oxygénase

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5533451A (en) * 1978-08-30 1980-03-08 Shugo Morita Preparation of cosmetic
JPS61289013A (ja) * 1985-06-18 1986-12-19 Pola Chem Ind Inc 皮膚外用剤
US4760096A (en) * 1985-09-27 1988-07-26 Schering Corporation Moisturizing skin preparation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5533451A (en) * 1978-08-30 1980-03-08 Shugo Morita Preparation of cosmetic
JPS61289013A (ja) * 1985-06-18 1986-12-19 Pola Chem Ind Inc 皮膚外用剤
US4760096A (en) * 1985-09-27 1988-07-26 Schering Corporation Moisturizing skin preparation

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
N. CHEMICAL ABSTRACT, Vol. 106, Abstract No. 162393Q, KANEKO et al.; & JP,A,61 289 013, 19 December 1986. *
N. CHEMICAL ABSTRACTS, Vol. 105, Abstract No. 66280J, HANDJANI et al.; DE,A,3537723, 24 April 1986. *
N. CHEMICAL ABSTRACTS, Vol. 93, Abstract No. 120270E, MORIA et al.; & JP,A,55 033 451, 08 March 1980. *

Cited By (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991019491A1 (fr) * 1988-12-13 1991-12-26 Le May David S Utilisation de savon de chaux pour le traitement de reactions inflammatoires de l'epiderme chez les chevaux et les poneys
EP0467218A2 (fr) * 1990-07-17 1992-01-22 Beiersdorf Aktiengesellschaft Combinaison d'agents actifs pour le soin de la peau
EP0467218A3 (en) * 1990-07-17 1993-03-03 Beiersdorf Aktiengesellschaft Combinations of active agents for skin care
EP0542549A1 (fr) * 1991-11-15 1993-05-19 Unilever Plc Utilisation d'une composition cosmétique
EP0556957A1 (fr) * 1992-01-23 1993-08-25 Unilever Plc Composition cosmétique pour le traitement de dessèchement cutané
US5372814A (en) * 1992-02-05 1994-12-13 Kao Corporation Sterol derivative, process for producing the same and dermatologic external preparation
EP0554897A2 (fr) * 1992-02-05 1993-08-11 Kao Corporation Nouveau dérivé de stérole, procédé pour sa préparation et les compositions dermatologique
EP0554897A3 (en) * 1992-02-05 1996-11-27 Kao Corp Novel sterol derivative, process for producing the same and dermatologic external preparation
EP0846698A1 (fr) * 1992-02-05 1998-06-10 Kao Corporation Compositions dermatologique
WO1994000127A1 (fr) * 1992-06-19 1994-01-06 The Regents Of The University Of California Lipides pour l'humidification de l'epiderme et la restauration de la fonction de barriere
US5643899A (en) * 1992-06-19 1997-07-01 Cellegy Pharmaceuticals, Inc. Lipids for epidermal moisturization and repair of barrier function
AU670613B2 (en) * 1992-06-19 1996-07-25 Regents Of The University Of California, The Lipids for epidermal moisturization and repair of barrier function
EP0587288A1 (fr) * 1992-07-24 1994-03-16 Unilever Plc Composition cosmétique contenant un lipide et un acide hydroxy ou Ketocarboxylique
WO1994028868A1 (fr) * 1993-06-09 1994-12-22 Unilever Plc Composition de soin pour la peau contenant du petrolatum
US5310556A (en) * 1993-06-09 1994-05-10 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Cosmetic composition
EP0646370A1 (fr) * 1993-09-30 1995-04-05 Roussel Uclaf Compositions cosmétiques et dermatologiques associant céramides et acide linoléique, leur préparation
FR2710527A1 (fr) * 1993-09-30 1995-04-07 Roussel Uclaf Nouvelles compositions cosmétiques et dermatologiques associant céramides et acide linoléique, leur préparation.
US5656278A (en) * 1993-09-30 1997-08-12 The Boots Company Plc Dermatological and cosmetic compositions
DE4401102A1 (de) * 1994-01-17 1995-07-20 Henkel Kgaa Pseudoceramide
US5753242A (en) * 1994-05-02 1998-05-19 Shiseido Company, Ltd. External skin treatment composition
EP0612513A2 (fr) * 1994-05-02 1994-08-31 Shiseido Company Limited Preparation pour les soins de la peau à l'application externe
EP0612513A3 (en) * 1994-05-02 1995-12-06 Shiseido Co Ltd External skin treatment composition.
US5912271A (en) * 1994-07-12 1999-06-15 Astra Ab Pharmaceutical preparation for pain management
WO1996001637A1 (fr) * 1994-07-12 1996-01-25 Astra Aktiebolag Nouvelle preparation pharmaceutique pour le traitement des algies
US5688752A (en) * 1994-10-20 1997-11-18 Lever Brothers Company, Division Of Conopco, Inc. Aqueous personal care cleanser comprising specific lipid composition
WO1996012469A1 (fr) * 1994-10-20 1996-05-02 Unilever Plc Composition de soins d'hygiene corporelle
EP0716848A2 (fr) 1994-12-02 1996-06-19 Unilever Plc Les émulsions cosmétiques avec un système lipide de déclenchement de dépÔt
FR2728164A1 (fr) * 1994-12-14 1996-06-21 Oreal Composition cosmetique ou dermatologique contenant un melange de ceramides, son utilisation pour hydrater la peau
US5776480A (en) * 1994-12-14 1998-07-07 L'oreal Cosmetic or dermatological composition containing a mixture of ceramides for moisturizing the skin
EP0716849A1 (fr) * 1994-12-14 1996-06-19 L'oreal Composition cosmetique ou dermatologique contenant un melange de ceramides, son utilisation pour hydrater la peau
US5552147A (en) * 1995-04-25 1996-09-03 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Petroleum jelly with alpha hydroxy carboxylic acids
US5552148A (en) * 1995-06-07 1996-09-03 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Petroleum jelly with inositol phosphates
US5662912A (en) * 1995-06-28 1997-09-02 Henkel Kommanditgesellschaft Auf Aktien Sugar monoacid amides in cosmetic preparations
US5882660A (en) * 1996-02-02 1999-03-16 Lever Brothers Company, Division Of Conopco, Inc. Personal care composition
WO1997027835A1 (fr) * 1996-02-02 1997-08-07 Unilever Plc Composition d'hygiene corporelle
WO1998017244A1 (fr) * 1996-10-17 1998-04-30 Henkel Kommanditgesellschaft Auf Aktien Utilisation de sterolsulfates comme substances actives pour la production de moyens destines a l'inhibition des serines proteases
US6589945B1 (en) 1996-10-17 2003-07-08 Cognis Deutschland Gmbh & Co. Kg Use of sterolsulfates as active substances for producing means to inhibit serin proteases
EP1002524A1 (fr) * 1997-05-30 2000-05-24 Marie Pratt Sarl Composition ayant notamment une action anti-vieillissement de la peau
WO1999018913A2 (fr) * 1997-10-10 1999-04-22 Cognis Deutschland Gmbh Utilisation de sterols esterifies comme reconstituants du film protecteur
WO1999018913A3 (fr) * 1997-10-10 1999-08-19 Henkel Kgaa Utilisation de sterols esterifies comme reconstituants du film protecteur
DE19751550C2 (de) * 1997-11-20 2001-03-08 Kao Corp Verwendung einer Wirkstoffzusammensetzung in Haarpflegemitteln
DE19751550A1 (de) * 1997-11-20 1999-07-29 Kao Corp Zur kosmetischen Anwendung geeignete Wirkstoffzusammensetzung
EP0943324A2 (fr) * 1998-03-17 1999-09-22 Shiseido Company, Ltd. Composition pour un soin externe de la peau
EP0943324A3 (fr) * 1998-03-17 2002-01-02 Shiseido Company, Ltd. Composition pour un soin externe de la peau
WO2000045786A1 (fr) * 1999-02-08 2000-08-10 Color Access, Inc. Compositions de sulfate de cholesterol destinees a ameliorer la fonction de la couche cornee
AU756361B2 (en) * 1999-02-08 2003-01-09 Color Access, Inc. Cholesterol sulfate compositions for enhancement of stratum corneum function
WO2001005388A2 (fr) * 1999-07-14 2001-01-25 Sucampo, A.G. Composition destinee au traitement des troubles de la secretion externe
WO2001005388A3 (fr) * 1999-07-14 2002-05-10 Sucampo Ag Composition destinee au traitement des troubles de la secretion externe
JP2009007360A (ja) * 1999-07-14 2009-01-15 Sucampo Ag 外分泌障害処置剤
US6566398B1 (en) 1999-07-14 2003-05-20 R-Tech Ueno, Ltd. Method for treatment of external secretion disorders
US6824785B1 (en) * 2000-02-09 2004-11-30 C. Neil Kitson Skin treatment composition and methods of use
US8710034B2 (en) 2000-04-04 2014-04-29 Color Access, Inc. Method and composition for improving skin barrier function
EP1420743A2 (fr) * 2001-01-31 2004-05-26 Color Access, Inc. Compositions de sulfate de cholesterol et de sucre amine permettant d'ameliorer la fonction de la couche cornee de l'epiderme
EP1420743A4 (fr) * 2001-01-31 2005-11-16 Color Access Inc Compositions de sulfate de cholesterol et de sucre amine permettant d'ameliorer la fonction de la couche cornee de l'epiderme
US7422756B2 (en) 2001-06-13 2008-09-09 Knut Haadem Ab Skin preparation
WO2002100373A1 (fr) * 2001-06-13 2002-12-19 Knut Haadem Ab Preparation pour la peau
WO2007020479A2 (fr) * 2005-08-19 2007-02-22 York Pharma Plc Ameliorations apportees a des compositions pharmaceutiques
WO2007020479A3 (fr) * 2005-08-19 2007-05-24 York Pharma Plc Ameliorations apportees a des compositions pharmaceutiques
JP2009504723A (ja) * 2005-08-19 2009-02-05 ヨーク・ファーマ・ピーエルシー 製薬組成物における改善
WO2020190015A1 (fr) * 2019-03-21 2020-09-24 주식회사 리포바이오메드 Composition s'appliquant par voie cutanée présentant un point de fusion contrôlé et une température de transition de phase de molécules de graisse, son procédé de préparation et sa méthode d'application
CN110179730A (zh) * 2019-06-19 2019-08-30 广东默默化妆品有限公司 一种无纹修护霜
CN110179730B (zh) * 2019-06-19 2020-07-14 广东默默化妆品有限公司 一种修护霜
WO2021008678A1 (fr) 2019-07-12 2021-01-21 Symrise Ag Utilisation d'ester d'acide n-acylhydroxyaminé pour induire l'expression de superoxyde dismutase et/ou d'hème oxygénase

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AU4216089A (en) 1990-03-05

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