WO1989008427A1 - Dispositif pour l'etablissement d'une angiographie - Google Patents

Dispositif pour l'etablissement d'une angiographie Download PDF

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Publication number
WO1989008427A1
WO1989008427A1 PCT/DE1989/000130 DE8900130W WO8908427A1 WO 1989008427 A1 WO1989008427 A1 WO 1989008427A1 DE 8900130 W DE8900130 W DE 8900130W WO 8908427 A1 WO8908427 A1 WO 8908427A1
Authority
WO
WIPO (PCT)
Prior art keywords
radiation source
pulse
radiation
camera
fluorescence
Prior art date
Application number
PCT/DE1989/000130
Other languages
German (de)
English (en)
Inventor
Falk RÜHL
Original Assignee
Fraunhofer-Gesellschaft Zur Förderung Der Angewand
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer-Gesellschaft Zur Förderung Der Angewand filed Critical Fraunhofer-Gesellschaft Zur Förderung Der Angewand
Publication of WO1989008427A1 publication Critical patent/WO1989008427A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4887—Locating particular structures in or on the body
    • A61B5/489—Blood vessels

Definitions

  • the invention relates to a device for producing an angiography, in particular fluorescence angiography, with a radiation source effecting an excitation-effective radiation of a vessel preferably supplied with fluorescent agent, and with a photographic film camera.
  • Angiography and in particular fluorescence angiography, is used for the high-contrast display of vessels in the image, in particular for the display of blood and other body vessels, such as arteries, veins and lymphatic vessels.
  • the examination of such vessels is important because they may have changed, e.g. are narrowed in the course of time, so that malfunctions occur, for the remedy of which it must be known to what extent there is a malfunction, for example a circulatory disorder caused by vasoconstriction.
  • PRIOR ART Angiographic devices which work on the basis of X-rays are widespread and work in such a way that a contrast medium is injected into the vessels to achieve sufficient image contrast, the radiation absorption of which can be used in the production of photographic recordings.
  • Devices are also known for fluorescence angiography, in which the propagation of a and introduced into the vessel investigated dye transported by the vascular fluid, which fluoresces with suitable excitation. This results in an excitation-effective irradiation with a light whose frequencies are matched to the absorption frequencies of the fluorescent agent. The fluorescent light is observed and used for image recordings, the observation taking place optically. However, the image recordings obtained are often blurred.
  • causes of unsharpness are movement processes due to the flow of the fluorescent agent in the vessels or other movements, for example movements of the patient during the recording and the associated displacements of the setting plane of the optics used for image recording and the resulting distortions of the observation area.
  • the properties of the examined organ can also lead to blurred, for example in eye examinations in which the lens of the eye also determines or changes the focal position of the image.
  • the object of the invention is to improve a device of the type mentioned at the outset in such a way that angiography can be produced with minimized radiation energy, compared with continuous irradiation or exposure, which in connection with briefly acting mechanical or optical Closure systems is used.
  • a pulse radiation source is present as the radiation source and a video camera is present as the film camera, and that the pulse radiation can be triggered when the camera is completely closed.
  • the radiation of the vessel takes place in pulses.
  • the pulses from such a pulse radiation source can be kept sufficiently short to exclude motion blur.
  • the pulse irradiation takes place exclusively during the time serving for the image acquisition in order to have a complete utilization of the radiation energy of the pulse for the image acquisition, in particular when working with a fluorescent agent to be excited.
  • the pulse radiation is carried out when the shutter of a camera is fully opened.
  • Such cameras can produce high quality image recordings, e.g. High resolution pictures. It is also important for the invention that a video camera is used to achieve the desired image series.
  • the device according to the invention differs from generally known video arrangements in that pulse exposure is provided, while the exposure time of the frame rate is known to be coupled. If conventional video arrangements were used to produce angiography, the latter would have the undesirable consequence that the motion blur described at the beginning occurs. An increase in the exposure radiation energy for the use of shorter exposure times would be disadvantageous in terms of tissue physiology.
  • the load on the irradiated tissue increases considerably.
  • the radiation energy can be used practically completely for exposure.
  • the device can therefore advantageously be used for eye examinations.
  • it can be used without fluorescent agents and filters, or with filters with overlapping transmission, which helps to suppress motion blur in examinations with higher magnifications, e.g. in examinations of the foreground of the eye.
  • video cameras are used in which the pulse radiation can be triggered while the video camera is rewinding.
  • the pulse radiation source advantageously emits incoherent light.
  • incoherent light is used when conventional optics are to be used for image acquisition, such as lens systems, fiber optics or mirrors.
  • filters can also be used which adjust the spectrum of the light to the Limit absorption frequencies of the fluorescent dye.
  • a pulse radiation source is advantageous
  • Spark flash source available, which, due to its low-induction design, allows particularly steep and short pulses to be generated with a correspondingly short lighting time and also with high luminance.
  • a laser operated in pulse mode is available as the pulse radiation source, with which the required luminance and the required short-term radiation pulses can be generated without problems.
  • a high excitation of a fluorescent agent matched to the wavelength of the laser radiation is therefore possible without any problems.
  • the laser since the laser provides coherent light, additional measures known per se for suppressing speckle phenomena must be taken.
  • the frequency spectrum of the radiation can be switched alternately between the areas of fluorescence excitation and fluorescence emission in order to increase the contrast in the vicinity of the fluorescent agent forming the fluorescence sources during successive image recordings.
  • it is possible to form a difference between successive image recordings by weighting an image recording produced in the area of fluorescence excitation, for example in the blue, and subtracting it from an image recording produced under fluorescence emission, for example in green / yellow.
  • the difference image is a representation of increased contrast.
  • Such an image subtraction can be carried out in a simple manner by means of devices for intermediate image storage when using video systems, with automation is easily possible and thus a corresponding increase in speed in the production of image recordings.
  • An Elitz source is present as the pulse radiation source 10, which emits, for example, coherent light if it is a laser, or incoherent light if it is a spark flash source.
  • the pulse radiation source 10 emits, for example, coherent light if it is a laser, or incoherent light if it is a spark flash source.
  • Their activity depends on the actuation of the pulse radiation source 10 by means of a trigger pulse 13.
  • the pulse radiation source 10 sends a signal to the synchronization 12, which initiates the opening of the shutter of the camera 11.
  • the synchronization takes place in such a way that the pulse radiation of the vessel to be examined, which is not shown here, takes place exclusively during the time serving for image acquisition, so that the camera 11 records the light reflected by the organ or emitted due to the fluorescence excitation of the fluorescent agent can.
  • the synchronization 12 is also able to switch the frequency spectrum in the case of successive image recordings between the areas of fluorescence excitation and fluorescence emission by causing a filter change in the beam path of the irradiation or illumination, for example by means of a filter wheel. which is also not shown.
  • a device 13 for recording is shown in the figure, namely for video recording.
  • the function of the video camera of 13 is coordinated with the synchronization 12 to the pulse radiation source 10.
  • monitor 14 on which the recording process can be monitored continuously, so that the person carrying out the method can intervene immediately.
  • angiography can be produced with reduced radiation energy.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Physiology (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

Dispositif pour l'établissement d'une angiographie, en particulier d'une angiographie par fluorescence, comportant une source établissant un rayonnement par excitation d'un récipient renfermant de préférence un agent fluorescent, ainsi qu'une caméra photographique. Le dispositif est employé en association avec des systèmes d'obturateurs mécaniques et optiques rapides. Il est constitué de telle manière que la source de rayonnement employée est une source de rayonnement pulsé et la caméra une caméra vidéo et que le rayonnement pulsé est déclenché lorsque l'obturateur de la caméra est entièrement ouvert.
PCT/DE1989/000130 1988-03-08 1989-03-03 Dispositif pour l'etablissement d'une angiographie WO1989008427A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3807486.9 1988-03-08
DE3807486 1988-03-08

Publications (1)

Publication Number Publication Date
WO1989008427A1 true WO1989008427A1 (fr) 1989-09-21

Family

ID=6349102

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1989/000130 WO1989008427A1 (fr) 1988-03-08 1989-03-03 Dispositif pour l'etablissement d'une angiographie

Country Status (2)

Country Link
EP (1) EP0404785A1 (fr)
WO (1) WO1989008427A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4161944A (en) * 1976-09-17 1979-07-24 Muckerheide Myron C Laser system and method and laser amplifier for use therewith
DE3131651A1 (de) * 1980-08-18 1982-05-27 General Electric Co., Schenectady, N.Y. "anordnung zum subtrahieren von roentgenbildern"
FR2498442A1 (fr) * 1981-01-28 1982-07-30 Gen Electric Procede et appareil de radioscopie
EP0088609A1 (fr) * 1982-03-09 1983-09-14 Kabushiki Kaisha Toshiba Dispositif pour diagnostic à rayons X

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4161944A (en) * 1976-09-17 1979-07-24 Muckerheide Myron C Laser system and method and laser amplifier for use therewith
DE3131651A1 (de) * 1980-08-18 1982-05-27 General Electric Co., Schenectady, N.Y. "anordnung zum subtrahieren von roentgenbildern"
FR2498442A1 (fr) * 1981-01-28 1982-07-30 Gen Electric Procede et appareil de radioscopie
EP0088609A1 (fr) * 1982-03-09 1983-09-14 Kabushiki Kaisha Toshiba Dispositif pour diagnostic à rayons X

Also Published As

Publication number Publication date
EP0404785A1 (fr) 1991-01-02

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