WO1989007589A1 - Procede de quaternisation - Google Patents
Procede de quaternisation Download PDFInfo
- Publication number
- WO1989007589A1 WO1989007589A1 PCT/FR1989/000037 FR8900037W WO8907589A1 WO 1989007589 A1 WO1989007589 A1 WO 1989007589A1 FR 8900037 W FR8900037 W FR 8900037W WO 8907589 A1 WO8907589 A1 WO 8907589A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- reaction
- quaternizing agent
- iii
- quaternary ammonium
- reactor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/38—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/08—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to an acyclic carbon atom of an acyclic unsaturated carbon skeleton
Definitions
- the subject of the present invention is a process for the preparation of aqueous solutions of unsaturated quaternary ammonium salts corresponding to the following formula (I):
- H 2 O CH - C (O) - A - R 3 - N + (R 1 ) (R 2 (R), X-
- - A is an oxygen atom or an NH group
- - R 3 is an alkyl radical, linear or branched from 1 to 6 carbon atoms
- - R 1 , R 2 and R, different or identical are each an alkyl radical or an aryl radical
- - X is chosen from Cl, Br, I, CH 3 -CO 3 and CH 3 -SO 4 .
- EP-A-250 325 discloses a process for the preparation of aqueous solutions of unsaturated quaternary ammonium salts corresponding to the following formula (I):
- - A is an oxygen atom or an NH group
- - R 3 is a hydrogen atom or a methyl radical
- - R 4 is an alkyl radical, linear or branched, from 2 to 4 at carbon atoms
- - R 1 and R 2 are each an alkyl radical or an aryl radical
- - R is an alkyl or aryl radical
- - X is chosen from Cl, Br, I, CH 3 -CO 3 or CH 3 -SO 4 , from at least one (meth) acrylic monomer (II) of formula:
- H 2 O C (R 3 ) - C (O) - A - R 4 - N (R 1 ) (R 2 ) and at least one quaternizing agent (III) of formula RX, in the presence of at least one polymerization inhibitor, process characterized in that: a) the (meth) acrylic monomer (II) is reacted in a closed reactor ) with 5 to 20% of the weight quantity necessary for the reaction of the quaternizing agent (III), the latter being introduced continuously into the reactor, b) then water and the remainder of the quaternizing agent are continuously added (III) until the desired concentration of quaternary ammonium salt (I) in water is obtained, c) the temperature is maintained during steps (a) and (b) at a value between 30 and 60oC, d) and during steps (a) and (b) and in the approach of the end of the reaction in particular, a stream of oxygenated gas is maintained in the reaction medium such that the volume ratio of total gas to the outlet of the reactor on the oxygen introduced at
- This process makes it possible to prepare aqueous solutions of unsaturated quaternary ammonium salts (I) which have a stability at room temperature greater than one year.
- the content of these impurities is particularly high when A is an oxygen atom.
- this process requires relatively long reaction times, which represents an obvious economic disadvantage.
- the problem which the present invention aims to solve consists in developing a process for the preparation of aqueous solutions of unsaturated quaternary ammonium salts (I) which makes it possible to considerably reduce both the formation of impurities and the duration of the quaternization reaction.
- the subject of the present invention is a process for the preparation of aqueous solutions of unsaturated quaternary ammonium salts (I) corresponding to the following formula:
- H 2 O CH - C (O) - A - R 3 - N + (R 4 ) (R 2 ) (R), X-,
- H 2 O CH - C (O) - A - R 3 - N (R 1 ) (R 2 )
- quaternizing agent (III) of formula RX in which R, R 1 , R 2 , R 3 , A and X have the abovementioned meanings, in the presence of at least one polymerization inhibitor, process according to which : - in a first step a), at least one acrylic monomer (II) is reacted with 0 to 30% by weight, and preferably 5 to 25% by weight, of the amount necessary for the reaction of at least one quaternizing agent (III), or with 5 to 50% by weight, and preferably 5 to 20% by weight, of an aqueous solution of unsaturated quaternary ammonium salts (I) containing 50 to 85% by weight of said salts , - and, in a second step (b), water and the quaternizing agent (III) are added continuously until the desired concentration of unsaturated quaternary ammonium salts in water is obtained, - the reaction, during steps (a) and (b) being carried out in the presence of oxygen, at a temperature between
- the reaction time does not exceed about 10 hours.
- step (b) the flow rates of water and of quaternizing agent (III) are adjusted so as to maintain in the reaction medium an aqueous solution saturated or close to saturation with unsaturated quaternary ammonium salts. (I). This is usually obtained by choosing a water / quaternizing agent molar ratio of between 1.5 and 3 approximately, this ratio being higher the lower the reaction temperature and the amount of quaternizing agent introduced into the step (a) is higher.
- the introduction of the quaternizing agent during the reaction is carried out so as to limit its losses in the gaseous vents. Losses are thus kept below 10% or even 3% of stoichiometry.
- the gas leaving the reactor is led to a treatment device aiming to rid it almost completely of the traces of quaternizing agent (III) which it contains.
- the gas is sent at the outlet of the reactor to a second reactor comprising acrylic monomer with which the quaternizing agent reacts.
- the method according to the invention is suitable for the quaternization of acrylic monomers (II) capable of hydrolyzing such as dimethylaminoethyl acrylate, dimethylaminopropyl acrylate, and dimethylaminopropyl acrylamide.
- the quaternizing agents (III) suitable for the present invention are in particular halogenated hydrocarbons such as methyl chloride, methyl bromide, methyl iodide, ethyl chloride, ethyl bromide, iodide d ethyl, benzyl chloride; dimethyl sulfate or dimethyl carbonate.
- polymerization inhibitors suitable for the process according to the invention mention may be made of toluene-3, 5-di terbutyl-4-hydroxy, methyl ether of hydroquinone, phenothiazine, hydroquinone, catechol and terbutylcatechol .
- from 100 ppm to 5000 ppm of polymerization inhibitor is used relative to the acrylic monomer (II).
- the aqueous solutions of unsaturated quaternary ammonium salts prepared according to the process according to the invention have a storage stability at room temperature greater than one year.
- the examples which follow, given by way of indication, will allow a better understanding of the invention. In these examples, the percentages are expressed by weight.
- the methyl chloride flow rate is gradually reduced to 10 g / h and the outlet flow rate of the vents is kept below
- the final product is then subjected to an air injection with a flow rate of 7 N1 / h for 1/2 hour hot then for 1/2 hour at room temperature.
- 357.5 g of stabilized dimethyl hylaminoethyl acrylate are charged to a jacketed reactor, with stirring, using 700 ppm of hydroquinone methyl ether.
- the outlet flow rate of the vents during the synthesis is kept below 0.8 NN / h (ie a ratio of the volumetric flow rates of the vents to the oxygen introduced into the reactor below 30).
- a first step 15 g of methyl chloride are injected into the reactor over a period of 30 minutes (ie 11% of the total amount of CH 3 Cl necessary for the reaction).
- the methyl chloride supplement and the water are injected simultaneously and continuously in a water / CH 3 Cl weight ratio equal to 0.95 over a 3 hour period.
- the air flow entering the reactor is increased to 1 N1 / h and the pressure of the system is gradually reduced over a period of 1 hour to atmospheric pressure by controlling the flow of the vents which remains below
- the final product is then subjected to an injection of air with a flow rate of 10 N1 / h for 1/2 hour hot, then for 1/2 hour at room temperature.
- the final product obtained has the following characteristics:
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19893990121 DE3990121T1 (de) | 1989-02-02 | 1989-02-02 | Quaternisationsverfahren |
DE3990121A DE3990121C2 (de) | 1988-02-11 | 1989-02-02 | Quaternisationsverfahren |
NL8920072A NL193088C (nl) | 1988-02-11 | 1989-02-02 | Werkwijze voor de bereiding van waterige oplossingen van onverzadigde quaternaire ammoniumzouten. |
GB9015070A GB2232980B (en) | 1988-02-11 | 1990-07-09 | Quaternization process |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8801636 | 1988-02-11 | ||
FR88/01636 | 1988-02-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1989007589A1 true WO1989007589A1 (fr) | 1989-08-24 |
Family
ID=9363186
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR1989/000037 WO1989007589A1 (fr) | 1988-02-11 | 1989-02-02 | Procede de quaternisation |
Country Status (10)
Country | Link |
---|---|
JP (1) | JP2773049B2 (nl) |
BE (1) | BE1006876A4 (nl) |
CA (1) | CA1333613C (nl) |
CH (1) | CH678724A5 (nl) |
DE (1) | DE3990121C2 (nl) |
ES (1) | ES2010133A6 (nl) |
GB (1) | GB2232980B (nl) |
IT (1) | IT1230445B (nl) |
NL (1) | NL193088C (nl) |
WO (1) | WO1989007589A1 (nl) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0428970A1 (de) * | 1989-11-21 | 1991-05-29 | BASF Aktiengesellschaft | Verfahren zur Herstellung wässriger Lösungen oder Suspensionen von Quaternierungsprodukten von tertiären Aminoalkylestern oder tertiären Aminoalkylamiden der Acryl- oder Methacrylsäure, beispielsweise von Dimethylaminoethylacrylat-Methochlorid |
WO2003053908A1 (en) * | 2001-12-21 | 2003-07-03 | Akzo Nobel Nv | Process for the continuous quaternisation of tertiary amines with an alkyl halide |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2608868A1 (de) * | 1975-03-05 | 1976-09-16 | Mitsubishi Chem Ind | Verfahren zur herstellung eines quartaeren ammoniumsalzes |
GB2067554A (en) * | 1979-12-27 | 1981-07-30 | Mitsubishi Rayon Co | Process for the preparation of unsaturated quaternary ammonium salts |
JPS57126452A (en) * | 1981-01-28 | 1982-08-06 | Sanyo Chem Ind Ltd | Preparation of quaternary ammonium salt |
EP0250325A2 (fr) * | 1986-06-20 | 1987-12-23 | Elf Atochem S.A. | Procédé de préparation de solution aqueuse de sels d'ammonium quaternaire insaturé |
-
1989
- 1989-02-02 DE DE3990121A patent/DE3990121C2/de not_active Expired - Fee Related
- 1989-02-02 WO PCT/FR1989/000037 patent/WO1989007589A1/fr active Application Filing
- 1989-02-02 CH CH3591/89A patent/CH678724A5/fr not_active IP Right Cessation
- 1989-02-02 JP JP1502099A patent/JP2773049B2/ja not_active Expired - Lifetime
- 1989-02-02 NL NL8920072A patent/NL193088C/nl not_active IP Right Cessation
- 1989-02-09 ES ES8900468A patent/ES2010133A6/es not_active Expired
- 1989-02-09 IT IT8947625A patent/IT1230445B/it active
- 1989-02-10 BE BE8900135A patent/BE1006876A4/fr not_active IP Right Cessation
- 1989-02-10 CA CA000590756A patent/CA1333613C/fr not_active Expired - Fee Related
-
1990
- 1990-07-09 GB GB9015070A patent/GB2232980B/en not_active Expired
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2608868A1 (de) * | 1975-03-05 | 1976-09-16 | Mitsubishi Chem Ind | Verfahren zur herstellung eines quartaeren ammoniumsalzes |
GB2067554A (en) * | 1979-12-27 | 1981-07-30 | Mitsubishi Rayon Co | Process for the preparation of unsaturated quaternary ammonium salts |
JPS57126452A (en) * | 1981-01-28 | 1982-08-06 | Sanyo Chem Ind Ltd | Preparation of quaternary ammonium salt |
EP0250325A2 (fr) * | 1986-06-20 | 1987-12-23 | Elf Atochem S.A. | Procédé de préparation de solution aqueuse de sels d'ammonium quaternaire insaturé |
Non-Patent Citations (1)
Title |
---|
Patent Abstracts of Japan, volume 6, no. 223 (C-133)(1101), 9 novembre 1982; & JP-A-57126452 (SANYO KASEI KOGYO) 6 aout 1982 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0428970A1 (de) * | 1989-11-21 | 1991-05-29 | BASF Aktiengesellschaft | Verfahren zur Herstellung wässriger Lösungen oder Suspensionen von Quaternierungsprodukten von tertiären Aminoalkylestern oder tertiären Aminoalkylamiden der Acryl- oder Methacrylsäure, beispielsweise von Dimethylaminoethylacrylat-Methochlorid |
WO2003053908A1 (en) * | 2001-12-21 | 2003-07-03 | Akzo Nobel Nv | Process for the continuous quaternisation of tertiary amines with an alkyl halide |
Also Published As
Publication number | Publication date |
---|---|
BE1006876A4 (fr) | 1995-01-17 |
GB9015070D0 (en) | 1990-09-26 |
ES2010133A6 (es) | 1989-10-16 |
CA1333613C (fr) | 1994-12-20 |
NL193088C (nl) | 1998-10-05 |
JP2773049B2 (ja) | 1998-07-09 |
IT8947625A0 (it) | 1989-02-09 |
DE3990121C2 (de) | 1999-02-11 |
CH678724A5 (nl) | 1991-10-31 |
NL8920072A (nl) | 1990-12-03 |
GB2232980B (en) | 1992-01-08 |
JPH03502451A (ja) | 1991-06-06 |
NL193088B (nl) | 1998-06-02 |
IT1230445B (it) | 1991-10-23 |
GB2232980A (en) | 1991-01-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0250325B1 (fr) | Procédé de préparation de solution aqueuse de sels d'ammonium quaternaire insaturé | |
EP0329512B1 (fr) | Procédé de quaternisation | |
EP0819671B1 (fr) | Solutions aqueuses stabilisées de sels d'ammoniums quaternaires insaturés | |
EP0739870A1 (fr) | Procédé de condensation de l'acide cyanhydrique avec un aldehyde | |
US5260480A (en) | Quaternization process | |
EP1362029A1 (fr) | Procede de preparation d'un peroxyester | |
CA1333613C (fr) | Procede de preparation de solutions de sels insatures d'ammonium quaternaire sous pression | |
JP2945355B2 (ja) | 不飽和第4級アンモニウム塩の水溶液の製造方法 | |
FR2642424A1 (fr) | Procede de preparation de solutions aqueuses de sels insatures d'ammonium quaternaire | |
JPS6233226B2 (nl) | ||
EP1144357B1 (fr) | Procede de fabrication de solutions aqueuses de sels insatures d'ammonium quaternaire | |
EP1144356B1 (fr) | Procede de fabrication de solutions aqueuses de sels insatures d'ammonium quaternaire | |
JP4518590B2 (ja) | 安定化された2,2,6,6−テトラメチル−4−ヒドロキシピペリジン−n−オキシル組成物 | |
JPS6054938B2 (ja) | メタクリル酸の製造方法 | |
JPS6150947A (ja) | 不飽和四級アンモニウム塩の製造方法 | |
JP3004735B2 (ja) | 光学活性カルボン酸エステルのラセミ化方法 | |
FR2700769A1 (fr) | Procédé catalytique de transestérification pour la préparation d'esters d'acide (méth)acrylique. | |
JPS6097967A (ja) | 2−オキサゾリジノン化合物の製造法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): CH DE GB JP NL |
|
RET | De translation (de og part 6b) |
Ref document number: 3990121 Country of ref document: DE Date of ref document: 19901122 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 3990121 Country of ref document: DE |