WO1988006619A1 - Preparation for prophylaxis and treatment of gastro-intestinal disturbances in farm animals - Google Patents

Preparation for prophylaxis and treatment of gastro-intestinal disturbances in farm animals Download PDF

Info

Publication number
WO1988006619A1
WO1988006619A1 PCT/SU1987/000024 SU8700024W WO8806619A1 WO 1988006619 A1 WO1988006619 A1 WO 1988006619A1 SU 8700024 W SU8700024 W SU 8700024W WO 8806619 A1 WO8806619 A1 WO 8806619A1
Authority
WO
WIPO (PCT)
Prior art keywords
biomass
treatment
tsmpm
tsμpμ
shτamma
Prior art date
Application number
PCT/SU1987/000024
Other languages
English (en)
French (fr)
Russian (ru)
Inventor
Valery Veniaminovich Smirnov
Svetlana Nikolaevna Kharchenko
Semen Rafailovich Reznik
Vladimir Petrovich Litvin
Valentina Alexeevna Vjunitskaya
Original Assignee
Institut Mikrobiologii I Virusologii Imeni D.K.Zab
Ukrainskaya Selskokhozyaistvennaya Akademia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Mikrobiologii I Virusologii Imeni D.K.Zab, Ukrainskaya Selskokhozyaistvennaya Akademia filed Critical Institut Mikrobiologii I Virusologii Imeni D.K.Zab
Priority to PCT/SU1987/000024 priority Critical patent/WO1988006619A1/ru
Priority to DE873790919T priority patent/DE3790919T1/de
Priority to JP62502918A priority patent/JPH01502340A/ja
Priority to CH4117/88A priority patent/CH674149A5/de
Publication of WO1988006619A1 publication Critical patent/WO1988006619A1/ru
Priority to GB8823554A priority patent/GB2209343B/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • A61K35/742Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/07Bacillus

Definitions

  • ⁇ e ⁇ ⁇ e ⁇ i ⁇ d of ⁇ uzhayuschey s ⁇ edy (from v ⁇ zdu ⁇ a, ⁇ edme ⁇ v u ⁇ da, ⁇ b ⁇ lny ⁇ zhiv ⁇ ny ⁇ , ⁇ ⁇ e ⁇ s ⁇ nala and d ⁇ ugi ⁇ is ⁇ chni ⁇ v) in ⁇ ganizm zhiv ⁇ ny ⁇ m ⁇ gu ⁇ ⁇ ada ⁇ ⁇ azlichnye ⁇ a ⁇ gennye and usl ⁇ vn ⁇ ⁇ a ⁇ gennye mi ⁇ ganizmy (en ⁇ e ⁇ a ⁇ gennye ⁇ ishechnye ⁇ al ⁇ ch ⁇ i, s ⁇ a- ⁇ il ⁇ i, ⁇ ei, ⁇ lebsielly 'and salm ⁇ nell
  • the drugs are more effective for the treatment and treatment of gastrointestinal diseases of the living from vascular microculture.
  • Eti ⁇ réelle -2- Injuries are at risk of physical injury to the stomach and the stomach, which is associated with gastrointestinal disease, ⁇ réelle ⁇ , for example ⁇ ,
  • the indications indicated include one type of microorganism that does not provide a wide range of its antagonistic features.
  • the basic task of the invention was to alter the biomass of bacteria and use new strains of microbial diseases to treat medications for the treatment of patients
  • the quick link is desirable with a dry link.
  • the culture produces glucose, arabinosis, beckoning, and the formation of an acid without gas.
  • the operation of Facebook - Positive is positive.
  • the culture does not produce gas from ⁇ 0 3 under anaerobic conditions; it does not produce arginine dihydrogenase.
  • the crop grows in a environment that contains 7% of ya
  • a meat and poultry bouillon is used to produce a small-film, sometimes with an extra-thick film.
  • the culture is exploring catalase.
  • the product is available on the market.
  • the inventive product provides a pure, crystallized dry mass of light and non-volatile light that is not consumable to us.
  • the bulk for water is not more than 5%.
  • the product is emitted in glass ampoules with a content of 250 mg of dry substance (300-400 milliliters of microcells) or in glass flasks with a content of 500 mg (600 mg).
  • the claimed ⁇ e ⁇ a ⁇ a ⁇ m ⁇ zhe ⁇ by ⁇ is ⁇ lz ⁇ van in ⁇ aches ⁇ ve s ⁇ eds ⁇ va ⁇ ila ⁇ i ⁇ i or ⁇ aches ⁇ ve s ⁇ eds ⁇ va treatment ⁇ s ⁇ y ⁇ zhelud ⁇ chn ⁇ - ⁇ ishechny ⁇ zab ⁇ levany m ⁇ l ⁇ dnya ⁇ a sels ⁇ - ⁇ zyays ⁇ venny ⁇ zhiv ⁇ ny ⁇ (disba ⁇ e ⁇ i ⁇ za, ⁇ liba ⁇ e ⁇ i ⁇ za, salm ⁇ nelleza, ⁇ azlichny ⁇ d ⁇ ugi ⁇ ⁇ s ⁇ y ⁇ zhelud ⁇ chn ⁇ - ⁇ ishechny ⁇ zab ⁇ levany sels ⁇ zyays venny ⁇ zhiv ⁇ ny ⁇ , vyzvanny ⁇ ⁇ a- ⁇ gennymi and usl ⁇ vn ⁇ pathogenic microorganisms).
  • test results of the claimed product showed that out of 328 newborn calves, which were purchased by the claimed device, 19 of them had any injuries. ⁇ live group of 185 live
  • the claimed medication was changed to 284 calves with various gastrointestinal diseases
  • the inventive process was designated as the next one.
  • Compound ampoules 300-400 milligrams of micro-cells were mixed in one milk or water, they were cooled and cooled to 25–30 ° C, and they were allowed to cool.
  • the claimed preparation showed a high therapeutic and preventive effect.
  • the product is characterized by a high rate of antagonism to the static response to various types of microorganisms - pathogens.
  • the product helps to increase the protective reactions of the organism of animals (induction of the endogenous interactions,
  • the claimed process is as follows.
  • ⁇ Brass As a filling medium, use a mixture of a quick-release mixture of quick-release or gelatin with sugar or glucose. The resulting mixture is poured into a stylish ampoule 1 and placed in a corner, a cracker for 24 hours at a temperature not exceeding -20 ° C. The product is licensed for at least 44 hours and operating at -20 ° to + 20 ° ⁇ . After filizirovaniya ampoules solder. The inventive preparation keeps the activity and the duration of the storage for at least 2 years.
  • the test for harmlessness leads to the following test: when administered directly, at least 5 mice weighing 18-22 grams are much more lively than the mouse, but the weight is very good. on the fifth day of observation.
  • the conversion of speci fi c activity is carried out by the following process. Researches the antagonistic properties of -10- sections of microcultures included in the composition of the drug, in addition to testing, the number of tests carried out by the Party is limited,
  • test results are presented in the table. For example, 2.
  • the inventive product is of the following composition, in% (%): biomass strain . ⁇ . ⁇ admir ⁇ transaction ⁇ ⁇ ⁇ £ ⁇ -2336 20 35 5th gelatin solution. 21 sugar 4 -II-
PCT/SU1987/000024 1987-02-24 1987-02-24 Preparation for prophylaxis and treatment of gastro-intestinal disturbances in farm animals WO1988006619A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
PCT/SU1987/000024 WO1988006619A1 (en) 1987-02-24 1987-02-24 Preparation for prophylaxis and treatment of gastro-intestinal disturbances in farm animals
DE873790919T DE3790919T1 (de) 1987-02-24 1987-02-24 Arzneimittel zur prophylaxe und behandlung von gastrointerfinalen erkrankungen des landwirtschaftsviehs
JP62502918A JPH01502340A (ja) 1987-02-24 1987-02-24 家畜の胃腸病の予防及び処置のための製剤
CH4117/88A CH674149A5 (de) 1987-02-24 1988-02-24
GB8823554A GB2209343B (en) 1987-02-24 1988-10-07 Preparation for prophylaxis and treatment of gastro-intestinal disturbances in farm animals

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/SU1987/000024 WO1988006619A1 (en) 1987-02-24 1987-02-24 Preparation for prophylaxis and treatment of gastro-intestinal disturbances in farm animals

Publications (1)

Publication Number Publication Date
WO1988006619A1 true WO1988006619A1 (en) 1988-09-07

Family

ID=21617080

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SU1987/000024 WO1988006619A1 (en) 1987-02-24 1987-02-24 Preparation for prophylaxis and treatment of gastro-intestinal disturbances in farm animals

Country Status (5)

Country Link
JP (1) JPH01502340A (de)
CH (1) CH674149A5 (de)
DE (1) DE3790919T1 (de)
GB (1) GB2209343B (de)
WO (1) WO1988006619A1 (de)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5364788A (en) * 1991-07-01 1994-11-15 Ahc Inc. Pure culture of Bacillus subtilis FERM BP-3418
EP1093803A2 (de) * 1996-10-23 2001-04-25 Sanofi-Synthelabo Kosmetische Zubereitung Antagonisten des Neuropeptid-Y-Rezeptors enthaltend
US9005601B2 (en) 2010-07-16 2015-04-14 The Board Of Trustees Of The University Of Arkansas Methods and compositions including spore-forming bacteria for increasing the health of animals
US9107938B2 (en) 2010-09-30 2015-08-18 The Board Of Trustees Of The University Of Arkansas Methods of selecting and using therapeutic and prophylactic probiotic cultures to reduce bacterial pathogen loads
US9393275B2 (en) 2012-08-01 2016-07-19 Novozymes A/S Probiotic for amelioration of coccidiosis vaccine reaction

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995004539A1 (fr) * 1993-08-11 1995-02-16 Ahc Inc. Adjuvant d'immunite et procede permettant de renforcer l'immunite d'un animal avec cet adjuvant
FR2758051B1 (fr) * 1997-01-06 1999-12-17 Cobiotex Procedes d'eradication systematique du portage d'agents pathogenes par des animaux et compositions mises en oeuvre dans ces procedes

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1554525A (en) * 1976-12-07 1979-10-24 Grace W R & Co Ruminant feed additive
GB2138023A (en) * 1983-03-29 1984-10-17 Mitsui Toatsu Chemicals Bacillus licheniformis used in animal feeds
EP0145798A1 (de) * 1983-12-09 1985-06-26 Miles Kali-Chemie GmbH & Co. KG Biochemisches Werk Bacillus subtilis DSM 2704 und Verfahren zur Herstellung von Alpha-Amylase

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1554525A (en) * 1976-12-07 1979-10-24 Grace W R & Co Ruminant feed additive
GB2138023A (en) * 1983-03-29 1984-10-17 Mitsui Toatsu Chemicals Bacillus licheniformis used in animal feeds
EP0145798A1 (de) * 1983-12-09 1985-06-26 Miles Kali-Chemie GmbH & Co. KG Biochemisches Werk Bacillus subtilis DSM 2704 und Verfahren zur Herstellung von Alpha-Amylase

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5364788A (en) * 1991-07-01 1994-11-15 Ahc Inc. Pure culture of Bacillus subtilis FERM BP-3418
EP1093803A2 (de) * 1996-10-23 2001-04-25 Sanofi-Synthelabo Kosmetische Zubereitung Antagonisten des Neuropeptid-Y-Rezeptors enthaltend
EP1093803A3 (de) * 1996-10-23 2004-03-31 Sanofi-Synthelabo Eine Kosmetische Zubereitung die Antagonisten des Neuropeptid-Y-Rezeptors enthaltet
US9005601B2 (en) 2010-07-16 2015-04-14 The Board Of Trustees Of The University Of Arkansas Methods and compositions including spore-forming bacteria for increasing the health of animals
US9107938B2 (en) 2010-09-30 2015-08-18 The Board Of Trustees Of The University Of Arkansas Methods of selecting and using therapeutic and prophylactic probiotic cultures to reduce bacterial pathogen loads
US9393275B2 (en) 2012-08-01 2016-07-19 Novozymes A/S Probiotic for amelioration of coccidiosis vaccine reaction

Also Published As

Publication number Publication date
CH674149A5 (de) 1990-05-15
GB2209343A (en) 1989-05-10
JPH01502340A (ja) 1989-08-17
GB2209343B (en) 1990-09-12
GB8823554D0 (en) 1989-01-25
DE3790919T1 (de) 1989-03-23

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