WO1987005517A1 - Sels de metaux lourds de l'acide hyaluronique utiles en tant qu'agents antimicrobiens - Google Patents
Sels de metaux lourds de l'acide hyaluronique utiles en tant qu'agents antimicrobiens Download PDFInfo
- Publication number
- WO1987005517A1 WO1987005517A1 PCT/US1987/000549 US8700549W WO8705517A1 WO 1987005517 A1 WO1987005517 A1 WO 1987005517A1 US 8700549 W US8700549 W US 8700549W WO 8705517 A1 WO8705517 A1 WO 8705517A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- silver
- hyaluronate
- compound
- effective amount
- hyaluronic acid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
Definitions
- Hyaluronic acid has been isolated from the various biological sources, as described above, including microbial broth. The isolation and characterization of hyaluronic acid has been described by Meyer et al., J. Biol. Chem. 107,629 (1934); J. Biol. Chem. 114,689 (1936), and has recently been reviewed in Methods in Enzymol. 28, 73 (1972). The structure of hyaluronic acid was elucidated by Weissman et al., J. Am. Chem. Soc. 76, 1753 (1954) and Meyer, Fed. Proc. 17, 1075 (1958). Other publications such as, U.S. Patent No. 4,141,973, February 27, 1979 by E.A. Balazs, concerned the production and purification of hyaluronic acid from the sources such as animal connective tissue.
- silver compounds produce thei r antimicrobial effect s by the time-dependent rel ease of silver ions and their effectiveness is directly related to the constant presence of the free ions in the tissues.
- simple silver salts such as silver nitrate
- silver nitrate as an antibacterial agent has been limited by the requirement of frequent applications to achieve effective concentrations of the silver ions (10-20 ug/ml) .
- the invention is al so directed to methods of inhibiting microbial growth util izing these heavy metal salts.
- the present invention concerns methods of producing silver hyaluronate, compositions containing silver hyal uronate, and the treatment of wounds, burns and infections, especial ly sof t-tissue infections and gonoccocal opthalmalogical infections, with silver hyaluronate.
- Heavy metal sal ts of hyaluronic acid may be incorporated into compositions, such as pharmaceutical compositions containing an effective amount of the heavy metal sal t, e. g. , silver hyaluronate or gol d hyaluronate, and a pharmaceutically acceptable ca rrier.
- compositions such as pharmaceutical compositions containing an effective amount of the heavy metal sal t, e. g. , silver hyaluronate or gol d hyaluronate, and a pharmaceutically acceptable ca rrier.
- This invention also concerns compositions containing heavy metal salts of radioactively labelled hyaluronic acid.
- the silver hyal uronate is prepared in the absence of l ight and the aqueous sodium hyaluronate and aqueous silver nitrate mixture is shaken for a suff icient period of time, ordinarily several hours, to formaqueous silver hyal uronate solution.
- the aqueous silver hyaluronate sol ution is then treated to effect precipitation of the silver hyaluronate which may be recovered by rinsing the silver hyaluronate precipitate with ethanol , drying the rinsed precipitate wi th nitrogen and further drying the nitrogen-dried precipitate by high vacuum drying.
- the other heavy metal salts of hyaluronic acid may be prepared by methods analogous to the preparation of silver hyaluronate.
- the heavy metal sal ts of hyaluronic acid and compositions containing same are useful as antimicrobial agents.
- microbial growth may be inhibited by contacting the microbes with an effective amount of silver hyaluronate.
- Silver hyaluronate may al so be used for treating burns, wounds, soft tissue infections, for example, gonoccocal opthalmalogical infections or sepsis by topically applying an effective amount of the silver hyaluronate to the site of the burn, wound, soft tissue infection or infection f rom which the sepsis stems.
- Silver hyaluronate compositions are also used for treating keratitis infections.
- Hyaluronic acid is a maj or constitutent of connective tissue, body fluids and skin, and hence is absolutely non-immunogenic. Due to thei r large size (M .W. 1.5x10 6 Daltons) , HA salts form viscous solutions, and after inj ection into the tissues the polysaccharide diffuses extremely slowly from the injection site.
- Minimal Inhibitory Concentration was tested on eight species of bacteria isolated from hospitalized patients. The eight species are E. coli; Seratia; Pseudomonas; Proteus; K. pneumoniae; Acinobacter; C. albicans; and M. morgani.
- a white-colored precipitate probably AgCl, appears immediately when the Ag-hyaluronate comes in contact with culture media or serum.
- the scoring resul ts were analyzed statistically by the two tailed Wilcoxon rank sum test.
- AgHA was shown to have an effective therapeutic effect against the viscous bacteria Pseudomonas aeruginosa. in vivo.
- the use of such a preparation on i ts own or in conjunction with the commonly-used antibiotics might prove highly benef icial in the topical treatment of bacterial keratiti s .
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Animal Behavior & Ethology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK597487A DK597487A (da) | 1986-03-14 | 1987-11-13 | Hyaluronsyre-tungmetalsalte til anvendelse som mikrobielle midler |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/840,419 US4746504A (en) | 1986-03-14 | 1986-03-14 | Heavy metal salts of hyaluronic acid and their use as antimicrobial agents |
US840,419 | 1986-03-14 | ||
US1947487A | 1987-02-26 | 1987-02-26 | |
US019,474 | 1987-02-26 | ||
US07/023,666 US4784991A (en) | 1986-03-14 | 1987-03-09 | Heavy metal salts of hyaluronic acid and their use as antimicrobial agents |
US023,666 | 1987-03-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1987005517A1 true WO1987005517A1 (fr) | 1987-09-24 |
Family
ID=27361231
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1987/000549 WO1987005517A1 (fr) | 1986-03-14 | 1987-03-13 | Sels de metaux lourds de l'acide hyaluronique utiles en tant qu'agents antimicrobiens |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0259485A4 (fr) |
AU (1) | AU600483B2 (fr) |
CA (1) | CA1291123C (fr) |
WO (1) | WO1987005517A1 (fr) |
Cited By (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0356435A1 (fr) * | 1987-03-19 | 1990-03-07 | Arthropharm Pty Ltd | Composes et compositions anti-inflammatoires. |
GR900100137A (en) * | 1989-02-24 | 1991-06-28 | Richter Gedeon Vegyeszet | Novel compositions containing hyaluronic acid associates and a process for preparing same |
WO1992020716A1 (fr) * | 1991-05-11 | 1992-11-26 | Basf Aktiengesellschaft | Hyaluronates ferriques |
WO1997011710A1 (fr) * | 1995-09-28 | 1997-04-03 | Sangstat Medical Corporation | Utilisation d'acide hyaluronique en qualite d'agent immunosuppresseur |
WO1998010773A1 (fr) * | 1996-09-12 | 1998-03-19 | Richter Gedeon Vegyészeti Gyár Rt. | Compositions pharmaceutiques a activite antimicrobienne |
WO2000053194A1 (fr) | 1999-03-10 | 2000-09-14 | Takata Seiyaku Co., Ltd. | Medicaments contre les affections articulaires |
EP1311276A1 (fr) * | 2000-07-31 | 2003-05-21 | Dermal Research Laboratories, Inc. | Procedes servant a prevenir ou a traiter des maladies et des etats au moyen de glucides complexes |
GB2392913A (en) * | 2002-09-11 | 2004-03-17 | Johnson & Johnson Medical Ltd | Complex of an anionic polysaccharide with silver |
WO2004024197A1 (fr) | 2002-09-11 | 2004-03-25 | Johnson & Johnson Medical Limited | Materiaux pour pansements contenant des complexes composes de polysaccharides anioniques et d'argent |
GB2402880A (en) * | 2003-06-20 | 2004-12-22 | Johnson & Johnson Medical Ltd | Antimicrobial silver complexes |
BG64458B1 (bg) * | 1997-04-29 | 2005-03-31 | Richter Gedeon Vegyeszeti Gyar Rt. | Използване на цинков хиалуронат срещу пептична язва |
WO2009063291A1 (fr) * | 2007-11-13 | 2009-05-22 | Bio-Technology General (Israel) Ltd. | Procédé de stérilisation par filtration à l'état dilué pour des biopolymères viscoélastiques |
US7879824B2 (en) | 2001-07-31 | 2011-02-01 | Dermal Research Laboratories, Inc. | Methods of preventing or treating diseases and conditions using complex carbohydrates |
EP2289522A1 (fr) | 2009-08-14 | 2011-03-02 | Holy Stone Healthcare Co.,Ltd. | Utilisation d'acide hyaluronique pour le traitement d'ulcers gastro-duodenaux |
EP2292243A1 (fr) | 2009-08-14 | 2011-03-09 | Holy Stone Healthcare Co.,Ltd. | Mélange d'acide hyaluronique pour traiter et empêcher les maladies intestinales inflammatoires |
US8124826B2 (en) | 2003-11-18 | 2012-02-28 | Systagenix Wound Management (Us), Inc. | Antioxidant and antimicrobial wound dressing materials |
ITPD20100349A1 (it) * | 2010-11-19 | 2012-05-20 | Fidia Farmaceutici | Composizioni farmaceutiche ad attivita' antibatterica e cicatrizzante |
CN102552309A (zh) * | 2010-12-15 | 2012-07-11 | 北京理工大学 | 一种透明质酸金的用途及其制备方法 |
KR101173962B1 (ko) * | 2003-06-20 | 2012-08-16 | 존슨 앤드 존슨 메디칼 리미티드 | 산화방지성 상처 드레싱 물질 |
EP2543357A1 (fr) | 2011-07-07 | 2013-01-09 | Holy Stone Healthcare Co.,Ltd. | Composition pour une utilisation dans le traitement et la prévention d'une maladie liée à l'inflammation |
EP2545925A1 (fr) | 2011-07-12 | 2013-01-16 | Holy Stone Healthcare Co.,Ltd. | Compositions comprenant de l'acide hyaluronique pour le traitement et la prévention de maladies liées aux muqueuses |
WO2013017807A1 (fr) | 2011-08-04 | 2013-02-07 | Petcare Innovation | Composition antiseptique |
CZ303722B6 (cs) * | 2012-01-16 | 2013-04-03 | Contipro Biotech S.R.O. | Kyselina hyaluronová znacená tritiem, zpusob znacení kyseliny hyaluronové tritiem a její pouzití |
US8425926B2 (en) | 2003-07-16 | 2013-04-23 | Yongxing Qiu | Antimicrobial medical devices |
WO2013121001A1 (fr) | 2012-02-17 | 2013-08-22 | Kimflexor, S.L. | Sels d'argent et d'or de glycosaminoglycane partiellement dépolymérisés |
US8575130B2 (en) | 2010-01-04 | 2013-11-05 | Holy Stone Healthcare Co., Ltd. | Mixture of hyaluronic acid for treating and preventing inflammatory bowel disease |
US8722644B2 (en) | 2010-01-04 | 2014-05-13 | Holy Stone Healthcare Co., Ltd. | Mixture of hyaluronic acid for treating and preventing peptic ulcer and duodenal ulcer |
WO2014131974A1 (fr) | 2013-02-28 | 2014-09-04 | Dermaconcept Jmc | Composition dermatologique antimicrobienne topique |
US9029347B2 (en) | 2010-08-05 | 2015-05-12 | Holy Stone Healthcare Co., Ltd. | Method and mixture for treating and preventing inflammatory bowel disease |
CN112500505A (zh) * | 2020-11-19 | 2021-03-16 | 徐州医科大学 | 一种高分子银复合物及其制备方法和应用 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4172128A (en) * | 1975-03-26 | 1979-10-23 | Erhard Thiele | Process of degrading and regenerating bone and tooth material and products |
US4211769A (en) * | 1977-08-24 | 1980-07-08 | Takeda Chemical Industries, Ltd. | Preparations for vaginal administration |
US4487865A (en) * | 1983-12-15 | 1984-12-11 | Biomatrix, Inc. | Polymeric articles modified with hyaluronate |
US4605691A (en) * | 1984-12-06 | 1986-08-12 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1229075B (it) * | 1985-04-05 | 1991-07-17 | Fidia Farmaceutici | Medicamenti per uso topico, ottenuti tramite l'impiego dell'acido ialuronico |
-
1987
- 1987-03-13 AU AU72068/87A patent/AU600483B2/en not_active Ceased
- 1987-03-13 EP EP19870902255 patent/EP0259485A4/fr not_active Ceased
- 1987-03-13 WO PCT/US1987/000549 patent/WO1987005517A1/fr not_active Application Discontinuation
- 1987-03-13 CA CA000531936A patent/CA1291123C/fr not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4172128A (en) * | 1975-03-26 | 1979-10-23 | Erhard Thiele | Process of degrading and regenerating bone and tooth material and products |
US4211769A (en) * | 1977-08-24 | 1980-07-08 | Takeda Chemical Industries, Ltd. | Preparations for vaginal administration |
US4487865A (en) * | 1983-12-15 | 1984-12-11 | Biomatrix, Inc. | Polymeric articles modified with hyaluronate |
US4605691A (en) * | 1984-12-06 | 1986-08-12 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
Non-Patent Citations (8)
Title |
---|
Arthritis and Rheumatism 25: (12), issued 1982, (BETTS et al.), "Effect of Metal Chelators and Antiinflammatory Drugs on the Degradation of Hyaluronic Acid, pages 1469-1476. * |
Biochemical and Biophysical Research Communications 74(2), issued 1977, (FIGUEROA et al.), "Chu2+-Hyaluronic Acid Complex: Spectrophotometric Detection", pages 460-465. * |
Biopolymers 17, issued 1978, (FIGUEROA et al.), "Circular Dichroism Studies of Copper (II).- Hyaluronic Acid Complex in Relation to Conformation of the Polymer" pages 2415-2426. * |
Connective Tissue Res. 6(2), issued 1978, (ATKINS et al.) "Hyaluronic Acid Conformations Observed for Various Salt Forms in the Crystaline Phase, page 116. * |
Current Eye Research 3(8), issued 1984, (LIU et al.), "Inhibition of Oxidative Degredation of Hyaluronic Acid by Uric Acid", pp 1049-1053. * |
Graefe's Arch. Clin. Exp. Ophthalmol. 218, issued 1982, (SCHMUT et al.), "Preparation of Gels from Hyaluronate Solutions", pages 311-314. * |
J. Biol. Chem., issued 1956, (VOURAS et al.), "The Outer Sphere Association of Chondroitin Sulfate with Polyvalent Complex Cations", pages 792-795. * |
See also references of EP0259485A4 * |
Cited By (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0356435A1 (fr) * | 1987-03-19 | 1990-03-07 | Arthropharm Pty Ltd | Composes et compositions anti-inflammatoires. |
EP0356435A4 (fr) * | 1987-03-19 | 1990-06-26 | Arthropharm Pty Ltd | Composes et compositions anti-inflammatoires. |
GR900100137A (en) * | 1989-02-24 | 1991-06-28 | Richter Gedeon Vegyeszet | Novel compositions containing hyaluronic acid associates and a process for preparing same |
LT3806B (en) | 1989-02-24 | 1996-03-25 | Richter Gedeon Vegyeszet | Hyaluronic acid associates, composition containing them, process for preparing the composition, process for preparing zinc hyaluronate aqueous solution |
WO1992020716A1 (fr) * | 1991-05-11 | 1992-11-26 | Basf Aktiengesellschaft | Hyaluronates ferriques |
AU719365B2 (en) * | 1995-09-28 | 2000-05-04 | Sangstat Medical Corporation | Use of hyaluronic acid as an immunosuppressant |
US6013641A (en) * | 1995-09-28 | 2000-01-11 | Sangstat Medical Corporation | Use of hyaluronic acid as an immunosuppressant |
WO1997011710A1 (fr) * | 1995-09-28 | 1997-04-03 | Sangstat Medical Corporation | Utilisation d'acide hyaluronique en qualite d'agent immunosuppresseur |
WO1998010773A1 (fr) * | 1996-09-12 | 1998-03-19 | Richter Gedeon Vegyészeti Gyár Rt. | Compositions pharmaceutiques a activite antimicrobienne |
BG64458B1 (bg) * | 1997-04-29 | 2005-03-31 | Richter Gedeon Vegyeszeti Gyar Rt. | Използване на цинков хиалуронат срещу пептична язва |
WO2000053194A1 (fr) | 1999-03-10 | 2000-09-14 | Takata Seiyaku Co., Ltd. | Medicaments contre les affections articulaires |
EP1166788A1 (fr) * | 1999-03-10 | 2002-01-02 | Takata Seiyaku Kabushiki Kaisha | Medicaments contre les affections articulaires |
EP1166788A4 (fr) * | 1999-03-10 | 2007-10-10 | Takata Seiyaku Kabushiki Kaish | Medicaments contre les affections articulaires |
EP1311276A4 (fr) * | 2000-07-31 | 2007-09-12 | Dermal Res Lab Inc | Procedes servant a prevenir ou a traiter des maladies et des etats au moyen de glucides complexes |
EP1311276A1 (fr) * | 2000-07-31 | 2003-05-21 | Dermal Research Laboratories, Inc. | Procedes servant a prevenir ou a traiter des maladies et des etats au moyen de glucides complexes |
US8367642B2 (en) | 2000-07-31 | 2013-02-05 | Dermal Research Laboratories, Inc. | Methods of preventing or treating diseases and conditions using complex carbohydrates |
US7879824B2 (en) | 2001-07-31 | 2011-02-01 | Dermal Research Laboratories, Inc. | Methods of preventing or treating diseases and conditions using complex carbohydrates |
GB2392913B (en) * | 2002-09-11 | 2007-04-04 | Johnson & Johnson Medical Ltd | Wound dressings comprising complexes of oxidised celluloses with silver |
US8461410B2 (en) | 2002-09-11 | 2013-06-11 | Ethicon, Inc. | Wound dressing materials comprising complexes of anionic polysaccharides with silver |
GB2392913A (en) * | 2002-09-11 | 2004-03-17 | Johnson & Johnson Medical Ltd | Complex of an anionic polysaccharide with silver |
WO2004024197A1 (fr) | 2002-09-11 | 2004-03-25 | Johnson & Johnson Medical Limited | Materiaux pour pansements contenant des complexes composes de polysaccharides anioniques et d'argent |
GB2402880B (en) * | 2003-06-20 | 2008-01-23 | Johnson & Johnson Medical Ltd | Antimicrobial compositions comprising silver |
GB2402880A (en) * | 2003-06-20 | 2004-12-22 | Johnson & Johnson Medical Ltd | Antimicrobial silver complexes |
KR101173962B1 (ko) * | 2003-06-20 | 2012-08-16 | 존슨 앤드 존슨 메디칼 리미티드 | 산화방지성 상처 드레싱 물질 |
US8425926B2 (en) | 2003-07-16 | 2013-04-23 | Yongxing Qiu | Antimicrobial medical devices |
US10143771B2 (en) | 2003-11-18 | 2018-12-04 | Kci Usa, Inc. | Antioxidant and antimicrobial wound dressing materials |
US8124826B2 (en) | 2003-11-18 | 2012-02-28 | Systagenix Wound Management (Us), Inc. | Antioxidant and antimicrobial wound dressing materials |
US20150352244A1 (en) * | 2003-11-18 | 2015-12-10 | Kci Usa, Inc. | Antioxidant and antimicrobial wound dressing materials |
US9896518B2 (en) | 2007-11-13 | 2018-02-20 | Bio-Technology General (Israel) Ltd. | Dilute filtration sterilization process for viscoelastic biopolymers |
WO2009063291A1 (fr) * | 2007-11-13 | 2009-05-22 | Bio-Technology General (Israel) Ltd. | Procédé de stérilisation par filtration à l'état dilué pour des biopolymères viscoélastiques |
AU2008322629B2 (en) * | 2007-11-13 | 2013-05-16 | Bio-Technology General (Israel) Ltd. | Dilute filtration sterilization process for viscoelastic biopolymers |
EP3842046A1 (fr) | 2009-08-14 | 2021-06-30 | Holy Stone Healthcare Co.,Ltd. | Mélange d'acide hyaluronique permettant de traiter et d'empêcher les maladies intestinales inflammatoires |
EP2292243A1 (fr) | 2009-08-14 | 2011-03-09 | Holy Stone Healthcare Co.,Ltd. | Mélange d'acide hyaluronique pour traiter et empêcher les maladies intestinales inflammatoires |
EP2289522A1 (fr) | 2009-08-14 | 2011-03-02 | Holy Stone Healthcare Co.,Ltd. | Utilisation d'acide hyaluronique pour le traitement d'ulcers gastro-duodenaux |
US8722644B2 (en) | 2010-01-04 | 2014-05-13 | Holy Stone Healthcare Co., Ltd. | Mixture of hyaluronic acid for treating and preventing peptic ulcer and duodenal ulcer |
US8575130B2 (en) | 2010-01-04 | 2013-11-05 | Holy Stone Healthcare Co., Ltd. | Mixture of hyaluronic acid for treating and preventing inflammatory bowel disease |
US9029347B2 (en) | 2010-08-05 | 2015-05-12 | Holy Stone Healthcare Co., Ltd. | Method and mixture for treating and preventing inflammatory bowel disease |
AU2011330855B2 (en) * | 2010-11-19 | 2016-09-15 | Fidia Farmaceutici S.P.A. | Compositions with antibacterial and wound healing activity |
WO2012066447A1 (fr) * | 2010-11-19 | 2012-05-24 | Fidia Farmaceutici S.P.A. | Compositions ayant une activité antibactérienne et de cicatrisation |
ITPD20100349A1 (it) * | 2010-11-19 | 2012-05-20 | Fidia Farmaceutici | Composizioni farmaceutiche ad attivita' antibatterica e cicatrizzante |
US9265793B2 (en) | 2010-11-19 | 2016-02-23 | Fidia Farmaceutici S.P.A | Compositions with antibacterial and wound healing activity |
CN102552309A (zh) * | 2010-12-15 | 2012-07-11 | 北京理工大学 | 一种透明质酸金的用途及其制备方法 |
EP2543357A1 (fr) | 2011-07-07 | 2013-01-09 | Holy Stone Healthcare Co.,Ltd. | Composition pour une utilisation dans le traitement et la prévention d'une maladie liée à l'inflammation |
US10709731B2 (en) | 2011-07-12 | 2020-07-14 | Aihol Corporation | Materials for treating and preventing mucosa related disease |
EP2545925A1 (fr) | 2011-07-12 | 2013-01-16 | Holy Stone Healthcare Co.,Ltd. | Compositions comprenant de l'acide hyaluronique pour le traitement et la prévention de maladies liées aux muqueuses |
WO2013017807A1 (fr) | 2011-08-04 | 2013-02-07 | Petcare Innovation | Composition antiseptique |
WO2013017808A1 (fr) | 2011-08-04 | 2013-02-07 | Dermaconcept Jmc | Composition antiseptique. |
CZ303722B6 (cs) * | 2012-01-16 | 2013-04-03 | Contipro Biotech S.R.O. | Kyselina hyaluronová znacená tritiem, zpusob znacení kyseliny hyaluronové tritiem a její pouzití |
WO2013121001A1 (fr) | 2012-02-17 | 2013-08-22 | Kimflexor, S.L. | Sels d'argent et d'or de glycosaminoglycane partiellement dépolymérisés |
JP2015507070A (ja) * | 2012-02-17 | 2015-03-05 | キムフレクサー エセ.エレ. | 部分的に解重合したグリコサミノグリカン銀及び金塩 |
CN104125964A (zh) * | 2012-02-17 | 2014-10-29 | 金弗莱克瑟有限公司 | 部分解聚的糖胺聚糖银盐和金盐 |
WO2014131974A1 (fr) | 2013-02-28 | 2014-09-04 | Dermaconcept Jmc | Composition dermatologique antimicrobienne topique |
EP3287171A1 (fr) | 2013-02-28 | 2018-02-28 | Laboratoires Thea S.A.S. | Composition dermatologique antimicrobienne topique pour une utilisation en ophtalmologie |
CN112500505A (zh) * | 2020-11-19 | 2021-03-16 | 徐州医科大学 | 一种高分子银复合物及其制备方法和应用 |
Also Published As
Publication number | Publication date |
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EP0259485A1 (fr) | 1988-03-16 |
CA1291123C (fr) | 1991-10-22 |
AU7206887A (en) | 1987-10-09 |
AU600483B2 (en) | 1990-08-16 |
EP0259485A4 (fr) | 1988-07-29 |
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