Classifications

• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
  • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
  • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
  • G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
  • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
  • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
  • G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
  • G01N27/048—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance for determining moisture content of the material

Definitions

• the present invention relates to a device for measuring the water content of a granular material from a physical quantity obtained by bringing a flowing granular material into contact with an electrode and applying an electric potential to the electrode, and a method for measuring the water content using this device. It is characterized in that the electrode pair is made thin from the body surface, and the surfaces of the electrode pairs are arranged flat on the surface of the insulator instead of facing each other as in the prior art.
• a powder characterized in that the electrode for detecting moisture of the present invention is provided in a tank of a fluidized-granulation coating apparatus, and a spray liquid is variably supplied so that a physical quantity obtained from the electrode maintains a predetermined value.
• the present invention relates to granulation and coating methods for granules. Background technology
• Known devices for measuring the water content of powdered granules include a cobalt chloride moisture meter, a capacitance moisture meter, a microwave moisture meter, an infrared moisture meter, a neutron moisture meter, and an electric resistance moisture meter. These devices are generally used to collect and measure samples, and it is often difficult to apply them to continuous measurement online.
• the granules are placed in a fluidized-granulation tank of a coating device, and gas such as air is sent in from the lower part to fluidize the liquid. It is a method of granulating. This method is frequently used in the pharmaceutical industry because each unit operation of mixing, granulation and drying can be performed in a single vessel and in a sealed container.
• the granules obtained can be added to, for example, tableted, filled with capsules, or packaged separately for particle size and It is strongly desired that physical properties such as distribution and specific volume are constant, and in the past, fluid granulation, for example, empirically set a fixed time for mixing and granulation, and drying raises the exhaust temperature to a constant temperature. And the method of ending it was taken.
• fluid granulation for example, empirically set a fixed time for mixing and granulation, and drying raises the exhaust temperature to a constant temperature. And the method of ending it was taken.
• the granulation mechanism is very complicated, physical properties such as the particle size distribution and specific volume of the obtained granules vary greatly between mouths by such simple operations.
• the distance between the electrodes of one or two or more pairs on the surface of the insulator provided in the fluidized state of the granular material is a distance at which the granular material cannot form a bridge.
• An electrode whose thickness from the body surface is such that the powder does not substantially stay at the electrode or its periphery, and a powder or granule comprising a measuring device for measuring a physical quantity obtained by applying a potential to the electrode The present invention further relates to a moisture measuring device of the type described above and a method of measuring the physical quantity obtained by applying an electric potential to the electrode and measuring the moisture in the flowing powder and granules by providing this electrode in the flowing powder and granules.
• a method for granulating and coating by providing the moisture detecting electrode of the present invention on the inner wall of a tank in which the powder forms a fluidized bed and controlling the amount of mist so as to keep the detected physical quantity constant.
• the electrode used in the present invention may be fixed to the surface of the insulator, Also, part or all of the electrode may be inside the insulator, but the surface of the electrode must be exposed.
• the structure of the electrode inside the insulator may be any structure.
• any other structure can be used as long as the surface of the electrode is flat.
• the shape of the exposed portion is generally elongated, such as paper, rod, plate, or tape.
• the length of this electrode is generally longer than the width between the electrodes.
• the shape of the cross section of the electrode may be any of a linear shape, a rectangular shape, a combined shape, a square shape, a circle, a partial circle, and the like. However, a shape that does not deposit powder particles when fixed to the tank wall is preferable.
• the number of electrodes used is generally an even number of 2 or more, but the tank body can be used as one electrode.
• the two electrodes may be the same or different, but usually have the same shape.
• the electrodes are placed on the surface of the insulator.
• the surface of the electrode preferably has less irregularities from the surface of the insulator, and most preferably, the surface of the electrode and the surface of the insulator are the same surface.
• the thickness of the electrode that is, the distance between the surface of the insulator and the surface of the electrode is 10 strokes or less, preferably 3 gangs or less.
• the surface area of the electrode depends on the flow state of the particles, but in the case of a rectangular shape, the width is 5 to 30 strokes, and the length is 10 to: about 100 mm.
• the two electrodes may be provided in any arrangement on the same surface, but the interval between the two shortest points is set to about 5 to 20 sleeps. Preferably, both electrodes are provided in parallel. Any electrode material can be used as long as it has conductivity, but metals such as copper, stainless steel, and aluminum, alloys, and graphite are exemplified.
• the insulator for fixing the electrodes is not limited in shape and material as long as insulation from the inner wall of the tank is maintained, but is flat (it may be curved like a cylinder). It is preferable that the insulator be as thin as possible, but it is more preferable that the insulator be fitted on the inner wall of the tank. If the tank itself is an insulator, the electrodes can be directly installed on the inner wall of the tank.
• the material used for the insulator is not limited as long as it can be insulated.
• synthetic resins such as polyvinyl chloride, tephron, nylon, rubber, ceramics, and the like are used.
• the shape of the insulator is not particularly limited, but is preferably a flat plate (which may be curved in one direction like a cylinder), and the shape viewed from the surface is not particularly limited.
• the number of electrodes is one or two or more.
• two or more electrodes can be connected in series or in parallel. Since the physical quantity, for example, the electrical resistance changes depending on the specific resistance or moisture of the powder, it is preferable that the measuring instrument can measure a wide range. If a plurality of electrode pairs can be connected from outside the tank in various combinations such as series and parallel, the number of electrodes to be used, the combination of series and parallel, etc. should be selected according to the type of powder and granules, processing conditions, etc. Facilitates the measurement.
• the surface of the insulator and the surface of the electrode are formed on the same surface, the surface shape is rectangular, and each electrode pair is provided in parallel at an interval of about 10 °. It is a moisture detector.
• two electrodes 2 are arranged on an insulator 1, and the electrodes 2 are connected to an electric resistance measuring instrument via connection terminals 3 and lead wires 4, respectively.
• FIG. 2 is a partial view in which the apparatus of FIG. 1 is provided on the wall of a tank.
• the moisture measuring apparatus of the present invention can measure the moisture of a granular material by applying the method to the processing of the granular material such as granulation, coating, mixing, feeding, and drying of the granular material.
• the amplitude of a moisture detection value is small compared with the method using the conventional electrode, and accurate moisture can be measured comparatively stably. Therefore, the data obtained by this apparatus can be used to easily control the water content of the granular material and to automate the processing of the granular material such as management.
• the moisture detecting electrode of the present invention is provided on the tank wall of a tank forming a fluidized bed of a fluidized granulation coating apparatus, and the electric resistance ⁇ obtained by applying a constant potential to the electrode is constant.
• the method of granulating and coating by supplying the spray liquid so as to maintain it will be described.
• a screen is provided at a lower part in a tank of a fluidized-granulation coating apparatus, and a nog filter is provided at an upper part.
• a temperature detector is provided between the screen and the bag filter, and the moisture detector of the present invention is used.
• An electrode is provided, and granulation coating is performed using the electrode in the following steps.
• the granulation process is performed between BCDs, and the fog amount is increased or decreased so as to maintain the set electric resistance between CDs.
• Point D is set according to the predetermined amount of fog liquid.
• the fog is stopped.
• the drying process is between DE and the point E is set by setting the temperature in the fluidized bed.
• Fig. 4 shows an example of the above operation, which will be explained along with this.
• Fluid granulation ⁇ Powder and granules are put into the coating tank 6, air is supplied from the air intake port 7 through the air supply damper 8, ripened to a predetermined temperature in the heat exchanger 9, and then into the container 11 through the screen 10. After introduction, the powder 12 in the container starts to flow. The air is forcibly exhausted from the exhaust port 14 through the bag filter 13 and the exhaust damper 15 and the exhaust fan 16.
• the spray liquid is supplied to the nozzle 19 from the spray liquid tank 17 through the variable discharge liquid feed pump 18. Also, compressed air for making the spray liquid fine is supplied to the nozzle through the air flow control valve 20, and is sprayed into the flowing powder while the spray liquid is made fine, whereby granulation or coating proceeds.
• Temperature sensor 2 1 Lower part of screen 10 1 Temperature sensor 2 2 in fluidized bed and electrode 23 for moisture detection, Air flow meter or anemometer at air intake or / and exhaust outlet 2 4 Is installed.
• the signal from the temperature detector 21 is sent to the heat exchanger 9 directly or through the control panel 25 to control the temperature of the air that fluidizes the powder to be constant.
• the signal of the moisture detection electrode 23 is controlled directly or through the control panel 25 to operate the variable volume pump 18 or change the volume to control the water content of the granules during granulation or coating.
• Anemometer or anemometer signal It is sent to the exhaust damper 15 or the exhaust fan 16 directly or through the control panel 25, and controls the amount of air or other gas to be blown so as to keep the flow state of the granular material constant.
• the relationship between the electric resistance and the moisture has an inverse relationship, and there is a proportional relationship between the moisture and the particle size by granulation. Therefore, the water content is specified from the target particle size, and if the electric resistance corresponding to the water content is maintained, particles having the target particle size can be easily obtained.
• FIG. 1 shows an example of an apparatus for measuring the water content of a granular material according to the present invention.
• FIG. 2 shows a state in which the moisture measuring device of FIG. 1 is installed on the inner wall of the tank.
• FIG. 3 shows a process diagram of moisture control in granulation, and
• FIG. 4 shows an example of a fluidized granulation apparatus.
• each index has the following meaning.
• Electric resistance measuring instrument 6 Fluidized granulation ⁇ Coating tank 7: Air intake
• Container 12 Powder 13: Knock-off
• Spray liquid tank 18 Discharge rate variable pump 19: Nozzle
• Air flow control valve 21 Temperature detector 22: Temperature detector
• Electrode for moisture detection 24 Anemometer or anemometer 25: Control panel
• Granulation was performed by supplying 5 kg of a 6% (W / V) aqueous solution of [Gothenol GL05, manufactured by Nippon Synthetic Chemical Co., Ltd.] as a spray liquid.
• a pair of 10 stainless steel plates (width) x 380 nun (length) are provided on the tank wall of the fluidized bed at intervals of 5 sq.m.
• the spray liquid was supplied so as to maintain the electrical resistance shown in the table.
• the water content (H) of the particles and the electrical resistance (E) have an inversely proportional relationship (which becomes a straight line on a logarithmic graph paper), and the water content (H) of the particles and the average particle size (S) of the particles It is understood that there is a proportional relationship between

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• Chemical & Material Sciences (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Electrochemistry (AREA)
• Physics & Mathematics (AREA)
• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
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• Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

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ID=16121454

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Cited By (1)

Citations (3)

• 1986
  • 1986-08-20 KR KR870700337A patent/KR880700262A/ko not_active Application Discontinuation
  • 1986-08-20 WO PCT/JP1986/000429 patent/WO1987001202A1/ja unknown

Patent Citations (3)

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