WO1987000427A1 - Topical composition and method for stimulating hair growth - Google Patents

Topical composition and method for stimulating hair growth Download PDF

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Publication number
WO1987000427A1
WO1987000427A1 PCT/US1986/001393 US8601393W WO8700427A1 WO 1987000427 A1 WO1987000427 A1 WO 1987000427A1 US 8601393 W US8601393 W US 8601393W WO 8700427 A1 WO8700427 A1 WO 8700427A1
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WO
WIPO (PCT)
Prior art keywords
percent
weight
composition
group
vehicle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1986/001393
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English (en)
French (fr)
Inventor
Peter H. Proctor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE8686904603T priority Critical patent/DE3688427T2/de
Priority to AT86904603T priority patent/ATE89159T1/de
Publication of WO1987000427A1 publication Critical patent/WO1987000427A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Definitions

  • Patent 4,139,619 described a process for stimulating the growth of mammalian hair by the application of 6-amino-4-(substituted amino)-l,2-dihydro- l-hydroxy-2-iminopyrimidines to mammalian skin in association with a topical pharmaceutical carrier.
  • U.S. Patent 4,347,245 described a composition containing spironolactone in a liquid carrier such as alcohol, urea, mineral oil or white petrolatum.
  • the present invention provides a pharmaceutical vehicle for topical application of hair growth stimulants which functions as a synergist to improve the effectiveness of the hair growth stimulant.
  • the vehicle consists essentially of an emulsion of oil and water and substantially homogenously dispersed therein, a pharmaceutically acceptable hydroxyl radical scavenger in a proportion which is synergistically effective to simulate hair growth when a hair growth stimulant is dispersed in the vehicle.
  • the vehicle also includes an antiandrogen which interferes with the binding of dihydrotestosterone to • receptors.
  • sulfoxides include, in addition to DMSO, hexyl methyl sulfoxide, decyl methyl sulfoxide, dodecyl methyl sulfoxide, tetradecyl methyl sulfoxide, ⁇ -hydroxydecyl methyl sulfoxide, ⁇ -hydroxydodecyl methyl sulfoxide, ⁇ -hydroxytetradecyl methyl sulfoxide, and the like.
  • DMSO hexyl methyl sulfoxide
  • decyl methyl sulfoxide dodecyl methyl sulfoxide
  • tetradecyl methyl sulfoxide ⁇ -hydroxydecyl methyl sulfoxide
  • ⁇ -hydroxydodecyl methyl sulfoxide ⁇ -hydroxytetradecyl methyl sulfoxide
  • Table I-A 1. Obtained from Owen Laboratories ; Dermovan emulsion contains water, glycerol stearate , glycerin, mineral oil , synthetic spermaceti , cetyl alcohol , butylparaben, propylparaben and methylparaben. 2. Obtained from The Upjohn Company under the designation Loniten.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PCT/US1986/001393 1985-07-18 1986-07-03 Topical composition and method for stimulating hair growth Ceased WO1987000427A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE8686904603T DE3688427T2 (de) 1985-07-18 1986-07-03 Topische zusammensetzung und verfahren zur anregung des haarwuchses.
AT86904603T ATE89159T1 (de) 1985-07-18 1986-07-03 Topische zusammensetzung und verfahren zur anregung des haarwuchses.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75713185A 1985-07-18 1985-07-18
US85805086A 1986-04-30 1986-04-30
US858,050 1986-04-30
US757,131 1991-09-10

Publications (1)

Publication Number Publication Date
WO1987000427A1 true WO1987000427A1 (en) 1987-01-29

Family

ID=27116334

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1986/001393 Ceased WO1987000427A1 (en) 1985-07-18 1986-07-03 Topical composition and method for stimulating hair growth

Country Status (5)

Country Link
EP (1) EP0232311B1 (https=)
AT (1) ATE89159T1 (https=)
AU (1) AU6131686A (https=)
DE (1) DE3688427T2 (https=)
WO (1) WO1987000427A1 (https=)

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2615389A1 (fr) * 1987-05-15 1988-11-25 Holden John Composition pour regenerer les cheveux
EP0327263A1 (en) * 1988-01-29 1989-08-09 PROCTOR, Peter H. Hair growth stimulation with nitroxide and other radicals
EP0376821A1 (fr) * 1988-12-30 1990-07-04 L'oreal Composition pour induire et stimuler la croissance des cheveux et/ou freiner leur chute, à base de dérivés de pyrimidine et de filtres solaires
DE3915133A1 (de) * 1987-11-13 1990-11-15 Luderschmidt Christoph Haarwuchsmittel
WO1992009259A1 (en) * 1990-11-29 1992-06-11 The Upjohn Company Stimulation of hair growth with potassium channel openers and an androgen receptor blocker
DE4213314A1 (de) * 1992-04-23 1993-10-28 Ingeborg Zingraf Haarwasser und Haarbehandlungsverfahren zur Verringerung des Haarausfalls und Förderung des Haarwachstums bei androgenetischem Haarausfall
US5352442A (en) * 1985-07-18 1994-10-04 Proctor Peter H Topical tempo
US5470876A (en) * 1985-07-18 1995-11-28 Proctor; Peter H. Topical sod for treating hair loss
US5472687A (en) * 1985-07-18 1995-12-05 Proctor; Peter H. Topical pyridine N-oxides
US5538945A (en) * 1994-06-17 1996-07-23 Procyte Corporation Stimulation of hair growth by peptide copper complexes
US5578599A (en) * 1990-08-10 1996-11-26 The Upjohn Company Stimulation of hair growth with minoxidil and a 5α-reductase inhibitor
US5714510A (en) * 1985-07-18 1998-02-03 Proctor; Peter H. Topical proxyl composition and method
US5714482A (en) * 1985-07-18 1998-02-03 Proctor; Peter H. Topical spin labels and method
US5716947A (en) * 1985-07-18 1998-02-10 Proctor; Peter H. Topical doxyl composition and method
US5723502A (en) * 1985-07-18 1998-03-03 Proctor; Peter H. Topical spin trap composition and method
US5728714A (en) * 1985-07-18 1998-03-17 Proctor; Peter H. Method for treating hair loss using tempo
GB2314019B (en) * 1996-06-10 2000-03-15 Bio Scient Ltd The use of L-Lysine in the treatment of hair loss
US6150405A (en) * 1985-07-18 2000-11-21 Proctor; Peter H. Hair loss treatment with ascorbates
WO2000048559A3 (en) * 1999-02-19 2000-12-07 Marcus R Jones Composition for promoting hair growth comprising derivatives of vitamins and dmso
US7435757B2 (en) * 2004-07-02 2008-10-14 Schering Ag 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
US20100055055A1 (en) * 2006-09-11 2010-03-04 Biomas Ltd. Topical formulations of tellurium-containing compounds
US9655833B2 (en) 2009-07-29 2017-05-23 Elise OLSEN Compositions and methods for inhibiting hair growth
CN113398248A (zh) * 2021-07-27 2021-09-17 上海交通大学医学院附属第九人民医院 一种改善皮瓣血运的外用药及其制备方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8606368D0 (en) * 1986-03-14 1986-04-23 Unilever Plc Skin treatment composition
GB8630720D0 (en) * 1986-12-23 1987-02-04 Unilever Plc Cosmetic compositions

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3551554A (en) * 1968-08-16 1970-12-29 Crown Zellerbach Corp Enhancing tissue penetration of physiologically active agents with dmso
US3896238A (en) * 1972-04-05 1975-07-22 Procter & Gamble Dermatological compositions
US4139619A (en) * 1976-05-24 1979-02-13 The Upjohn Company 6-Amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidine, topical compositions and process for hair growth
US4367227A (en) * 1976-03-11 1983-01-04 Lever Brothers Company Method and cosmetic composition for reducing sebum secretion

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2942666A1 (de) * 1979-10-23 1981-05-07 Wella Ag, 6100 Darmstadt Kosmetisches mittel zur behandlung der haare und der kopfhaut

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3551554A (en) * 1968-08-16 1970-12-29 Crown Zellerbach Corp Enhancing tissue penetration of physiologically active agents with dmso
US3896238A (en) * 1972-04-05 1975-07-22 Procter & Gamble Dermatological compositions
US4367227A (en) * 1976-03-11 1983-01-04 Lever Brothers Company Method and cosmetic composition for reducing sebum secretion
US4139619A (en) * 1976-05-24 1979-02-13 The Upjohn Company 6-Amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidine, topical compositions and process for hair growth

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP0232311A4 *

Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728714A (en) * 1985-07-18 1998-03-17 Proctor; Peter H. Method for treating hair loss using tempo
US5714482A (en) * 1985-07-18 1998-02-03 Proctor; Peter H. Topical spin labels and method
US5723502A (en) * 1985-07-18 1998-03-03 Proctor; Peter H. Topical spin trap composition and method
US5716947A (en) * 1985-07-18 1998-02-10 Proctor; Peter H. Topical doxyl composition and method
US6150405A (en) * 1985-07-18 2000-11-21 Proctor; Peter H. Hair loss treatment with ascorbates
US5714510A (en) * 1985-07-18 1998-02-03 Proctor; Peter H. Topical proxyl composition and method
US5472687A (en) * 1985-07-18 1995-12-05 Proctor; Peter H. Topical pyridine N-oxides
US5352442A (en) * 1985-07-18 1994-10-04 Proctor Peter H Topical tempo
US5470876A (en) * 1985-07-18 1995-11-28 Proctor; Peter H. Topical sod for treating hair loss
FR2615389A1 (fr) * 1987-05-15 1988-11-25 Holden John Composition pour regenerer les cheveux
DE3915133A1 (de) * 1987-11-13 1990-11-15 Luderschmidt Christoph Haarwuchsmittel
DE3915133C2 (de) * 1987-11-13 2003-04-03 Christoph Luderschmidt Haarwuchsmittel
EP0327263A1 (en) * 1988-01-29 1989-08-09 PROCTOR, Peter H. Hair growth stimulation with nitroxide and other radicals
FR2641184A1 (fr) * 1988-12-30 1990-07-06 Oreal Composition pour induire et stimuler la croissance des cheveux et/ou freiner leur chute, a base de derives de pyrimidine et de filtres solaires
EP0376821A1 (fr) * 1988-12-30 1990-07-04 L'oreal Composition pour induire et stimuler la croissance des cheveux et/ou freiner leur chute, à base de dérivés de pyrimidine et de filtres solaires
US5578599A (en) * 1990-08-10 1996-11-26 The Upjohn Company Stimulation of hair growth with minoxidil and a 5α-reductase inhibitor
WO1992009259A1 (en) * 1990-11-29 1992-06-11 The Upjohn Company Stimulation of hair growth with potassium channel openers and an androgen receptor blocker
DE4213314A1 (de) * 1992-04-23 1993-10-28 Ingeborg Zingraf Haarwasser und Haarbehandlungsverfahren zur Verringerung des Haarausfalls und Förderung des Haarwachstums bei androgenetischem Haarausfall
US5538945A (en) * 1994-06-17 1996-07-23 Procyte Corporation Stimulation of hair growth by peptide copper complexes
GB2314019B (en) * 1996-06-10 2000-03-15 Bio Scient Ltd The use of L-Lysine in the treatment of hair loss
US6136860A (en) * 1996-06-10 2000-10-24 Bio-Scientific Limited Use of L-lysine in the treatment of hair loss
WO2000048559A3 (en) * 1999-02-19 2000-12-07 Marcus R Jones Composition for promoting hair growth comprising derivatives of vitamins and dmso
US7435757B2 (en) * 2004-07-02 2008-10-14 Schering Ag 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
US7732493B2 (en) 2004-07-02 2010-06-08 Bayer Schering Pharma Aktiengesellschaft 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
US9700536B2 (en) 2006-09-11 2017-07-11 Biomas Ltd. Topical formulations of tellurium-containing compounds
US20100055055A1 (en) * 2006-09-11 2010-03-04 Biomas Ltd. Topical formulations of tellurium-containing compounds
US9216197B2 (en) * 2006-09-11 2015-12-22 Biomas Ltd. Topical formulations of tellurium-containing compounds
US9655833B2 (en) 2009-07-29 2017-05-23 Elise OLSEN Compositions and methods for inhibiting hair growth
US9707169B2 (en) 2009-07-29 2017-07-18 Elise OLSEN Compositions and methods for inhibiting hair growth
US10159634B2 (en) 2009-07-29 2018-12-25 Elise A. Olsen Compositions and methods for inhibiting hair growth
EP3871671A2 (en) 2009-07-29 2021-09-01 Olsen, Elise Fp receptor antagonists for inhibiting hair growth
CN113398248A (zh) * 2021-07-27 2021-09-17 上海交通大学医学院附属第九人民医院 一种改善皮瓣血运的外用药及其制备方法
CN113398248B (zh) * 2021-07-27 2023-08-15 上海交通大学医学院附属第九人民医院 一种改善皮瓣血运的外用药及其制备方法

Also Published As

Publication number Publication date
DE3688427T2 (de) 1993-08-26
ATE89159T1 (de) 1993-05-15
AU6131686A (en) 1987-02-10
EP0232311A1 (en) 1987-08-19
EP0232311A4 (en) 1988-02-15
EP0232311B1 (en) 1993-05-12
DE3688427D1 (https=) 1993-06-17

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