WO1998034610A1 - Composition for improving hair regrowth and method of use - Google Patents

Composition for improving hair regrowth and method of use Download PDF

Info

Publication number
WO1998034610A1
WO1998034610A1 PCT/US1998/002491 US9802491W WO9834610A1 WO 1998034610 A1 WO1998034610 A1 WO 1998034610A1 US 9802491 W US9802491 W US 9802491W WO 9834610 A1 WO9834610 A1 WO 9834610A1
Authority
WO
WIPO (PCT)
Prior art keywords
carnitine
ascorbic acid
hair
niacin
composition
Prior art date
Application number
PCT/US1998/002491
Other languages
French (fr)
Inventor
Robert B. Groton
Original Assignee
Groton Robert B
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Groton Robert B filed Critical Groton Robert B
Publication of WO1998034610A1 publication Critical patent/WO1998034610A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C

Definitions

  • the present invention generally relates to formulations for hair growth. More specifically, the present invention relates to a formulation for decreasing hair loss and increasing new hair growth, and a method for administering the formulation.
  • the prior art contains a number of formulations which purport to increase hair growth. However, none of the prior art is seen to utilize the combination of active ingredients of the present invention. Prior art having a perceived relevance to the present is discussed below.
  • compositions and methods for improving or healing skin conditions, and improving or preventing scar formation comprises L-carnitine in a suitable vehicle for topical application in an effective amount.
  • Aqueous compositions preferably contain between about 1-20% by weight L-carnitine, and liquid vehicle compositions contain between 1-25% by weight L-carnitine.
  • the discussion therein of the metabolism of L-carnitine is hereby incorporated by reference.
  • compositions comprising ascorbic acid (vitamin C) and proanthocyanidine for topical administration.
  • the composition preferably contains between about 10-25% ascorbic acid and between about 0.5-5% proanthocyanidine in combination with a high ratio water surfactant.
  • the composition and its method of application is directed entirely to the prevention and repair of Collagen damage in the skin.
  • U.S. Patent No. 5,122,369 discloses an orally acceptable vitamin and mineral composition for reducing hair loss.
  • the composition contains pantothenic acid, methionine, and divalent iron with approximately a 1 :3 ratio of divalent iron to pantothenic acid.
  • ingredients include folic acid, niacin, biotin, iodine, inositol, p-amino benzoic acid, and l-lysine in amounts corresponding to U.S. Food and Drug Administration recommended daily allowances.
  • Other prior art disclose hair growth formulations which are less relevant to the present invention.
  • U.S. Patent No. 5,026,553 issued to Swinney on June 25, 1991 discloses a topical composition and a method of using the composition for treating male pattern baldness.
  • the composition contains by weight approximately 90-95% vegetable (soybean) oil, 2-3% olive oil, 2-3% isopropyl alcohol and 1 % water.
  • the composition in the form of a cream vehicle, contains by weight at least 90% marrow, approximately 2-5% oil, 1 -4% vegetable alcohol, 1 -3% flowers of sulphur, and 0.75-2% bergamot oil.
  • U.S. Patent No. 5, 043, 162 issued to Trager on August 27, 1991 discloses a topically applied composition for promoting hair growth.
  • the composition contains a mixture of approximately 1 -3% lower alkyl nicotinate and 0.005-5.0% histamine HCI in a pharmaceutically acceptable vehicle, other ingredients may include vitamins A, D and E, bacteriocides and bacteriostats, and suitable anionic, cationic, and nonionic surfactants.
  • European Patent No. 232,311 B1 discloses a topical composition and method for treating baldness and androgenic alopecia.
  • the composition contains between about 1.0-20% 5, 5-diarylhydantoin and 5-25% of a hydroxyl radical scavenger such as dimethyl sulfoxide (DMSO) in a pharmaceutically acceptable carrier.
  • DMSO dimethyl sulfoxide
  • the composition may include between about 0.01 -5.0% of an antiandrogen which interferes with the binding of dihydrotestosterone to receptors.
  • European Patent No. 293,790 B1 discloses a topical composition for preventing hair loss and facilitating hair growth.
  • the compositions contains approximately 1.0% of extract from lllicium religiosum in a suitable vehicle.
  • the extract contains water 63.2 (w/v%) , ethanol 36.7 (w/v%;) , hexadecanoic acid
  • European Pat. Application No. 279,244 A2 published on August 24, 1988, by Ferro, discloses a topical composition for the treatment and stimulation of hair growth.
  • the composition comprises at least one active ingredient selected from the group consisting of heparin, vitamin K, and clofibrate, suspended in a suitable carrier.
  • European Patent Application No. 593,093 A1 published April 20, 1994 by Thornfeldt, discloses a topical composition foy treatment of hair loss resulting from alopecia areata, male pattern baldness, and other similar conditions.
  • the composition may include 2-40% dicarboxylic acids having 7 to 13 carbon atoms, inclusive, and/or mono- or di-mercapto derivatives of the dicarboxylic acids, and their salts.
  • the composition may also contain biologically active or inactive ingredients, such as keratolytic agents.
  • the present invention is a topical composition for improving the regrowth of hair when topically applied to the hair and scalp of mammals such as humans.
  • the composition comprises L-carnitine, ascorbic acid, and niacin in a pharmaceutically acceptable carrier for topical application.
  • a preferred composition contains ascorbic acid and L-carnitine in a weight/weight ratio of about 3:2.
  • the present invention also relates to a method of using the composition to improve hair regrowth.
  • the present invention is a topical composition effective for improving the regrowth of hair when topically applied to the hair and scalp of mammals, and especially humans.
  • the composition comprises- L-carnitine, ascorbic acid and niacin in a pharmaceutically acceptable carrier for topical application.
  • L-carnitine also known as ⁇ -trimethylamino-6-hydroxybutyrate or
  • Vitamin By is an effective agent for alleviating certain skin disorders.
  • L-carnitine has been known to improve skin disorders, it has now been found that L-carnitine in conjunction with ascorbic acid (Vitamin C) and niacin improves the regrowth of hair when applied topically to the hair and scalp in a pharmaceutically acceptable carrier.
  • L-carnitine, ascorbic acid and niacin are all readily available from a number of commercial suppliers.
  • the pharmaceutically, acceptable carrier may be in the form of aqueous and non-aqueous solutions, ointments, lotions, gels, suspensions, emulsions, and creams.
  • the composition may be manufactured using carriers prepared according to conventional techniques using, conventional ingredients and agents which are well known in the industry.
  • Adjuvants and other agents which may also be dispersed in the carrier include the following: moisturizers, humectants, anti-dusting agents, emulsifiers, and selected amino acids.
  • the composition may contain any effective amount of L-carnitine, ascorbic acid and niacin. However, the composition preferably contains ascorbic acid and L-carnitine in a weight/weight ratio of about 3:2.
  • One formulation of the carrier (as an emulsion) utilizes distilled water, glycerin as a humectant, And sorbitol as an emulsifier. In a 3 ml. sample of the composition, 1000 mg of L-carnitine, 1500 mg ascorbic acid, and 60 mg niacin are dispersed in an emulsion formed from distilled water, glycerin, and sorbitol. The compositions will be applied topically to the hair and scalp.
  • the composition will be applied at least once per day for several weeks, and more preferably at least twice per day for several weeks. It also is contemplated to continue use of the composition for prolonged periods of time such as, for example, several months or several years. The duration of use depends in part upon the how long the user's hair has been thinning. Initial results are usually visible within the first 30 days of use, and often within 7-14 days of use. It is preferred to apply the composition to the hair and scalp following treatment of the scalp with hot water. For example, the composition may be applied following a hot, shower or following the treatment of the hair and scalp with a towel soaked in hot water.
  • the course of treating the hair and scalp with a composition of the present invention may be supplemented with oral doses of L-carnitine containing between about 300-600 mg. It is contemplated that such oral doses of L-carnitine will be necessary only for persons over 30 years of age.
  • the present invention also provides a method for improving regrowth of hair using the previously described compositions.
  • the method includes the step of applying the composition to the hair and scalp at least once per day.
  • the preferred method also includes treating the hair and scalp with hot water, as described above, prior to applying the composition.
  • the method may also include the consumption of an oral dose of L-carnitine.
  • Example 1 User 1 , a thirty year old male with a receding hair line, used the composition of the present invention for seventeen weeks in accordance with the described method of use. Following two weeks of use, new hair growth was visible and new hair was beginning to thicken within approximately one half inch from the receding hair line. Following seventeen weeks of use, user 1 stopped treatment with the composition. Since cessation of treatment, the new hair growth remained firmly rooted in the scalp. No additional new hair growth occurred following cessation of treatment.
  • Example 3 User 3, a thirty-five year old male with distinct bald patches and thinning hair, used the composition for thirty-six weeks in accordance with the described method of use. Following three weeks of treatment, new hair growth was visibly noticeable. Following four weeks of treatment, thinning patches of hair had begun to thicken. Following twenty weeks of use, bald patches had begun filling with new hair growth. User 3 is continuing treatment with the composition.
  • the present formulation and method of application has proven itself effective on numerous occasions, and this effectiveness is uniquely attributable to the topical use L-carnitine, ascorbic acid, and niacin in a pharmaceutically acceptable carrier.
  • the composition of the present invention is inexpensive, dependable and fully effective in accomplishing its intended purposes.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A topical composition for improving the regrowth of hair when topically applied to the hair and scalp of mammals such as humans. The composition comprises L-carnitine, ascorbic acid, and niacin in a pharmaceutically acceptable carrier for topical application. A preferred composition contains ascorbic acid and L-carnitine in a weight-weight ratio of about 3:2. The present invention also relates to a method of using the composition to improve hair regrowth.

Description

COMPOSITION FOR IMPROVING HAIR REGROWTH
AND METHOD OF USE
Technical Field The present invention generally relates to formulations for hair growth. More specifically, the present invention relates to a formulation for decreasing hair loss and increasing new hair growth, and a method for administering the formulation.
Background Art While many persons proclaim that they are proud to be bald, a far greater number of persons are likely to be sensitive about the loss of hair and developing baldness. The exact cause of balding may be due to the process of aging, due to chemical damage of the hair follicle from chemotherapy or the like, or due to afflictions such as alopecia. Of these, balding due to the process of aging results in the greatest number of cases. Reference is hereby made to the description of the hair follicle growth cycle, which is thoroughly discussed in U.S. Patent No. 5,122,369 issued to Dye on June 16, 1992.
The prior art contains a number of formulations which purport to increase hair growth. However, none of the prior art is seen to utilize the combination of active ingredients of the present invention. Prior art having a perceived relevance to the present is discussed below.
Of particular interest is U.S. Patent No. 4,839,159, issued to Winter et al. on June 13, 1989, as this patent discloses a composition and method for improving or healing skin conditions, and improving or preventing scar formation. The composition comprises L-carnitine in a suitable vehicle for topical application in an effective amount. Aqueous compositions preferably contain between about 1-20% by weight L-carnitine, and liquid vehicle compositions contain between 1-25% by weight L-carnitine. The discussion therein of the metabolism of L-carnitine is hereby incorporated by reference.
l - Also of interest is U.S. Patent No. 5,470,874, issued to Lerner on
November 28, 1995, which discloses a composition comprising ascorbic acid (vitamin C) and proanthocyanidine for topical administration. The composition preferably contains between about 10-25% ascorbic acid and between about 0.5-5% proanthocyanidine in combination with a high ratio water surfactant. The composition and its method of application is directed entirely to the prevention and repair of Collagen damage in the skin. U.S. Patent No. 5,122,369, noted above, discloses an orally acceptable vitamin and mineral composition for reducing hair loss. The composition contains pantothenic acid, methionine, and divalent iron with approximately a 1 :3 ratio of divalent iron to pantothenic acid. Other ingredients include folic acid, niacin, biotin, iodine, inositol, p-amino benzoic acid, and l-lysine in amounts corresponding to U.S. Food and Drug Administration recommended daily allowances. Other prior art disclose hair growth formulations which are less relevant to the present invention. For example, U.S. Patent No. 5,026,553 issued to Swinney on June 25, 1991 , discloses a topical composition and a method of using the composition for treating male pattern baldness. The composition contains by weight approximately 90-95% vegetable (soybean) oil, 2-3% olive oil, 2-3% isopropyl alcohol and 1 % water.
U.S. Patent No. 4,520,012 issued to Alfonsi on May 28, 1985, discloses a topical composition for promoting hair growth. The composition, in the form of a cream vehicle, contains by weight at least 90% marrow, approximately 2-5% oil, 1 -4% vegetable alcohol, 1 -3% flowers of sulphur, and 0.75-2% bergamot oil.
U.S. Patent No. 5, 043, 162 issued to Trager on August 27, 1991 , discloses a topically applied composition for promoting hair growth. The composition contains a mixture of approximately 1 -3% lower alkyl nicotinate and 0.005-5.0% histamine HCI in a pharmaceutically acceptable vehicle, other ingredients may include vitamins A, D and E, bacteriocides and bacteriostats, and suitable anionic, cationic, and nonionic surfactants.
European Patent No. 232,311 B1 , issued to Proctor on May 12, 1993, and published on August 19, 1987, discloses a topical composition and method for treating baldness and androgenic alopecia. The composition contains between about 1.0-20% 5, 5-diarylhydantoin and 5-25% of a hydroxyl radical scavenger such as dimethyl sulfoxide (DMSO) in a pharmaceutically acceptable carrier. In addition, the composition may include between about 0.01 -5.0% of an antiandrogen which interferes with the binding of dihydrotestosterone to receptors.
European Patent No. 293,790 B1 , issued to Matsuoko on January! 30, 1991 , and published on December 7, 1988, discloses a topical composition for preventing hair loss and facilitating hair growth. The compositions contains approximately 1.0% of extract from lllicium religiosum in a suitable vehicle. The extract contains water 63.2 (w/v%) , ethanol 36.7 (w/v%;) , hexadecanoic acid
0.88 (mg/l), tetradecanoic acid 0.58 (mg/l), decanoic acid 0.46 (mg/l), dodecanoic acid 0.27 (mg/l), octadecanoic acid 0.23 (mg/l), C11 hydrocarbon 0.10 (mg/l) , octanoic acid 0.10 (mg/l) and other organic compounds (as n-dodecanoic acid 1.61 mg/l).
European Pat. Application No. 279,244 A2, published on August 24, 1988, by Ferro, discloses a topical composition for the treatment and stimulation of hair growth. The composition comprises at least one active ingredient selected from the group consisting of heparin, vitamin K, and clofibrate, suspended in a suitable carrier.
European Patent Application No. 593,093 A1 , published April 20, 1994 by Thornfeldt, discloses a topical composition foy treatment of hair loss resulting from alopecia areata, male pattern baldness, and other similar conditions. The composition may include 2-40% dicarboxylic acids having 7 to 13 carbon atoms, inclusive, and/or mono- or di-mercapto derivatives of the dicarboxylic acids, and their salts. The composition may also contain biologically active or inactive ingredients, such as keratolytic agents.
None of the above inventions and patents, taken either singly or in combination, is seen to describe the instant invention as claimed.
Disclosure of Invention The present invention is a topical composition for improving the regrowth of hair when topically applied to the hair and scalp of mammals such as humans. The composition comprises L-carnitine, ascorbic acid, and niacin in a pharmaceutically acceptable carrier for topical application. A preferred composition contains ascorbic acid and L-carnitine in a weight/weight ratio of about 3:2. The present invention also relates to a method of using the composition to improve hair regrowth.
Best Mode(s) for Carrying Out the Invention The present invention is a topical composition effective for improving the regrowth of hair when topically applied to the hair and scalp of mammals, and especially humans. The composition comprises- L-carnitine, ascorbic acid and niacin in a pharmaceutically acceptable carrier for topical application. L-carnitine, also known as γ-trimethylamino-6-hydroxybutyrate or
Vitamin By, is an effective agent for alleviating certain skin disorders. For a brief description of the metabolic activity of L-carnitine and the effectiveness of L-carnitine therapy for treatment of various skin disorders, reference is again made to U.S. Patent No. 4,839,159. While L-carnitine has been known to improve skin disorders, it has now been found that L-carnitine in conjunction with ascorbic acid (Vitamin C) and niacin improves the regrowth of hair when applied topically to the hair and scalp in a pharmaceutically acceptable carrier.
L-carnitine, ascorbic acid and niacin are all readily available from a number of commercial suppliers.
The pharmaceutically, acceptable carrier may be in the form of aqueous and non-aqueous solutions, ointments, lotions, gels, suspensions, emulsions, and creams. The composition may be manufactured using carriers prepared according to conventional techniques using, conventional ingredients and agents which are well known in the industry. Adjuvants and other agents which may also be dispersed in the carrier include the following: moisturizers, humectants, anti-dusting agents, emulsifiers, and selected amino acids.
The composition may contain any effective amount of L-carnitine, ascorbic acid and niacin. However, the composition preferably contains ascorbic acid and L-carnitine in a weight/weight ratio of about 3:2. One formulation of the carrier (as an emulsion) utilizes distilled water, glycerin as a humectant, And sorbitol as an emulsifier. In a 3 ml. sample of the composition, 1000 mg of L-carnitine, 1500 mg ascorbic acid, and 60 mg niacin are dispersed in an emulsion formed from distilled water, glycerin, and sorbitol. The compositions will be applied topically to the hair and scalp.
Usually the composition will be applied at least once per day for several weeks, and more preferably at least twice per day for several weeks. It also is contemplated to continue use of the composition for prolonged periods of time such as, for example, several months or several years. The duration of use depends in part upon the how long the user's hair has been thinning. Initial results are usually visible within the first 30 days of use, and often within 7-14 days of use. It is preferred to apply the composition to the hair and scalp following treatment of the scalp with hot water. For example, the composition may be applied following a hot, shower or following the treatment of the hair and scalp with a towel soaked in hot water. In addition, the course of treating the hair and scalp with a composition of the present invention may be supplemented with oral doses of L-carnitine containing between about 300-600 mg. It is contemplated that such oral doses of L-carnitine will be necessary only for persons over 30 years of age.
In addition to the compositions described above, the present invention also provides a method for improving regrowth of hair using the previously described compositions. The method includes the step of applying the composition to the hair and scalp at least once per day. The preferred method also includes treating the hair and scalp with hot water, as described above, prior to applying the composition. In addition, the method may also include the consumption of an oral dose of L-carnitine.
It should be understood that the following Examples are offered as only to illustrate the preferred embodiments and that the examples are intended in no way to limit the scope of the invention.
Example 1 User 1 , a thirty year old male with a receding hair line, used the composition of the present invention for seventeen weeks in accordance with the described method of use. Following two weeks of use, new hair growth was visible and new hair was beginning to thicken within approximately one half inch from the receding hair line. Following seventeen weeks of use, user 1 stopped treatment with the composition. Since cessation of treatment, the new hair growth remained firmly rooted in the scalp. No additional new hair growth occurred following cessation of treatment.
Example 2
User 2, a thirty-seven year old male with visibly thin patches of hair, used the composition of the present invention for four weeks in accordance with the described method of use. Following two weeks of use, noticeable thickening of the thin patches of hair occurred. User 2 is continuing treatment with the composition.
Example 3 User 3, a thirty-five year old male with distinct bald patches and thinning hair, used the composition for thirty-six weeks in accordance with the described method of use. Following three weeks of treatment, new hair growth was visibly noticeable. Following four weeks of treatment, thinning patches of hair had begun to thicken. Following twenty weeks of use, bald patches had begun filling with new hair growth. User 3 is continuing treatment with the composition.
While the invention has been described in conjunction with various preferred embodiments thereof, it will be understood that it is capable of further modifications. The claims are intended to cover any variation, use or adaptations of the invention which are generally consistent with the principles of the invention, and including such departures from the invention as come within known and customary practice within the art to which the invention pertains.
Industrial Applicability There is a high degree of sensitivity to the loss of hair and developing baldness. The exact cause of balding may be due to aging, chemical damage, or afflictions such as alopecia. Of these, balding due to the process of aging results in the greatest number of cases. The sensitivity to balding has created a significant consumer demand for products which combat male pattern baldness, and there are a number of existing formulations which purport to increase hair growth. However, their effectiveness is questionable. Nevertheless, there is a demand even for marginally effective formulations. Those that are proven effective enjoy an immense consumer demand. The present formulation and method of application has proven itself effective on numerous occasions, and this effectiveness is uniquely attributable to the topical use L-carnitine, ascorbic acid, and niacin in a pharmaceutically acceptable carrier. The composition of the present invention is inexpensive, dependable and fully effective in accomplishing its intended purposes.

Claims

I Claim:
1. A topical composition for improving regrowth of hair, comprising L-carnitine, ascorbic acid and niacin dispersed in a pharmacologically acceptable carrier for topical application.
2. The topical composition according to claim 1 , wherein the weight/weight ratio of ascorbic acid to L-carnitine is approximately 3:2.
3. The topical composition according to claim 2, wherein said L-carnitine, ascorbic acid and niacin are combined according to the following proportionate amounts: 1000 mg L-carnitine; 1500 mg ascorbic acid; and 60 mg niacin.
4. The topical composition according to claim 3, wherein said
L-carnitine, ascorbic acid and niacin are combined and dispersed in a proportionate 3 ml of said carrier, said carrier being an emulsion formed of distilled water, glycerin, and sorbitol.
5. The topical composition according to claim 1 , further comprising at least one agent selected from the group consisting of moisturizers, humectants, anti-dusting agents, and emulsifiers.
6. The topical composition according to claim 5, further comprising amino acids dispersed in said pharmaceutically acceptable carrier.
7. The topical composition according to claim 1 , wherein the pharmaceutically acceptable carrier is selected from the group consisting of solutions, ointments, lotions, gels, suspensions, emulsions, and creams.
8. A method for encouraging regrowth of hair, comprising the step of applying to the hair and scalp at least once per day, a composition comprising L-carnitine, ascorbic acid and niacin dispersed in a pharmaceutically acceptable carrier for topical application.
9. The method according to claim 8, including an initial step of treating the hair and scalp with hot water prior to applying the composition.
10. The method according to claim 8, including the step of consuming an oral dose of L-carnitine.
11. The method according to claim 10, wherein the oral dose of L-carnitine comprises approximately 300-600 mg of L-carnitine.
12. The method according to claim 8, wherein said L-carnitine, ascorbic acid and niacin are combined according to the following proportionate amounts: 1000 mg L-carnitine; 1500 mg ascorbic acid; and 60 mg niacin.
13. The method according to claim 12, wherein wherein said L-carnitine, ascorbic acid and niacin are combined and dispersed in a proportionate 3 ml of said carrier, said carrier being an emulsion formed of distilled water, glycerin, and sorbitol.
PCT/US1998/002491 1997-02-10 1998-02-09 Composition for improving hair regrowth and method of use WO1998034610A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3815397P 1997-02-10 1997-02-10
US60/038,153 1997-02-10

Publications (1)

Publication Number Publication Date
WO1998034610A1 true WO1998034610A1 (en) 1998-08-13

Family

ID=21898348

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/002491 WO1998034610A1 (en) 1997-02-10 1998-02-09 Composition for improving hair regrowth and method of use

Country Status (1)

Country Link
WO (1) WO1998034610A1 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2861595A1 (en) * 2003-10-29 2005-05-06 Oreal PEELING COMPOSITION COMPRISING VITAMIN B3 AND VITAMIN C
DE102005011957A1 (en) * 2005-03-14 2006-12-07 Henkel Kgaa New hair treatment composition containing L-carnitine or L-carnitine derivatives
EP1800654A3 (en) * 2005-12-23 2007-11-28 Henkel Kommanditgesellschaft auf Aktien Reduction of ageing of hair
WO2008028895A1 (en) * 2006-09-06 2008-03-13 Henkel Ag & Co. Kgaa Reducing aging of hair
WO2015118281A1 (en) 2014-02-10 2015-08-13 Dermaconcept Jmc Composition for controlling hair loss
EP1404286B2 (en) † 2001-03-19 2015-12-09 Henkel AG & Co. KGaA Hair treatment agent with carnitine tartrate

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5122369A (en) * 1990-03-30 1992-06-16 Harmony Health Products, Inc. Nutrient composition for preventing hair loss
EP0640333A2 (en) * 1993-08-09 1995-03-01 Tsumura & Co. Hair growth promoting aerosol formulation
DE4335454A1 (en) * 1993-10-19 1995-04-20 Schleicher Peter Geriatric medical composition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5122369A (en) * 1990-03-30 1992-06-16 Harmony Health Products, Inc. Nutrient composition for preventing hair loss
EP0640333A2 (en) * 1993-08-09 1995-03-01 Tsumura & Co. Hair growth promoting aerosol formulation
DE4335454A1 (en) * 1993-10-19 1995-04-20 Schleicher Peter Geriatric medical composition

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1404286B2 (en) † 2001-03-19 2015-12-09 Henkel AG & Co. KGaA Hair treatment agent with carnitine tartrate
FR2861595A1 (en) * 2003-10-29 2005-05-06 Oreal PEELING COMPOSITION COMPRISING VITAMIN B3 AND VITAMIN C
EP1529522A1 (en) * 2003-10-29 2005-05-11 L'oreal Peeling composition comprising vitamin B3 and vitamin C
DE102005011957A1 (en) * 2005-03-14 2006-12-07 Henkel Kgaa New hair treatment composition containing L-carnitine or L-carnitine derivatives
EP1800654A3 (en) * 2005-12-23 2007-11-28 Henkel Kommanditgesellschaft auf Aktien Reduction of ageing of hair
WO2008028895A1 (en) * 2006-09-06 2008-03-13 Henkel Ag & Co. Kgaa Reducing aging of hair
WO2015118281A1 (en) 2014-02-10 2015-08-13 Dermaconcept Jmc Composition for controlling hair loss

Similar Documents

Publication Publication Date Title
US8632759B2 (en) Hair restorer
CA2144509C (en) Skin-conditioning composition, its application and manufacture
EP0273952B1 (en) A two phase cleansing, conditioning and medicinal treatment shampoo
KR20060049895A (en) Compositions containing antiacne agents and uses thereof
MXPA03003133A (en) Scalp cosmetic and dermatological compositions.
MXPA00001000A (en) A hair lotion with improved properties in its hair protecting action and prevention of hair loss, and the reduction of external effects of androgenic alopecia and resulting hair loss.
KR20010082500A (en) Topical compositions for regulating the oily/shiny appearance of skin
MXPA03003132A (en) Packaged scalp cosmetic compositions.
US20100278948A1 (en) Use of a cosmetic composition for the care of fatty skin
PL212984B1 (en) Formulations containing melatonin, ginkgo biloba, and biotin
JP2676154B2 (en) Hair restoration
US20070154432A1 (en) Compositions and methods for hair growth
MXPA05013032A (en) Novel dermatological composition.
WO1998034610A1 (en) Composition for improving hair regrowth and method of use
JPH101410A (en) Skin cosmetic
JPH11116446A (en) External preparation for head
JPH0574566B2 (en)
JPH101414A (en) Skin cosmetic
JP3205601B2 (en) Hair restorer
JPH11302133A (en) Cosmetic for scalp and hair
JP2003503336A (en) Makeup method
CA2338325C (en) Novel uses of ascorbyl-phosphoryl-cholesterol and compositions for practicing same
JP2001131025A (en) Cosmetic for scalp and hair
US20060263452A1 (en) Topical composition containing essential oils
JP2528661B2 (en) Hair restorer

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): CA JP MX US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 09367245

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: JP

Ref document number: 1998534984

Format of ref document f/p: F

122 Ep: pct application non-entry in european phase