WO1983003410A1 - Derives d'isoindoline - Google Patents

Derives d'isoindoline Download PDF

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Publication number
WO1983003410A1
WO1983003410A1 PCT/JP1982/000096 JP8200096W WO8303410A1 WO 1983003410 A1 WO1983003410 A1 WO 1983003410A1 JP 8200096 W JP8200096 W JP 8200096W WO 8303410 A1 WO8303410 A1 WO 8303410A1
Authority
WO
WIPO (PCT)
Prior art keywords
group
reaction
compound
substituted
acid
Prior art date
Application number
PCT/JP1982/000096
Other languages
English (en)
Japanese (ja)
Inventor
Ltd. Takeda Chemical Industries
Kentaro Hiraga
Yoshiaki Saji
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to PCT/JP1982/000096 priority Critical patent/WO1983003410A1/fr
Priority to AT83301656T priority patent/ATE39483T1/de
Priority to EP83301656A priority patent/EP0091241B1/fr
Priority to US06/478,478 priority patent/US4590189A/en
Priority to DE8383301656T priority patent/DE3378763D1/de
Priority to DK136983A priority patent/DK161311C/da
Priority to CA000424994A priority patent/CA1196330A/fr
Priority to JP58057228A priority patent/JPS58189163A/ja
Priority to HU831142A priority patent/HU189679B/hu
Priority to KR1019830001350A priority patent/KR900007780B1/ko
Publication of WO1983003410A1 publication Critical patent/WO1983003410A1/fr
Priority to SU843773895A priority patent/SU1376941A3/ru
Priority to US06/832,138 priority patent/US4788191A/en
Priority to US07/241,851 priority patent/US4879293A/en
Priority to HK1041/90A priority patent/HK104190A/xx
Priority to SG993/90A priority patent/SG99390G/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5532—Seven-(or more) membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings

Abstract

Des nouveaux dérivés d'isoindoline et leurs sels sont représentés par la formule (I), dans laquelle A représente un anneau benzénique substitué facultativement par un halogène, X représente un groupe cyclique facultativement substitué, Y représente un groupe carboxylique facultativement esterifié ou amidé, et n représente un nombre entier entre 1 et 3). Ces composés présentent un effet anxiolytique prononcé, et sont utiles dans la prophylaxie et le traitement de maladies telles que les maladies psychosomatiques ou les névroses d'angoisse.
PCT/JP1982/000096 1982-04-02 1982-04-02 Derives d'isoindoline WO1983003410A1 (fr)

Priority Applications (15)

Application Number Priority Date Filing Date Title
PCT/JP1982/000096 WO1983003410A1 (fr) 1982-04-02 1982-04-02 Derives d'isoindoline
AT83301656T ATE39483T1 (de) 1982-04-02 1983-03-24 Kondensierte pyrrolinon-derivate, und ihre herstellung.
EP83301656A EP0091241B1 (fr) 1982-04-02 1983-03-24 Dérivés condensés de pyrrolinone, et leur préparation
US06/478,478 US4590189A (en) 1982-04-02 1983-03-24 Condensed pyrrolinone derivatives, their production and use
DE8383301656T DE3378763D1 (en) 1982-04-02 1983-03-24 Condensed pyrrolinone derivatives, and their production
DK136983A DK161311C (da) 1982-04-02 1983-03-25 Analogifremgangsmaade til fremstilling af 2-substituerede 3-karboxyalkyl-4,5-kondenserede pyrrolin-1-onderivater eller salte deraf
JP58057228A JPS58189163A (ja) 1982-04-02 1983-03-31 縮合ピロリノン誘導体
CA000424994A CA1196330A (fr) 1982-04-02 1983-03-31 Produits de condensation de la pyrrolinone; preparation et utilisation
HU831142A HU189679B (en) 1982-04-02 1983-04-01 Process for producing condensed pyrrolinone derivatives
KR1019830001350A KR900007780B1 (ko) 1982-04-02 1983-04-01 축합된 피롤리논 유도체의 제조방법
SU843773895A SU1376941A3 (ru) 1982-04-02 1984-07-10 Способ получени производных пирролинона или их кислотно-аддитивных солей
US06/832,138 US4788191A (en) 1982-04-02 1986-04-23 1,3-dithiolano-, 1,4-dithiino- and 1,4-dithiepino[2,3-C]pyrrole derivatives, their production and use
US07/241,851 US4879293A (en) 1982-04-02 1988-09-08 Pyrrols [3,4-8]pyrazine derivatives, their production and use as anti-anxiety agents
HK1041/90A HK104190A (en) 1982-04-02 1990-12-13 Condensed pyrrolinone derivatives,and their production
SG993/90A SG99390G (en) 1982-04-02 1990-12-13 Condensed pyrrolinone derivatives,and their production

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP1982/000096 WO1983003410A1 (fr) 1982-04-02 1982-04-02 Derives d'isoindoline

Publications (1)

Publication Number Publication Date
WO1983003410A1 true WO1983003410A1 (fr) 1983-10-13

Family

ID=13762229

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1982/000096 WO1983003410A1 (fr) 1982-04-02 1982-04-02 Derives d'isoindoline

Country Status (4)

Country Link
DK (1) DK161311C (fr)
SG (1) SG99390G (fr)
SU (1) SU1376941A3 (fr)
WO (1) WO1983003410A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7064135B2 (en) 2001-10-12 2006-06-20 Novo Nordisk Inc. Substituted piperidines
US7767695B2 (en) 2001-09-14 2010-08-03 High Point Pharmaceuticals, Llc Substituted piperidines
EP2243776A1 (fr) 2001-10-12 2010-10-27 High Point Pharmaceuticals, LLC Piperidines substituées et leur utilisation dans le traitement de maladies liées au recepteur histaminique H3

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2101081A1 (fr) * 1970-08-19 1972-03-31 Rhone Poulenc Sa
US3987174A (en) * 1972-03-16 1976-10-19 Rhone-Poulenc S.A. Isoindolin-1-one derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2101081A1 (fr) * 1970-08-19 1972-03-31 Rhone Poulenc Sa
US3987174A (en) * 1972-03-16 1976-10-19 Rhone-Poulenc S.A. Isoindolin-1-one derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Chemical Abstracts, 85, 142944q, 8. November. 1976 (08.11.76) *
Chemical Abstracts, 86, 4433s, 3. January. 1977 (03.01.77) *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7767695B2 (en) 2001-09-14 2010-08-03 High Point Pharmaceuticals, Llc Substituted piperidines
US7064135B2 (en) 2001-10-12 2006-06-20 Novo Nordisk Inc. Substituted piperidines
EP2243776A1 (fr) 2001-10-12 2010-10-27 High Point Pharmaceuticals, LLC Piperidines substituées et leur utilisation dans le traitement de maladies liées au recepteur histaminique H3

Also Published As

Publication number Publication date
DK136983A (da) 1983-10-03
DK161311B (da) 1991-06-24
DK161311C (da) 1991-12-30
SG99390G (en) 1991-02-14
DK136983D0 (da) 1983-03-25
SU1376941A3 (ru) 1988-02-23

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