Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/178—Syringes
  • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/178—Syringes
  • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
  • A61M5/204—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically connected to external reservoirs for multiple refilling

Definitions

• the present invention relates to a needle-less injection device for liquid medicinal substances. More specifically, the present invention relates to a jet injection device, intended for needle-free injection of medicinal substances by percutaneous route.
• a number of devices for injecting medicinal substances are already known, including a reserve of medicament, namely a bottle, an ejection chamber, the fixed front wall of which has a fine ejection nozzle and the rear wall of which is consisting of an ejection piston, means of communication between the reserve and the chamber, provided with suitable sealing means, for example valves or needles, as well as motor means, generally with spring returned by a fluid, to activate the piston.
• the known devices have the drawback of not always ensuring sufficient accuracy of the volume ejected, since the transfer must be rapidly carried out from the bottle to the ejection chamber over a relatively large distance and by narrow passages. In addition, air bubbles often occur, which is an additional cause. ejected volume errors.
• the present invention proposes to remedy these drawbacks and to provide an injection device allowing both the injection of an extremely precise volume and this at high speed.
• the invention proposes to provide such a device which is of simple construction and which has great ease of asepsis or sterilization.
• the subject of the invention is an injection device without a needle for liquid medicinal substances, characterized in that it comprises, in a cylinder body,
• (E) a valve, controlled by said rod, allowing "to open the passage between the intermediate chamber and the ejection chamber during at least the final part of the return movement of the ejection piston and to interrupt said passage during the final part of the ejection movement of the ejection piston.
• - (f) means for depressurizing the ejection chamber with respect to the intermediate chamber during said final part of the return movement of the ejection piston, so as to fill said ejection chamber.
• the device comprising the elements (a) to (g) mentioned above constitutes an "injection head".
• the seat for the reserve of drug substance is a receptacle mounted on the body of the injection head and having a shape suitable for receiving, for example, the end of an inverted vial containing the liquid drug substance to be administered.
• This seat is preferably provided with a double needle system intended to pierce the stopper of the bottle and to act as an air intake so as to put the bottle in communication with atmospheric pressure.
• Said seat further comprises passage means for the drug substance towards the cylindrical body of the injection head.
• the passage means for the medicinal substance may be any; these are for example radial, annular, axial conduits. etc ... and combinations of these conduits.
• the device of the present invention may also have the following characteristics, taken individually or in combination: - the controlled valve consists of a sleeve in which the rod of the ejection piston can slide freely between two stops, the contact with one of the stops allowing said rod to drive in its return movement said bushing and the contact with the other stop allowing said rod to drive in its movement towards the front said bushing by interrupting the passage of said medicinal substance between said intermediate chamber and said ejection chamber.
• the middle part of said ejection piston rod and the rear part of said sleeve have a shape capable to constitute a needle and corresponding conical seat system, and the contact of said needle with said seat allows the rod driving said bush forward while closing the passage for the drug substance between said intermediate chamber and said ejection chamber.
• Said means for depressurizing the ejection chamber with respect to said intermediate chamber can be constituted by a valve located between the ejection chamber and said end of ejection passage, said valve allowing the fluids to pass only in the direction ejection.
• the intermediate chamber is formed by the passage means from the reserve of medicinal substance towards the cylindrical body of the injection head.
• the depression is created by the increase in the volume of the ejection chamber during the return of the piston, and, the communication between the ejection chamber and the intermediate chamber (that is to say here in practice between the ejection chamber and the reserve) being then open, the medicinal substance passes into the ejection chamber under the action of atmospheric pressure.
• said means for depressurizing the ejection chamber relative to the intermediate chamber can comprise, on the one hand, a part, driven by the ejection piston rod, the backward movement during the return movement of the piston decreases the volume of the intermediate chamber and, conversely, forward movement during the ejection movement increases the volume of the intermediate chamber, and secondly, a second piloted valve for closing the passage between said intermediate chamber and said reserve during said backward movement and opening said passage during said forward movement.
• the intermediate chamber is produced in the cylinder body and said relative depression between the ejection chamber and the intermediate chamber is created by the fact that the volume of the intermediate chamber decreases (and that the pressure y increases since the communication with the reserve is closed) while the volume of the ejection chamber increases, so that the drug substance passes from the intermediate chamber to the ejection chamber.
• said part making it possible to modify the volume of the intermediate chamber can be constituted by the socket
• Said second piloted valve can be constituted by a socket in which the rod of the ejection piston can slide freely between two stops, the contact with one of the stops allowing the rod to drive in
• the middle part of said rod and the second piloted valve have a shape capable of constituting a system of needle and corresponding conical seat, and the contact of said needle with said seat allows the rod to drive said second valve piloted towards the rear while closing the passage for the medicinal substance between said reserve and said intermediate chamber.
• the rod may carry on its central part a double needle capable of alternately placing the reserve in communication with the intermediate chamber or the intermediate chamber with the ejection chamber, said rod being capable of sliding in the assembly formed by the two flaps controlled with a small clearance to be able to pass from the position where it opens the communication between the reserve and the intermediate chamber to the position in which it closes this communication and on the contrary opens the communication between the intermediate chamber and the chamber 'ejection.
• the front part of the cylinder body comprising the ejection chamber, the ejection piston and its rod, the intermediate chamber, the controlled valve (s) and the seat for the reserve of medicinal substance, constitutes a head d 'removable injection can be coupled with said motor means, or uncoupled.
• the coupling and uncoupling of the injection head with the motor means can be carried out using additional quick coupling means such as for example a coupling spout and a corresponding groove, or a ball snap in a corresponding circular groove, and / or a threaded ring and a corresponding male thread,
• additional quick coupling means such as for example a coupling spout and a corresponding groove, or a ball snap in a corresponding circular groove, and / or a threaded ring and a corresponding male thread
• Said motor means comprise a spring, an arming piston sliding in an arming chamber, means for bringing a pressurized fluid into said arming chamber so as to move said arming piston backwards by compressing the spring, means for holding said spring in the compressed position, and means for releasing said spring so as to project said cocking piston forwards
• said device comprises means for coupling said rod with said piston of weapons.
• the arming piston has a front extension, and the rear end of the rod of the ejection piston and the front end of said extension include complementary means for quick attachment allowing coupling and uncoupling of said rod and / or of said injection head.
• Said additional rapid attachment means are in particular those which have been mentioned above.
• said means for maintaining said compressed spring comprise a non-return valve of the pressurized fluid
• said means for releasing said spring comprise a lever capable of being actuated manually and of acting on said valve to allow the return of the fluid under .. pressure.
• - Said cocking piston has a rear extension constituted by a rod provided with at least one mark, said marks becoming alternately visible as the cocking piston moves back.
• the operator can thus adjust the recoil of the weapon piston and therefore the volume of drug substance to be injected. Indeed, as long as he does not see the chosen benchmark appear, he knows that he must continue to actuate the means making it possible to bring the fluid under pressure into the cocking chamber.
• Said pressurized fluid is a liquid and the said means for supplying said pressurized liquid include a piston pump and a conduit connecting said pump to the arming chamber.
• Said piston pump can be actuated in any manner (with a pedal, electrically, etc.) by the operator.
• the hydraulic pressure can be established by means of a piston pump actuated by a pedal, having a support with a lever-shaped pedal pivoted on the support, and a piston pump body capable of being quickly mounted on the support. by means " of reception such as guides of said support, the small arm of the lever formed by the pedal then being capable of actuating the piston of the pump.
• means for adjusting the volume of the arming chamber can be provided, as mentioned above.
• said piston pump comprises, next to the main chamber of the pump body, regulating means comprising a compensation chamber filled, like the main chamber, with said pressurized liquid, and connected to the main chamber by a narrow passage, said compensation chamber being constantly under the pressure of a secondary piston urged by a spring, said narrow passage opening into the main chamber a short distance from the rest position of the main piston.
• said means for holding said spring compri ⁇ tone comprise a spout allowing to immobilize by hooking an anterior extension of the cocking piston, and said means for releasing said spring comprise a lever or a trigger for detaching said spout, thanks to which said spring projects forwards said arming piston which in turn actuates the ejection piston while forcing the fluid out of the arming chamber. . -
• the invention also relates to the motor means described above, making it possible to actuate the injection heads described, or any other injection head for injection devices without a needle.
• FIG. 1 represents a schematic sectional view of the front part of an injection head of a device according to the invention
• FIG. 2 represents a schematic view in partial section of said device showing more particularly an actuation device according to the invention
• FIG. 3 represents a sectional view of the device for actuating a hydraulic pump which can supply the device
• FIG. 4 represents a view of an improved hydraulic pump which can supply the device
• FIG. 5 shows a schematic view in partial section of another embodiment of an injection head according to the invention
• FIG. 6 shows a schematic sectional view of another embodiment of an action system for the device of the invention.
• the device shown is in the form of an automatic injection gun intended for collective vaccination. It comprises a generally cylindrical body 1 on which is fixed a handle 2. The rear part of the body 1 and the handle 2 are occu ⁇ pated by the actuation mechanism intended to allow a rapid advance movement for ejection and mo 'uve- lies back in position after the ejection.
• an interchangeable assembly which comprises in particular a bush 3 capable of being held in position by a nut 4 screwed onto the front end of the body 1.
• the bush 3 supports a support towards its rear end of bottle 5 extending radially and having a seat 6 intended to receive the end of an inverted bottle.
• a double needle 7 intended to pierce the bottle, this double needle leading on the one hand to a conduit 8 directed towards the sleeve 3 and on the other hand to an outlet in the open air 9.
• the body 1 is provided at its front part with a longitudinal slot 10 allowing the passage of the lower part of the part 5.
• the part 3 has in its center a bore in which can slide a cylindrical sliding part 11 ending at its rear end, beyond the rear extremity of the part 3 by a flange 12 sliding in the bore of the body 1 then by an extension 13 having a circular groove.
• a rod 14 having towards its middle part a conical flare or rear needle 15 immediately followed by a conical flare or front needle 16.
• On the rod 14 and in the bore of the sleeve 3 is slidably mounted a sleeve 17 provided with a central narrowing so as to leave between it and the wall of the sleeve 3 an annular slot 18 into which opens a channel 19 formed in said sleeve and connected to the passage 8.
• the rod 14 in the part which substantially corresponds to the front half of the part 17 is reduced in diameter to leave between it and the said part a passage or an annular slot 20 which points towards the rear face. of the needle 15 and which is in communication with the slot 18 by radial passages 21 pra . ticked in part 17.
• the anterior end of this part 17 has the shape of a frustoconical seat 22 capable of cooperating with the rear needle 15.
• the orifice made in the part 3 is widened to form an intermediate chamber 23 in which the posterior end 24 of a dou ⁇ " i ⁇ S ⁇ ⁇ A _ can move.
• the rear end 24 also has a corresponding seat of conical shape with regard to the front needle 16.
• a socket 26 secured to the front end of the socket 3 forms the side wall of the ejection chamber This socket 26 is closed at its front end by an ejection head 27 provided at its center with the end of ejection passage 28.
• the sleeve 29 slides with friction with the front end 30 behind the ejection chamber 31, the front limit of which is formed by the rear wall of the part 27.
• the assembly thus contained in the socket 3, or carried by the latter can thus be easily separated from the body by simple unscrewing of the nut 4 and extraction towards the front.
• the motor means housed at the rear of the body 1, comprise a powerful spring 34 bearing on a fixed part 35 secured to the body 1 and on a sliding part 36 including an anteriorly extended 37 carries radial balls 38 sol ⁇ licit inwardly by suitable elastic means. These balls 38 penetrate into the groove of the posterior extension 13 of the sliding sleeve 11.
• the front end of the extension 37 is ap ⁇ plicated against the rear face of the flange 12, this in order to be able to directly transmit the thrust of the spring to said flange 12 and therefore to the part 11 and to the rod 14, while during the backward movement, which requires only a reduced force, the drive of the part 11 and the
• the part 36 is integral with a long rod 39 sliding in the part 35 and carrying a return piston 40 towards its rear end.
• a chamber 41 is arranged, the front face of which is limited by a part 42 integral with the part 35.
• This part 42 comprises an annular slot 43 into which opens a conduit 44 connected by a flexible pipe 45 to any motor device, for example a pedal pump.
• a detent device comprising the detent itself 46 and intermediate parts leading to a lever 47 provided with a hooking spout 48.
• This spout 48 is capable, when the part 36 is called back toward the rear against the thrust of the spring, to come into place against the front face 49 of the part 36 to maintain the latter immobilized until the support on the trigger, releasing the spout A3, then releases the spring and the part 38, the rod 39 and the rod 14.
• the operator actuates the fluid pump and the pressurized fluid is addressed by the conduit 45 and the passage 44 to the chamber 41 so that it repels the piston 40 towards the rear which carries with it the rod 39 and the part 36 which compresses the spring 34 until the front face 49 of the part 36 is hooked by the spout 48.
• This same return movement causes the rear part 11 and rod 14, part 17 remaining for its part immobile during the very beginning of this return movement due to the friction against the part 3.
• the space between the seat 22 and the rear needle 15 is canceled and the continuation of the rearward movement then drives the part 17 also towards the rear, the communication between the passages 8, 19 and the chamber 23 then being interrupted.
• the volume of the chamber 23 is minimum and the volume of the injection chamber 31 is maximum, the medicamentous substance having passed from one to the other.
• the assembly which has retreated (39,36,11,14,32) is suddenly thrown forward.
• the part 17 remains stationary due to friction until it is driven by the part 11 which has come into contact with it.
• the passage between the needle 15 and the seat 22 is open and the liquid coming from the source or the bottle of medicinal substance is sucked by the needle 7, the channel 8, the passage 19, 0 the slot 18, the passage 20 and the chamber 23 which increases in volume.
• the sleeve 29 remains stationary until the needle 16 has traversed the short interval which separates it from the seat 25. From this moment the commu - 5 connection between the chamber 31 'and the chamber 23 is interrupted and the chamber 31 which rapidly decreases in volume sees its pressure increase suddenly and the liquid is ejected through nozzle 28.
• the device thus described has great simplicity of manufacture and use. It can be sterilized by extraction prior together with the rapid binding to beads to undergo a tempering or otherwise sterilization can be performed by mounting the ai ⁇ guille 7 and the seat 6 years a liquid bottle disinfecting and by carrying out some projections of this liquid.
• a device ac ⁇ tioning pedal of a pump this device 1 action ⁇ ment having a body 51 on which is mounted a pivot 52 around which is rotated a pedal 53.
• This pedal is extended by a small lever arm 54 capable of pressing on a plunger 55 capable of transmitting its movement to the rod 56 of a piston 57 penetrating into a pump cylinder 58, said pump being for example detachably mounted on an extension 59 of the body 51, said extension 59 having a hori ⁇ zontal section shaped 'horseshoe being provided with an upper flange for receiving and retaining the body of the pump cylinder.
• FIG. 4 In the variant of the pump shown, the interior of the cylinder 58a of the pump forms la. chamber in which the action 57a piston 57a moves, via 56, for example by means of a pedal (not shown) similar to that of FIG. 3.
• a single conduit 45a. walks towards the device.
• To cylinder 58a. is attached a compensation cylinder 61 communicating with the cylinder 58a_ by a thin transverse passage 62.
• a secondary piston biased by a spring 64 so as to tend to decrease the volume of the chamber in the cylinder 61.
• liquid is then expelled through duct 45a_ ...
• a loss of liquid eg due to a microleakage, or a deformation of the flexible conduits
• liquid is l ⁇ then fed from the cylinder 61 to the cylinder 58a to compensate for loss of liquid and thus ensure in all cases the constancy of the action of the piston 57a_ and consequently of the injection volume.
• this arrangement also allows a perfect adaptation to 15 volume changes caused either by mechanical deformations or 'by changes in temperature.
• the injection head shown has a body 65 of generally cylindrical shape in which a piston 66 can slide, the front part 67, of reduced diameter, having flats such as 68.
• the junction wall between the rear part and the front part of the piston 66 forms a needle 69.
• a screw 70 whose head forms a stop and has radial notches such as 71.
• the front part the piston can slide in the bore of the piloted valve 72 whose front end has a recess for the housing of the screw head 70.
• the rear end wall 73 of the piloted valve 72 forms a seat for the needle 69.
• the front end of the screw head 70 and the rear end of the socket 74 and of the valve 75 define an ejection chamber 77.
• the sleeve 74 is fixed by screwing an injection nozzle fitted with a filter 79 and comprising a fine passage 80.
• the body 65 is surmounted by a seat 81 for the reserve of medicinal substance (such as an inverted bottle).
• FIG. 5 shows a removable protective cap 82 which can be placed on said seat 81 when the device is not in use.
• a double hollow needle 83 making it possible to pierce the cap of the inverted bottle containing the medicinal substance during use, said double needle communicating on the one hand with an air intake 84 and with a chamber 85 which here plays the role of the intermediate chamber mentioned in the description of the present application.
• a filter seal 86 makes it possible to avoid the introduction into the device, in particular of plug debris from the bottle containing the medicinal substance.
• the chamber 85 communicates with the cylindrical chamber of the body 65 via the conduit 87.
• the rear end of the body 65 comprises a hooking spout 88 and is surrounded by a ring 89 internally threaded.
• FIG. 6 describes the actuation system on which the removable injection head shown in FIG. 5 can be mounted.
• This actuation device comprises a cylindrical body 90 extended by a handle or butt 90a .
• In the cylindrical body 90 can move a piston 91 extended forward by the rod 92 and rearward by the rod 93.
• the piston 91 is actuated by a hydraulic fluid (oil) arriving in the chamber 94, comprising a bleed screw 95-, via the conduit 96 and the flexible conduit 97.
• a hydraulic fluid (oil) arriving in the chamber 94, comprising a bleed screw 95-, via the conduit 96 and the flexible conduit 97.
• the communication between these two latter conduits is made by the 'through a non-return ball valve 98, main ⁇ held by a spring 99, the movement in the return direction can be effected by pressing the pusher 100 actuated by the trigger 101.
• the intermediate piece 102 which can slide in the chamber 103 produced at the front end of the body 90.
• a groove 104 in the piece 102 and a pin 105 prevent the rotation of the piece 102.
• the part 102 is provided with grooves complementary to the ribs which is provided with the rear end of the piston 66 of FIG. 5, as can be seen in the drawing.
• a removable sheath 106 in which is housed a spring 107 resting at rest on a stop ring 108 intended to facilitate disassembly of the sheath.
• the rod 93 has a stop 109 making it possible to compress the spring 107 when the piston moves backwards.
• a control rod 110 protruding from the sheath by a central orifice located at the rear end thereof.
• the control rod 110 has a reference 111.
• the hose 97 is connected to a hydraulic pump, not shown.
• a hydraulic pump not shown.
• the piston 66 is then secured to the piston 91 by means of the rod 92 and the part 102.
• the protective cap 82 having been removed and replaced by a bottle provided with a medicinal substance before the start of operation, said medicinal substance will flow, due to this depression, - via conduit 87, the passage formed between the walls 73 and 69 which are spaced apart from one another, the flat 68 and the notches 71, and will fill the chamber 77.
• the operator pulls the trigger 101 via the pusher 100 pushes the ball 98 to the right, which 'allows the return of the oil under pressure contained in the chamber 94 and in the ' conduit 96 towards the hose 97 and the pump body. Under the action of the spring 107 the piston 91, the part 102 and the piston 66 are suddenly thrown forward.
• the valve 72 remains stationary due to the friction against the body 65. But when the needle 69 comes into contact with the wall 73, the communication between the conduit 87 and the conduit formed by the flat 68 is interrupted, and the part 72 will then be pushed forward by the piston 66 which continues movement.
• the volume of the chamber 77 decreases and the communication with the intermediate chamber being interrupted, the pressure inside the chamber 77 increases sharply, which has the effect of pushing the valve 75 back, allowing the substance to pass drug contained in the chamber 77. ans the ejection nozzle 78. Finally the liquid substance is ejected in a powerful jet by the end passage 80.
• FIGS. 5 and 6 present the advantages of the devices of FIGS. 1 and 2. They also have the advantage of simpler manufacture, assembly and disassembly.

Landscapes

• Health & Medical Sciences (AREA)
• Vascular Medicine (AREA)
• Engineering & Computer Science (AREA)
• Anesthesiology (AREA)
• Biomedical Technology (AREA)
• Heart & Thoracic Surgery (AREA)
• Hematology (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Infusion, Injection, And Reservoir Apparatuses (AREA)
• Medicines Containing Plant Substances (AREA)

Priority Applications (3)

Applications Claiming Priority (2)

Publications (1)

Family

ID=9221345

Family Applications (1)

Country Status (17)

Cited By (1)

Citations (3)

Family Cites Families (2)

• 1979
  • 1979-01-30 FR FR7902295A patent/FR2447724A1/fr active Granted
• 1980
  • 1980-01-29 IL IL59255A patent/IL59255A/xx unknown
  • 1980-01-29 BE BE0/199156A patent/BE881407A/fr unknown
  • 1980-01-30 OA OA57009A patent/OA06449A/xx unknown
  • 1980-01-30 WO PCT/FR1980/000012 patent/WO1980001539A1/fr active Application Filing
  • 1980-01-30 AR AR279802A patent/AR218193A1/es active
  • 1980-01-30 DE DE803030671T patent/DE3030671T1/de active Granted
  • 1980-01-30 GB GB8030580A patent/GB2057890B/en not_active Expired
  • 1980-01-30 IT IT19572/80A patent/IT1130919B/it active
  • 1980-01-30 NL NLAANVRAGE8020017,A patent/NL178058C/xx not_active IP Right Cessation
  • 1980-02-25 IN IN131/DEL/80A patent/IN153760B/en unknown
  • 1980-09-29 SE SE8006796D patent/SE8006796L/xx not_active Application Discontinuation
  • 1980-09-29 BR BR8006250A patent/BR8006250A/pt unknown
  • 1980-09-29 SE SE8006796A patent/SE436324B/sv not_active IP Right Cessation
  • 1980-09-29 NO NO802880A patent/NO150586C/no unknown
  • 1980-09-29 SU SU802987388A patent/SU1135426A3/ru active
  • 1980-09-29 DK DK411580A patent/DK411580A/da not_active Application Discontinuation
• 1984
  • 1984-04-30 KE KE3406A patent/KE3406A/xx unknown

Patent Citations (3)

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