UY36112A - Compuestos de imidazo[4,5-c]quinolin-2-ona y su uso para tratar cáncer - Google Patents
Compuestos de imidazo[4,5-c]quinolin-2-ona y su uso para tratar cáncerInfo
- Publication number
- UY36112A UY36112A UY0001036112A UY36112A UY36112A UY 36112 A UY36112 A UY 36112A UY 0001036112 A UY0001036112 A UY 0001036112A UY 36112 A UY36112 A UY 36112A UY 36112 A UY36112 A UY 36112A
- Authority
- UY
- Uruguay
- Prior art keywords
- compounds
- quinolin
- ona
- treat cancer
- salts
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 4
- XRKYMMUGXMWDAO-UHFFFAOYSA-N 2-(4-morpholinyl)-6-(1-thianthrenyl)-4-pyranone Chemical compound O1C(C=2C=3SC4=CC=CC=C4SC=3C=CC=2)=CC(=O)C=C1N1CCOCC1 XRKYMMUGXMWDAO-UHFFFAOYSA-N 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- NSHFLKZNBPJNPA-UHFFFAOYSA-N imidazo[4,5-c]quinolin-2-one Chemical class C1=CC=C2C3=NC(=O)N=C3C=NC2=C1 NSHFLKZNBPJNPA-UHFFFAOYSA-N 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461990232P | 2014-05-08 | 2014-05-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY36112A true UY36112A (es) | 2015-10-30 |
Family
ID=53264681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY0001036112A UY36112A (es) | 2014-05-08 | 2015-05-06 | Compuestos de imidazo[4,5-c]quinolin-2-ona y su uso para tratar cáncer |
Country Status (39)
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2880626T3 (es) * | 2015-04-02 | 2021-11-25 | Merck Patent Gmbh | Imidazolonilquinolinas |
| GB201516504D0 (en) | 2015-09-17 | 2015-11-04 | Astrazeneca Ab | Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer |
| GB201519406D0 (en) * | 2015-11-03 | 2015-12-16 | Astrazeneca Ab | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer |
| GB201519568D0 (en) * | 2015-11-05 | 2015-12-23 | Astrazeneca Ab | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer |
| JP6865762B2 (ja) * | 2016-02-15 | 2021-04-28 | アストラゼネカ アクチボラグ | セジラニブの一定間欠投与を含む方法 |
| MA43733A (fr) * | 2016-03-21 | 2018-11-28 | Astrazeneca Ab | Composés cinnolin-4-amine et leur utilisation pour traiter le cancer |
| EP3440079A1 (en) * | 2016-04-07 | 2019-02-13 | Astrazeneca AB | N,n-dimethyl-3-[[5-(3-methyl-2-oxo-1-tetrahydropyran-4-yl-imidazo[4,5-c]quinolin-8-yl)-2-pyridyl]oxy]propan-1-amine oxide as atm (ataxia telangiectasia mutated) kinase modulator for treating cancer |
| GB201608227D0 (en) * | 2016-05-11 | 2016-06-22 | Astrazeneca Ab | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer |
| AU2017384388B2 (en) | 2016-12-20 | 2020-09-17 | Astrazeneca Ab | Amino-triazolopyridine compounds and their use in treating cancer |
| US10874670B2 (en) | 2017-01-09 | 2020-12-29 | Impact Therapeutics, Inc. | Substituted fused heteroaromatic compounds as kinase inhibitors and the use thereof |
| CN106798741A (zh) * | 2017-02-07 | 2017-06-06 | 宫英 | 一种治疗抑郁症的药物组合物 |
| CN106692147A (zh) * | 2017-02-07 | 2017-05-24 | 李明英 | 一种治疗男性不育的药物组合物 |
| CN106822123A (zh) * | 2017-02-09 | 2017-06-13 | 王艳苓 | 一种治疗心脑血管疾病的药物组合物 |
| WO2018153365A1 (zh) * | 2017-02-27 | 2018-08-30 | 上海瑛派药业有限公司 | 取代的稠合杂芳三环化合物作为激酶抑制剂及其应用 |
| JOP20190209A1 (ar) * | 2017-03-16 | 2019-09-12 | Astrazeneca Ab | مركبات إيميدازو [ 4، 5-c ] كينولين-2-أون ديوترومية واستخدامها في علاج السرطان |
| CN111344293A (zh) | 2017-09-20 | 2020-06-26 | 阿斯利康(瑞典)有限公司 | 1，3-二氢咪唑并[4，5-c]噌啉-2-酮化合物及其在治疗癌症中的用途 |
| CN110386932A (zh) | 2018-04-20 | 2019-10-29 | 艾科思莱德制药公司 | 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂 |
| WO2019201283A1 (en) * | 2018-04-20 | 2019-10-24 | Xrad Therapeutics, Inc. | Dual atm and dna-pk inhibitors for use in anti-tumor therapy |
| CN115636833B (zh) * | 2018-09-14 | 2024-11-29 | 苏州赞荣医药科技有限公司 | 作为ATM激酶选择性调节剂的取代的咪唑并[4,5-c]噌啉-2-酮化合物及其用途 |
| CN113164447A (zh) * | 2018-10-15 | 2021-07-23 | 默克专利股份公司 | 利用dna烷化剂和atr抑制剂的组合疗法 |
| BR112021017408A2 (pt) * | 2019-03-05 | 2022-01-18 | Astrazeneca Ab | Compostos tricíclicos fundidos úteis como agentes anticancerosos |
| TW202102497A (zh) * | 2019-03-29 | 2021-01-16 | 瑞典商阿斯特捷利康公司 | 化合物及它們在治療癌症中之用途 |
| CN111909147B (zh) * | 2019-05-10 | 2021-07-20 | 山东轩竹医药科技有限公司 | Dna-pk抑制剂 |
| WO2021004482A1 (zh) * | 2019-07-10 | 2021-01-14 | 上海瑛派药业有限公司 | 取代的吡唑并喹唑啉酮化合物及其应用 |
| CN119215050A (zh) * | 2019-09-12 | 2024-12-31 | 上海瑛派药业有限公司 | 取代的咪唑并喹喔啉化合物在制备抗癌症药物中的应用 |
| CN115003672A (zh) * | 2020-01-09 | 2022-09-02 | 南京明德新药研发有限公司 | 喹啉并咪唑类化合物及其应用 |
| WO2021146127A1 (en) * | 2020-01-13 | 2021-07-22 | Zhanggui Wu | Use of n2-quincline or isoquinoline substituted purine derivatives in cancer treatment |
| EP4171651A1 (en) | 2020-06-24 | 2023-05-03 | AstraZeneca UK Limited | Combination of antibody-drug conjugate and atm inhibitor |
| EP3992191A1 (en) | 2020-11-03 | 2022-05-04 | Deutsches Krebsforschungszentrum | Imidazo[4,5-c]quinoline compounds and their use as atm kinase inhibitors |
| CN117015534A (zh) * | 2021-02-03 | 2023-11-07 | 艾科思莱德制药公司 | 用于癌症疗法的双重atm和dna-pk抑制剂以及免疫治疗剂的组合 |
| WO2022193166A1 (en) * | 2021-03-17 | 2022-09-22 | Suzhou Zanrong Pharma Limited | Selective modulators of ataxia telangiectasia mutated (atm) kinase and uses thereof |
| CN118434736A (zh) * | 2022-01-26 | 2024-08-02 | 正大天晴药业集团股份有限公司 | 含有肼基的化合物 |
| TW202446421A (zh) | 2023-04-10 | 2024-12-01 | 日商第一三共股份有限公司 | 抗ｂ７－ｈ３抗體－藥物結合物與ａｔｒ抑制劑或ａｔｍ抑制劑之組合 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0211649D0 (en) * | 2002-05-21 | 2002-07-03 | Novartis Ag | Organic compounds |
| ATE400573T1 (de) | 2003-11-21 | 2008-07-15 | Novartis Pharma Gmbh | 1h-imidazochinolinderivate als proteinkinaseinhibitoren |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| PE20090717A1 (es) * | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | Derivados de quinolina como inhibidores de la pi3 quinasa |
| US8841462B2 (en) | 2008-07-01 | 2014-09-23 | Robert A. Heald | Bicyclic heterocycles as MEK kinase inhibitors |
| WO2010038165A1 (en) | 2008-09-30 | 2010-04-08 | Pfizer Inc. | Imidazo[1,5]naphthyridine compounds, their pharmaceutical use and compositions |
| TW201041888A (en) * | 2009-05-06 | 2010-12-01 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
| CN102803259A (zh) * | 2009-06-04 | 2012-11-28 | 诺瓦提斯公司 | 用于治疗增殖性疾病的1H-咪唑并[4,5-c]喹啉酮化合物 |
| KR101445458B1 (ko) | 2009-06-04 | 2014-10-07 | 노파르티스 아게 | １Ｈ-이미다조［４,５-ｃ］퀴놀리논 유도체 |
| BR112012006802A2 (pt) * | 2009-09-28 | 2020-08-18 | F.Hoffmann-La Roche Ag | composto, composição farmacêutica, método para tratar câncer, usos de um composto, kit e invenção |
| GB0919423D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| CN102199152A (zh) | 2010-03-25 | 2011-09-28 | 高大新 | 杂环咪唑类磷脂激酶抑制剂 |
| CN102372711B (zh) * | 2010-08-18 | 2014-09-17 | 山东轩竹医药科技有限公司 | 咪唑并喹啉类PI3K和mTOR双重抑制剂 |
| RU2013113177A (ru) | 2010-08-26 | 2014-10-10 | Хитачи Констракшн Машинери Ко., Лтд. | Строительная машина |
| DE102010035744A1 (de) | 2010-08-28 | 2012-03-01 | Merck Patent Gmbh | Imidazolonylchinoline |
| CN102399218A (zh) * | 2010-09-16 | 2012-04-04 | 和记黄埔医药（上海）有限公司 | 一类并合三杂环及其作为pi3k抑制剂的用途 |
| CA2819955A1 (en) | 2010-12-06 | 2012-06-14 | Piramal Enterprises Limited | Substituted imidazoquinoline derivatives |
| EP2694678A2 (en) | 2011-04-04 | 2014-02-12 | Netherland Cancer Institute | Methods and compositions for predicting resistance to anticancer treatment |
| JP6042060B2 (ja) * | 2011-09-26 | 2016-12-14 | サノフイ | ピラゾロキノリノン誘導体、その調製および治療上の使用 |
-
2012
- 2012-05-25 NO NO12793015A patent/NO2714752T3/no unknown
-
2015
- 2015-05-05 EA EA201692095A patent/EA031674B1/ru not_active IP Right Cessation
- 2015-05-05 LT LTEP15724351.0T patent/LT3140303T/lt unknown
- 2015-05-05 ES ES15724351.0T patent/ES2670416T3/es active Active
- 2015-05-05 DK DK15724351.0T patent/DK3140303T3/en active
- 2015-05-05 KR KR1020167034005A patent/KR102013021B1/ko active Active
- 2015-05-05 PE PE2016002124A patent/PE20170403A1/es unknown
- 2015-05-05 SI SI201530247T patent/SI3140303T1/en unknown
- 2015-05-05 TN TN2016000458A patent/TN2016000458A1/en unknown
- 2015-05-05 EP EP15724351.0A patent/EP3140303B1/en active Active
- 2015-05-05 PT PT157243510T patent/PT3140303T/pt unknown
- 2015-05-05 TR TR2018/07101T patent/TR201807101T4/tr unknown
- 2015-05-05 HU HUE15724351A patent/HUE037558T2/hu unknown
- 2015-05-05 CR CR20160523A patent/CR20160523A/es unknown
- 2015-05-05 AP AP2016009532A patent/AP2016009532A0/en unknown
- 2015-05-05 NZ NZ726042A patent/NZ726042A/en not_active IP Right Cessation
- 2015-05-05 SG SG11201609164VA patent/SG11201609164VA/en unknown
- 2015-05-05 CN CN201580022454.1A patent/CN106255692B/zh active Active
- 2015-05-05 SM SM20180259T patent/SMT201800259T1/it unknown
- 2015-05-05 JP JP2016567002A patent/JP6505131B2/ja active Active
- 2015-05-05 AU AU2015257456A patent/AU2015257456B2/en active Active
- 2015-05-05 HR HRP20180697TT patent/HRP20180697T1/hr unknown
- 2015-05-05 CA CA2946459A patent/CA2946459C/en active Active
- 2015-05-05 WO PCT/GB2015/051312 patent/WO2015170081A1/en not_active Ceased
- 2015-05-05 RS RS20180593A patent/RS57223B1/sr unknown
- 2015-05-05 MA MA039960A patent/MA39960A/fr unknown
- 2015-05-05 PL PL15724351T patent/PL3140303T3/pl unknown
- 2015-05-05 MX MX2016014639A patent/MX374401B/es active IP Right Grant
- 2015-05-05 US US14/704,031 patent/US9428503B2/en active Active
- 2015-05-06 UY UY0001036112A patent/UY36112A/es not_active Application Discontinuation
- 2015-05-07 AR ARP150101395A patent/AR100340A1/es not_active Application Discontinuation
- 2015-05-08 TW TW104114814A patent/TWI662034B/zh active
-
2016
- 2016-07-22 US US15/217,079 patent/US9822111B2/en active Active
- 2016-10-19 IL IL248397A patent/IL248397B/en active IP Right Grant
- 2016-10-19 DO DO2016000281A patent/DOP2016000281A/es unknown
- 2016-10-27 CL CL2016002735A patent/CL2016002735A1/es unknown
- 2016-11-02 PH PH12016502168A patent/PH12016502168B1/en unknown
- 2016-11-04 NI NI201600166A patent/NI201600166A/es unknown
- 2016-11-08 SV SV2016005312A patent/SV2016005312A/es unknown
-
2017
- 2017-10-17 US US15/785,974 patent/US10189834B2/en active Active
-
2018
- 2018-05-22 CY CY20181100532T patent/CY1120248T1/el unknown
- 2018-12-12 US US16/217,190 patent/US20190185468A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 109 | Application deemed to be withdrawn |
Effective date: 20220620 |