UY30878A1 - La sal tosilato de trans-n-etil-3-fluoro-3-[3-fluoro-4 (pirrolidin-1-ilmetil)fenil] ciclobutanocarboxamida, composición farmacéutica conteniéndola y aplicaciones - Google Patents

La sal tosilato de trans-n-etil-3-fluoro-3-[3-fluoro-4 (pirrolidin-1-ilmetil)fenil] ciclobutanocarboxamida, composición farmacéutica conteniéndola y aplicaciones

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Publication number
UY30878A1
UY30878A1 UY030878A UY30878A UY30878A1 UY 30878 A1 UY30878 A1 UY 30878A1 UY 030878 A UY030878 A UY 030878A UY 30878 A UY30878 A UY 30878A UY 30878 A1 UY30878 A1 UY 30878A1
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UY
Uruguay
Prior art keywords
fluoro
disorders
trans
phenyl
salt
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UY030878A
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English (en)
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Todd William Butler
Travis T Wager
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Publication of UY30878A1 publication Critical patent/UY30878A1/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
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    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
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    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Sal tosilato de trans-N-etil-3-fluoro-3-[3-fluoro-4-(pirrolidin-1-ilmetil)fenil]ciclobutanocarboxamida (1): a solvatos, a polimorfos, a composiciones farmacéuticas de la misma y a un procedimiento de tratamiento de depresión, trastornos del ánimo, esquizofrenia,trastorno de ansiedad, trastonos cognitovos, enfermedad de Alzheimer, trastornos de déficit de atención (TDA), trastorno de déficit de atención con hiperactividad (TDAH), trastonos psicóticos, trastornos del sueno, obesidad, vértigo, epilepsia, cinetosis, enfermedades respiratorias, alergia, respuestas de las vías aéreas inducidas por alergia, rinitis alérgica, congestión nasal, congestión alérgica, congestión, hipotensión, enfermedad cardiovascular, enfermedades del tracto GI, hiper-e hipomotilidad y secreción ácida del tracto gastrointestinal.
UY030878A 2007-01-22 2008-01-21 La sal tosilato de trans-n-etil-3-fluoro-3-[3-fluoro-4 (pirrolidin-1-ilmetil)fenil] ciclobutanocarboxamida, composición farmacéutica conteniéndola y aplicaciones UY30878A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US88593107P 2007-01-22 2007-01-22

Publications (1)

Publication Number Publication Date
UY30878A1 true UY30878A1 (es) 2009-08-31

Family

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Family Applications (1)

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UY030878A UY30878A1 (es) 2007-01-22 2008-01-21 La sal tosilato de trans-n-etil-3-fluoro-3-[3-fluoro-4 (pirrolidin-1-ilmetil)fenil] ciclobutanocarboxamida, composición farmacéutica conteniéndola y aplicaciones

Country Status (25)

Country Link
US (1) US8314139B2 (es)
EP (1) EP2124933B1 (es)
JP (1) JP4585610B2 (es)
KR (1) KR101108109B1 (es)
CN (1) CN101631545B (es)
AR (1) AR064963A1 (es)
AU (1) AU2008208653B2 (es)
BR (1) BRPI0806473A2 (es)
CA (1) CA2676456C (es)
CL (1) CL2008000180A1 (es)
DK (1) DK2124933T3 (es)
ES (1) ES2395744T3 (es)
HK (1) HK1137660A1 (es)
IL (1) IL199587A (es)
MX (1) MX2009007782A (es)
NZ (1) NZ577951A (es)
PE (1) PE20081690A1 (es)
PL (1) PL2124933T3 (es)
PT (1) PT2124933E (es)
RU (1) RU2430099C2 (es)
SI (1) SI2124933T1 (es)
TW (1) TWI358294B (es)
UY (1) UY30878A1 (es)
WO (1) WO2008090429A1 (es)
ZA (1) ZA200905827B (es)

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ES2395744T3 (es) 2013-02-14
BRPI0806473A2 (pt) 2011-09-27
PT2124933E (pt) 2013-01-07
TWI358294B (en) 2012-02-21
KR101108109B1 (ko) 2012-02-06
EP2124933B1 (en) 2012-10-17
JP2010516749A (ja) 2010-05-20
WO2008090429A1 (en) 2008-07-31
PL2124933T3 (pl) 2013-02-28
US20080176925A1 (en) 2008-07-24
TW200838499A (en) 2008-10-01
CL2008000180A1 (es) 2008-08-01
AU2008208653A1 (en) 2008-07-31
ZA200905827B (en) 2010-05-26
RU2009124541A (ru) 2011-02-27
IL199587A0 (en) 2010-03-28
CN101631545A (zh) 2010-01-20
DK2124933T3 (da) 2012-11-19
RU2430099C2 (ru) 2011-09-27
NZ577951A (en) 2012-02-24
EP2124933A1 (en) 2009-12-02
PE20081690A1 (es) 2008-11-28
KR20090101948A (ko) 2009-09-29
JP4585610B2 (ja) 2010-11-24
HK1137660A1 (en) 2010-08-06
AU2008208653B2 (en) 2012-11-22
MX2009007782A (es) 2009-07-31
IL199587A (en) 2014-06-30
AR064963A1 (es) 2009-05-06
SI2124933T1 (sl) 2012-12-31
CA2676456C (en) 2012-03-27
CA2676456A1 (en) 2008-07-31
CN101631545B (zh) 2013-03-13
US8314139B2 (en) 2012-11-20

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