UY30602A1 - Mutante de un pestivirus, vacuna y aplicaciones - Google Patents

Mutante de un pestivirus, vacuna y aplicaciones

Info

Publication number
UY30602A1
UY30602A1 UY30602A UY30602A UY30602A1 UY 30602 A1 UY30602 A1 UY 30602A1 UY 30602 A UY30602 A UY 30602A UY 30602 A UY30602 A UY 30602A UY 30602 A1 UY30602 A1 UY 30602A1
Authority
UY
Uruguay
Prior art keywords
pestivirus
mutants
virus
mutant
npro
Prior art date
Application number
UY30602A
Other languages
English (en)
Inventor
Patricia Koenig
Ilona Reimann
Martin Beer
Original Assignee
Intervet Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intervet Int Bv filed Critical Intervet Int Bv
Publication of UY30602A1 publication Critical patent/UY30602A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24361—Methods of inactivation or attenuation
    • C12N2770/24362—Methods of inactivation or attenuation by genetic engineering

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Nuevos mutantes de pestivirus para vacunas. Los inventores trabajaron con mutantes de pestivirus conteniendo mutaciones en la region codificante para la proteína Npro del virus. Dichos mutantes se caracterizan por que el mutante se basa en una cepa cp del virus donde se borra parte de la secuencia génica docificante de la region Npro, donde lo borrado no abarca la secuencia codificante para los doce aminoácidos N-terminales de la proteína Npro. Preferentemente, el pestivirus es el Virus de la Diarrea Viral Bovina (BVDV). Los mutantes de la invencion, son candidato de vacuna seguro y eficiente.
UY30602A 2006-09-22 2007-09-21 Mutante de un pestivirus, vacuna y aplicaciones UY30602A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84666206P 2006-09-22 2006-09-22
EP06121147 2006-09-22

Publications (1)

Publication Number Publication Date
UY30602A1 true UY30602A1 (es) 2008-05-02

Family

ID=38658456

Family Applications (1)

Application Number Title Priority Date Filing Date
UY30602A UY30602A1 (es) 2006-09-22 2007-09-21 Mutante de un pestivirus, vacuna y aplicaciones

Country Status (8)

Country Link
US (1) US8071108B2 (es)
EP (1) EP2066342B1 (es)
JP (1) JP5775665B2 (es)
AR (1) AR062917A1 (es)
CA (1) CA2663142C (es)
CL (1) CL2007002704A1 (es)
UY (1) UY30602A1 (es)
WO (1) WO2008034857A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2449013C2 (ru) * 2010-07-05 2012-04-27 Федеральное государственное учреждение "Федеральный центр охраны здоровья животных" (ФГУ "ВНИИЗЖ") Штамм "nadl-вниизж" вируса вирусной диареи крупного рогатого скота diarrhea virus bovinum для изготовления биопрепаратов для диагностики, специфической профилактики и лечения вирусной диареи крупного рогатого скота
ES2757927T3 (es) * 2014-05-23 2020-04-30 Boehringer Ingelheim Vetmedica Gmbh Virus de la peste porcina clásica (VPPC) recombinante que comprende sustituciones en el epítopo TAV de la proteína E2
CN108456663B (zh) * 2018-03-26 2021-09-21 中国农业科学院兰州兽医研究所 一种1型牛病毒性腹泻病毒样颗粒及其制备与应用
CN114921495A (zh) * 2022-06-15 2022-08-19 中国农业科学院兰州兽医研究所 一种猪瘟病毒病毒样颗粒疫苗的制备方法及应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6168942B1 (en) 1998-11-10 2001-01-02 Pfizer Inc. Attenuated forms of bovine viral diarrhea virus
EP1035205A1 (en) 1999-03-08 2000-09-13 Stichting Dienst Landbouwkundig Onderzoek Non-spreading pestivirus
DE102004025452A1 (de) 2004-05-19 2006-01-19 Boehringer Ingelheim Vetmedica Gmbh Vakzine enthaltend BVDV
US7572455B2 (en) * 2004-05-19 2009-08-11 Boehringer Ingelheim Vetmedica Gmbh Vaccine comprising an attenuated pestivirus

Also Published As

Publication number Publication date
CA2663142C (en) 2016-05-03
EP2066342A1 (en) 2009-06-10
US20090232846A1 (en) 2009-09-17
CL2007002704A1 (es) 2008-05-30
JP2010504084A (ja) 2010-02-12
WO2008034857A1 (en) 2008-03-27
EP2066342B1 (en) 2014-07-23
US8071108B2 (en) 2011-12-06
JP5775665B2 (ja) 2015-09-09
AR062917A1 (es) 2008-12-17
CA2663142A1 (en) 2008-03-27

Similar Documents

Publication Publication Date Title
MX2021011687A (es) Composiciones inmunogenicas y vacunas que comprenden peptidos y proteinas del virus de la peste porcina africana y usos de las mismas.
CL2019002134A1 (es) Composiciones terapéuticas inmunomoduladoras de arnm que codifican péptidos de activación de mutaciones oncogénicas.
ES2722773T3 (es) Polipéptidos de fHbp meningocócicos modificados
ES2570758T3 (es) Materiales y métodos para el control de enfermedades respiratorias en cánidos
EP3552622A3 (en) Priming of an immune response
UY30602A1 (es) Mutante de un pestivirus, vacuna y aplicaciones
TW200641126A (en) N protein mutants of porcine reproductive and respiratory syndrome virus
ECSP066495A (es) Composiciones y metodos para inhibir la infección por virus de síndrome de punto blanco (wssv)
MX9207113A (es) Fragmento de adn, peptido que comprende una proteina superficial ha de un virus de gripe a y vacuna que comprende tal peptido.
ZA202300548B (en) Self-amplifying sars-cov-2 rna vaccine
CY1111286T1 (el) Ανοσοποιηση διαμεσολαβουμενη απο βακτηριοφαγα
AR067980A1 (es) Peptidos de cdh3 y agentes que los comprenden
UY37576A (es) Anticuerpos dirigidos a hueso
RS51402B (en) IMMUNOSTIMULATORY COMBINATIONS FOR PROPHYLAXIS AND TREATMENT OF HEPATITIS C
MX2023015327A (es) Antigenos de la influenza novedosos.
ES2572367T3 (es) Péptidos con epítopos de la MELK y vacunas que los contienen
AR051853A1 (es) Vacuna para aumentar el crecimiento basada en epitopes neutralizantes
ATE234628T1 (de) Therapeutische anwendungen von antigenen oder epitopen assoziert mit unvollständiger zellulärer peptidprozesierung , z.b.: exprimiert in rma-s zellen transfiziert mit b7-1 gen
BR112018072592A2 (pt) vetor de vacina de levedura que inclui polipeptídeos imunoestimulantes e antigênicos, e métodos de uso dos mesmos
PE20190967A1 (es) Aislados modificados de streptomyces fungicidicus y su uso
NZ570708A (en) Peptides of regulatory or accessory proteins of HIV, compositions and the utilization thereof
ES2077017T3 (es) Vacuna contra el virus de la bronquitis infecciosa.
ATE449611T1 (de) Bakteriophagen-vermittelte immunisierung gegen hepatitis
AR041169A1 (es) Polinucleotidos aislados que regulan la floracion de hierbas forrajeras y metodos de uso
DE50304603D1 (de) Impfstoff gegen infektionen mit onkoviren, wie dem felinen leukosevirus der katze

Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20170725