UY27717A1 - Nuevos derivados de azepano. - Google Patents

Nuevos derivados de azepano.

Info

Publication number
UY27717A1
UY27717A1 UY27717A UY27717A UY27717A1 UY 27717 A1 UY27717 A1 UY 27717A1 UY 27717 A UY27717 A UY 27717A UY 27717 A UY27717 A UY 27717A UY 27717 A1 UY27717 A1 UY 27717A1
Authority
UY
Uruguay
Prior art keywords
new derivatives
azepano
azepane
elaboration
pharmaceutically acceptable
Prior art date
Application number
UY27717A
Other languages
English (en)
Inventor
Birgit Masjost
Ralf Schumacher
Walter-Gunar Friebe
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of UY27717A1 publication Critical patent/UY27717A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L a invención proporciona nuevas derivados de azepano sales farmacéuticamente aceptable de los mismos, de acuerdo con la fórmula general ( I ) en donde los símbolos restantes tienen el significado dado en la especificación, así como los procesos para su elaboración . Los compustos de acuerdo a esta invención poseen actividad de anti-proliferación celular y muestran un aumento de la estabilidad en plasma.
UY27717A 2002-03-12 2003-03-11 Nuevos derivados de azepano. UY27717A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02005287 2002-03-12
EP02006648 2002-03-26

Publications (1)

Publication Number Publication Date
UY27717A1 true UY27717A1 (es) 2003-09-30

Family

ID=27806513

Family Applications (1)

Application Number Title Priority Date Filing Date
UY27717A UY27717A1 (es) 2002-03-12 2003-03-11 Nuevos derivados de azepano.

Country Status (12)

Country Link
US (1) US6887864B2 (es)
EP (1) EP1487819A2 (es)
JP (1) JP2005524671A (es)
CN (1) CN1321116C (es)
AR (1) AR038916A1 (es)
AU (1) AU2003218715A1 (es)
CA (1) CA2478276A1 (es)
PA (1) PA8568901A1 (es)
PE (1) PE20040205A1 (es)
TW (1) TW200401644A (es)
UY (1) UY27717A1 (es)
WO (1) WO2003076429A2 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2696598T3 (es) * 2005-03-21 2019-01-17 Univ Columbia Compuestos de balanol para su uso en el tratamiento de dolor
US8846742B2 (en) 2006-02-14 2014-09-30 The Trustees Of Columbia University In The City Of New York Neuronal pain pathway modulators
RU2016105998A (ru) * 2013-07-23 2017-08-29 Ф.Хоффманн-Ля Рош Аг Конверсия на основе малых молекул соматических клеток в клетки нейрального гребня
CN109311908B (zh) * 2016-06-16 2021-05-07 哈尔滨珍宝制药有限公司 作为Akt抑制剂的二氢吡唑氮杂卓类化合物
WO2019089729A1 (en) * 2017-10-31 2019-05-09 University Of Miami Kinase inhibitors for the treatment of central and peripheral nervous system disorders
CN107759606B (zh) * 2017-11-29 2018-12-21 南京诺希生物科技有限公司 具有抗肿瘤活性的氮杂环烯烃并二氮卓药物分子及其制备方法
KR102394934B1 (ko) * 2017-12-13 2022-05-04 하얼빈 젠바오 파마슈티컬 컴퍼니, 리미티드 Akt 억제제로서의 염 형태 및 이의 결정 형태

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL86632A0 (en) 1987-06-15 1988-11-30 Ciba Geigy Ag Derivatives substituted at methyl-amino nitrogen
EP0687249A1 (en) 1993-03-03 1995-12-20 Eli Lilly And Company Balanoids
PL182124B1 (pl) 1993-12-07 2001-11-30 Lilly Co Eli Nowe zwiazki oraz srodek farmaceutyczny przeznaczony do leczenia powiklan cukrzycowych lub do leczenia nowotworów PL PL PL PL PL PL PL PL
AU686691B2 (en) * 1994-01-12 1998-02-12 F. Hoffmann-La Roche Ag Novel azepanes and homologs thereof
US5583221A (en) 1994-05-04 1996-12-10 Eli Lilly And Company Substituted fused and bridged bicyclic compounds as therapeutic agents
TW339325B (en) 1995-07-05 1998-09-01 Hoffmann La Roche Novel azepane derivatives, process for the preparation thereof and pharmaceutical composition containing the same
EP0802190A1 (de) 1996-04-17 1997-10-22 F. Hoffmann-La Roche Ag Verfahren zur Herstellung von Azepinen
JP2000186092A (ja) 1998-12-22 2000-07-04 Kyowa Hakko Kogyo Co Ltd Ｕｃｎ−０１の製造法

Also Published As

Publication number Publication date
TW200401644A (en) 2004-02-01
CN1321116C (zh) 2007-06-13
US6887864B2 (en) 2005-05-03
WO2003076429A3 (en) 2004-01-08
WO2003076429A2 (en) 2003-09-18
JP2005524671A (ja) 2005-08-18
EP1487819A2 (en) 2004-12-22
PA8568901A1 (es) 2003-12-10
CA2478276A1 (en) 2003-09-18
AR038916A1 (es) 2005-02-02
AU2003218715A1 (en) 2003-09-22
US20030181716A1 (en) 2003-09-25
CN1639151A (zh) 2005-07-13
AU2003218715A8 (en) 2003-09-22
PE20040205A1 (es) 2004-04-08

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20150520