UY26157A1 - Aril y heteroaril policíclicos sustituidos útiles para la i nhibición selectiva de la cascada de coagulación - Google Patents

Aril y heteroaril policíclicos sustituidos útiles para la i nhibición selectiva de la cascada de coagulación

Info

Publication number
UY26157A1
UY26157A1 UY26157A UY26157A UY26157A1 UY 26157 A1 UY26157 A1 UY 26157A1 UY 26157 A UY26157 A UY 26157A UY 26157 A UY26157 A UY 26157A UY 26157 A1 UY26157 A1 UY 26157A1
Authority
UY
Uruguay
Prior art keywords
polycyclic aryl
nhibition
selective
substituted polycyclic
heteroaryl
Prior art date
Application number
UY26157A
Other languages
English (en)
Inventor
South Rueppel Jones
Melvin L Rueppel
Darin E Jones
Michael South
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Publication of UY26157A1 publication Critical patent/UY26157A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención se refiere a los compuestos de aril y heteroaril uracilos policíclicos, útiles como inhibidores de proteasas de serina de la serie de reacciones del proceso de coagulación y compuestos, composiciones y métodos para terapia de anticoagulación para el tratamiento y prevención de condiciones trombóticas, incluyendo enfermedades de la arteria coronaria y cerebrovasculares.
UY26157A 1999-05-19 2000-05-19 Aril y heteroaril policíclicos sustituidos útiles para la i nhibición selectiva de la cascada de coagulación UY26157A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13495799P 1999-05-19 1999-05-19

Publications (1)

Publication Number Publication Date
UY26157A1 true UY26157A1 (es) 2000-12-29

Family

ID=22465795

Family Applications (1)

Application Number Title Priority Date Filing Date
UY26157A UY26157A1 (es) 1999-05-19 2000-05-19 Aril y heteroaril policíclicos sustituidos útiles para la i nhibición selectiva de la cascada de coagulación

Country Status (14)

Country Link
EP (1) EP1178971A1 (es)
JP (1) JP2002544263A (es)
KR (1) KR20010113969A (es)
CN (1) CN1152023C (es)
AR (1) AR043677A1 (es)
AU (1) AU771740B2 (es)
BR (1) BR0011273A (es)
CA (1) CA2373610A1 (es)
MX (1) MXPA01011806A (es)
NZ (1) NZ514877A (es)
PE (1) PE20010217A1 (es)
UY (1) UY26157A1 (es)
WO (1) WO2000069833A1 (es)
ZA (2) ZA200109338B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750342B1 (en) 1999-05-19 2004-06-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6716838B1 (en) 1999-05-19 2004-04-06 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents
US7015230B1 (en) 1999-05-19 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6653316B1 (en) 1999-05-19 2003-11-25 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6458952B1 (en) 1999-05-19 2002-10-01 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6867217B1 (en) 1999-05-19 2005-03-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
US6664255B1 (en) 1999-05-19 2003-12-16 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
KR100814269B1 (ko) 2000-01-25 2008-03-18 뉴로크린 바이오사이언시즈 인코퍼레이티드 고나도트로핀-분비 호르몬 수용체 길항제 및 이를 포함하는 약제학적 조성물
AU2004200664B2 (en) * 2000-01-25 2007-08-16 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
US6852761B2 (en) 2000-03-13 2005-02-08 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
ES2236211T3 (es) 2000-04-05 2005-07-16 Pharmacia Corporation 4-pironas policiclicas, aril y heteroaril sustituidas, utiles para la inhibicion selectiva de la cascada de la coagulacion.
EP1268428A2 (en) 2000-04-05 2003-01-02 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade
US6686484B2 (en) 2000-04-17 2004-02-03 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade
US6710058B2 (en) 2000-11-06 2004-03-23 Bristol-Myers Squibb Pharma Company Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
MXPA03004458A (es) 2000-11-20 2005-01-25 Pharmacia Corp Arilpiridinas y heteroarilpiridinas sustituidas utiles para inhibicion selectiva de la cascada de coagulacion.
US7119094B1 (en) 2000-11-20 2006-10-10 Warner-Lambert Company Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade
US7015223B1 (en) 2000-11-20 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade
WO2003093242A2 (en) 2001-10-03 2003-11-13 Pharmacia Corporation Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade
JP2005519866A (ja) 2001-10-03 2005-07-07 ファルマシア・コーポレーション 凝固カスケードの選択阻害に有用な６員複素環式化合物
TW200307667A (en) 2002-05-06 2003-12-16 Bristol Myers Squibb Co Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
GB0622472D0 (en) * 2006-11-10 2006-12-20 Addex Pharmaceuticals Sa Novel heterocyclic derivatives
PE20141295A1 (es) 2011-11-29 2014-10-01 Perosphere Inc Agentes de reversion anticoagulante
CN116410143A (zh) * 2021-12-29 2023-07-11 杭州奥默医药股份有限公司 一种多取代脲嘧啶衍生物及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9509994A (pt) * 1994-12-13 1997-12-30 Corvas Int Inc Derivados heterocíclicos aromáticos como inibidores de enzimas
IL146243A0 (en) * 1999-05-19 2002-07-25 Pharmacia Corp Substituted polycyclic aryl and heteroaryl pyrymidinones useful as anticoagulants

Also Published As

Publication number Publication date
CN1152023C (zh) 2004-06-02
JP2002544263A (ja) 2002-12-24
KR20010113969A (ko) 2001-12-28
WO2000069833A1 (en) 2000-11-23
BR0011273A (pt) 2002-06-18
MXPA01011806A (es) 2003-09-04
CN1351594A (zh) 2002-05-29
ZA200109338B (en) 2004-05-26
AU771740B2 (en) 2004-04-01
AR043677A1 (es) 2005-08-10
EP1178971A1 (en) 2002-02-13
CA2373610A1 (en) 2000-11-23
AU4972400A (en) 2000-12-05
PE20010217A1 (es) 2001-03-07
ZA200400450B (en) 2004-09-29
NZ514877A (en) 2004-10-29

Similar Documents

Publication Publication Date Title
UY26157A1 (es) Aril y heteroaril policíclicos sustituidos útiles para la i nhibición selectiva de la cascada de coagulación
UY26154A1 (es) Aril y heteroaril piridonas policíclicas sustituidas útiles para la inhibición selectiva de la cascada de coagulación
UY26156A1 (es) Aril y heteroaril pirimidonas policíclicas sustituidas útiles para la inhibición selectiva de la cascada de coagulación
DE60107687D1 (de) Cyclpentanoindole, mischungen derartige verbindungen enthaltend und behandlungsmethoden
ECSP066447A (es) Derivados de isoquinolina 1,4-disustituida como inhibidores raf-quinasa útiles para el tratamiento de enfermedades proliferativas
ECSP045178A (es) Compuestos de aril úrea en combinación con otros agentes citostáticos o citotóxicos para el tratamiento de cáncer en humanos
CR20130506A (es) PIRROL[2,3-b]PIRIDINAS Y PIRROL[2,3-b]PIRIMIDINAS HETEROARILO SUSTITUIDAS COMO INHIBIDORES DE QUINASAS JANUS (DIVISIONAL EXP. 10065)
ATE404552T1 (de) Substituierte isochinolinderivate und anwendungsverfahren
DE60118003D1 (de) Harnstoffderivate und ihre verwendung
EA200400971A1 (ru) Фторзамещенные циклоалканоиндолы, композиции, содержащие такие соединения, и способы лечения
AR029752A1 (es) Compuesto derivado de pirazinona policiclica, sustituida, composicion que lo comprende y el uso,de dicha composicion y de dicho compuesto en la fabricacion de medicamentos utiles para la inhibicion selectiva de la cascada de coagulacion
ECSP045469A (es) El uso de cianopirrolidinas sustituidas y preparaciones de combinacion que las contienen para tratar hiperlipidemia y enfermedades asociadas
DK1594885T3 (da) Lægemiddel til vækstinhibering af tumorer
ATE367380T1 (de) Zur behandlung von zns-erkrankungen geeignete piperazinylchinolinderivate
EA200401319A1 (ru) Новые гетероциклические соединения, способы их получения и фармацевтические композиции, содержащие эти соединения, и их использование в медицине
MX9305093A (es) Nuevos derivadosindano-2 mercaptoacetilamina triciclicos 2-sustituidos, utiles como inhibidores de la encefalinasa.
ES2182035T3 (es) Derivados del bisarilciclobuteno como inhibidores de ciclooxigenasa.
EA201991095A1 (ru) Замещенные азотсодержащие соединения
ATE432936T1 (de) Imidazotriazin verbindungen zur behandlung von krebserkrankungen
ATE289299T1 (de) Polyzyclisch aryl und heteroaryl substituierte 4- pyronen verwendbar als selektive hemmung von dem koagulationsprozess
UY27680A1 (es) Agonistas del receptor b3 - andrenérgicos.
ECSP003478A (es) Aril policiclico substituido y uracilos heteroaril utiles para la inhibicion selectiva de la cascada de coagulacion
ECSP003476A (es) Aril policiclico substituido y pirimidinonas heteroaril utiles para la inhibicion selectiva de la cascada de coagulacion
ES2169399T3 (es) Procedimiento para preparar heterociclos de fenilo utiles como inhibidores de la cox-2.
PA8579401A1 (es) Derivados de 2,3-dihidro-isoindol-1-ona como inhibidores de mao-b