UY26157A1 - SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL USEFUL FOR THE SELECTIVE I NHIBITION OF THE COAGULATION WATERFALL - Google Patents

SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL USEFUL FOR THE SELECTIVE I NHIBITION OF THE COAGULATION WATERFALL

Info

Publication number
UY26157A1
UY26157A1 UY26157A UY26157A UY26157A1 UY 26157 A1 UY26157 A1 UY 26157A1 UY 26157 A UY26157 A UY 26157A UY 26157 A UY26157 A UY 26157A UY 26157 A1 UY26157 A1 UY 26157A1
Authority
UY
Uruguay
Prior art keywords
polycyclic aryl
nhibition
selective
substituted polycyclic
heteroaryl
Prior art date
Application number
UY26157A
Other languages
Spanish (es)
Inventor
South Rueppel Jones
Melvin L Rueppel
Darin E Jones
Michael South
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Publication of UY26157A1 publication Critical patent/UY26157A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención se refiere a los compuestos de aril y heteroaril uracilos policíclicos, útiles como inhibidores de proteasas de serina de la serie de reacciones del proceso de coagulación y compuestos, composiciones y métodos para terapia de anticoagulación para el tratamiento y prevención de condiciones trombóticas, incluyendo enfermedades de la arteria coronaria y cerebrovasculares.The invention relates to polycyclic aryl and heteroaryl uracil compounds, useful as serine protease inhibitors of the series of coagulation process reactions and compounds, compositions and methods for anticoagulation therapy for the treatment and prevention of thrombotic conditions, including coronary artery and cerebrovascular diseases.

UY26157A 1999-05-19 2000-05-19 SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL USEFUL FOR THE SELECTIVE I NHIBITION OF THE COAGULATION WATERFALL UY26157A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13495799P 1999-05-19 1999-05-19

Publications (1)

Publication Number Publication Date
UY26157A1 true UY26157A1 (en) 2000-12-29

Family

ID=22465795

Family Applications (1)

Application Number Title Priority Date Filing Date
UY26157A UY26157A1 (en) 1999-05-19 2000-05-19 SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL USEFUL FOR THE SELECTIVE I NHIBITION OF THE COAGULATION WATERFALL

Country Status (14)

Country Link
EP (1) EP1178971A1 (en)
JP (1) JP2002544263A (en)
KR (1) KR20010113969A (en)
CN (1) CN1152023C (en)
AR (1) AR043677A1 (en)
AU (1) AU771740B2 (en)
BR (1) BR0011273A (en)
CA (1) CA2373610A1 (en)
MX (1) MXPA01011806A (en)
NZ (1) NZ514877A (en)
PE (1) PE20010217A1 (en)
UY (1) UY26157A1 (en)
WO (1) WO2000069833A1 (en)
ZA (2) ZA200109338B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750342B1 (en) 1999-05-19 2004-06-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6716838B1 (en) 1999-05-19 2004-04-06 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents
US7015230B1 (en) 1999-05-19 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6653316B1 (en) 1999-05-19 2003-11-25 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6458952B1 (en) 1999-05-19 2002-10-01 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6867217B1 (en) 1999-05-19 2005-03-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
US6664255B1 (en) 1999-05-19 2003-12-16 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
KR100814269B1 (en) 2000-01-25 2008-03-18 뉴로크린 바이오사이언시즈 인코퍼레이티드 Gonadotropin-releasing hormone receptor antagonists and a pharmaceutical composition comprising them
AU2004200664B2 (en) * 2000-01-25 2007-08-16 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
US6852761B2 (en) 2000-03-13 2005-02-08 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
ES2236211T3 (en) 2000-04-05 2005-07-16 Pharmacia Corporation 4-POLYCLY PIRONAS, ARIL AND HETEROARIL SUBSTITUTED, USEFUL FOR THE SELECTIVE INHIBITION OF THE COAGULATION WATERFALL.
EP1268428A2 (en) 2000-04-05 2003-01-02 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade
US6686484B2 (en) 2000-04-17 2004-02-03 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade
US6710058B2 (en) 2000-11-06 2004-03-23 Bristol-Myers Squibb Pharma Company Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
MXPA03004458A (en) 2000-11-20 2005-01-25 Pharmacia Corp Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade.
US7119094B1 (en) 2000-11-20 2006-10-10 Warner-Lambert Company Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade
US7015223B1 (en) 2000-11-20 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade
WO2003093242A2 (en) 2001-10-03 2003-11-13 Pharmacia Corporation Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade
JP2005519866A (en) 2001-10-03 2005-07-07 ファルマシア・コーポレーション 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade
TW200307667A (en) 2002-05-06 2003-12-16 Bristol Myers Squibb Co Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
GB0622472D0 (en) * 2006-11-10 2006-12-20 Addex Pharmaceuticals Sa Novel heterocyclic derivatives
PE20141295A1 (en) 2011-11-29 2014-10-01 Perosphere Inc ANTICOAGULANT REVERSAL AGENTS
CN116410143A (en) * 2021-12-29 2023-07-11 杭州奥默医药股份有限公司 Polysubstituted uracil derivative, preparation method and application thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9509994A (en) * 1994-12-13 1997-12-30 Corvas Int Inc Aromatic heterocyclic derivatives as enzyme inhibitors
IL146243A0 (en) * 1999-05-19 2002-07-25 Pharmacia Corp Substituted polycyclic aryl and heteroaryl pyrymidinones useful as anticoagulants

Also Published As

Publication number Publication date
CN1152023C (en) 2004-06-02
JP2002544263A (en) 2002-12-24
KR20010113969A (en) 2001-12-28
WO2000069833A1 (en) 2000-11-23
BR0011273A (en) 2002-06-18
MXPA01011806A (en) 2003-09-04
CN1351594A (en) 2002-05-29
ZA200109338B (en) 2004-05-26
AU771740B2 (en) 2004-04-01
AR043677A1 (en) 2005-08-10
EP1178971A1 (en) 2002-02-13
CA2373610A1 (en) 2000-11-23
AU4972400A (en) 2000-12-05
PE20010217A1 (en) 2001-03-07
ZA200400450B (en) 2004-09-29
NZ514877A (en) 2004-10-29

Similar Documents

Publication Publication Date Title
UY26157A1 (en) SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL USEFUL FOR THE SELECTIVE I NHIBITION OF THE COAGULATION WATERFALL
UY26154A1 (en) ARIL AND HETEROARIL REPLACED POLYCYCLIC PYRIDONES USEFUL FOR THE SELECTIVE INHIBITION OF THE COAGULATION WATERFALL
UY26156A1 (en) ARIL AND HETEROARIL POLYCYCLIC PIRIMIDONES SUBSTITUTED USEFUL FOR THE SELECTIVE INHIBITION OF THE COAGULATION WATERFALL
DE60107687D1 (en) CYCLPENTANOINDOLE, MIXTURES CONTAINING SUCH COMPOUNDS AND TREATMENT METHODS
ECSP066447A (en) DERIVATIVES OF ISOQUINOLINE 1,4-DISPOSED AS RAF-KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES
ECSP045178A (en) ARIL ÚREA COMPOUNDS IN COMBINATION WITH OTHER CITTATIC OR CYTOTOXIC AGENTS FOR CANCER TREATMENT IN HUMANS
CR20130506A (en) PIRROL [2,3-b] PIRIDINES AND PIRROL [2,3-b] HETEROARILO PYRIMIDINES REPLACED AS INHIBITORS OF JANUS KINASES (DIVISIONAL EXP. 10065)
ATE404552T1 (en) SUBSTITUTED ISOQUINOLINE DERIVATIVES AND METHODS OF USE
DE60118003D1 (en) UREA DERIVATIVES AND ITS USE
EA200400971A1 (en) Fluorine-substituted cycloalkanoylindoles, compositions containing such compounds, and methods of treatment
AR029752A1 (en) COMPOUND DERIVED FROM POLICE, REPLACED PIRAZINONA, COMPOSITION THAT INCLUDES IT AND THE USE OF SUCH COMPOSITION AND SUCH COMPOUND IN THE MANUFACTURE OF USEFUL MEDICINES FOR THE SELECTIVE INHIBITION OF THE COAGULATION WATERFALL
ECSP045469A (en) THE USE OF REPLACED CYANOPIRROLIDINS AND COMBINATION PREPARATIONS CONTAINING THEM TO TREAT HYPERLIPIDEMIA AND ASSOCIATED DISEASES
DK1594885T3 (en) Drug for growth inhibition of tumors
ATE367380T1 (en) PIPERAZINYLQUINOLINE DERIVATIVES SUITABLE FOR THE TREATMENT OF CNS DISEASES
EA200401319A1 (en) NEW HETEROCYCLIC COMPOUNDS, METHODS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND THEIR USE IN MEDICINE
MX9305093A (en) NEW DERIVATIVESINDANO-2 MERCAPTOACETILAMINA TRICICLICOS 2-SUBSTITUTED, USEFUL AS ENCEPHALINASE INHIBITORS.
ES2182035T3 (en) DERIVATIVES OF BISARILCICLOBUTENO AS CICLOOXIGENASA INHIBITORS
EA201991095A1 (en) SUBSTITUTED NITROGEN CONTAINING COMPOUNDS
ATE432936T1 (en) IMIDAZOTRIAZINE COMPOUNDS USED TO TREAT CANCER DISEASES
ATE289299T1 (en) POLYCYCLIC ARYL AND HETEROARYL SUBSTITUTED 4-PYRONES USABLE FOR SELECTIVE INHIBITION OF THE COAGULATION PROCESS
UY27680A1 (en) B3 RECEIVER AGONISTS - ANDRENÉRGICOS.
ECSP003478A (en) SUBSTITUTED POLYCLIC ARYL AND HETEROARIL URACILS USEFUL FOR THE SELECTIVE INHIBITION OF THE COAGULATION WATERFALL
ECSP003476A (en) SUBSTITUTED POLYCLIC ARYL AND HETEROARIL PIRIMIDINONES USEFUL FOR THE SELECTIVE INHIBITION OF THE COAGULATION WATERFALL
ES2169399T3 (en) PROCEDURE TO PREPARE USEFUL FENYL CYCLES AS INHIBITORS OF COX-2.
PA8579401A1 (en) DERIVATIVES OF 2,3-DIHIDRO-ISOINDOL-1-ONA AS MAO-B INHIBITORS