UY26056A1 - Compuestos heterociclicos aromaticos utiles como secretagogos de la hormona del crecimiento - Google Patents

Compuestos heterociclicos aromaticos utiles como secretagogos de la hormona del crecimiento

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Publication number
UY26056A1
UY26056A1 UY26056A UY26056A UY26056A1 UY 26056 A1 UY26056 A1 UY 26056A1 UY 26056 A UY26056 A UY 26056A UY 26056 A UY26056 A UY 26056A UY 26056 A1 UY26056 A1 UY 26056A1
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Uruguay
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alkyl
aryl
cycloalkyl
alkenyl
independently
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UY26056A
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English (en)
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Jeffrey A Robl
Joseph A Tino
Andres S Hernandez
James J Li
Jun Li
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Bristol Myers Squibb Co
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Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of UY26056A1 publication Critical patent/UY26056A1/es

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Abstract

Compuestos heterocíclicos aromáticos los cuales son útiles en la estimulación de la producción endógena o liberación de la hormona del crecimiento y en el tratamiento de la obesidad, osteoporosis (mejoramiento de la densidad del hueso) y en el mejoramiento de la masa muscular. Los compuestos heterocíclicos aromáticos tienen la estructura (Fig. 1), que incluyen sales farmacéuticamente aceptables de los mismos y todos los estereoisómeros de los mismos, en donde: R1 es alquilo, arilo, alquenilo, alquinilo, arilalquilo, cicloalquilo, alcoxialquilo, heteroarilalquilo, cicloheteroalquilo o cicloheteroalquilalquilo; R1a es H, alquilo o cicloalquilo; Xa es heteroarilo (Fig. 2) en el que: A es oxígeno, azufre, -NH-, -N-R5, o -NC(O)-R2; B es -CR5b, o -N-; Z es un enlace o -S-; R2 es alquilo, arilo, alquenilo, alquinilo, arilalquilo, cicloalquilo, heteroarilo; R3 es H, halógeno, alquilo, arilo, alquenilo, alquinilo, alcoxi; R4 y R4a se seleccionan de manera independiente de H, halógeno, -CF3, alquilo o arilo; R5 y R5a son independientemente H, alquilo, arilo, alquenilo, alquinilo, alcoxialquilo, heteroarilo; Y es fig.3 donde x e y son independientemente 0 a 3 y z es 1 a 3; Xc es un enlace, -N-R6a o -O-; R7 y R7a se seleccionan de manera independiente de H, alquilo, -CF3, fenilo, arilo, arilalquilo y cicloalquilo; R6, R6a, R8d, R8e son indpendientemente H, alquilo, cicloalquilo, alquenilo o arilo; Xb es fig.4 donde R9 y R10 son seleccionados independientemente de H, alquilo; R11 es H, alquilo, -CF3, arilalquilo o arilo; R12 y R13 son independientemente H, alquilo,-CF3, arilo o halógeno.
UY26056A 1999-03-12 2000-03-10 Compuestos heterociclicos aromaticos utiles como secretagogos de la hormona del crecimiento UY26056A1 (es)

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ATE310728T1 (de) * 2000-05-11 2005-12-15 Bristol Myers Squibb Co Tetrahydroisochinolin-analoga als wachstumshormon-sekretagoga
WO2002057241A1 (en) * 2000-12-22 2002-07-25 Bayer Pharmaceuticals Corporation 8-(AMINOALKOXYMINO)-8H-DIBENZO[a,e]TRIAZOLO[4,5-c]CYCLOHEPTENES AS GROWTH HORMONE SECRETAGOGUES
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MY139563A (en) * 2002-09-04 2009-10-30 Bristol Myers Squibb Co Heterocyclic aromatic compounds useful as growth hormone secretagogues
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