UY26041A1 - Heterociclos biciclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparacion - Google Patents

Heterociclos biciclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparacion

Info

Publication number
UY26041A1
UY26041A1 UY26041A UY26041A UY26041A1 UY 26041 A1 UY26041 A1 UY 26041A1 UY 26041 A UY26041 A UY 26041A UY 26041 A UY26041 A UY 26041A UY 26041 A1 UY26041 A1 UY 26041A1
Authority
UY
Uruguay
Prior art keywords
group
alkylene
substituted
atom
optionally substituted
Prior art date
Application number
UY26041A
Other languages
English (en)
Inventor
Dr Frank Himmelsbach
Dr Elke Langkopf
Dr Birgit Jung
Dr Thomas Metz
Dr Flavio Solca
Dr Stefan Blech
Original Assignee
Boehringer Ingelheim Pharma
Amp
Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999108567 external-priority patent/DE19908567A1/de
Priority claimed from DE1999111366 external-priority patent/DE19911366A1/de
Priority claimed from DE1999128306 external-priority patent/DE19928306A1/de
Priority claimed from DE19954816A external-priority patent/DE19954816A1/de
Application filed by Boehringer Ingelheim Pharma, Amp, Co Kg filed Critical Boehringer Ingelheim Pharma
Publication of UY26041A1 publication Critical patent/UY26041A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Heterociclos bicíclicos de la fórmula general (I), en donde: Ra contiene un átomo de hidrógeno o un grupo alquilo; Rb contiene un grupo fenilo, bencilo ó 1-feniletilo, en los que el núcleo de fenilo está sustituido; Rc y Rd, que pueden ser iguales o diferentes, contienen en cada caso un átomo de hidrógeno, flúor o cloro, un grupo metoxi o metilo eventualmente sustituido; X contiene un grupo metino sustituido con un grupo ciano, o un átomo de nitrógeno; A contiene un átomo de oxígeno o un grupo imino eventualmente sustituido con un grupo alquilo; B contiene un grupo carbonilo o sulfonilo; C contiene un grupo 1,3-alenileno, 1,1- ó 1,2-vinileno, que en cada caso pueden estar sustituidos, un grupo etinileno o un grupo 1,3-butadien-1,4-ileno eventualmente sustituido; D contiene grupo alquileno, CO-alquileno o SO2-alquileno, o en el caso de que D esté unido a un átomo de carbono del radical E, contiene también un enlace o, en el caso de que D esté unido a un átomo de nitrógeno del radical E, contiene también un grupo carbonilo o sulfonilo; E contiene un grupo R6O-CO-alquilen-NR5, (R7O-PO-OR8)-alquilen-NR5 ó (R7O-PO-R9)-alquilen-NR5. Por ejemplo: 4-((3-bromofenil)amino)-7-(3-(4-((etoxicarbonil)metil)-piperazin-1-il)propiloxi)-6-((vinilcarbonil)amino)-quinazolina. La invención presenta también sus tautómeros, sus esteroisómeros y sus sales, en particular sus sales fisiologicamente compatibles con ácidos o bases inorgánicas u rogánicas, que presentan valiosas propiedades farmacológicas, en particular un efecto inhibidor sobre las transducción de senales inducidas por tirosina-quinasas, a su empleo para el tratamiento de enfermedades, en particular tumorales. pulmonares y de las vías respiratorias, y a su preparación.
UY26041A 1999-02-27 2000-02-28 Heterociclos biciclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparacion UY26041A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE1999108567 DE19908567A1 (de) 1999-02-27 1999-02-27 Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE1999111366 DE19911366A1 (de) 1999-03-15 1999-03-15 Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE1999128306 DE19928306A1 (de) 1999-06-21 1999-06-21 Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE19954816A DE19954816A1 (de) 1999-11-13 1999-11-13 Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
UY26041A1 true UY26041A1 (es) 2000-09-29

Family

ID=37516076

Family Applications (1)

Application Number Title Priority Date Filing Date
UY26041A UY26041A1 (es) 1999-02-27 2000-02-28 Heterociclos biciclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparacion

Country Status (5)

Country Link
AR (1) AR031668A1 (es)
CO (1) CO5251386A1 (es)
EA (1) EA200100830A1 (es)
UY (1) UY26041A1 (es)
YU (1) YU60501A (es)

Also Published As

Publication number Publication date
CO5251386A1 (es) 2003-02-28
YU60501A (sh) 2004-07-15
AR031668A1 (es) 2003-10-01
EA200100830A1 (ru) 2002-04-25

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20100111