UY23929A1 - Procedimiento de preparacion de derivados del indol - Google Patents

Procedimiento de preparacion de derivados del indol

Info

Publication number
UY23929A1
UY23929A1 UY23929A UY23929A UY23929A1 UY 23929 A1 UY23929 A1 UY 23929A1 UY 23929 A UY23929 A UY 23929A UY 23929 A UY23929 A UY 23929A UY 23929 A1 UY23929 A1 UY 23929A1
Authority
UY
Uruguay
Prior art keywords
indole
preparation
derivatives
aminoethyl
boron hydride
Prior art date
Application number
UY23929A
Other languages
English (en)
Inventor
Duran Carles Puig
Forner Dolors Fernandez
Original Assignee
Almirall Prodesfarma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Prodesfarma Sa filed Critical Almirall Prodesfarma Sa
Publication of UY23929A1 publication Critical patent/UY23929A1/es

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invencion se refiere a un nuevo procedimiento de preparacion de derivados del indol de formula (I) (figura 1) y sales farmacéuticamente aceptables de los mismos, donde Z representa a un anillo, el cual comprende: metilar un aminoetil-indol con formaldehído y un hidruro complejo de boro (como hidruro de boro y sodio o cianoborohidruro de sodio). También es de alcance un procedimiento para la obtención del aminoetil-indol mencionado a partir de una hidrazina con 4-clorobutiraldehído o un derivado reactivo delmismo para formar una hidrazona (para luego ser calentada). Ejemplo no limitante: 1-[[3-(2-dimetilaminoetil)-5-indolil]metanosulfonil]pirrolidina. Los productos de la invención son adecuados para el tratamiento o prevención de la migraña y otros dolores asociados con trastornos vasculares, depresión, ansiedad, trastornos del equilibrio.
UY23929A 1994-03-09 1995-03-09 Procedimiento de preparacion de derivados del indol UY23929A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9400481A ES2084560B1 (es) 1994-03-09 1994-03-09 Procedimiento de preparacion de derivados el indol.

Publications (1)

Publication Number Publication Date
UY23929A1 true UY23929A1 (es) 1995-03-21

Family

ID=8285486

Family Applications (1)

Application Number Title Priority Date Filing Date
UY23929A UY23929A1 (es) 1994-03-09 1995-03-09 Procedimiento de preparacion de derivados del indol

Country Status (6)

Country Link
BR (1) BR9500821A (es)
CO (1) CO4340738A1 (es)
EG (1) EG20611A (es)
ES (1) ES2084560B1 (es)
FI (1) FI116837B (es)
UY (1) UY23929A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007013098A1 (en) * 2005-07-25 2007-02-01 Matrix Laboratories Limited A process for the preparation of almotriptan
ES2505715T1 (es) 2013-02-06 2014-10-10 Galenicum Health S.L. Composición farmacéutica que comprende almotriptán malato que tiene una distribución y potencia uniforme
CN106478484B (zh) * 2016-08-31 2017-11-10 重庆华森制药股份有限公司 一种制备阿莫曲坦关键中间体的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1171449B (it) * 1980-08-12 1987-06-10 Glaxo Group Ltd Composti eterociclici indolici procedimento per produrli e composizioni farmaceutiche che li contengono
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
ES2033577B1 (es) * 1991-06-06 1995-01-16 Quimica Sint S A Con El 50 Procedimiento para la obtencion de la 2-carboxi-3-(2-(dimetilamino)etil)-n-metil-1h-indol-5-metanosulfonamida y sus esteres alquilicos inferiores.
ES2033578B1 (es) * 1991-06-06 1995-01-16 Quimica Sint S A Con El 50 Procedimiento para la obtencion de 3-(2-(dimetilamino)etil)-n-metil-1h-indol-5-metanosulfonamida.

Also Published As

Publication number Publication date
FI951047A0 (fi) 1995-03-07
FI116837B (fi) 2006-03-15
CO4340738A1 (es) 1996-07-30
BR9500821A (pt) 1995-11-21
ES2084560A1 (es) 1996-05-01
ES2084560B1 (es) 1997-01-16
FI951047A (fi) 1995-09-10
EG20611A (en) 1999-09-30

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Legal Events

Date Code Title Description
VENC Patent expired

Effective date: 20141115